Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_H10
(811 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth musc... 62 1e-09
sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89... 51 3e-06
sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth musc... 50 6e-06
sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth musc... 50 1e-05
sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 ... 46 1e-04
sp|P13591|NCA11_HUMAN Neural cell adhesion molecule 1, 140 ... 46 1e-04
sp|O70468|MYPC3_MOUSE Myosin-binding protein C, cardiac-typ... 45 2e-04
sp|P13590|NCAM1_CHICK Neural cell adhesion molecule 1, 180 ... 45 2e-04
sp|P13596|NCAM1_RAT Neural cell adhesion molecule 1, 140 kD... 45 3e-04
sp|P31836|NCAM1_BOVIN Neural cell adhesion molecule 1, 140 ... 44 5e-04
>sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth muscle and non-muscle isozymes
(MLCK) [Contains: Telokin]
Length = 1906
Score = 62.4 bits (150), Expect = 1e-09
Identities = 52/198 (26%), Positives = 87/198 (43%), Gaps = 2/198 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITC 191
+ W N Q + ++ F+ G L + PEDDG+YTC+A+N+ G A S +Q+T
Sbjct: 559 ITWLLNEQPIQYA---HSTFEAGVAKLTVQDALPEDDGIYTCLAENNAGRASCS-AQVT- 613
Query: 192 IPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDE 371
+ ++K KK E ++N F AP F KGL D+ + +
Sbjct: 614 VKEKK-------------SSKKAEGTQAAKLNKTF----------APIFLKGLTDLKVMD 650
Query: 372 GNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGT--INYLELTRCTEIGKHNIR 545
G+ + + ++P I+W N +E+ F G Y++ + GK+
Sbjct: 651 GSQVIMTVEVSANPCPEIIWLHNGKEIQETEDFHFEKKGNEYSLYIQEVFPEDTGKYTCE 710
Query: 546 VVATNPLGQQSSECVLTV 599
A N LG+ ++ LTV
Sbjct: 711 --AWNELGETQTQATLTV 726
Score = 41.6 bits (96), Expect = 0.003
Identities = 47/212 (22%), Positives = 78/212 (36%), Gaps = 6/212 (2%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFD-RGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 188
+ W++NG + G + RG +L I D G YTC A N G +
Sbjct: 59 ITWYRNGHPLPEGDHYVVDHSIRGIFSLVIKGVQEGDSGKYTCEAANDGGVRQ------- 111
Query: 189 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 368
+ E V + L + S+ K H + P+F V++
Sbjct: 112 -VTVELTVEGNSLKKYSLPSSAKTPGGRLSV--PPVEHRPSIWGESPPKFATKPNRVVVR 168
Query: 369 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLEL--TRCTEIGKHNI 542
EG +F I P+ + W+ + + + + I YLE+ + + G +
Sbjct: 169 EGQTGRFSCKITGRPQPQVTWTKGDIHLQQNERFNMFEKTGIQYLEIQNVQLADAGIYTC 228
Query: 543 RVVATNPLGQQSSECVLTV---NSINNYAQDL 629
VV N G+ S LTV + + +AQ L
Sbjct: 229 TVV--NSAGKASVSAELTVQGPDKTDTHAQPL 258
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/150 (22%), Positives = 60/150 (40%)
Frame = +3
Query: 291 AFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN 470
A + T + AP F + LQD + +G I S P A++ W+++++ + S
Sbjct: 1071 ASKPTPPPSKGTAPSFTEKLQDAKVADGEKLVLQCRISSDPPASVSWTLDSKAIKSSKSI 1130
Query: 471 KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPEN 650
+GT+ L + + + +A N G+ C + V +D
Sbjct: 1131 VISQEGTLCSLTIEKVMPEDGGEYKCIAENAAGKAECACKVLV-------EDTSSTKAAK 1183
Query: 651 PYKKMASLKKVEVTPELTTALHKPKATAEK 740
P +K K + P L+T +AT +K
Sbjct: 1184 PAEKKTKKPKTTLPPVLST--ESSEATVKK 1211
Score = 38.9 bits (89), Expect = 0.017
Identities = 32/118 (27%), Positives = 46/118 (38%), Gaps = 14/118 (11%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS------ 173
