DrC_00331
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00331 (1753 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89... 82 5e-15 sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth musc... 81 8e-15 sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth musc... 56 3e-07 sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth musc... 53 3e-06 sp|Q05623|MYBPH_CHICK Myosin-binding protein H (MyBP-H) (H-... 53 3e-06 sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 ... 51 9e-06 sp|P21804|FGFR1_CHICK Basic fibroblast growth factor recept... 51 1e-05 sp|P16092|FGFR1_MOUSE Basic fibroblast growth factor recept... 50 2e-05 sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor recept... 50 3e-05 sp|Q04589|FGFR1_RAT Basic fibroblast growth factor receptor... 50 3e-05
>sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) Length = 8081 Score = 82.0 bits (201), Expect = 5e-15 Identities = 89/371 (23%), Positives = 151/371 (40%), Gaps = 9/371 (2%) Frame = +2 Query: 95 ESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTV 274 E + AP LE++ TVN +PIRLS +V SV W KDG PL +R S Sbjct: 5376 EKRREYAPKINPPLEDK-TVNGGQPIRLSCKVDAIP--RASVVWYKDGLPLRADSRTSIQ 5432 Query: 275 FER-GYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYV 451 +E G L I S EED G Y CVA + G ++ + +P+ +V Sbjct: 5433 YEEDGTATLAINDSTEEDIGAYRCVATNAHGTINTSCSVNVKVPKQEVK----------- 5481 Query: 452 QQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQ 631 + + P+F+K L ++ ++G L+ V D + W++NGQ Sbjct: 5482 -------------KEGEEPFFTKGLV-DLWADRGDSFTLKCAVT--GDPFPEIKWYRNGQ 5525 Query: 632 SMSMGSRFNAIFDR---GYCALDILYTYPEDDGVYTCVAKNSQGEAES---SHSQITCIP 793 + G R + + G C+L + + D+G+Y C A+N+ G+A++ +H Q+ Sbjct: 5526 LLRNGPR--TVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATAHVQMALGK 5583 Query: 794 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGN 973 EK +E + P+F L D+ + GN Sbjct: 5584 TEK---------------------------------PKMDEGKPPKFILELSDMSVSLGN 5610 Query: 974 AAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGT--INYLELTRCTEIGKHNIRVV 1147 + P ++ WS + ++ DS ++ + + + L + T + R V Sbjct: 5611 VIDLECKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCV 5670 Query: 1148 ATNPLGQQSSE 1180 ATN G +++ Sbjct: 5671 ATNENGSATTK 5681
Score = 67.0 bits (162), Expect = 2e-10
Identities = 85/338 (25%), Positives = 128/338 (37%), Gaps = 6/338 (1%)
Frame = +2
Query: 47 VASFNKSKGHGVQSQYESKEFEAPHFLSNL-ENEITVNEEEPIRLSSQVSPAGDNSLSVE 223
V F + GH S+ + + P F L + I V + I +P + VE
Sbjct: 5256 VCEFQQGAGHDDGSRDDLRY--PPRFNVPLWDRRIPVGDPMFIECHVDANPTAE----VE 5309
Query: 224 WLKDGRPL--LTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRV 397
W KDG+ + T + G + I+ E D GVY+CVA ++ GQ ++ AT +V
Sbjct: 5310 WFKDGKKIEHTAHTEIRNTVD-GACRIKIIPFEESDIGVYMCVAVNELGQAETQ-ATYQV 5367
Query: 398 IPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETI 577
+ + E + + PP K TVN G P+ L
Sbjct: 5368 ----------------EILEHVEEEKRREYAPKINPPLEDK------TVNGGQPIRLSCK 5405
Query: 578 VD--PRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNS 748
VD PR +V W+K+G + SR + ++ G L I + ED G Y CVA N+
Sbjct: 5406 VDAIPR----ASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNA 5461
Query: 749 QGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAP 928
G +S S +P + EV++E E P
Sbjct: 5462 HGTINTSCSVNVKVPKQ----------------------------------EVKKEGEEP 5487
Query: 929 RFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNE 1042
F KGL D+ D G++ + P I W N +
Sbjct: 5488 FFTKGLVDLWADRGDSFTLKCAVTGDPFPEIKWYRNGQ 5525
Score = 62.8 bits (151), Expect = 3e-09
Identities = 93/381 (24%), Positives = 141/381 (37%), Gaps = 6/381 (1%)
Frame = +2
Query: 80 VQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGT 259
V Q KE E P F L ++ + + L V+ GD ++W ++G+ L G
Sbjct: 5475 VPKQEVKKEGEEPFFTKGLV-DLWADRGDSFTLKCAVT--GDPFPEIKWYRNGQLLRNGP 5531
Query: 260 RFSTVFER---GYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVN 430
R TV E G L + S D G+Y C A++ G+ ++ AT V
Sbjct: 5532 R--TVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQ-ATAHV----------- 5577
Query: 431 FIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTV 610
Q +P K + +PP F +L S+++V+ G + LE V + +V
Sbjct: 5578 ----QMALGKTEKP----KMDEGKPPKFILEL-SDMSVSLGNVIDLECKVTGLPN--PSV 5626
Query: 611 DWHKNGQSMSMGSRFNAIFD--RGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 784
W K+G + SRF + +G L I D+G Y CVA N G A
Sbjct: 5627 KWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSA-------- 5678
Query: 785 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 964
+KS + D + V + PRF + DV
Sbjct: 5679 -------TTKSFVRM------------------DDGLGSGVVTASQPPRFTLKMGDVRTT 5713
Query: 965 EGNAAKFIINIYSHPRANIVWSINNEEVV-SDSVNKFYCDGTINYLELTRCTEIGKHNIR 1141
EG K + + P +VW + V SD + + L + C R
Sbjct: 5714 EGQPLKLECKVDASPLPEMVWYKDGAIVTPSDRIQISLSPDGVATLLIPSCVYDDDGIYR 5773
Query: 1142 VVATNPLGQQSSECVLTVNSI 1204
V+ATNP G + TV +
Sbjct: 5774 VIATNPSGTAQDKGTATVKKL 5794
Score = 62.8 bits (151), Expect = 3e-09
Identities = 83/370 (22%), Positives = 146/370 (39%), Gaps = 6/370 (1%)
Frame = +2
Query: 104 EFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRF--STVF 277
E + P F+ L ++++V+ I L +V+ G + SV+W KDG PL+ +RF S
Sbjct: 5591 EGKPPKFILEL-SDMSVSLGNVIDLECKVT--GLPNPSVKWSKDGGPLIEDSRFEWSNEA 5647
Query: 278 ERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQ 457
+G L I + D G Y CVA +++G AT + +V+
Sbjct: 5648 SKGVYQLRIKNATVHDEGTYRCVATNENGS-----ATTK----------------SFVRM 5686
Query: 458 DQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVD--PRNDFTLTVDWHKNGQ 631
D + +SQPP F+ + ++ +G P+ LE VD P + W+K+G
Sbjct: 5687 DDGLGSGVVT--ASQPPRFTLKM-GDVRTTEGQPLKLECKVDASPLPEMV----WYKDGA 5739
Query: 632 SMSMGSRFN-AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIV 808
++ R ++ G L I +DDG+Y +A N G A+
Sbjct: 5740 IVTPSDRIQISLSPDGVATLLIPSCVYDDDGIYRVIATNPSGTAQDK------------- 5786
Query: 809 SKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFI 988
+++ +L + + D F + ++AP+ + L+++ I E + +
Sbjct: 5787 -----GTATVKKLPRDSGARRSADRDVF------DANKAPKLMEPLENIRIPEKQSFRLR 5835
Query: 989 INIYSHPRANIVWSINNEEVVS-DSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLG 1165
P+ I W + E V + + L + T R VA N G
Sbjct: 5836 CKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCVAENTYG 5895
Query: 1166 QQSSECVLTV 1195
+ C + V
Sbjct: 5896 SARTSCDVNV 5905
Score = 62.4 bits (150), Expect = 4e-09
Identities = 80/335 (23%), Positives = 133/335 (39%), Gaps = 8/335 (2%)
Frame = +2
Query: 215 SVEWLKDGRPLLTGTRFSTV-FERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATV 391
+++W +G P+ R + G L I EED G C+AK+++G +++
Sbjct: 5201 TLQWFLNGIPIKFDDRITLDDMADGNYCLTIRDVREEDFGTLKCIAKNENGTDET----- 5255
Query: 392 RVIPEAKVDNNVNFIENQYVQQDQNEPQHLD--KHESSQPPYFSKDLQSNITVNQGGPVH 565
V + Q H D + + PP F+ L + G P+
Sbjct: 5256 -------------------VCEFQQGAGHDDGSRDDLRYPPRFNVPLWDR-RIPVGDPMF 5295
Query: 566 LETIVDPRNDFTLTVDWHKNGQSM--SMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVA 739
+E VD T V+W K+G+ + + + D G C + I+ D GVY CVA
Sbjct: 5296 IECHVDANP--TAEVEWFKDGKKIEHTAHTEIRNTVD-GACRIKIIPFEESDIGVYMCVA 5352
Query: 740 KNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEED 919
N G+AE+ ++ Q EI H E ++
Sbjct: 5353 VNELGQAET------------------------------QATYQVEI---LEHVEEEKRR 5379
Query: 920 E-APRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTI 1090
E AP+ + L+D ++ G + + + PRA++VW + + +DS ++ DGT
Sbjct: 5380 EYAPKINPPLEDKTVNGGQPIRLSCKVDAIPRASVVWYKDGLPLRADSRTSIQYEEDGTA 5439
Query: 1091 NYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 1195
L + TE R VATN G ++ C + V
Sbjct: 5440 T-LAINDSTEEDIGAYRCVATNAHGTINTSCSVNV 5473
