Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_B23
(790 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89... 49 1e-05
sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth musc... 47 5e-05
sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 ... 47 6e-05
sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth musc... 47 6e-05
sp|P13596|NCAM1_RAT Neural cell adhesion molecule 1, 140 kD... 44 5e-04
sp|P13591|NCA11_HUMAN Neural cell adhesion molecule 1, 140 ... 44 5e-04
sp|P31836|NCAM1_BOVIN Neural cell adhesion molecule 1, 140 ... 43 9e-04
sp|P13590|NCAM1_CHICK Neural cell adhesion molecule 1, 180 ... 42 0.002
sp|P29294|MYLK_RABIT Myosin light chain kinase, smooth musc... 42 0.002
sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth musc... 42 0.003
>sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89 (Uncoordinated protein 89)
Length = 8081
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/155 (24%), Positives = 73/155 (47%), Gaps = 6/155 (3%)
Frame = +1
Query: 76 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVS-DSVNKFYC 252
+V ++ E P+F + D + EG KF N+ +P ++ W++N E V ++
Sbjct: 2359 KVDKKTEVPKFTTNMDDRQVKEGEDVKFTANVEGYPEPSVAWTLNGEPVSKHPNITVTDK 2418
Query: 253 DGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINN---YAQDLK-HIAPEN 420
DG + +E++ T + ATNP+G + + L V + + +A++L+ + E
Sbjct: 2419 DGE-HTIEISAVTPEQAGELSCEATNPVGSKKRDVQLAVKKVGDAPTFAKNLEDRLITEG 2477
Query: 421 PYKKM-ASLKKVEVTPELTTALHKPKATAEKIVKI 522
M A L V+ P++T + T++ KI
Sbjct: 2478 ELTLMDAKLNIVKPKPKITWLKDGVEITSDGHYKI 2512
Score = 45.8 bits (107), Expect = 1e-04
Identities = 48/229 (20%), Positives = 91/229 (39%), Gaps = 13/229 (5%)
Frame = +1
Query: 79 VQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV--VSDSVNKFYC 252
VQ++ AP FD + +++G+ A F + + P WS+N +V +
Sbjct: 1133 VQKKPFAPEFDLRPVSLTVEKGSEAVFSAHAFGIPLPTYEWSVNGRKVRDGQEGARVTRD 1192
Query: 253 DGTINYLEL------TRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAP 414
+ T++ + T +E+ I VVA N LG + + LT+ K
Sbjct: 1193 ESTVDGASILTIDTATYYSEVNHLTISVVAENTLGAEETGAQLTIEPKKESVVVEKQDLS 1252
Query: 415 ENPYKKMASLKKVEVTPELTTAL-HKPKATAEKIVKIERNVEVNARHAKTADIKEAEDLY 591
+ +K + + E +PE TT + + T+ K + + T + KE+E
Sbjct: 1253 SSEVQKEIAQQVKEASPEATTTITMETSLTSTKTTTMSTTEVTSTVGGVTVETKESESES 1312
Query: 592 DKVAANLKS----KGNISTGRRPVMTQGDSRMPPQPVAARSNVEYEHTE 726
S +G+IS + V+++ DS+ + + V + E
Sbjct: 1313 ATTVIGGGSGGVTEGSISVSKIEVVSKTDSQTDVREGTPKRRVSFAEEE 1361
Score = 39.7 bits (91), Expect = 0.010
Identities = 25/100 (25%), Positives = 46/100 (46%), Gaps = 4/100 (4%)
Frame = +1
Query: 82 QEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNK----FY 249
+ E+ PR +GL ++ I EGN + I+ P + W + +E+V D + F
Sbjct: 6032 EPEECKPRIRRGLYNMSIHEGNVVEMIVCATGIPTPTVKWYKDGQEIVGDGPDGKRVIFT 6091
Query: 250 CDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
+ I++L + + + + ATN LG +E L +
Sbjct: 6092 DERGIHHLVIVNASPDDEGEYSLEATNKLGSAKTEGSLNI 6131
Score = 38.9 bits (89), Expect = 0.016
Identities = 39/133 (29%), Positives = 60/133 (45%), Gaps = 4/133 (3%)