V W K + RFN G L+I D G+YTC NS G+A S
Sbjct: 187 VTWTKGDIHLQQNERFNMFEKTGIQYLEIQNVQLADAGIYTCTVVNSAGKASVSAELTVQ 246
Query: 174 -------HSQITCIPDEKIVSKSHLNESSISQLKKFESN-IQEEINDAFRHTEVQEED 323
H+Q C+P + + E+ S K+ SN I +E+ V+ +D
Sbjct: 247 GPDKTDTHAQPLCMPPKPTTLATKAIEN--SDFKQATSNGIAKELKSTSTELMVETKD 302
Score = 38.9 bits (89), Expect = 0.017
Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEA 164
V W+K+ Q + F +D G C+L I +DD YTC A NS GEA
Sbjct: 1825 VMWYKDDQPVKESRHFQIDYDEEGNCSLTISEVCGDDDAKYTCKAVNSLGEA 1876
Score = 35.0 bits (79), Expect = 0.24
Identities = 16/53 (30%), Positives = 27/53 (50%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAE 167
+V W + +++ + C+L I PED G Y C+A+N+ G+AE
Sbjct: 1114 SVSWTLDSKAIKSSKSIVISQEGTLCSLTIEKVMPEDGGEYKCIAENAAGKAE 1166
Score = 33.1 bits (74), Expect = 0.92
Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 1/59 (1%)
Frame = +3
Query: 279 EINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV 452
E DAF +E+ P F K + D+ + EG+AA+F I +P ++W +++ V
Sbjct: 1776 ENEDAFLEEVAEEKPHVKPYFTKTILDMEVVEGSAARFDCKIEGYPDPEVMWYKDDQPV 1834
Score = 32.3 bits (72), Expect = 1.6
Identities = 19/64 (29%), Positives = 28/64 (43%)
Frame = +3
Query: 18 WHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIP 197
W NG+ + F+ +L I +PED G YTC A N GE ++ + P
Sbjct: 670 WLHNGKEIQETEDFHFEKKGNEYSLYIQEVFPEDTGKYTCEAWNELGETQTQATLTVQEP 729
Query: 198 DEKI 209
+ I
Sbjct: 730 QDGI 733
Score = 31.6 bits (70), Expect = 2.7
Identities = 21/90 (23%), Positives = 37/90 (41%)
Frame = +3
Query: 330 PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLEL 509
P+F+ Q + EG KF + P+ ++ W + + + Y + + L L
Sbjct: 429 PQFESRPQSLEASEGQEIKFKSKVSGKPKPDVEWFKEGVPIKTGEGIQIYEEDGTHCLWL 488
Query: 510 TRCTEIGKHNIRVVATNPLGQQSSECVLTV 599
+ + A NP GQ S+ +LTV
Sbjct: 489 KKACLGDSGSYSCAAFNPRGQTSTSWLLTV 518
>sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89 (Uncoordinated protein 89)
Length = 8081
Score = 51.2 bits (121), Expect = 3e-06
Identities = 65/312 (20%), Positives = 118/312 (37%), Gaps = 65/312 (20%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAI-FDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 188
V W NGQ ++ + G + I PE G T AKN+ GE E+S +++T
Sbjct: 2203 VSWLLNGQPLTKSDTVQVVDHGDGTYHVTIAEAKPEMSGTLTAKAKNAAGECETS-AKVT 2261
Query: 189 CIPDEK---IVSKSHLNESSISQLKKFESNI-------------------QEEINDAFRH 302
K V +E+++ + KF + + EE+ + H
Sbjct: 2262 VNGGNKKPEFVQAPQNHETTLEESVKFSAIVTGKPMPNVTWYLNNKKLIQSEEVKVKYVH 2321
Query: 303 T------------------------------------EVQEEDEAPRFDKGLQDVIIDEG 374
+V ++ E P+F + D + EG
Sbjct: 2322 ETGKTSIRIQKPLMEHNGTIRVEAENVSGKVQATAQLKVDKKTEVPKFTTNMDDRQVKEG 2381
Query: 375 NAAKFIINIYSHPRANIVWSINNEEVVS-DSVNKFYCDGTINYLELTRCTEIGKHNIRVV 551
KF N+ +P ++ W++N E V ++ DG + +E++ T +
Sbjct: 2382 EDVKFTANVEGYPEPSVAWTLNGEPVSKHPNITVTDKDGE-HTIEISAVTPEQAGELSCE 2440
Query: 552 ATNPLGQQSSECVLTVNSINN---YAQDLK-HIAPENPYKKM-ASLKKVEVTPELTTALH 716
ATNP+G + + L V + + +A++L+ + E M A L V+ P++T
Sbjct: 2441 ATNPVGSKKRDVQLAVKKVGDAPTFAKNLEDRLITEGELTLMDAKLNIVKPKPKITWLKD 2500
Query: 717 KPKATAEKIVKI 752
+ T++ KI
Sbjct: 2501 GVEITSDGHYKI 2512
Score = 50.8 bits (120), Expect = 4e-06
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 5/204 (2%)
Frame = +3
Query: 3 TLTVDWHKNGQSM--SMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSH 176