Score = 60.5 bits (145), Expect = 2e-08
Identities = 86/364 (23%), Positives = 138/364 (37%), Gaps = 4/364 (1%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTR--FSTV 274
+E EAP F+ L+ V + +P L +V G V+W KDG P+ +
Sbjct: 3575 EEIEAPLFVQGLK-PYEVEQGKPAELVVRVE--GKPEPEVKWFKDGVPIAIDNQHVIEKK 3631
Query: 275 FERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQ 454
E G L I + D G Y C A +K+G++++ + E K+ + + +
Sbjct: 3632 GENGSHTLVIKDTNNADFGKYTCQATNKAGKDET-------VGELKIP------KYSFEK 3678
Query: 455 QDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQS 634
Q E + P F + L+ V +G V LE V+ + + + KN Q
Sbjct: 3679 QTAEEVK----------PLFIEPLKETFAV-EGDTVVLECKVNKESH--PQIKFFKNDQP 3725
Query: 635 MSMGSRFNA-IFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVS 811
+ +G + + G L I ED G Y C A N G+A ++ D KI
Sbjct: 3726 VEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTN-------ADLKIQF 3778
Query: 812 KSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFII 991
+ + E + + E Q E ++ AP F + L+ + E A
Sbjct: 3779 AAKVEEHVTDESGQLEEIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAILKC 3838
Query: 992 NIYSHPRANIVWSINNEEV-VSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQ 1168
+ PR I W+ +EV +S V + D L T+ R A N G
Sbjct: 3839 KVKGEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGS 3898
Query: 1169 QSSE 1180
+E
Sbjct: 3899 AWTE 3902
Score = 60.1 bits (144), Expect = 2e-08
Identities = 82/372 (22%), Positives = 145/372 (38%), Gaps = 10/372 (2%)
Frame = +2
Query: 110 EAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFER-G 286
+AP + LEN I + E++ RL + S GD +++W KDG + R + G
Sbjct: 5813 KAPKLMEPLEN-IRIPEKQSFRLRCKFS--GDPKPTIKWFKDGERVFPYGRLQLIESPDG 5869
Query: 287 YVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQN 466
L + + +D+G Y CVA++ G A+ +VN I
Sbjct: 5870 VCELVVDSATRQDAGGYRCVAENTYGS-------------ARTSCDVNVIRGD------R 5910
Query: 467 EPQHLDKH-ESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSM 643
+P+ +D + P F+ L G V E + P + ++ W K+G +
Sbjct: 5911 KPRDIDSSIREGKAPGFTTPLTIR-RAKPGDSVTFECL--PFGNPFPSIKWLKDGLELFS 5967
Query: 644 GSRFN----AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVS 811
+ A + D+ + +G + CVA N G A S+ +++ D I S
Sbjct: 5968 DEKIKMEAAADGTQRLILSDVTFL---SEGYFRCVATNEHGTA-STKAELVIEGDRTIGS 6023
Query: 812 KSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFII 991
+ E+N + E+ PR +GL ++ I EGN + I+
Sbjct: 6024 RP-----------------LPEVNG-------EPEECKPRIRRGLYNMSIHEGNVVEMIV 6059
Query: 992 NIYSHPRANIVWSINNEEVVSDSVNK----FYCDGTINYLELTRCTEIGKHNIRVVATNP 1159
P + W + +E+V D + F + I++L + + + + ATN
Sbjct: 6060 CATGIPTPTVKWYKDGQEIVGDGPDGKRVIFTDERGIHHLVIVNASPDDEGEYSLEATNK 6119
Query: 1160 LGQQSSECVLTV 1195
LG +E L +
Sbjct: 6120 LGSAKTEGSLNI 6131
Score = 59.3 bits (142), Expect = 3e-08
Identities = 118/460 (25%), Positives = 176/460 (38%), Gaps = 66/460 (14%)
Frame = +2
Query: 116 PHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTV----FER 283
P + LE+++ V+ PI+L + S + +V+W K+G+ L G T+ +
Sbjct: 4588 PKIIKGLEDQV-VSIGSPIKLEIETS---GSPKTVKWYKNGKEL-PGAAAKTIKIQKIDD 4642
Query: 284 GYVVLDILYSIEEDSGVY-VCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQD 460
VL+I S+ ED+G Y V VA N S TV E K+
Sbjct: 4643 NKYVLEIPSSVVEDTGDYKVEVANEAGSANSSGKITV----EPKIT-------------- 4684
Query: 461 QNEPQHLDKHESSQPPYFSKDLQS-NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSM 637
F K L+ +IT + +ET PR V W+KNGQ +
Sbjct: 4685 -----------------FLKPLKDQSITEGENAEFSVETNTKPR-----IVKWYKNGQEI 4722
Query: 638 SMGSRF--NAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVS 811
SRF D Y L I +D Y V +N+ GEAESS +Q+T + +
Sbjct: 4723 KPNSRFIIEQKTDTKY-QLVIKNAVRDDADTYKIVLENTAGEAESS-AQLTVKKAKAGLC 4780
Query: 812 K--SHLNESSISQLKK--FESNIQEE---------------------------------- 877
K L + +++ K FE IQ E
Sbjct: 4781 KIVKGLEDQVVAKGAKMVFEVKIQGEPEDVRWLRDANVISAGANAIIEKIDDTTYRLIIP 4840
Query: 878 ---INDAFRHT-EVQEE------------DEAPRFDKGLQDVIIDEGNAAKFIINIYSHP 1009
+ DA +T EV E DE P +GL+++ I EG+ F + + S P
Sbjct: 4841 SADLKDAGEYTVEVINESGKAKSDAKGEVDEKPEIVRGLENIEIPEGDDDVFKVEV-SAP 4899
Query: 1010 RANIVWSINNEEVVSDSVNKFYCDGTINY-LELTRCTEIGKHNIRVVATNPLGQQSSECV 1186
+ W N++E+ +S + G Y L + R + +VV +N G S
Sbjct: 4900 VRQVKWYKNDQEIKPNSHLEAKKIGPKKYELAINRAQLDDGADYKVVLSNAAGDCDSSAA 4959
Query: 1187 LTVNSIN--NYAQDLKHIAPENPYKKMASLK-KVEVTPEL 1297
LTV N LK + E P + LK KVE P++
Sbjct: 4960 LTVVKPNVLKIVDGLKDVDVEEP--QPVELKVKVEGIPKV 4997
Score = 58.9 bits (141), Expect = 4e-08
Identities = 99/460 (21%), Positives = 172/460 (37%), Gaps = 79/460 (17%)
Frame = +2
Query: 98 SKEFEAPHFLSNL-ENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTR--FS 268
++ E P F+ L E+ +NE + V+ G SVEWLKDG+P+ T + +
Sbjct: 3280 TQSLEKPTFVRELVTTEVKINETATL----SVTVKGVPDPSVEWLKDGQPVQTDSSHVIA 3335
Query: 269 TVFERGYVVLDILYSIEEDSGVYVCVAKSKSG---------------------------- 364
V G + I + EDSG Y C A + +G
Sbjct: 3336 KVEGSGSYSITIKDARLEDSGKYACRATNPAGEAKTEANFAVVKNLVPPEFVEKLSPLEV 3395
Query: 365 -QNQSNPATVRVI--PEAKV----DNNVNFIENQYVQQDQ----------NEPQHLD--- 484
+ +S +V+V+ PE V D+ I+N +V Q Q N+ + D
Sbjct: 3396 KEKESTTLSVKVVGTPEPSVEWFKDDTPISIDNVHVIQKQTAVGSFSLTINDARQGDVGI 3455
Query: 485 -----KHESSQ--------------PPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLT 607
++E+ + PP F++ L+ + V + + L+ V
Sbjct: 3456 YSCRARNEAGEALTTANFGIIRDSIPPEFTQKLRP-LEVREQETLDLKVTV--IGTPVPN 3512
Query: 608 VDWHKNGQSMSMGSRFNAIFDR--GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 781
V+W K+ + +++ + D G+ L I ED GVYTC A N GEA+++
Sbjct: 3513 VEWFKDDKPINIDNSHIFAKDEGSGHHTLTIKQARGEDVGVYTCKATNEAGEAKTT---- 3568
Query: 782 TCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVII 961
+ VQEE EAP F +GL+ +
Sbjct: 3569 -------------------------------------ANMAVQEEIEAPLFVQGLKPYEV 3591
Query: 962 DEGNAAKFIINIYSHPRANIVW-------SINNEEVVSDSVNKFYCDGTINYLELTRCTE 1120
++G A+ ++ + P + W +I+N+ V+ K ++ T +
Sbjct: 3592 EQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIE---KKGENGSHTLVIKDTNNAD 3648
Query: 1121 IGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAP 1240
GK+ + ATN G+ + L + + Q + + P
Sbjct: 3649 FGKYTCQ--ATNKAGKDETVGELKIPKYSFEKQTAEEVKP 3686
Score = 58.5 bits (140), Expect = 6e-08
Identities = 92/466 (19%), Positives = 171/466 (36%), Gaps = 65/466 (13%)
Frame = +2
Query: 146 ITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEED 325
+T+ E E + +S G + +V+W + + + +T+ L I + E
Sbjct: 2084 VTIKETETAEFKATIS--GFPAPTVKWTINEKIVEESRTITTIKTEDVYTLKISNAKIEQ 2141
Query: 326 SGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQP 505
+G A++ +GQ+ S A ++V P K
Sbjct: 2142 TGTVKVTAQNSAGQD-SKQADLKVEPNVKA------------------------------ 2170
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAI-FDRGYC 682
P F L + ++G P+ +D + T V W NGQ ++ + G
Sbjct: 2171 PKFKSQLTDKVA-DEGEPLRWNLELDGPSPGT-EVSWLLNGQPLTKSDTVQVVDHGDGTY 2228
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEK---IVSKSHLNESSISQLKK 853
+ I PE G T AKN+ GE E+S +++T K V +E+++ + K
Sbjct: 2229 HVTIAEAKPEMSGTLTAKAKNAAGECETS-AKVTVNGGNKKPEFVQAPQNHETTLEESVK 2287
Query: 854 FESNI-------------------QEEINDAFRHT------------------------- 901
F + + EE+ + H
Sbjct: 2288 FSAIVTGKPMPNVTWYLNNKKLIQSEEVKVKYVHETGKTSIRIQKPLMEHNGTIRVEAEN 2347
Query: 902 -----------EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV 1048
+V ++ E P+F + D + EG KF N+ +P ++ W++N E V
Sbjct: 2348 VSGKVQATAQLKVDKKTEVPKFTTNMDDRQVKEGEDVKFTANVEGYPEPSVAWTLNGEPV 2407
Query: 1049 VS-DSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINN---YA 1216
++ DG + +E++ T + ATNP+G + + L V + + +A
Sbjct: 2408 SKHPNITVTDKDGE-HTIEISAVTPEQAGELSCEATNPVGSKKRDVQLAVKKVGDAPTFA 2466
Query: 1217 QDLK-HIAPENPYKKM-ASLKKVEVTPELTTALHKPKATAEKIVKI 1348