Frame = +1
Query: 85 EEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTI 264
E DE P +GL+++ I EG+ F + + S P + W N++E+ +S + G
Sbjct: 4868 EVDEKPEIVRGLENIEIPEGDDDVFKVEV-SAPVRQVKWYKNDQEIKPNSHLEAKKIGPK 4926
Query: 265 NY-LELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSIN--NYAQDLKHIAPENPYKKM 435
Y L + R + +VV +N G S LTV N LK + E P +
Sbjct: 4927 KYELAINRAQLDDGADYKVVLSNAAGDCDSSAALTVVKPNVLKIVDGLKDVDVEEP--QP 4984
Query: 436 ASLK-KVEVTPEL 471
LK KVE P++
Sbjct: 4985 VELKVKVEGIPKV 4997
Score = 38.9 bits (89), Expect = 0.016
Identities = 31/124 (25%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Frame = +1
Query: 7 SISQLKKFESNIQEEINDAFRHTEVQEEDE-APRFDKGLQDVIIDEGNAAKFIINIYSHP 183
++++L + E+ ++ + H E ++ E AP+ + L+D ++ G + + + P
Sbjct: 5352 AVNELGQAETQATYQV-EILEHVEEEKRREYAPKINPPLEDKTVNGGQPIRLSCKVDAIP 5410
Query: 184 RANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSEC 357
RA++VW + + +DS ++ DGT L + TE R VATN G ++ C
Sbjct: 5411 RASVVWYKDGLPLRADSRTSIQYEEDGTAT-LAINDSTEEDIGAYRCVATNAHGTINTSC 5469
Query: 358 VLTV 369
+ V
Sbjct: 5470 SVNV 5473
Score = 38.1 bits (87), Expect = 0.028
Identities = 28/119 (23%), Positives = 53/119 (44%), Gaps = 7/119 (5%)
Frame = +1
Query: 79 VQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVW-------SINNEEVVSDSV 237
VQEE EAP F +GL+ +++G A+ ++ + P + W +I+N+ V+
Sbjct: 3573 VQEEIEAPLFVQGLKPYEVEQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIE--- 3629
Query: 238 NKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAP 414
K ++ T + GK+ + ATN G+ + L + + Q + + P
Sbjct: 3630 KKGENGSHTLVIKDTNNADFGKYTCQ--ATNKAGKDETVGELKIPKYSFEKQTAEEVKP 3686
Score = 37.7 bits (86), Expect = 0.036
Identities = 29/120 (24%), Positives = 52/120 (43%), Gaps = 2/120 (1%)
Frame = +1
Query: 64 FRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNK 243
FR +V++E P F L+D EG+ F + P +VW ++++ + +
Sbjct: 636 FRVLKVEKEAAPPAFVTKLRDKECKEGDVIDFECEVEGWPEPELVWLVDDQPLRPSHDFR 695
Query: 244 FYCDGTINYLEL--TRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPE 417
DG LE+ + + G + +++ N G S+ L V + D H+APE
Sbjct: 696 LQYDGQTAKLEIRDAQPDDTGVYTVKI--QNEFGSIESKAELFVQA----DPDKNHVAPE 749
Score = 37.4 bits (85), Expect = 0.047
Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Frame = +1
Query: 82 QEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYCDG 258
+++ + P+F + L D N F + + P+ + W + EE+ SD V DG
Sbjct: 1038 EKQKKPPKFVEILVDKTETVDNTVVFEVRVEGEPKPTVTWYLKGEELKQSDRVEIREFDG 1097
Query: 259 TINY-LELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
+I ++ + + G+ IR VATN G ++ LTV
Sbjct: 1098 SIKISIKNIKIEDAGE--IRAVATNSEGSDETKAKLTV 1133
Score = 36.6 bits (83), Expect = 0.081
Identities = 53/233 (22%), Positives = 95/233 (40%), Gaps = 21/233 (9%)
Frame = +1
Query: 76 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYS-HPRANIVWSINNEEVV-SDSVNKF- 246
+V+ +AP+F L D + DEG ++ + + P + W +N + + SD+V
Sbjct: 2163 KVEPNVKAPKFKSQLTDKVADEGEPLRWNLELDGPSPGTEVSWLLNGQPLTKSDTVQVVD 2222