T V+W K+G+ + + + D G C + I+ D GVY CVA N G+AE+
Sbjct: 5305 TAEVEWFKDGKKIEHTAHTEIRNTVD-GACRIKIIPFEESDIGVYMCVAVNELGQAET-- 5361
Query: 177 SQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-APRFDKGLQ 353
++ Q EI H E ++ E AP+ + L+
Sbjct: 5362 ----------------------------QATYQVEI---LEHVEEEKRREYAPKINPPLE 5390
Query: 354 DVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEI 527
D ++ G + + + PRA++VW + + +DS ++ DGT L + TE
Sbjct: 5391 DKTVNGGQPIRLSCKVDAIPRASVVWYKDGLPLRADSRTSIQYEEDGTAT-LAINDSTEE 5449
Query: 528 GKHNIRVVATNPLGQQSSECVLTV 599
R VATN G ++ C + V
Sbjct: 5450 DIGAYRCVATNAHGTINTSCSVNV 5473
Score = 46.6 bits (109), Expect = 8e-05
Identities = 41/199 (20%), Positives = 80/199 (40%), Gaps = 8/199 (4%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDR---GYCALDILYTYPEDDGVYTCVAKNSQGEAES---S 173
+ W++NGQ + G R + + G C+L + + D+G+Y C A+N+ G+A++ +
Sbjct: 5518 IKWYRNGQLLRNGPR--TVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATA 5575
Query: 174 HSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQ 353
H Q+ EK +E + P+F L
Sbjct: 5576 HVQMALGKTEK---------------------------------PKMDEGKPPKFILELS 5602
Query: 354 DVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGT--INYLELTRCTEI 527
D+ + GN + P ++ WS + ++ DS ++ + + + L + T
Sbjct: 5603 DMSVSLGNVIDLECKVTGLPNPSVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVH 5662
Query: 528 GKHNIRVVATNPLGQQSSE 584
+ R VATN G +++
Sbjct: 5663 DEGTYRCVATNENGSATTK 5681
Score = 45.8 bits (107), Expect = 1e-04
Identities = 47/220 (21%), Positives = 84/220 (38%), Gaps = 9/220 (4%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDRG--YCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 185
V+W K+ + +++ + D G + L I ED GVYTC A N GEA+++ +
Sbjct: 3513 VEWFKDDKPINIDNSHIFAKDEGSGHHTLTIKQARGEDVGVYTCKATNEAGEAKTTANMA 3572
Query: 186 TCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVII 365
VQEE EAP F +GL+ +
Sbjct: 3573 -----------------------------------------VQEEIEAPLFVQGLKPYEV 3591
Query: 366 DEGNAAKFIINIYSHPRANIVW-------SINNEEVVSDSVNKFYCDGTINYLELTRCTE 524
++G A+ ++ + P + W +I+N+ V+ K ++ T +
Sbjct: 3592 EQGKPAELVVRVEGKPEPEVKWFKDGVPIAIDNQHVIE---KKGENGSHTLVIKDTNNAD 3648
Query: 525 IGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAP 644
GK+ + ATN G+ + L + + Q + + P
Sbjct: 3649 FGKYTCQ--ATNKAGKDETVGELKIPKYSFEKQTAEEVKP 3686
Score = 44.3 bits (103), Expect = 4e-04
Identities = 77/290 (26%), Positives = 113/290 (38%), Gaps = 60/290 (20%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRF--NAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 185
V W+KNGQ + SRF D Y L I +D Y V +N+ GEAESS +Q+
Sbjct: 4713 VKWYKNGQEIKPNSRFIIEQKTDTKY-QLVIKNAVRDDADTYKIVLENTAGEAESS-AQL 4770
Query: 186 TCIPDEKIVSK--SHLNESSISQLKK--FESNIQEE------------------------ 281
T + + K L + +++ K FE IQ E
Sbjct: 4771 TVKKAKAGLCKIVKGLEDQVVAKGAKMVFEVKIQGEPEDVRWLRDANVISAGANAIIEKI 4830
Query: 282 -------------INDAFRHT-EVQEE------------DEAPRFDKGLQDVIIDEGNAA 383
+ DA +T EV E DE P +GL+++ I EG+
Sbjct: 4831 DDTTYRLIIPSADLKDAGEYTVEVINESGKAKSDAKGEVDEKPEIVRGLENIEIPEGDDD 4890
Query: 384 KFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINY-LELTRCTEIGKHNIRVVATN 560
F + + S P + W N++E+ +S + G Y L + R + +VV +N
Sbjct: 4891 VFKVEV-SAPVRQVKWYKNDQEIKPNSHLEAKKIGPKKYELAINRAQLDDGADYKVVLSN 4949