++L+ + E M A L V+ P++T + T++ KI
Sbjct: 2467 KNLEDRLITEGELTLMDAKLNIVKPKPKITWLKDGVEITSDGHYKI 2512
Score = 55.8 bits (133), Expect = 4e-07
Identities = 85/375 (22%), Positives = 144/375 (38%), Gaps = 8/375 (2%)
Frame = +2
Query: 95 ESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFST- 271
++ E P F+ L+ V E + + L +V+ ++ +++ K+ +P+ G
Sbjct: 3679 QTAEEVKPLFIEPLKETFAV-EGDTVVLECKVNK--ESHPQIKFFKNDQPVEIGQHMQLE 3735
Query: 272 VFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYV 451
V E G + L I + +ED G Y C A + +G+ +N A +++ AKV+ +V Q
Sbjct: 3736 VLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTN-ADLKIQFAAKVEEHVTDESGQLE 3794
Query: 452 QQDQNE---PQHLDKHESSQ-PPYFSKDLQS-NITVNQGGPVHLETIVDPRNDFTLTVDW 616
+ Q E K ++ + P F + L+S +T Q + + +PR + W
Sbjct: 3795 EIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAILKCKVKGEPRP----KIKW 3850
Query: 617 HKNGQSMSMGSRFNAIF-DRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIP 793
K G+ + M +R A D G L D G Y C A+N G A + I +
Sbjct: 3851 TKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSAWTEGPIIVTLE 3910
Query: 794 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGN 973
+ + EAP F + ++ ++ G
Sbjct: 3911 GAPKI-----------------------------------DGEAPDFLQPVKPAVVTVGE 3935
Query: 974 AAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVA 1150
A I P+ ++ W N EE+ SD V D L +T R A
Sbjct: 3936 TAVLEGKISGKPKPSVKWYKNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYRCEA 3995
Query: 1151 TNPLGQQSSECVLTV 1195
+N G S+ LTV
Sbjct: 3996 SNEFGDVWSDVTLTV 4010
Score = 50.1 bits (118), Expect = 2e-05
Identities = 85/428 (19%), Positives = 155/428 (36%), Gaps = 71/428 (16%)
Frame = +2
Query: 482 DKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNA 661
++ ES P F KD++ TV G ET V R + V W NG M GS
Sbjct: 938 EEEESRSAPTFLKDIEDQ-TVKTGEFAVFETTV--RGNPNPEVTWFINGHKMDQGSPGVK 994
Query: 662 IFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEK---------IVSK 814
I + + + G C A+N+ G E+ + P+++ +V K
Sbjct: 995 IEAHNHDH-KLTIDSAQYAGTVLCRAENAVGRFETKARLVVLAPEKQKKPPKFVEILVDK 1053
Query: 815 SH----------------------------LNESSISQLKKFESNIQ-----------EE 877
+ L +S ++++F+ +I+ E
Sbjct: 1054 TETVDNTVVFEVRVEGEPKPTVTWYLKGEELKQSDRVEIREFDGSIKISIKNIKIEDAGE 1113
Query: 878 INDAFRHTE----------VQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVW 1027
I ++E VQ++ AP FD + +++G+ A F + + P W
Sbjct: 1114 IRAVATNSEGSDETKAKLTVQKKPFAPEFDLRPVSLTVEKGSEAVFSAHAFGIPLPTYEW 1173
Query: 1028 SINNEEV--VSDSVNKFYCDGTINYLEL------TRCTEIGKHNIRVVATNPLGQQSSEC 1183
S+N +V + + T++ + T +E+ I VVA N LG + +
Sbjct: 1174 SVNGRKVRDGQEGARVTRDESTVDGASILTIDTATYYSEVNHLTISVVAENTLGAEETGA 1233
Query: 1184 VLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTAL-HKPKATAEKIVKIERNV 1360
LT+ K + +K + + E +PE TT + + T+ K +
Sbjct: 1234 QLTIEPKKESVVVEKQDLSSSEVQKEIAQQVKEASPEATTTITMETSLTSTKTTTMSTTE 1293
Query: 1361 EVNARHAKTADIKEAEDLYDKVAANLKS----KGNISTGRRPVMTQGDSRMPPQPVAARS 1528
+ T + KE+E S +G+IS + V+++ DS+ + +
Sbjct: 1294 VTSTVGGVTVETKESESESATTVIGGGSGGVTEGSISVSKIEVVSKTDSQTDVREGTPKR 1353
Query: 1529 NVEYEHTE 1552
V + E
Sbjct: 1354 RVSFAEEE 1361
Score = 50.1 bits (118), Expect = 2e-05
Identities = 68/372 (18%), Positives = 136/372 (36%), Gaps = 10/372 (2%)
Frame = +2
Query: 110 EAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGY 289
E P FL L N V ++ +V GD S+ W + + +L ++ V +
Sbjct: 2752 EPPDFLEWLSN---VRARTGTKVVHKVVFTGDPKPSLTWYINNKEILNSDLYTIVTDDKT 2808
Query: 290 VVLDI-LYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQN 466
L I ++ + G +C A++ +G+ + + ++ ++V D
Sbjct: 2809 STLTINSFNPDVHVGEIICKAENDAGEVSCTANMITYTSDMFSESESEAQAEEFVGDDLT 2868
Query: 467 EPQHL--DKHESSQPPYFSKDLQS--NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQS 634
E + L + H + P K + + +G E +V + W K+G+
Sbjct: 2869 EDESLREEMHRTPTPVMAPKFITKIKDTKAKKGHSAVFECVVPDTKG--VCCKWLKDGKE 2926
Query: 635 MSMGSRFNA---IFDRGYCALDILY--TYPEDDGVYTCVAKNSQGEAESSHSQITCIPDE 799
+ + +R G+ +++ PED G YTC+ +N+ G+ TC
Sbjct: 2927 IELIARIRVQTRTGPEGHITQELVLDNVTPEDAGKYTCIVENTAGKD-------TC---- 2975
Query: 800 KIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAA 979
E++++ ++ E + E +AP F LQD
Sbjct: 2976 ---------EATLTVIESLEK---------------KSEKKAPEFIVALQDKTTKTSEKV 3011
Query: 980 KFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNP 1159
+ P+ + W +N+ + +S+ +G + + +T + +A N
Sbjct: 3012 VLECKVIGEPKPKVSWLHDNKTITQESITVESVEG-VERVTITSSELSHQGKYTCIAENT 3070
Query: 1160 LGQQSSECVLTV 1195
G +E LTV
Sbjct: 3071 EGTSKTEAFLTV 3082
Score = 48.5 bits (114), Expect = 6e-05
Identities = 76/379 (20%), Positives = 129/379 (34%), Gaps = 63/379 (16%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE 280
KE P F++ L ++ E + I +V G + WL D +PL F ++
Sbjct: 643 KEAAPPAFVTKLRDK-ECKEGDVIDFECEVE--GWPEPELVWLVDDQPLRPSHDFRLQYD 699
Query: 281 RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQD 460
L+I + +D+GVY K+ N IE++
Sbjct: 700 GQTAKLEIRDAQPDDTGVYT----------------------VKIQNEFGSIESKAELFV 737
Query: 461 QNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIV--DPRNDFTLTVDWHKNGQS 634
Q +P DK+ + P F ++ + ++G V ++++ DP + + W NG+
Sbjct: 738 QADP---DKNHVA--PEFQATIEY-VECDEGEEVRFKSVITGDPNPE----IIWFINGKP 787
Query: 635 MSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSK 814
+S + I + G C L I DG+ TC N G A +P
Sbjct: 788 LSESEKVKFISEDGICILTIKDVTRHFDGMVTCQGSNRLGSASCDGRLKVRVPPAPPTFN 847
Query: 815 SHLNESSI--------------------------SQLKKFESNIQEEINDAF-------- 892
L + ++ +LK E ++ +D F
Sbjct: 848 KPLEDKTVQEKSTVVFEVDVSGWPEPTLTFTLCGKELKNGEEGVEIVGHDGFYRISIPNT 907
Query: 893 ------------------------RHTEVQEEDE---APRFDKGLQDVIIDEGNAAKFII 991
R T QEE+E AP F K ++D + G A F
Sbjct: 908 SMDKHDGEIVAKAQNEHGTAESRARLTVEQEEEESRSAPTFLKDIEDQTVKTGEFAVFET 967
Query: 992 NIYSHPRANIVWSINNEEV 1048
+ +P + W IN ++
Sbjct: 968 TVRGNPNPEVTWFINGHKM 986
Score = 47.4 bits (111), Expect = 1e-04
Identities = 59/252 (23%), Positives = 103/252 (40%), Gaps = 7/252 (2%)
Frame = +2
Query: 32 DQFNHVASFNKSKGHGVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNS 211
D ++ A S G + + + EAP F L+ + +V E+E I++ +V G ++
Sbjct: 3161 DIVSYKAIATNSIGTATSTSKITTKVEAPVFEQGLK-KTSVKEKEEIKMEVKV---GGSA 3216
Query: 212 LSVEWLKDGRPLLTGTRFSTVF--ERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPA 385
VEW KD +P+ E G L + + D+G Y A + +G +S+
Sbjct: 3217 PDVEWFKDDKPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSA- 3275
Query: 386 TVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDL-QSNITVNQGGP- 559
EA+V +S + P F ++L + + +N+
Sbjct: 3276 ------EAEVT------------------------QSLEKPTFVRELVTTEVKINETATL 3305
Query: 560 -VHLETIVDPRNDFTLTVDWHKNGQSMSMGSR--FNAIFDRGYCALDILYTYPEDDGVYT 730
V ++ + DP +V+W K+GQ + S + G ++ I ED G Y
Sbjct: 3306 SVTVKGVPDP------SVEWLKDGQPVQTDSSHVIAKVEGSGSYSITIKDARLEDSGKYA 3359
Query: 731 CVAKNSQGEAES 766
C A N GEA++
Sbjct: 3360 CRATNPAGEAKT 3371
Score = 46.6 bits (109), Expect = 2e-04
Identities = 52/242 (21%), Positives = 88/242 (36%), Gaps = 6/242 (2%)
Frame = +2
Query: 533 NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSM---GSRFNAIFDRGYCALDILYT 703
++ V + PV L+ V+ + W+KNGQ + G +F + G +L I +
Sbjct: 4976 DVDVEEPQPVELKVKVE---GIPKVIKWYKNGQELKPDADGFKFEEKPESGEFSLTIPSS 5032
Query: 704 YPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEIN 883
D G Y V N +GE S S+ +K +S+
Sbjct: 5033 KKSDGGAYRVVLGNDKGEVYS---------------------GSVVHVKSAKSS------ 5065
Query: 884 DAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDS- 1060
E F L+D ++EG+ I P ++W + + D
Sbjct: 5066 ---------EPTSGANFLSPLKDTEVEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKDDR 5116
Query: 1061 -VNKFYCDGTINY-LELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHI 1234