Query: 247 YCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPEN-- 420
+ DGT ++ + + A N G+ + +TVN N + ++ AP+N
Sbjct: 2223 HGDGTY-HVTIAEAKPEMSGTLTAKAKNAAGECETSAKVTVNGGNKKPEFVQ--APQNHE 2279
Query: 421 ----PYKKMASLKKVEVTPELTTALHKPKATAEKIVKIERNVEVN----------ARHAK 558
K +++ + P +T L+ K + VK++ E H
Sbjct: 2280 TTLEESVKFSAIVTGKPMPNVTWYLNNKKLIQSEEVKVKYVHETGKTSIRIQKPLMEHNG 2339
Query: 559 TADIKEAEDLYDKVAANLKSKGNISTGRRPVMTQGDSRM--PPQPVAARSNVE 711
T + EAE++ KV A + K + T T D R + V +NVE
Sbjct: 2340 TIRV-EAENVSGKVQATAQLKVDKKTEVPKFTTNMDDRQVKEGEDVKFTANVE 2391
Score = 36.2 bits (82), Expect = 0.11
Identities = 26/104 (25%), Positives = 40/104 (38%)
Frame = +1
Query: 58 DAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSV 237
+ F + + AP F ++ V DEG +F I P I+W IN + +
Sbjct: 734 ELFVQADPDKNHVAPEFQATIEYVECDEGEEVRFKSVITGDPNPEIIWFINGKPLSESEK 793
Query: 238 NKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
KF + I L + T + +N LG S + L V
Sbjct: 794 VKFISEDGICILTIKDVTRHFDGMVTCQGSNRLGSASCDGRLKV 837
Score = 34.7 bits (78), Expect = 0.31
Identities = 26/113 (23%), Positives = 45/113 (39%), Gaps = 3/113 (2%)
Frame = +1
Query: 85 EEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDS--VNKFYCDG 258
E F L+D ++EG+ I P ++W + + D + DG
Sbjct: 5066 EPTSGANFLSPLKDTEVEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKDDRITMRVALDG 5125
Query: 259 TINY-LELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAP 414
T + + ++IG++ RV A N G +S+C +TV K + P
Sbjct: 5126 TATLRIRSAKKSDIGQY--RVTAKNEAGSATSDCKVTVTEQGEQPSKPKFVIP 5176
Score = 33.5 bits (75), Expect = 0.68
Identities = 18/55 (32%), Positives = 27/55 (49%), Gaps = 3/55 (5%)
Frame = +1
Query: 67 RHTEVQEEDE---APRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV 222
R T QEE+E AP F K ++D + G A F + +P + W IN ++
Sbjct: 932 RLTVEQEEEESRSAPTFLKDIEDQTVKTGEFAVFETTVRGNPNPEVTWFINGHKM 986
Score = 33.1 bits (74), Expect = 0.89
Identities = 37/152 (24%), Positives = 65/152 (42%), Gaps = 4/152 (2%)
Frame = +1
Query: 76 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKF-YC 252
EV + E P F + L + A + + P ++ W + + V +DS +
Sbjct: 3278 EVTQSLEKPTFVRELVTTEVKINETATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAKV 3337
Query: 253 DGTINY---LELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENP 423
+G+ +Y ++ R + GK+ R ATNP G+ +E V +K++ P
Sbjct: 3338 EGSGSYSITIKDARLEDSGKYACR--ATNPAGEAKTEANFAV---------VKNLVPPEF 3386
Query: 424 YKKMASLKKVEVTPELTTALHKPKATAEKIVK 519
+K++ L+ E E TT K T E V+
Sbjct: 3387 VEKLSPLEVKE--KESTTLSVKVVGTPEPSVE 3416
Score = 33.1 bits (74), Expect = 0.89
Identities = 26/95 (27%), Positives = 39/95 (41%), Gaps = 1/95 (1%)
Frame = +1
Query: 88 EDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYCDGTI 264
+ EAP F + ++ ++ G A I P+ ++ W N EE+ SD V D
Sbjct: 3916 DGEAPDFLQPVKPAVVTVGETAVLEGKISGKPKPSVKWYKNGEELKPSDRVKIENLDDGT 3975
Query: 265 NYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
L +T R A+N G S+ LTV
Sbjct: 3976 QRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLTV 4010
Score = 33.1 bits (74), Expect = 0.89