Query: 561 PLGQQSSECVLTVNSIN--NYAQDLKHIAPENPYKKMASLK-KVEVTPEL 701
G S LTV N LK + E P + LK KVE P++
Sbjct: 4950 AAGDCDSSAALTVVKPNVLKIVDGLKDVDVEEP--QPVELKVKVEGIPKV 4997
Score = 44.3 bits (103), Expect = 4e-04
Identities = 47/217 (21%), Positives = 78/217 (35%), Gaps = 6/217 (2%)
Frame = +3
Query: 12 VDWHKNGQSMSM---GSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQ 182
+ W+KNGQ + G +F + G +L I + D G Y V N +GE S
Sbjct: 4998 IKWYKNGQELKPDADGFKFEEKPESGEFSLTIPSSKKSDGGAYRVVLGNDKGEVYS---- 5053
Query: 183 ITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVI 362
S+ +K +S+ E F L+D
Sbjct: 5054 -----------------GSVVHVKSAKSS---------------EPTSGANFLSPLKDTE 5081
Query: 363 IDEGNAAKFIINIYSHPRANIVWSINNEEVVSDS--VNKFYCDGTINY-LELTRCTEIGK 533
++EG+ I P ++W + + D + DGT + + ++IG+
Sbjct: 5082 VEEGDMLTLQCTIAGEPFPEVIWEKDGVVLQKDDRITMRVALDGTATLRIRSAKKSDIGQ 5141
Query: 534 HNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAP 644
+ RV A N G +S+C +TV K + P
Sbjct: 5142 Y--RVTAKNEAGSATSDCKVTVTEQGEQPSKPKFVIP 5176
Score = 43.9 bits (102), Expect = 5e-04
Identities = 46/215 (21%), Positives = 78/215 (36%), Gaps = 3/215 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 188
+ W+K+ + R D G+ A+ I D G YTC+A N G+A +S
Sbjct: 579 ITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQASTSAF--- 635
Query: 189 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 368
FR +V++E P F L+D
Sbjct: 636 -----------------------------------FRVLKVEKEAAPPAFVTKLRDKECK 660
Query: 369 EGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLEL--TRCTEIGKHNI 542
EG+ F + P +VW ++++ + + DG LE+ + + G + +
Sbjct: 661 EGDVIDFECEVEGWPEPELVWLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTV 720
Query: 543 RVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPE 647
++ N G S+ L V + D H+APE
Sbjct: 721 KI--QNEFGSIESKAELFVQA----DPDKNHVAPE 749
Score = 43.5 bits (101), Expect = 7e-04
Identities = 37/147 (25%), Positives = 56/147 (38%), Gaps = 1/147 (0%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 185
+V W+K+G + SR + ++ G L I + ED G Y CVA N+ G +S S
Sbjct: 5413 SVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNAHGTINTSCSVN 5472
Query: 186 TCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVII 365
+P + EV++E E P F KGL D+
Sbjct: 5473 VKVPKQ----------------------------------EVKKEGEEPFFTKGLVDLWA 5498
Query: 366 DEGNAAKFIINIYSHPRANIVWSINNE 446
D G++ + P I W N +
Sbjct: 5499 DRGDSFTLKCAVTGDPFPEIKWYRNGQ 5525
Score = 43.1 bits (100), Expect = 9e-04
Identities = 50/243 (20%), Positives = 86/243 (35%), Gaps = 8/243 (3%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 188
TV W+ G+ + R G + I ED G VA NS+G E+ +++T
Sbjct: 1074 TVTWYLKGEELKQSDRVEIREFDGSIKISIKNIKIEDAGEIRAVATNSEGSDETK-AKLT 1132
Query: 189 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 368
VQ++ AP FD + ++
Sbjct: 1133 ----------------------------------------VQKKPFAPEFDLRPVSLTVE 1152
Query: 369 EGNAAKFIINIYSHPRANIVWSINNEEV--VSDSVNKFYCDGTINYLEL------TRCTE 524
+G+ A F + + P WS+N +V + + T++ + T +E
Sbjct: 1153 KGSEAVFSAHAFGIPLPTYEWSVNGRKVRDGQEGARVTRDESTVDGASILTIDTATYYSE 1212
Query: 525 IGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELT 704
+ I VVA N LG + + LT+ K + +K + + E +PE T
Sbjct: 1213 VNHLTISVVAENTLGAEETGAQLTIEPKKESVVVEKQDLSSSEVQKEIAQQVKEASPEAT 1272