+ DGT + + ++IG++ RV A N G +S+C +TV K +
Sbjct: 5117 ITMRVALDGTATLRIRSAKKSDIGQY--RVTAKNEAGSATSDCKVTVTEQGEQPSKPKFV 5174
Query: 1235 AP 1240
P
Sbjct: 5175 IP 5176
Score = 45.8 bits (107), Expect = 4e-04
Identities = 70/327 (21%), Positives = 105/327 (32%), Gaps = 1/327 (0%)
Frame = +2
Query: 218 VEWLKDGRPLLTGTRFSTVF-ERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVR 394
+ W KD L R + E G+ + I D+G Y C+A ++ GQ S A R
Sbjct: 579 ITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQ-ASTSAFFR 637
Query: 395 VIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLET 574
V+ K + PP F L+ +G + E
Sbjct: 638 VLKVEK---------------------------EAAPPAFVTKLRDK-ECKEGDVIDFEC 669
Query: 575 IVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQG 754
V+ + L W + Q + F +D L+I P+D GVYT +N G
Sbjct: 670 EVEGWPEPELV--WLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTVKIQNEFG 727
Query: 755 EAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRF 934
ES + F + + AP F
Sbjct: 728 SIESKA-------------------------------------ELFVQADPDKNHVAPEF 750
Query: 935 DKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRC 1114
++ V DEG +F I P I+W IN + + KF + I L +
Sbjct: 751 QATIEYVECDEGEEVRFKSVITGDPNPEIIWFINGKPLSESEKVKFISEDGICILTIKDV 810
Query: 1115 TEIGKHNIRVVATNPLGQQSSECVLTV 1195
T + +N LG S + L V
Sbjct: 811 TRHFDGMVTCQGSNRLGSASCDGRLKV 837
Score = 45.1 bits (105), Expect = 7e-04
Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 1/104 (0%)
Frame = +2
Query: 116 PHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYVV 295
P+F+ L N+ T + +P+R+ +V G+ ++W+K+ RP++ +R V + Y+
Sbjct: 6507 PNFIQPLVNK-TFSSAQPMRMDVRVD--GEPFPELKWMKEWRPIVESSRIKFVQDGPYLC 6563
Query: 296 LDILYS-IEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNN 424
I+ + DSG+Y CVA + +GQ + TV V EA+ D N
Sbjct: 6564 SLIINDPMWRDSGIYSCVAVNDAGQ-ATTSCTVTV--EAEGDYN 6604
Score = 43.9 bits (102), Expect = 0.001
Identities = 46/215 (21%), Positives = 78/215 (36%), Gaps = 3/215 (1%)
Frame = +2
Query: 608 VDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 784
+ W+K+ + R D G+ A+ I D G YTC+A N G+A +S
Sbjct: 579 ITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQASTSAF--- 635
Query: 785 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 964
FR +V++E P F L+D
Sbjct: 636 -----------------------------------FRVLKVEKEAAPPAFVTKLRDKECK 660
Query: 965 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLEL--TRCTEIGKHNI 1138
EG+ F + P +VW ++++ + + DG LE+ + + G + +
Sbjct: 661 EGDVIDFECEVEGWPEPELVWLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTV 720
Query: 1139 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPE 1243
++ N G S+ L V + D H+APE
Sbjct: 721 KI--QNEFGSIESKAELFVQA----DPDKNHVAPE 749
Score = 40.0 bits (92), Expect = 0.021
Identities = 51/230 (22%), Positives = 90/230 (39%), Gaps = 5/230 (2%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE 280
K+ E P F +N+++ V E E ++ ++ V G SV W +G P+ + +
Sbjct: 2362 KKTEVPKFTTNMDDR-QVKEGEDVKFTANVE--GYPEPSVAWTLNGEPVSKHPNITVTDK 2418
Query: 281 RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSN-PATVRVIPEAKVDNNVNFIENQYVQQ 457
G ++I E +G C A + G + + V+ + +A
Sbjct: 2419 DGEHTIEISAVTPEQAGELSCEATNPVGSKKRDVQLAVKKVGDA---------------- 2462
Query: 458 DQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLE---TIVDPRNDFTLTVDWHKNG 628
P F+K+L+ + + +G ++ IV P+ T W K+G
Sbjct: 2463 ----------------PTFAKNLEDRL-ITEGELTLMDAKLNIVKPKPKIT----WLKDG 2501
Query: 629 QSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHS 775
++ + + + G L IL T ED G T A++ G AE S S
Sbjct: 2502 VEITSDGHYKIVEEEDGSLKLSILQTKLEDKGRITIKAESEFGVAECSAS 2551
Score = 40.0 bits (92), Expect = 0.021
Identities = 64/298 (21%), Positives = 111/298 (37%), Gaps = 13/298 (4%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVF-ERGY 289
AP F+ L + TV E++ L +V G+ ++W K+G+ + R + G
Sbjct: 3816 APEFVELLRS-CTVTEKQQAILKCKVK--GEPRPKIKWTKEGKEVEMSARVRAEHKDDGT 3872
Query: 290 VVLDILYSIEEDSGVYVCVAKSKSGQNQSN-PATVRVIPEAKVDNNVNFIENQYVQQDQN 466
+ L + D+G Y C A+++ G + P V + K+D
Sbjct: 3873 LTLTFDNVTQADAGEYRCEAENEYGSAWTEGPIIVTLEGAPKIDGEA------------- 3919
Query: 467 EPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMG 646
P + + +TV + + + P+ +V W+KNG+ +
Sbjct: 3920 ------------PDFLQPVKPAVVTVGETAVLEGKISGKPKP----SVKWYKNGEELKPS 3963
Query: 647 SRFN-AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHL 823
R D G L + +D Y C A N G+ S + P + V+
Sbjct: 3964 DRVKIENLDDGTQRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLTVKEPAQ--VAPGFF 4021
Query: 824 NESSISQLK-----KFESNIQEEINDA--FRHTEVQEEDEAPRF---DKGLQDVIIDE 967
E S Q+K KFE + D F+ +ED+ F D G Q ++I++
Sbjct: 4022 KELSAIQVKETETAKFECKVSGTKPDVKWFKDGTPLKEDKRVHFESTDDGTQRLVIED 4079
Score = 38.9 bits (89), Expect = 0.048
Identities = 50/183 (27%), Positives = 81/183 (44%), Gaps = 9/183 (4%)
Frame = +2
Query: 350 KSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQH---LDKHESSQPPYFSK 520
K++ G + N + VIP+A D+ + + +D N L ++ P K
Sbjct: 4535 KAQPGSDGDNKPQL-VIPDAGDDDAAEY-KVVLTDEDGNTADSSCALTVKLPAKEPKIIK 4592
Query: 521 DLQSNITVNQGGPVHLE--TIVDPRNDFTLTVDWHKNGQSMSMGS----RFNAIFDRGYC 682
L+ + V+ G P+ LE T P+ TV W+KNG+ + + + I D Y
Sbjct: 4593 GLEDQV-VSIGSPIKLEIETSGSPK-----TVKWYKNGKELPGAAAKTIKIQKIDDNKY- 4645
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFES 862
L+I + ED G Y N G A SS +IT P KI L + SI++ + E
Sbjct: 4646 VLEIPSSVVEDTGDYKVEVANEAGSANSS-GKITVEP--KITFLKPLKDQSITEGENAEF 4702
Query: 863 NIQ 871
+++
Sbjct: 4703 SVE 4705
Score = 38.1 bits (87), Expect = 0.081
Identities = 87/438 (19%), Positives = 163/438 (37%), Gaps = 77/438 (17%)
Frame = +2
Query: 455 QDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQS 634
+ + E + L+ + ++ P F+ L+ ++ V +G V ++ I + W++NG
Sbjct: 1965 ETKTELKVLETPKETKKPEFTDKLR-DMEVTKGDTVQMDVIAL----HSPLYKWYQNGNL 2019
Query: 635 MSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIP------- 793
+ G I + + ++ +D G T A N G +ESS +Q+T P
Sbjct: 2020 LEDGKNGVTIKNEENKS-SLIIPNAQDSGKITVEASNEVGSSESS-AQLTVNPPSTTPIV 2077
Query: 794 ---------------------------------DEKIVSKSH--------------LNES 832
+EKIV +S ++ +
Sbjct: 2078 VDGPKSVTIKETETAEFKATISGFPAPTVKWTINEKIVEESRTITTIKTEDVYTLKISNA 2137
Query: 833 SISQLKKFESNIQEEINDAFRHTEVQEED--EAPRFDKGLQDVIIDEGNAAKFIINIYS- 1003
I Q + Q + +++ E +AP+F L D + DEG ++ + +
Sbjct: 2138 KIEQTGTVKVTAQNSAGQDSKQADLKVEPNVKAPKFKSQLTDKVADEGEPLRWNLELDGP 2197
Query: 1004 HPRANIVWSINNEEVV-SDSVNKF-YCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSS 1177
P + W +N + + SD+V + DGT ++ + + A N G+ +
Sbjct: 2198 SPGTEVSWLLNGQPLTKSDTVQVVDHGDGTY-HVTIAEAKPEMSGTLTAKAKNAAGECET 2256
Query: 1178 ECVLTVNSINNYAQDLKHIAPEN------PYKKMASLKKVEVTPELTTALHKPKATAEKI 1339
+TVN N + ++ AP+N K +++ + P +T L+ K +
Sbjct: 2257 SAKVTVNGGNKKPEFVQ--APQNHETTLEESVKFSAIVTGKPMPNVTWYLNNKKLIQSEE 2314
Query: 1340 VKIERNVEVN----------ARHAKTADIKEAEDLYDKVAANLKSKGNISTGRRPVMTQG 1489
VK++ E H T + EAE++ KV A + K + T T
Sbjct: 2315 VKVKYVHETGKTSIRIQKPLMEHNGTIRV-EAENVSGKVQATAQLKVDKKTEVPKFTTNM 2373
Query: 1490 DSRM--PPQPVAARSNVE 1537
D R + V +NVE
Sbjct: 2374 DDRQVKEGEDVKFTANVE 2391
Score = 37.7 bits (86), Expect = 0.11
Identities = 98/488 (20%), Positives = 174/488 (35%), Gaps = 66/488 (13%)
Frame = +2
Query: 80 VQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGT 259
++S + E +AP F+ L+++ T E+ + + G+ V WL D + + T
Sbjct: 2982 IESLEKKSEKKAPEFIVALQDKTTKTSEKVVL---ECKVIGEPKPKVSWLHDNKTI-TQE 3037
Query: 260 RFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIE 439
+ G + I S G Y C+A++ G +++ A + V EA
Sbjct: 3038 SITVESVEGVERVTITSSELSHQGKYTCIAENTEGTSKTE-AFLTVQGEA---------- 3086