Identities = 25/96 (26%), Positives = 37/96 (38%), Gaps = 1/96 (1%)
Frame = +1
Query: 94 EAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVV-SDSVNKFYCDGTINY 270
+ PRF + DV EG K + + P +VW + V SD + +
Sbjct: 5699 QPPRFTLKMGDVRTTEGQPLKLECKVDASPLPEMVWYKDGAIVTPSDRIQISLSPDGVAT 5758
Query: 271 LELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSI 378
L + C RV+ATNP G + TV +
Sbjct: 5759 LLIPSCVYDDDGIYRVIATNPSGTAQDKGTATVKKL 5794
Score = 32.3 bits (72), Expect = 1.5
Identities = 21/98 (21%), Positives = 38/98 (38%)
Frame = +1
Query: 76 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCD 255
E + E +AP F LQD + P+ + W +N+ + +S+ +
Sbjct: 2986 EKKSEKKAPEFIVALQDKTTKTSEKVVLECKVIGEPKPKVSWLHDNKTITQESITVESVE 3045
Query: 256 GTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
G + + +T + +A N G +E LTV
Sbjct: 3046 G-VERVTITSSELSHQGKYTCIAENTEGTSKTEAFLTV 3082
Score = 31.6 bits (70), Expect = 2.6
Identities = 25/114 (21%), Positives = 48/114 (42%), Gaps = 4/114 (3%)
Frame = +1
Query: 25 KFESNIQEEINDAFRHTEVQEEDEA--PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 198
K ++ + A TE + DE P+F L D+ + GN + P ++
Sbjct: 5568 KAKTQATAHVQMALGKTEKPKMDEGKPPKFILELSDMSVSLGNVIDLECKVTGLPNPSVK 5627
Query: 199 WSINNEEVVSDSVNKFYCDGT--INYLELTRCTEIGKHNIRVVATNPLGQQSSE 354
WS + ++ DS ++ + + + L + T + R VATN G +++
Sbjct: 5628 WSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSATTK 5681
Score = 31.2 bits (69), Expect = 3.4
Identities = 18/60 (30%), Positives = 26/60 (43%)
Frame = +1
Query: 37 NIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNE 216
N +N EV++E E P F KGL D+ D G++ + P I W N +
Sbjct: 5466 NTSCSVNVKVPKQEVKKEGEEPFFTKGLVDLWADRGDSFTLKCAVTGDPFPEIKWYRNGQ 5525
Score = 30.4 bits (67), Expect = 5.8
Identities = 46/209 (22%), Positives = 82/209 (39%), Gaps = 27/209 (12%)
Frame = +1
Query: 73 TEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV----VSDSVN 240
T+ E+ P F KGL D + +G + I P+ ++ W N +E+ V D N
Sbjct: 4203 TKAAEKISLPSFKKGLADQSVPKGTPLVLEVEIEGKPK-DVKWYKNGDEIKDGKVEDLGN 4261
Query: 241 KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLK------ 402
Y ++ E ++G+++ V A N G+ S+ + V++ L
Sbjct: 4262 GKYRLTIPDFQE----KDVGEYS--VTAANEAGEIESKAKVNVSAKPEIVSGLVPTTVKQ 4315
Query: 403 ------HIAPENPYKKMASLKKVEVTPELTT--------ALHKPKATAEKIVKIERNVEV 540
++ + P K + K + P+ T +L P A E + V
Sbjct: 4316 GETATFNVKVKGPVKGVKWYKNGKEIPDAKTKDNGDGSYSLEIPNAQVEDAADYKVVVSN 4375
Query: 541 NARHAKTA---DIKEAEDLYDKVAANLKS 618
+A A ++ +K A+D DKV + S
Sbjct: 4376 DAGDADSSAALTVKLADDGKDKVKPEIVS 4404
Score = 30.0 bits (66), Expect = 7.5
Identities = 19/85 (22%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Frame = +1
Query: 145 NAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINY---LELTRCTEIGKHNIR 315
++AK + + +P +I W ++ ++ D + FY D + ++ + T+ G++
Sbjct: 563 SSAKMCLKVTGYPLPDITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYT-- 620
Query: 316 VVATNPLGQQSSECVLTVNSINNYA 390
+ATN GQ S+ V + A
Sbjct: 621 CMATNEYGQASTSAFFRVLKVEKEA 645
>sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth muscle (MLCK) [Contains: Telokin]
Length = 1176
Score = 47.4 bits (111), Expect = 5e-05
Identities = 43/208 (20%), Positives = 87/208 (41%), Gaps = 14/208 (6%)
Frame = +1
Query: 22 KKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQDVIIDEGNAAKFIINIYSH 180
++ + I+ ++N H + ++ AP F++ LQD+ + EG + S
Sbjct: 323 EELKKEIKNDVNCKKGHAGATDSEKRPESRGTAPTFEEKLQDLHVAEGQKLLLQCRVSSD 382
Query: 181 PRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECV 360
P A I W++N + + + +G++ + + + + + VA N GQ S C
Sbjct: 383 PPATITWTLNGKTLKTTKFIVLSQEGSLCSVSIEKALPEDRGLYKCVAKNSAGQAESSCQ 442
Query: 361 LTVN------SINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKPKAT-AEKIVK 519
+TV+ S N A ++K P++ + + + PKA +I++
Sbjct: 443 VTVDVPDAPTSENAKAPEMKARRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ 502
Query: 520 IERNVEVNARHAKTADIKEAEDLYDKVA 603
+ +V A E+ +L+ KVA
Sbjct: 503 FPEDQKVRA--------GESVELFGKVA 522
Score = 37.7 bits (86), Expect = 0.036
Identities = 20/68 (29%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Frame = +1
Query: 22 KKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 198
+K ES E+++ AF +E+ P F K ++D+ + EG+AA+F I +P +V
Sbjct: 1045 EKLES---EDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVV 1101
Query: 199 WSINNEEV 222
W +++ +
Sbjct: 1102 WFKDDQSI 1109
>sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM
120) (NCAM-120) (CD56 antigen)
Length = 761
Score = 47.0 bits (110), Expect = 6e-05
Identities = 56/220 (25%), Positives = 81/220 (36%), Gaps = 15/220 (6%)
Frame = +1
Query: 139 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNI 312
EGN ++++P A I W + + + S + + K Y + +YLE+T +E N
Sbjct: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
Query: 313 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 492
A N +GQ+S E +L + I PY A ++ E PE T +
Sbjct: 478 NCTAVNRIGQESLEFIL----VQADTPSSPSIDQVEPYSSTAQVQFDE--PEATGGVPIL 531
Query: 493 KATAEKIVKIERNVEVNARHAKTADIKEA-------------EDLYDKVAANLKSKGNIS 633
K AE R V H+K D KEA E Y A L KG
Sbjct: 532 KYKAE-----WRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGE 586
Query: 634 TGRRPVMTQGDSRMPPQPVAARSNVEYEHTESDDMPPPPS 753
PP P +A S+ + D P P+
Sbjct: 587 ISAASEFKTQPVHSPPPPASASSSTPVPLSPPDTTWPLPA 626
>sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth muscle and non-muscle isozymes
(MLCK) [Contains: Telokin (Kinase related protein) (KRP)]
Length = 1914
Score = 47.0 bits (110), Expect = 6e-05
Identities = 42/174 (24%), Positives = 75/174 (43%), Gaps = 11/174 (6%)
Frame = +1
Query: 4 SSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQDVIIDEGNAAKFI 162
+S +LKK +++ ++N H + ++ AP F + LQDV + EG
Sbjct: 1062 ASKEELKK---DVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQ 1118
Query: 163 INIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQ 342
+ S P A I+W++N + + + +G++ + + + + + VA N GQ
Sbjct: 1119 CQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQ 1178
Query: 343 QSSECVLTVN----SINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 492