Query: 705 TAL 713
T +
Sbjct: 1273 TTI 1275
Score = 43.1 bits (100), Expect = 9e-04
Identities = 51/200 (25%), Positives = 77/200 (38%), Gaps = 3/200 (1%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 185
T+ W K+G+ + R I G C L + +D G Y CVA+N+ G A +S
Sbjct: 5845 TIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCVAENTYGSARTSCDVN 5904
Query: 186 TCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVII 365
D K +I+ + R E +AP F L
Sbjct: 5905 VIRGDRK----------------------PRDIDSSIR------EGKAPGFTTPLTIRRA 5936
Query: 366 DEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKF--YCDGTINYLELTRCTEIGKHN 539
G++ F + +P +I W + E+ SD K DGT L L+ T + +
Sbjct: 5937 KPGDSVTFECLPFGNPFPSIKWLKDGLELFSDEKIKMEAAADGT-QRLILSDVTFLSEGY 5995
Query: 540 IRVVATNPLGQQSSECVLTV 599
R VATN G S++ L +
Sbjct: 5996 FRCVATNEHGTASTKAELVI 6015
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/164 (23%), Positives = 67/164 (40%), Gaps = 4/164 (2%)
Frame = +3
Query: 120 DGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFR 299
+G + CVA N G A S+ +++ D I S+ E+N
Sbjct: 5993 EGYFRCVATNEHGTA-STKAELVIEGDRTIGSRP-----------------LPEVNG--- 6031
Query: 300 HTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNK-- 473
+ E+ PR +GL ++ I EGN + I+ P + W + +E+V D +
Sbjct: 6032 ----EPEECKPRIRRGLYNMSIHEGNVVEMIVCATGIPTPTVKWYKDGQEIVGDGPDGKR 6087
Query: 474 --FYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 599
F + I++L + + + + ATN LG +E L +
Sbjct: 6088 VIFTDERGIHHLVIVNASPDDEGEYSLEATNKLGSAKTEGSLNI 6131
Score = 41.6 bits (96), Expect = 0.003
Identities = 42/194 (21%), Positives = 62/194 (31%)
Frame = +3
Query: 18 WHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIP 197
W + Q + F +D L+I P+D GVYT +N G ES
Sbjct: 681 WLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTVKIQNEFGSIESKA------- 733
Query: 198 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGN 377
+ F + + AP F ++ V DEG
Sbjct: 734 ------------------------------ELFVQADPDKNHVAPEFQATIEYVECDEGE 763
Query: 378 AAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVAT 557
+F I P I+W IN + + KF + I L + T + +
Sbjct: 764 EVRFKSVITGDPNPEIIWFINGKPLSESEKVKFISEDGICILTIKDVTRHFDGMVTCQGS 823
Query: 558 NPLGQQSSECVLTV 599
N LG S + L V
Sbjct: 824 NRLGSASCDGRLKV 837
Score = 40.4 bits (93), Expect = 0.006
Identities = 48/203 (23%), Positives = 69/203 (33%), Gaps = 3/203 (1%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFD--RGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQ 182
+V W K+G + SRF + +G L I D+G Y CVA N G A
Sbjct: 5625 SVKWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSA------ 5678
Query: 183 ITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVI 362
+KS + D + V + PRF + DV
Sbjct: 5679 ---------TTKSFVRM------------------DDGLGSGVVTASQPPRFTLKMGDVR 5711
Query: 363 IDEGNAAKFIINIYSHPRANIVWSINNEEVV-SDSVNKFYCDGTINYLELTRCTEIGKHN 539
EG K + + P +VW + V SD + + L + C
Sbjct: 5712 TTEGQPLKLECKVDASPLPEMVWYKDGAIVTPSDRIQISLSPDGVATLLIPSCVYDDDGI 5771
Query: 540 IRVVATNPLGQQSSECVLTVNSI 608
RV+ATNP G + TV +
Sbjct: 5772 YRVIATNPSGTAQDKGTATVKKL 5794
Score = 40.0 bits (92), Expect = 0.008
Identities = 45/193 (23%), Positives = 70/193 (36%), Gaps = 2/193 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNA-IFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 188