Query: 440 NQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIV----DPRNDFTLT 607
P F+K+LQ N ++ G + L V P DF
Sbjct: 3087 ----------------------PVFTKELQ-NKELSIGEKLVLSCSVKGSPQPHVDFYSF 3123
Query: 608 VDWHKNGQSMSMGSRFNAIFDRG--YCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 781
+ K ++ SR D+ + + I ED Y +A NS G A S+
Sbjct: 3124 SETTKVETKITSSSRIAIEHDQTNTHWRMVISQITKEDIVSYKAIATNSIGTATSTSKIT 3183
Query: 782 TCIPDEKIVSKSHLNESSISQLKKFESNI------------------------------- 868
T + E V + L ++S+ + ++ + +
Sbjct: 3184 TKV--EAPVFEQGLKKTSVKEKEEIKMEVKVGGSAPDVEWFKDDKPVSEDGNHEMKKNPE 3241
Query: 869 ---------QEEINDAFRHT----------------EVQEEDEAPRFDKGLQDVIIDEGN 973
Q DA ++T EV + E P F + L +
Sbjct: 3242 TGVFTLVVKQAATTDAGKYTAKASNPAGTAESSAEAEVTQSLEKPTFVRELVTTEVKINE 3301
Query: 974 AAKFIINIYSHPRANIVWSINNEEVVSDSVNKF-YCDGTINY---LELTRCTEIGKHNIR 1141
A + + P ++ W + + V +DS + +G+ +Y ++ R + GK+ R
Sbjct: 3302 TATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAKVEGSGSYSITIKDARLEDSGKYACR 3361
Query: 1142 VVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKPK 1321
ATNP G+ +E V +K++ P +K++ L+ E E TT K
Sbjct: 3362 --ATNPAGEAKTEANFAV---------VKNLVPPEFVEKLSPLEVKE--KESTTLSVKVV 3408
Query: 1322 ATAEKIVK 1345
T E V+
Sbjct: 3409 GTPEPSVE 3416
Score = 36.6 bits (83), Expect = 0.24
Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 1/114 (0%)
Frame = +2
Query: 431 FIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTV 610
F +N Y QN L + P +K T + P+ ++ VD + +
Sbjct: 6487 FAKNDYGDAQQNIMVDLATRPNFIQPLVNK------TFSSAQPMRMDVRVD--GEPFPEL 6538
Query: 611 DWHKNGQSMSMGSRFNAIFDRGY-CALDILYTYPEDDGVYTCVAKNSQGEAESS 769
W K + + SR + D Y C+L I D G+Y+CVA N G+A +S
Sbjct: 6539 KWMKEWRPIVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTS 6592
>sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth muscle and non-muscle isozymes (MLCK) [Contains: Telokin] Length = 1906 Score = 81.3 bits (199), Expect = 8e-15 Identities = 94/377 (24%), Positives = 151/377 (40%), Gaps = 4/377 (1%) Frame = +2 Query: 77 GVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTG 256 G+ Q+ES+ + +E + I+ S+VS G VEW K+G P+ TG Sbjct: 426 GIPPQFESRP-----------QSLEASEGQEIKFKSKVS--GKPKPDVEWFKEGVPIKTG 472 Query: 257 TRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFI 436 E G L + + DSG Y C A + GQ ++ + + KV+ Sbjct: 473 EGIQIYEEDGTHCLWLKKACLGDSGSYSCAAFNPRGQTSTS--WLLTVKRPKVEEVA--- 527 Query: 437 ENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVD--PRNDFTLTV 610 P FS L+ TV++G L+ V P + T Sbjct: 528 -----------------------PCFSSVLKG-CTVSEGQDFVLQCYVGGVPVPEIT--- 560 Query: 611 DWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCI 790 W N Q + ++ F+ G L + PEDDG+YTC+A+N+ G A S +Q+T + Sbjct: 561 -WLLNEQPIQYA---HSTFEAGVAKLTVQDALPEDDGIYTCLAENNAGRASCS-AQVT-V 614 Query: 791 PDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEG 970 ++K KK E ++N F AP F KGL D+ + +G Sbjct: 615 KEKK-------------SSKKAEGTQAAKLNKTF----------APIFLKGLTDLKVMDG 651 Query: 971 NAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGT--INYLELTRCTEIGKHNIRV 1144 + + + ++P I+W N +E+ F G Y++ + GK+ Sbjct: 652 SQVIMTVEVSANPCPEIIWLHNGKEIQETEDFHFEKKGNEYSLYIQEVFPEDTGKYTCE- 710 Query: 1145 VATNPLGQQSSECVLTV 1195 A N LG+ ++ LTV Sbjct: 711 -AWNELGETQTQATLTV 726
Score = 51.2 bits (121), Expect = 9e-06
Identities = 62/258 (24%), Positives = 92/258 (35%), Gaps = 24/258 (9%)
Frame = +2
Query: 218 VEWLKDGRPLLTGTRFSTVFE-RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVR 394
+ W ++G PL G + RG L I E DSG Y C A + G Q TV
Sbjct: 59 ITWYRNGHPLPEGDHYVVDHSIRGIFSLVIKGVQEGDSGKYTCEAANDGGVRQ---VTVE 115
Query: 395 VIPEAKVDNNVNFIENQYVQQDQNEP---------QHLDKHESSQPPYFSKDLQSNITVN 547
+ E N ++ + P +H PP F+ + + V
Sbjct: 116 LTVEG------NSLKKYSLPSSAKTPGGRLSVPPVEHRPSIWGESPPKFATK-PNRVVVR 168
Query: 548 QGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVY 727
+G + R +T W K + RFN G L+I D G+Y
Sbjct: 169 EGQTGRFSCKITGRPQPQVT--WTKGDIHLQQNERFNMFEKTGIQYLEIQNVQLADAGIY 226
Query: 728 TCVAKNSQGEAESS-------------HSQITCIPDEKIVSKSHLNESSISQLKKFESN- 865
TC NS G+A S H+Q C+P + + E+ S K+ SN
Sbjct: 227 TCTVVNSAGKASVSAELTVQGPDKTDTHAQPLCMPPKPTTLATKAIEN--SDFKQATSNG 284
Query: 866 IQEEINDAFRHTEVQEED 919
I +E+ V+ +D
Sbjct: 285 IAKELKSTSTELMVETKD 302
Score = 49.7 bits (117), Expect = 3e-05
Identities = 59/234 (25%), Positives = 96/234 (41%), Gaps = 3/234 (1%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYV 292
AP F S L+ TV+E + L V G + WL + +P+ + FE G
Sbjct: 527 APCFSSVLKG-CTVSEGQDFVLQCYVG--GVPVPEITWLLNEQPIQYA---HSTFEAGVA 580
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQNQ-SNPATVRVIPEAKVDNNVNFIENQYVQQDQNE 469
L + ++ ED G+Y C+A++ +G+ S TV+ +K + E
Sbjct: 581 KLTVQDALPEDDGIYTCLAENNAGRASCSAQVTVKEKKSSK----------------KAE 624
Query: 470 PQHLDKHESSQPPYFSKDLQSNITVNQGGPVHL--ETIVDPRNDFTLTVDWHKNGQSMSM 643
K + P F K L +++ V G V + E +P + + W NG+ +
Sbjct: 625 GTQAAKLNKTFAPIFLKGL-TDLKVMDGSQVIMTVEVSANPCPE----IIWLHNGKEIQE 679
Query: 644 GSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKI 805
F+ +L I +PED G YTC A N GE ++ + P + I
Sbjct: 680 TEDFHFEKKGNEYSLYIQEVFPEDTGKYTCEAWNELGETQTQATLTVQEPQDGI 733
Score = 46.6 bits (109), Expect = 2e-04
Identities = 38/135 (28%), Positives = 61/135 (45%), Gaps = 1/135 (0%)
Frame = +2
Query: 359 SGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNI 538
SG+ S + I KV+N E+ ++++ E H+ PYF+K + ++
Sbjct: 1757 SGRKASGSSPTSPINADKVEN-----EDAFLEEVAEEKPHVK-------PYFTKTIL-DM 1803
Query: 539 TVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPED 715
V +G + ++ D V W+K+ Q + F +D G C+L I +D
Sbjct: 1804 EVVEGSAARFDCKIEGYPD--PEVMWYKDDQPVKESRHFQIDYDEEGNCSLTISEVCGDD 1861
Query: 716 DGVYTCVAKNSQGEA 760
D YTC A NS GEA
Sbjct: 1862 DAKYTCKAVNSLGEA 1876
Score = 42.4 bits (98), Expect = 0.004
Identities = 61/299 (20%), Positives = 109/299 (36%), Gaps = 6/299 (2%)
Frame = +2
Query: 533 NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFD-RGYCALDILYTYP 709
NI V G E V + +T W++NG + G + RG +L I
Sbjct: 36 NIRVQLGATARFEGKVRGYPEPQIT--WYRNGHPLPEGDHYVVDHSIRGIFSLVIKGVQE 93
Query: 710 EDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDA 889
D G YTC A N G + + E V + L + S+ K
Sbjct: 94 GDSGKYTCEAANDGGVRQ--------VTVELTVEGNSLKKYSLPSSAKTPGGRLSV--PP 143
Query: 890 FRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNK 1069
H + P+F V++ EG +F I P+ + W+ + + +
Sbjct: 144 VEHRPSIWGESPPKFATKPNRVVVREGQTGRFSCKITGRPQPQVTWTKGDIHLQQNERFN 203
Query: 1070 FYCDGTINYLEL--TRCTEIGKHNIRVVATNPLGQQSSECVLTV---NSINNYAQDLKHI 1234
+ I YLE+ + + G + VV N G+ S LTV + + +AQ L +
Sbjct: 204 MFEKTGIQYLEIQNVQLADAGIYTCTVV--NSAGKASVSAELTVQGPDKTDTHAQPL-CM 260
Query: 1235 APENPYKKMASLKKVEVTPELTTALHKPKATAEKIVKIERNVEVNARHAKTADIKEAED 1411
P+ +++ + + + K + + +E ++A+ +EA+D
Sbjct: 261 PPKPTTLATKAIENSDFKQATSNGIAKELKSTSTELMVETKDRLSAKKETFYTSREAKD 319
Score = 41.6 bits (96), Expect = 0.007
Identities = 33/150 (22%), Positives = 60/150 (40%)
Frame = +2
Query: 887 AFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN 1066
A + T + AP F + LQD + +G I S P A++ W+++++ + S
Sbjct: 1071 ASKPTPPPSKGTAPSFTEKLQDAKVADGEKLVLQCRISSDPPASVSWTLDSKAIKSSKSI 1130
Query: 1067 KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPEN 1246
+GT+ L + + + +A N G+ C + V +D
Sbjct: 1131 VISQEGTLCSLTIEKVMPEDGGEYKCIAENAAGKAECACKVLV-------EDTSSTKAAK 1183
Query: 1247 PYKKMASLKKVEVTPELTTALHKPKATAEK 1336
P +K K + P L+T +AT +K
Sbjct: 1184 PAEKKTKKPKTTLPPVLST--ESSEATVKK 1211
Score = 39.3 bits (90), Expect = 0.037
Identities = 56/255 (21%), Positives = 95/255 (37%)
Frame = +2
Query: 59 NKSKGHGVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDG 238
+ K G Q+ +K F AP FL L ++ V + + ++ +VS + + WL +G