C +TV+ S N A ++K P+ +SL V T T KP
Sbjct: 1179 AECSCQVTVDDAPASENTKAPEMKSRRPK------SSLPPVLGTESDATVKKKP 1226
Score = 38.9 bits (89), Expect = 0.016
Identities = 20/68 (29%), Positives = 39/68 (57%), Gaps = 1/68 (1%)
Frame = +1
Query: 22 KKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 198
+K ES +E+++ AF +E+ P F K ++D+ + EG+AA+F I +P +V
Sbjct: 1784 EKLES--EEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVV 1841
Query: 199 WSINNEEV 222
W +++ +
Sbjct: 1842 WFKDDQSI 1849
Score = 32.0 bits (71), Expect = 2.0
Identities = 33/130 (25%), Positives = 50/130 (38%), Gaps = 4/130 (3%)
Frame = +1
Query: 94 EAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCD----GT 261
EAP F +++ I EG AKF + +P + W N + + S +F D GT
Sbjct: 31 EAPAFILPPRNLCIKEGATAKFEGRVRGYPEPQVTWHRNGQPITSG--GRFLLDCGIRGT 88
Query: 262 INYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMAS 441
+ L + E + ATN G + LTV ++A+ L S
Sbjct: 89 FS-LVIHAVHEEDRGKYTCEATNGSGARQVTVELTVE--GSFAKQLGQPVVSKTLGDRFS 145
Query: 442 LKKVEVTPEL 471
VE P +
Sbjct: 146 ASAVETRPSI 155
Score = 31.2 bits (69), Expect = 3.4
Identities = 23/102 (22%), Positives = 37/102 (36%), Gaps = 1/102 (0%)
Frame = +1
Query: 76 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYC 252
E Q + P+F+ Q + E KF + P+ + W + V + + Y
Sbjct: 406 EGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYE 465
Query: 253 DGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSI 378
D +YL L + A+N GQ S L V +
Sbjct: 466 DAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVERL 507
Score = 31.2 bits (69), Expect = 3.4
Identities = 25/111 (22%), Positives = 43/111 (38%), Gaps = 2/111 (1%)
Frame = +1
Query: 97 APRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLE 276
AP F L+D + EG ++ P I W +N + + + C+ + L
Sbjct: 513 APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITWLLNGQPI---QYARSTCEAGVAELH 569
Query: 277 LTRCTEIGKHNIRVVATNPLGQQSSECVLTVN--SINNYAQDLKHIAPENP 423
+ +A N LGQ S +TV+ + ++ L +AP P
Sbjct: 570 IQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKKSSRKSEYLLPVAPSKP 620
>sp|P13596|NCAM1_RAT Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140)
Length = 858
Score = 43.9 bits (102), Expect = 5e-04
Identities = 41/149 (27%), Positives = 65/149 (43%), Gaps = 2/149 (1%)
Frame = +1
Query: 139 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNI 312
EGN ++++P A I W + + + S + + K Y + +YLE+T +E N
Sbjct: 429 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 488
Query: 313 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 492
A N +GQ+S E +L + I PY A ++ E PE T +
Sbjct: 489 NCTAVNRIGQESLEFIL----VQADTPSSPSIDRVEPYSSTAQVQFDE--PEATGGVPIL 542
Query: 493 KATAEKIVKIERNVEVNARHAKTADIKEA 579
K AE +++ A H+K D KEA
Sbjct: 543 KYKAE-----WKSLGEEAWHSKWYDAKEA 566
>sp|P13591|NCA11_HUMAN Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140) (CD56 antigen)
Length = 848
Score = 43.9 bits (102), Expect = 5e-04
Identities = 42/149 (28%), Positives = 63/149 (42%), Gaps = 2/149 (1%)
Frame = +1