+ + KN Q + +G + + G L I ED G Y C A N G+A ++
Sbjct: 3717 IKFFKNDQPVEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTN----- 3771
Query: 189 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 368
D KI + + E + + E Q E ++ AP F + L+ +
Sbjct: 3772 --ADLKIQFAAKVEEHVTDESGQLEEIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVT 3829
Query: 369 EGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYCDGTINYLELTRCTEIGKHNIR 545
E A + PR I W+ +EV +S V + D L T+ R
Sbjct: 3830 EKQQAILKCKVKGEPRPKIKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYR 3889
Query: 546 VVATNPLGQQSSE 584
A N G +E
Sbjct: 3890 CEAENEYGSAWTE 3902
Score = 38.5 bits (88), Expect = 0.022
Identities = 38/199 (19%), Positives = 74/199 (37%), Gaps = 5/199 (2%)
Frame = +3
Query: 18 WHKNGQSMSMGSRFNA---IFDRGYCALDILY--TYPEDDGVYTCVAKNSQGEAESSHSQ 182
W K+G+ + + +R G+ +++ PED G YTC+ +N+ G+
Sbjct: 2920 WLKDGKEIELIARIRVQTRTGPEGHITQELVLDNVTPEDAGKYTCIVENTAGKD------ 2973
Query: 183 ITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVI 362
TC E++++ ++ E + E +AP F LQD
Sbjct: 2974 -TC-------------EATLTVIESLEK---------------KSEKKAPEFIVALQDKT 3004
Query: 363 IDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNI 542
+ P+ + W +N+ + +S+ +G + + +T +
Sbjct: 3005 TKTSEKVVLECKVIGEPKPKVSWLHDNKTITQESITVESVEG-VERVTITSSELSHQGKY 3063
Query: 543 RVVATNPLGQQSSECVLTV 599
+A N G +E LTV
Sbjct: 3064 TCIAENTEGTSKTEAFLTV 3082
Score = 37.4 bits (85), Expect = 0.049
Identities = 27/98 (27%), Positives = 47/98 (47%), Gaps = 2/98 (2%)
Frame = +3
Query: 312 QEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYCDG 488
+++ + P+F + L D N F + + P+ + W + EE+ SD V DG
Sbjct: 1038 EKQKKPPKFVEILVDKTETVDNTVVFEVRVEGEPKPTVTWYLKGEELKQSDRVEIREFDG 1097
Query: 489 TINY-LELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 599
+I ++ + + G+ IR VATN G ++ LTV
Sbjct: 1098 SIKISIKNIKIEDAGE--IRAVATNSEGSDETKAKLTV 1133
Score = 37.0 bits (84), Expect = 0.064
Identities = 41/206 (19%), Positives = 63/206 (30%), Gaps = 61/206 (29%)
Frame = +3
Query: 18 WHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIP 197
W NG+ +S + I + G C L I DG+ TC N G A +P
Sbjct: 781 WFINGKPLSESEKVKFISEDGICILTIKDVTRHFDGMVTCQGSNRLGSASCDGRLKVRVP 840
Query: 198 DEKIVSKSHLNESSISQ--------------------------LKKFESNIQEEINDAF- 296
L + ++ + LK E ++ +D F
Sbjct: 841 PAPPTFNKPLEDKTVQEKSTVVFEVDVSGWPEPTLTFTLCGKELKNGEEGVEIVGHDGFY 900
Query: 297 -------------------------------RHTEVQEEDE---APRFDKGLQDVIIDEG 374
R T QEE+E AP F K ++D + G
Sbjct: 901 RISIPNTSMDKHDGEIVAKAQNEHGTAESRARLTVEQEEEESRSAPTFLKDIEDQTVKTG 960
Query: 375 NAAKFIINIYSHPRANIVWSINNEEV 452
A F + +P + W IN ++
Sbjct: 961 EFAVFETTVRGNPNPEVTWFINGHKM 986
Score = 37.0 bits (84), Expect = 0.064
Identities = 44/198 (22%), Positives = 65/198 (32%), Gaps = 2/198 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIF-DRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 188
+ W K G+ + M +R A D G L D G Y C A+N G A + I
Sbjct: 3848 IKWTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSAWTEGPIIV 3907
Query: 189 CIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIID 368
+ + + EAP F + ++ ++
Sbjct: 3908 TLEGAPKI-----------------------------------DGEAPDFLQPVKPAVVT 3932
Query: 369 EGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYCDGTINYLELTRCTEIGKHNIR 545