Sbjct: 619 SSKKAEGTQAAKLNKTF-APIFLKGL-TDLKVMDGSQVIMTVEVS--ANPCPEIIWLHNG 674
Query: 239 RPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVD 418
+ + F + L I ED+G Y C A ++ G+ Q+ AT+ V
Sbjct: 675 KEIQETEDFHFEKKGNEYSLYIQEVFPEDTGKYTCEAWNELGETQTQ-ATLTV------- 726
Query: 419 NNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDF 598
EPQ + QP + SK Q + DP
Sbjct: 727 ---------------QEPQ-----DGIQPWFISKPRSVTAAAGQNVLISCAIAGDPFP-- 764
Query: 599 TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQ 778
TV W K+GQ ++ G+ + + L + G Y +N GE Q
Sbjct: 765 --TVHWFKDGQEITPGTGCEILQNEDIFTLILRNVQSRHAGQYEIQLRNQVGECS---CQ 819
Query: 779 ITCIPDEKIVSKSHL 823
++ + E S++ +
Sbjct: 820 VSLMLRESSASRAEM 834
Score = 36.6 bits (83), Expect = 0.24
Identities = 24/86 (27%), Positives = 42/86 (48%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCA 685
P F++ LQ + V G + L+ + +D +V W + +++ + C+
Sbjct: 1084 PSFTEKLQ-DAKVADGEKLVLQCRIS--SDPPASVSWTLDSKAIKSSKSIVISQEGTLCS 1140
Query: 686 LDILYTYPEDDGVYTCVAKNSQGEAE 763
L I PED G Y C+A+N+ G+AE
Sbjct: 1141 LTIEKVMPEDGGEYKCIAENAAGKAE 1166
Score = 35.4 bits (80), Expect = 0.53
Identities = 34/136 (25%), Positives = 59/136 (43%), Gaps = 3/136 (2%)
Frame = +2
Query: 371 QSNPA-TVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVN 547
Q NP+ T +V P ++ N + V++++ EP + PP F QS + +
Sbjct: 391 QENPSLTGQVSPRSRETENRAGVRKS-VKEEKREPLGI-------PPQFESRPQS-LEAS 441
Query: 548 QGGPVHLETIVD--PRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDG 721
+G + ++ V P+ D V+W K G + G + G L + D G
Sbjct: 442 EGQEIKFKSKVSGKPKPD----VEWFKEGVPIKTGEGIQIYEEDGTHCLWLKKACLGDSG 497
Query: 722 VYTCVAKNSQGEAESS 769
Y+C A N +G+ +S
Sbjct: 498 SYSCAAFNPRGQTSTS 513
Score = 33.1 bits (74), Expect = 2.6
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Frame = +2
Query: 875 EINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV 1048
E DAF +E+ P F K + D+ + EG+AA+F I +P ++W +++ V
Sbjct: 1776 ENEDAFLEEVAEEKPHVKPYFTKTILDMEVVEGSAARFDCKIEGYPDPEVMWYKDDQPV 1834
Score = 31.6 bits (70), Expect = 7.6
Identities = 23/85 (27%), Positives = 38/85 (44%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYV 292
AP F L+ + V + E + L ++S D SV W D + + + E
Sbjct: 1083 APSFTEKLQ-DAKVADGEKLVLQCRIS--SDPPASVSWTLDSKAIKSSKSIVISQEGTLC 1139
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQ 367
L I + ED G Y C+A++ +G+
Sbjct: 1140 SLTIEKVMPEDGGEYKCIAENAAGK 1164
>sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth muscle and non-muscle isozymes (MLCK) [Contains: Telokin (Kinase related protein) (KRP)] Length = 1914 Score = 56.2 bits (134), Expect = 3e-07 Identities = 83/369 (22%), Positives = 135/369 (36%), Gaps = 1/369 (0%) Frame = +2 Query: 116 PHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE-RGYV 292 P F S +++ V E + ++ +VS G V W +G P+ V+E G Sbjct: 414 PKFESKPQSQ-EVKENQTVKFRCEVS--GIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSH 470 Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEP 472 L +L + DSG Y C A + GQ S T++V A ++ Sbjct: 471 YLCLLKARTRDSGTYSCTASNAQGQ-VSCSWTLQVERLAVME------------------ 511 Query: 473 QHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSR 652 P FS L+ + V +G L+ V R + W NGQ + Sbjct: 512 ---------VAPSFSSVLK-DCAVIEGQDFVLQCSV--RGTPVPRITWLLNGQPIQYA-- 557 Query: 653 FNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNES 832 + + G L I PED G YTC+A+N+ G+ S S + ++K KS Sbjct: 558 -RSTCEAGVAELHIQDALPEDHGTYTCLAENALGQV--SCSAWVTVHEKKSSRKSE---- 610 Query: 833 SISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPR 1012 + + AP F +GL D+ + +G+ + + +P Sbjct: 611 -------------------YLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPP 651 Query: 1013 ANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLT 1192 ++W N E+ F GT + L + A N G+ ++ VLT Sbjct: 652 PEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRTQAVLT 711 Query: 1193 VNSINNYAQ 1219 V ++ Q Sbjct: 712 VQEPHDGTQ 720
Score = 53.5 bits (127), Expect = 2e-06
Identities = 64/263 (24%), Positives = 101/263 (38%), Gaps = 4/263 (1%)
Frame = +2
Query: 110 EAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE-RG 286
EAP F+ N + + E + +V G V W ++G+P+ +G RF RG
Sbjct: 31 EAPAFILPPRN-LCIKEGATAKFEGRVR--GYPEPQVTWHRNGQPITSGGRFLLDCGIRG 87
Query: 287 YVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQN 466
L I EED G Y C A + SG Q TV + E + D+
Sbjct: 88 TFSLVIHAVHEEDRGKYTCEATNGSGARQ---VTVELTVEGSFAKQLGQPVVSKTLGDRF 144
Query: 467 EPQHLDKHES---SQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSM 637
++ S PP F+ L + V +G + R +T W K +
Sbjct: 145 SASAVETRPSIWGECPPKFATKL-GRVVVKEGQMGRFSCKITGRPQPQVT--WLKGNVPL 201
Query: 638 SMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKS 817
+R + G L+I +D GVYTC+ N G+A S + I
Sbjct: 202 QPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS-------AELSIQGLD 254
Query: 818 HLNESSISQLKKFESNIQEEIND 886
N S + + K S++++E+ +
Sbjct: 255 SANRSFVRETKATNSDVRKEVTN 277
Score = 52.4 bits (124), Expect = 4e-06
Identities = 49/199 (24%), Positives = 79/199 (39%), Gaps = 8/199 (4%)
Frame = +2
Query: 467 EPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMG 646
+P +D ++ P F + N+ + +G E V R V WH+NGQ ++ G
Sbjct: 20 DPSRVDSMPLTEAPAFILPPR-NLCIKEGATAKFEGRV--RGYPEPQVTWHRNGQPITSG 76
Query: 647 SRFNAIFD---RGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKS 817
RF + D RG +L I + ED G YTC A N G + + +
Sbjct: 77 GRF--LLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQ-------------VTVEL 121
Query: 818 HLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEA-----PRFDKGLQDVIIDEGNAAK 982
+ S QL + + + + D F + V+ P+F L V++ EG +
Sbjct: 122 TVEGSFAKQLG--QPVVSKTLGDRFSASAVETRPSIWGECPPKFATKLGRVVVKEGQMGR 179
Query: 983 FIINIYSHPRANIVWSINN 1039
F I P+ + W N
Sbjct: 180 FSCKITGRPQPQVTWLKGN 198
Score = 49.3 bits (116), Expect = 4e-05
Identities = 43/155 (27%), Positives = 74/155 (47%), Gaps = 14/155 (9%)
Frame = +2
Query: 347 AKSKSGQNQSNPA-TVRVIPEAKVDNNVNFIENQYVQQDQNEPQHL----------DKHE 493
A++ + PA T++ + AK D N+ + +++D + +K
Sbjct: 1032 AETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRS 1091
Query: 494 SSQ--PPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIF 667
SQ P F + LQ ++ V +G + L+ V +D T+ W NG+++ ++F +
Sbjct: 1092 ESQGTAPAFKQKLQ-DVHVAEGKKLLLQCQVS--SDPPATIIWTLNGKTLKT-TKFIILS 1147
Query: 668 DRG-YCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
G C++ I PED G+Y CVAKN G+AE S
Sbjct: 1148 QEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182
Score = 49.3 bits (116), Expect = 4e-05
Identities = 46/187 (24%), Positives = 80/187 (42%), Gaps = 11/187 (5%)
Frame = +2
Query: 791 PDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQ 949
PDE +L +S +LKK +++ ++N H + ++ AP F + LQ
Sbjct: 1055 PDE------NLKSASKEELKK---DVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQ 1105
Query: 950 DVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGK 1129
DV + EG + S P A I+W++N + + + +G++ + + + +
Sbjct: 1106 DVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1165
Query: 1130 HNIRVVATNPLGQQSSECVLTVN----SINNYAQDLKHIAPENPYKKMASLKKVEVTPEL 1297
+ VA N GQ C +TV+ S N A ++K P+ +SL V T
Sbjct: 1166 GLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPK------SSLPPVLGTESD 1219
Query: 1298 TTALHKP 1318
T KP
Sbjct: 1220 ATVKKKP 1226
Score = 48.9 bits (115), Expect = 5e-05
Identities = 58/220 (26%), Positives = 91/220 (41%), Gaps = 2/220 (0%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYV 292
AP F S L++ + ++ + Q S G + WL +G+P+ + E G
Sbjct: 513 APSFSSVLKDCAVIEGQDFVL---QCSVRGTPVPRITWLLNGQPIQYAR---STCEAGVA 566
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEP 472
L I ++ ED G Y C+A++ GQ S A V V + ++ +