Query: 139 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNI 312
EGN ++++P A I W + + + S + + K Y + +YLE+T +E N
Sbjct: 418 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
Query: 313 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 492
A N +GQ+S E +L + I PY A ++ E PE T +
Sbjct: 478 NCTAVNRIGQESLEFIL----VQADTPSSPSIDQVEPYSSTAQVQFDE--PEATGGVPIL 531
Query: 493 KATAEKIVKIERNVEVNARHAKTADIKEA 579
K AE R V H+K D KEA
Sbjct: 532 KYKAE-----WRAVGEEVWHSKWYDAKEA 555
>sp|P31836|NCAM1_BOVIN Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140)
Length = 853
Score = 43.1 bits (100), Expect = 9e-04
Identities = 42/149 (28%), Positives = 63/149 (42%), Gaps = 2/149 (1%)
Frame = +1
Query: 139 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNI 312
EGN ++++P A I W + + + S + + K Y + +YLE+T +E N
Sbjct: 427 EGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 486
Query: 313 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 492
A N +GQ+S E VL + I PY A ++ E PE T +
Sbjct: 487 NCTAVNRIGQESLEFVL----VQADTPSSPSIDQVEPYSSTAQVQFDE--PEATGGVPIL 540
Query: 493 KATAEKIVKIERNVEVNARHAKTADIKEA 579
K AE R + H+K D KEA
Sbjct: 541 KYKAE-----WRAMGEEVWHSKWYDAKEA 564
>sp|P13590|NCAM1_CHICK Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM
180)
Length = 1091
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/149 (27%), Positives = 64/149 (42%), Gaps = 2/149 (1%)
Frame = +1
Query: 139 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNI 312
EGN ++++P A I W + + + S + + K Y + +YLE+T +E N
Sbjct: 418 EGNQVNITCEVFAYPSAVISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNY 477
Query: 313 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 492
A N +GQ+SSE +L + I PY A ++ E PE T +
Sbjct: 478 NCTAVNRIGQESSEFIL----VQADTPSSPSIDRVEPYSSTARVEFDE--PEATGGVPIL 531
Query: 493 KATAEKIVKIERNVEVNARHAKTADIKEA 579
K AE R + H++ D KEA
Sbjct: 532 KYKAE-----WRALGEGEWHSRLYDAKEA 555
>sp|P29294|MYLK_RABIT Myosin light chain kinase, smooth muscle (MLCK) [Contains: Telokin]
Length = 1147
Score = 42.0 bits (97), Expect = 0.002
Identities = 39/171 (22%), Positives = 73/171 (42%), Gaps = 13/171 (7%)
Frame = +1
Query: 97 APRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLE 276
AP F + LQDV + EG + S P A I W++N + + + +G++ +
Sbjct: 328 APTFKEKLQDVRVAEGEKLLLQCQVSSEPPATITWTLNGKTLKTTKFVILSQEGSLCSVS 387
Query: 277 LTRCTEIGKHNIRVVATNPLGQQSSECVLTVN----SINNYAQDLKHIAPENPYKKM--- 435
+ + + + VA N + C +TV+ S N A ++K P++ +
Sbjct: 388 IEKALPEDRGLYKCVAKNAAPEAECSCHVTVHDAPASENAKAPEMKSRRPKSSLPPVLGT 447
Query: 436 ---ASLKK---VEVTPELTTALHKPKATAEKIVKIERNVEVNARHAKTADI 570
A++KK + P+ T P+ ++ V+ VE+ + A T I
Sbjct: 448 ESDATVKKKPAPKTPPKAATPPQIPQFPEDQKVRAGERVELFGKVAGTQPI 498
Score = 38.5 bits (88), Expect = 0.021
Identities = 20/74 (27%), Positives = 38/74 (51%), Gaps = 1/74 (1%)
Frame = +1
Query: 4 SSISQLKKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSH 180
S S L +E+++ AF +E+ P F K ++D+ + EG+AA+F I +
Sbjct: 1008 SPTSPLTAERLETEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGY 1067