G A I P+ ++ W N EE+ SD V D L +T R
Sbjct: 3933 VGETAVLEGKISGKPKPSVKWYKNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYR 3992
Query: 546 VVATNPLGQQSSECVLTV 599
A+N G S+ LTV
Sbjct: 3993 CEASNEFGDVWSDVTLTV 4010
Score = 36.6 bits (83), Expect = 0.083
Identities = 47/204 (23%), Positives = 72/204 (35%), Gaps = 5/204 (2%)
Frame = +3
Query: 3 TLTVDWHKNGQSM----SMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAES 170
T TV W+K+GQ + G R +RG L I+ P+D+G Y+ A N G A++
Sbjct: 6066 TPTVKWYKDGQEIVGDGPDGKRVIFTDERGIHHLVIVNASPDDEGEYSLEATNKLGSAKT 6125
Query: 171 SHSQITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGL 350
S I+ H+ ++ F P F + L
Sbjct: 6126 EGSL-------NIIRPRHIADADERGGMPF----------------------PPGFVRQL 6156
Query: 351 QDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFY-CDGTINYLELTRCTEI 527
++ + F + HP + W N +++V K C G + L + T
Sbjct: 6157 KNKHVFNHMPTIFDCLVVGHPAPEVEWFHNGKKIVPGGRIKIQSCGGGSHALIILDTTLE 6216
Query: 528 GKHNIRVVATNPLGQQSSECVLTV 599
A N G SS VL V
Sbjct: 6217 DAGEYVATAKNSHGSASSSAVLDV 6240
Score = 35.4 bits (80), Expect = 0.19
Identities = 42/202 (20%), Positives = 85/202 (42%), Gaps = 11/202 (5%)
Frame = +3
Query: 183 ITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEED--EAPRFDKGLQD 356
IT I E + + ++ + I Q + Q + +++ E +AP+F L D
Sbjct: 2121 ITTIKTEDVYTLK-ISNAKIEQTGTVKVTAQNSAGQDSKQADLKVEPNVKAPKFKSQLTD 2179
Query: 357 VIIDEGNAAKFIINIYS-HPRANIVWSINNEEVV-SDSVNKF-YCDGTINYLELTRCTEI 527
+ DEG ++ + + P + W +N + + SD+V + DGT ++ +
Sbjct: 2180 KVADEGEPLRWNLELDGPSPGTEVSWLLNGQPLTKSDTVQVVDHGDGTY-HVTIAEAKPE 2238
Query: 528 GKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPEN------PYKKMASLKKVEV 689
+ A N G+ + +TVN N + ++ AP+N K +++ +
Sbjct: 2239 MSGTLTAKAKNAAGECETSAKVTVNGGNKKPEFVQ--APQNHETTLEESVKFSAIVTGKP 2296
Query: 690 TPELTTALHKPKATAEKIVKIE 755
P +T L+ K + VK++
Sbjct: 2297 MPNVTWYLNNKKLIQSEEVKVK 2318
Score = 34.3 bits (77), Expect = 0.41
Identities = 29/93 (31%), Positives = 44/93 (47%), Gaps = 4/93 (4%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGS----RFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSH 176
TV W+KNG+ + + + I D Y L+I + ED G Y N G A SS
Sbjct: 4617 TVKWYKNGKELPGAAAKTIKIQKIDDNKY-VLEIPSSVVEDTGDYKVEVANEAGSANSS- 4674
Query: 177 SQITCIPDEKIVSKSHLNESSISQLKKFESNIQ 275
+IT P KI L + SI++ + E +++
Sbjct: 4675 GKITVEP--KITFLKPLKDQSITEGENAEFSVE 4705
Score = 33.5 bits (75), Expect = 0.71
Identities = 37/196 (18%), Positives = 70/196 (35%), Gaps = 2/196 (1%)
Frame = +3
Query: 18 WHKNGQSMSMGSRFN-AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCI 194
W+K+G ++ R ++ G L I +DDG+Y +A N G A+
Sbjct: 5734 WYKDGAIVTPSDRIQISLSPDGVATLLIPSCVYDDDGIYRVIATNPSGTAQDK------- 5786
Query: 195 PDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEG 374
+++ +L + + D F + ++AP+ + L+++ I E
Sbjct: 5787 -----------GTATVKKLPRDSGARRSADRDVF------DANKAPKLMEPLENIRIPEK 5829
Query: 375 NAAKFIINIYSHPRANIVWSINNEEVVS-DSVNKFYCDGTINYLELTRCTEIGKHNIRVV 551
+ + P+ I W + E V + + L + T R V
Sbjct: 5830 QSFRLRCKFSGDPKPTIKWFKDGERVFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCV 5889
Query: 552 ATNPLGQQSSECVLTV 599
A N G + C + V
Sbjct: 5890 AENTYGSARTSCDVNV 5905
Score = 33.5 bits (75), Expect = 0.71
Identities = 19/53 (35%), Positives = 27/53 (50%), Gaps = 1/53 (1%)
Frame = +3