Sbjct: 567 ELHIQDALPEDHGTYTCLAENALGQ-VSCSAWVTV----------------HEKKSSRKS 609
Query: 473 QHLDKHESSQP--PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMG 646
++L S+P P F + L S++ V G V + V + V W NG +
Sbjct: 610 EYLLPVAPSKPTAPIFLQGL-SDLKVMDGSQVTMTVQVS--GNPPPEVIWLHNGNEIQES 666
Query: 647 SRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAES 766
F+ +L I +PED G YTC A NS GE +
Sbjct: 667 EDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRT 706
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYC 682
PYFSK ++ ++ V +G + ++ D V W K+ QS+ F +D G C
Sbjct: 1809 PYFSKTIR-DLEVVEGSAARFDCKIEGYPD--PEVVWFKDDQSIRESRHFQIDYDEDGNC 1865
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEA 760
+L I +DD YTC A NS GEA
Sbjct: 1866 SLIISDVCGDDDAKYTCKAVNSLGEA 1891
Score = 42.7 bits (99), Expect = 0.003
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 19/255 (7%)
Frame = +2
Query: 59 NKSKGHGVQSQYESK---EFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWL 229
N +GH + E + + AP F L+ ++ V E + + L QVS D ++ W
Sbjct: 1076 NCKRGHAGTTDNEKRSESQGTAPAFKQKLQ-DVHVAEGKKLLLQCQVS--SDPPATIIWT 1132
Query: 230 KDGRPLLTGTRFSTVFERGYVV-LDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPE 406
+G+ L T T+F + + G + + I ++ ED G+Y CVAK+ +GQ + + + +
Sbjct: 1133 LNGKTLKT-TKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQV--TVDD 1189
Query: 407 AKVDNNVNFIENQYVQQDQNEPQHLDKH---------------ESSQPPYFSKDLQSNIT 541
A N E + + + P L +++ PP + +
Sbjct: 1190 APASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ-FPEDQK 1248
Query: 542 VNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDG 721
V G V L V T T W K + + L IL E G
Sbjct: 1249 VRAGESVELFGKVTGTQPITCT--WMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1306
Query: 722 VYTCVAKNSQGEAES 766
YT + +N G ++
Sbjct: 1307 CYTLLVENKLGSRQA 1321
Score = 39.3 bits (90), Expect = 0.037
Identities = 35/119 (29%), Positives = 49/119 (41%), Gaps = 14/119 (11%)
Frame = +2
Query: 53 SFNKSKGHGVQSQYESKEFEA--------------PHFLSNLENEITVNEEEPIRLSSQV 190
SF K G V S+ F A P F + L + V E + R S ++
Sbjct: 126 SFAKQLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKL-GRVVVKEGQMGRFSCKI 184
Query: 191 SPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQ 367
+ G V WLK PL R S + G VL+I ++D GVY C+ + SG+
Sbjct: 185 T--GRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGK 241
Score = 38.9 bits (89), Expect = 0.048
Identities = 20/68 (29%), Positives = 39/68 (57%), Gaps = 1/68 (1%)
Frame = +2
Query: 848 KKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 1024
+K ES +E+++ AF +E+ P F K ++D+ + EG+AA+F I +P +V
Sbjct: 1784 EKLES--EEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVV 1841
Query: 1025 WSINNEEV 1048
W +++ +
Sbjct: 1842 WFKDDQSI 1849
Score = 37.7 bits (86), Expect = 0.11
Identities = 61/303 (20%), Positives = 102/303 (33%), Gaps = 4/303 (1%)
Frame = +2
Query: 353 SKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLD-KHESSQPPYFSKDLQ 529
S SG+ + PA R P V + N ++ + +S+ P + SK
Sbjct: 365 SPSGEERKRPAPPR--PATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQS 422
Query: 530 SNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIF-DRGYCALDILYTY 706
+ NQ E P+ + V W G + ++ D G L +L
Sbjct: 423 QEVKENQTVKFRCEVSGIPKPE----VAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKAR 478
Query: 707 PEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEIND 886
D G Y+C A N+QG Q++C +Q E
Sbjct: 479 TRDSGTYSCTASNAQG-------QVSC-----------------------SWTLQVE--- 505
Query: 887 AFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN 1066
+ + AP F L+D + EG ++ P I W +N + +
Sbjct: 506 -----RLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---QYA 557
Query: 1067 KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVN--SINNYAQDLKHIAP 1240
+ C+ + L + +A N LGQ S +TV+ + ++ L +AP
Sbjct: 558 RSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAP 617
Query: 1241 ENP 1249
P
Sbjct: 618 SKP 620
Score = 35.8 bits (81), Expect = 0.40
Identities = 42/172 (24%), Positives = 68/172 (39%), Gaps = 4/172 (2%)
Frame = +2
Query: 794 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGN 973
D K+V+ SH++++S+S + D+ TE AP F +++ I EG
Sbjct: 3 DVKLVASSHISKTSLS--------VDPSRVDSMPLTE------APAFILPPRNLCIKEGA 48
Query: 974 AAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCD----GTINYLELTRCTEIGKHNIR 1141
AKF + +P + W N + + S +F D GT + L + E +
Sbjct: 49 TAKFEGRVRGYPEPQVTWHRNGQPITSG--GRFLLDCGIRGTFS-LVIHAVHEEDRGKYT 105
Query: 1142 VVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPEL 1297
ATN G + LTV ++A+ L S VE P +
Sbjct: 106 CEATNGSGARQVTVELTVE--GSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
>sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth muscle (MLCK) [Contains: Telokin] Length = 1176 Score = 52.8 bits (125), Expect = 3e-06 Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 1/98 (1%) Frame = +2 Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRG-YC 682 P F + LQ ++ V +G + L+ V +D T+ W NG+++ ++F + G C Sbjct: 356 PTFEEKLQ-DLHVAEGQKLLLQCRVS--SDPPATITWTLNGKTLKT-TKFIVLSQEGSLC 411 Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPD 796 ++ I PED G+Y CVAKNS G+AESS +PD Sbjct: 412 SVSIEKALPEDRGLYKCVAKNSAGQAESSCQVTVDVPD 449
Score = 48.5 bits (114), Expect = 6e-05
Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 4/126 (3%)
Frame = +2
Query: 59 NKSKGHGVQSQYESKEFE---APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWL 229
N KGH + E + AP F L+ ++ V E + + L +VS D ++ W
Sbjct: 334 NCKKGHAGATDSEKRPESRGTAPTFEEKLQ-DLHVAEGQKLLLQCRVS--SDPPATITWT 390
Query: 230 KDGRPLLTGTRFSTVFERGYVV-LDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPE 406
+G+ L T T+F + + G + + I ++ ED G+Y CVAK+ +GQ +S+ +P+
Sbjct: 391 LNGKTLKT-TKFIVLSQEGSLCSVSIEKALPEDRGLYKCVAKNSAGQAESSCQVTVDVPD 449
Query: 407 AKVDNN 424
A N
Sbjct: 450 APTSEN 455
Score = 47.4 bits (111), Expect = 1e-04
Identities = 43/208 (20%), Positives = 87/208 (41%), Gaps = 14/208 (6%)
Frame = +2
Query: 848 KKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQDVIIDEGNAAKFIINIYSH 1006
++ + I+ ++N H + ++ AP F++ LQD+ + EG + S
Sbjct: 323 EELKKEIKNDVNCKKGHAGATDSEKRPESRGTAPTFEEKLQDLHVAEGQKLLLQCRVSSD 382
Query: 1007 PRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECV 1186
P A I W++N + + + +G++ + + + + + VA N GQ S C
Sbjct: 383 PPATITWTLNGKTLKTTKFIVLSQEGSLCSVSIEKALPEDRGLYKCVAKNSAGQAESSCQ 442
Query: 1187 LTVN------SINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKPKAT-AEKIVK 1345
+TV+ S N A ++K P++ + + + PKA +I++
Sbjct: 443 VTVDVPDAPTSENAKAPEMKARRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ 502
Query: 1346 IERNVEVNARHAKTADIKEAEDLYDKVA 1429
+ +V A E+ +L+ KVA
Sbjct: 503 FPEDQKVRA--------GESVELFGKVA 522
Score = 43.9 bits (102), Expect = 0.001
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYC 682
PYFSK ++ ++ V +G + ++ D V W K+ QS+ F +D G C
Sbjct: 1069 PYFSKTIR-DLEVVEGSAARFDCKIEGYPD--PEVVWFKDDQSIRESRHFQIDYDEDGNC 1125
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEA 760
+L I +DD YTC A NS GEA
Sbjct: 1126 SLIISDVCGDDDAKYTCKAVNSLGEA 1151
Score = 37.7 bits (86), Expect = 0.11
Identities = 20/68 (29%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Frame = +2
Query: 848 KKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 1024
+K ES E+++ AF +E+ P F K ++D+ + EG+AA+F I +P +V
Sbjct: 1045 EKLES---EDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVV 1101
Query: 1025 WSINNEEV 1048
W +++ +
Sbjct: 1102 WFKDDQSI 1109