Query: 181 PRANIVWSINNEEV 222
P +VW +++ +
Sbjct: 1068 PDPEVVWFKDDQSI 1081
>sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth muscle and non-muscle isozymes
(MLCK) [Contains: Telokin]
Length = 1906
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/150 (22%), Positives = 60/150 (40%)
Frame = +1
Query: 61 AFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN 240
A + T + AP F + LQD + +G I S P A++ W+++++ + S
Sbjct: 1071 ASKPTPPPSKGTAPSFTEKLQDAKVADGEKLVLQCRISSDPPASVSWTLDSKAIKSSKSI 1130
Query: 241 KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPEN 420
+GT+ L + + + +A N G+ C + V +D
Sbjct: 1131 VISQEGTLCSLTIEKVMPEDGGEYKCIAENAAGKAECACKVLV-------EDTSSTKAAK 1183
Query: 421 PYKKMASLKKVEVTPELTTALHKPKATAEK 510
P +K K + P L+T +AT +K
Sbjct: 1184 PAEKKTKKPKTTLPPVLST--ESSEATVKK 1211
Score = 36.6 bits (83), Expect = 0.081
Identities = 30/118 (25%), Positives = 50/118 (42%), Gaps = 2/118 (1%)
Frame = +1
Query: 22 KKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVW 201
KK E ++N F AP F KGL D+ + +G+ + + ++P I+W
Sbjct: 621 KKAEGTQAAKLNKTF----------APIFLKGLTDLKVMDGSQVIMTVEVSANPCPEIIW 670
Query: 202 SINNEEVVSDSVNKFYCDGT--INYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
N +E+ F G Y++ + GK+ A N LG+ ++ LTV
Sbjct: 671 LHNGKEIQETEDFHFEKKGNEYSLYIQEVFPEDTGKYTCE--AWNELGETQTQATLTV 726
Score = 33.1 bits (74), Expect = 0.89
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Frame = +1
Query: 49 EINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV 222
E DAF +E+ P F K + D+ + EG+AA+F I +P ++W +++ V
Sbjct: 1776 ENEDAFLEEVAEEKPHVKPYFTKTILDMEVVEGSAARFDCKIEGYPDPEVMWYKDDQPV 1834
Score = 31.6 bits (70), Expect = 2.6
Identities = 32/170 (18%), Positives = 68/170 (40%), Gaps = 5/170 (2%)
Frame = +1
Query: 91 DEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINY 270
+ P+F V++ EG +F I P+ + W+ + + + + I Y
Sbjct: 153 ESPPKFATKPNRVVVREGQTGRFSCKITGRPQPQVTWTKGDIHLQQNERFNMFEKTGIQY 212
Query: 271 LEL--TRCTEIGKHNIRVVATNPLGQQSSECVLTV---NSINNYAQDLKHIAPENPYKKM 435
LE+ + + G + VV N G+ S LTV + + +AQ L + P+
Sbjct: 213 LEIQNVQLADAGIYTCTVV--NSAGKASVSAELTVQGPDKTDTHAQPL-CMPPKPTTLAT 269
Query: 436 ASLKKVEVTPELTTALHKPKATAEKIVKIERNVEVNARHAKTADIKEAED 585
+++ + + + K + + +E ++A+ +EA+D
Sbjct: 270 KAIENSDFKQATSNGIAKELKSTSTELMVETKDRLSAKKETFYTSREAKD 319
Score = 31.6 bits (70), Expect = 2.6
Identities = 21/90 (23%), Positives = 37/90 (41%)
Frame = +1
Query: 100 PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLEL 279
P+F+ Q + EG KF + P+ ++ W + + + Y + + L L
Sbjct: 429 PQFESRPQSLEASEGQEIKFKSKVSGKPKPDVEWFKEGVPIKTGEGIQIYEEDGTHCLWL 488
Query: 280 TRCTEIGKHNIRVVATNPLGQQSSECVLTV 369
+ + A NP GQ S+ +LTV
Sbjct: 489 KKACLGDSGSYSCAAFNPRGQTSTSWLLTV 518
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,254,051
Number of Sequences: 369166
Number of extensions: 1474849
Number of successful extensions: 5267
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5021
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5244
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)