>sp|Q05623|MYBPH_CHICK Myosin-binding protein H (MyBP-H) (H-protein) (86 kDa protein) Length = 537 Score = 52.8 bits (125), Expect = 3e-06 Identities = 32/105 (30%), Positives = 53/105 (50%) Frame = +2 Query: 446 YVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKN 625 ++++ +PQ + + + +PP F++ L T +G HL V R + W KN Sbjct: 424 HIKKTVYQPQKIPERDMMEPPKFTQPLTDRATT-RGYSTHLFCSV--RGFPQPKIIWMKN 480 Query: 626 GQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEA 760 + ++ A+ ++G C+L+I P D GVYTC A N GEA Sbjct: 481 KMEIREDPKYIAMIEQGVCSLEIRKPSPFDAGVYTCKAVNPLGEA 525
Score = 39.7 bits (91), Expect = 0.028
Identities = 27/126 (21%), Positives = 50/126 (39%), Gaps = 2/126 (1%)
Frame = +2
Query: 824 NESSISQLKKFESNIQEEINDAFRHTEVQEED--EAPRFDKGLQDVIIDEGNAAKFIINI 997
N +S+ + + ++ ++ E D E P+F + L D G + ++
Sbjct: 408 NACGMSETAAVAAGVAHIKKTVYQPQKIPERDMMEPPKFTQPLTDRATTRGYSTHLFCSV 467
Query: 998 YSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSS 1177
P+ I+W N E+ D + + LE+ + + A NPLG+ S
Sbjct: 468 RGFPQPKIIWMKNKMEIREDPKYIAMIEQGVCSLEIRKPSPFDAGVYTCKAVNPLGEASV 527
Query: 1178 ECVLTV 1195
+C L V
Sbjct: 528 DCKLDV 533
>sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM 120) (NCAM-120) (CD56 antigen) Length = 761 Score = 51.2 bits (121), Expect = 9e-06 Identities = 97/420 (23%), Positives = 143/420 (34%), Gaps = 71/420 (16%) Frame = +2 Query: 533 NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNA-IFDRGYCALDILYTYP 709 N T N G V L + D T+ W K+G+ + IF L I Sbjct: 222 NATANLGQSVTL--VCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDK 279 Query: 710 EDDGVYTCVAKNSQGEAESS------------------------HSQITC------IP-- 793 D+ Y C+A+N GE +++ +TC IP Sbjct: 280 NDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSI 339 Query: 794 ----------------DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE- 922 D +V +SH SS++ LK + E +T Q+ Sbjct: 340 TWRTSTRNISSEEKTLDGHMVVRSHARVSSLT-LKSIQYTDAGEYICTASNTIGQDSQSM 398 Query: 923 ------APRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYC 1078 AP+ +G V EGN ++++P A I W + + + S + + K Y Sbjct: 399 YLEVQYAPKL-QGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYN 457 Query: 1079 DGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKK 1258 + +YLE+T +E N A N +GQ+S E +L + I PY Sbjct: 458 TPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFIL----VQADTPSSPSIDQVEPYSS 513 Query: 1259 MASLKKVEVTPELTTALHKPKATAEKIVKIERNVEVNARHAKTADIKEA----------- 1405 A ++ E PE T + K AE R V H+K D KEA Sbjct: 514 TAQVQFDE--PEATGGVPILKYKAE-----WRAVGEEVWHSKWYDAKEASMEGIVTIVGL 566 Query: 1406 --EDLYDKVAANLKSKGNISTGRRPVMTQGDSRMPPQPVAARSNVEYEHTESDDMPPPPS 1579 E Y A L KG PP P +A S+ + D P P+ Sbjct: 567 KPETTYAVRLAALNGKGLGEISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPA 626
>sp|P21804|FGFR1_CHICK Basic fibroblast growth factor receptor 1 precursor Length = 819 Score = 50.8 bits (120), Expect = 1e-05 Identities = 62/297 (20%), Positives = 110/297 (37%), Gaps = 10/297 (3%) Frame = +2 Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNP 382 D+ S+ W++DG L R E +++ ++ EDSG+Y C+ S SG +++ Sbjct: 58 DDVQSINWVRDGVQLPENNRTRITGEE----VEVRDAVPEDSGLYACMTNSPSG-SETTY 112 Query: 383 ATVRV---IPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQG 553 +V V +P A+ D++ + ++ + D +P + P K L + V Sbjct: 113 FSVNVSDALPSAEDDDDEDDSSSEEKEADNTKPNQAVAPYWTYPEKMEKKLHA---VPAA 169 Query: 554 GPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727 V + + TL W KNG+ R R Y I+ P D G Y Sbjct: 170 KTVKFKCPSGGTPNPTLR--WLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 226 Query: 728 TCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEV 907 TC+ +N G IN ++ V Sbjct: 227 TCIVENKYG----------------------------------------SINHTYQLDVV 246 Query: 908 QEEDEAPRFDKGL-QDVIIDEGNAAKFIINIYSHPRANIVW----SINNEEVVSDSV 1063 + P GL + + G+ +F+ +YS P+ +I W +N ++ D++ Sbjct: 247 ERSPHRPILQAGLPANKTVALGSNVEFVCKVYSDPQPHIQWLKHIEVNGSKIGPDNL 303
>sp|P16092|FGFR1_MOUSE Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 50.1 bits (118), Expect = 2e-05 Identities = 59/297 (19%), Positives = 108/297 (36%), Gaps = 10/297 (3%) Frame = +2 Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQS-- 376 D+ S+ WL+DG L+ R E +++ SI DSG+Y CV S SG + + Sbjct: 59 DDVQSINWLRDGVQLVESNRTRITGEE----VEVRDSIPADSGLYACVTSSPSGSDTTYF 114 Query: 377 NPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGG 556 + +P ++ D++ + ++ + D +P + PY++ + ++ Sbjct: 115 SVNVSDALPSSEDDDDDDDSSSEEKETDNTKP-----NRRPVAPYWTSPEKMEKKLHAVP 169 Query: 557 PVHLETIVDPRNDF-TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727 P + T+ W KNG+ R R Y I+ P D G Y Sbjct: 170 AAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 228 Query: 728 TCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEV 907 TC+ +N G IN ++ V Sbjct: 229 TCIVENEYG----------------------------------------SINHTYQLDVV 248 Query: 908 QEEDEAPRFDKGL-QDVIIDEGNAAKFIINIYSHPRANIVW----SINNEEVVSDSV 1063 + P GL + + G+ +F+ +YS P+ +I W +N ++ D++ Sbjct: 249 ERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNL 305
>sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen) Length = 822 Score = 49.7 bits (117), Expect = 3e-05 Identities = 58/297 (19%), Positives = 107/297 (36%), Gaps = 10/297 (3%) Frame = +2 Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQS-- 376 D+ S+ WL+DG L R E +++ S+ DSG+Y CV S SG + + Sbjct: 59 DDVQSINWLRDGVQLAESNRTRITGEE----VEVQDSVPADSGLYACVTSSPSGSDTTYF 114 Query: 377 NPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGG 556 + +P ++ D++ + ++ + D +P + PY++ + ++ Sbjct: 115 SVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRM-----PVAPYWTSPEKMEKKLHAVP 169 Query: 557 PVHLETIVDPRNDF-TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727 P + T+ W KNG+ R R Y I+ P D G Y Sbjct: 170 AAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 228 Query: 728 TCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEV 907 TC+ +N G IN ++ V Sbjct: 229 TCIVENEYG----------------------------------------SINHTYQLDVV 248 Query: 908 QEEDEAPRFDKGL-QDVIIDEGNAAKFIINIYSHPRANIVW----SINNEEVVSDSV 1063 + P GL + + G+ +F+ +YS P+ +I W +N ++ D++ Sbjct: 249 ERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNL 305
>sp|Q04589|FGFR1_RAT Basic fibroblast growth factor receptor 1 precursor (FGFR-1) (bFGF-R) (MFR) Length = 822 Score = 49.7 bits (117), Expect = 3e-05 Identities = 59/297 (19%), Positives = 108/297 (36%), Gaps = 10/297 (3%) Frame = +2 Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQS-- 376 D+ S+ WL+DG L R E +++ SI DSG+Y CV S SG + + Sbjct: 59 DDVQSINWLRDGVQLAESNRTRITGEE----VEVRDSIPADSGLYACVTNSPSGSDTTYF 114 Query: 377 NPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGG 556 + +P ++ D++ + ++ + D +P + PY++ + ++ Sbjct: 115 SVNVSDALPSSEDDDDDDDSSSEEKETDNTKP-----NRRPVAPYWTSPEKMEKKLHAVP 169 Query: 557 PVHLETIVDPRNDF-TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727 P + + T+ W KNG+ R R Y I+ P D G Y Sbjct: 170 AAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 228 Query: 728 TCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEV 907 TC+ +N G IN ++ V Sbjct: 229 TCIVENEYG----------------------------------------SINHTYQLDVV 248 Query: 908 QEEDEAPRFDKGL-QDVIIDEGNAAKFIINIYSHPRANIVW----SINNEEVVSDSV 1063 + P GL + + G+ +F+ +YS P+ +I W +N ++ D++ Sbjct: 249 ERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNL 305
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 184,166,025
Number of Sequences: 369166
Number of extensions: 3747304
Number of successful extensions: 12960
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 10951
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 12754
length of database: 68,354,980
effective HSP length: 116
effective length of database: 46,925,720
effective search space used: 21914311240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