Query: 18 WHKNGQSMSMGSRFNAIFDRGY-CALDILYTYPEDDGVYTCVAKNSQGEAESS 173
W K + + SR + D Y C+L I D G+Y+CVA N G+A +S
Sbjct: 6540 WMKEWRPIVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTS 6592
Score = 33.1 bits (74), Expect = 0.92
Identities = 37/152 (24%), Positives = 65/152 (42%), Gaps = 4/152 (2%)
Frame = +3
Query: 306 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKF-YC 482
EV + E P F + L + A + + P ++ W + + V +DS +
Sbjct: 3278 EVTQSLEKPTFVRELVTTEVKINETATLSVTVKGVPDPSVEWLKDGQPVQTDSSHVIAKV 3337
Query: 483 DGTINY---LELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENP 653
+G+ +Y ++ R + GK+ R ATNP G+ +E V +K++ P
Sbjct: 3338 EGSGSYSITIKDARLEDSGKYACR--ATNPAGEAKTEANFAV---------VKNLVPPEF 3386
Query: 654 YKKMASLKKVEVTPELTTALHKPKATAEKIVK 749
+K++ L+ E E TT K T E V+
Sbjct: 3387 VEKLSPLEVKE--KESTTLSVKVVGTPEPSVE 3416
Score = 32.3 bits (72), Expect = 1.6
Identities = 34/132 (25%), Positives = 53/132 (40%), Gaps = 11/132 (8%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFN-AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 185
+V W+KNG+ + R D G L + +D Y C A N G+ S +
Sbjct: 3950 SVKWYKNGEELKPSDRVKIENLDDGTQRLTVTNAKLDDMDEYRCEASNEFGDVWSDVTLT 4009
Query: 186 TCIPDEKIVSKSHLNESSISQLK-----KFESNIQEEINDA--FRHTEVQEEDEAPRF-- 338
P + V+ E S Q+K KFE + D F+ +ED+ F
Sbjct: 4010 VKEPAQ--VAPGFFKELSAIQVKETETAKFECKVSGTKPDVKWFKDGTPLKEDKRVHFES 4067
Query: 339 -DKGLQDVIIDE 371
D G Q ++I++
Sbjct: 4068 TDDGTQRLVIED 4079
Score = 30.0 bits (66), Expect = 7.8
Identities = 19/85 (22%), Positives = 40/85 (47%), Gaps = 3/85 (3%)
Frame = +3
Query: 375 NAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINY---LELTRCTEIGKHNIR 545
++AK + + +P +I W ++ ++ D + FY D + ++ + T+ G++
Sbjct: 563 SSAKMCLKVTGYPLPDITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYT-- 620
Query: 546 VVATNPLGQQSSECVLTVNSINNYA 620
+ATN GQ S+ V + A
Sbjct: 621 CMATNEYGQASTSAFFRVLKVEKEA 645
Score = 30.0 bits (66), Expect = 7.8
Identities = 26/105 (24%), Positives = 48/105 (45%), Gaps = 4/105 (3%)
Frame = +3
Query: 303 TEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV----VSDSVN 470
T+ E+ P F KGL D + +G + I P+ ++ W N +E+ V D N
Sbjct: 4203 TKAAEKISLPSFKKGLADQSVPKGTPLVLEVEIEGKPK-DVKWYKNGDEIKDGKVEDLGN 4261
Query: 471 KFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNS 605
Y ++ E ++G+++ V A N G+ S+ + V++
Sbjct: 4262 GKYRLTIPDFQE----KDVGEYS--VTAANEAGEIESKAKVNVSA 4300
>sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth muscle and non-muscle isozymes
(MLCK) [Contains: Telokin (Kinase related protein)
(KRP)]
Length = 1914
Score = 50.4 bits (119), Expect = 6e-06
Identities = 40/152 (26%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFD---RGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQ 182
V WH+NGQ ++ G RF + D RG +L I + ED G YTC A N G +
Sbjct: 64 VTWHRNGQPITSGGRF--LLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQ----- 116
Query: 183 ITCIPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-----APRFDKG 347
+ E V S + + + + + D F + V+ P+F
Sbjct: 117 ---VTVELTVEGSFAKQLG-------QPVVSKTLGDRFSASAVETRPSIWGECPPKFATK 166
Query: 348 LQDVIIDEGNAAKFIINIYSHPRANIVWSINN 443
L V++ EG +F I P+ + W N
Sbjct: 167 LGRVVVKEGQMGRFSCKITGRPQPQVTWLKGN 198
Score = 49.7 bits (117), Expect = 1e-05
Identities = 45/204 (22%), Positives = 76/204 (37%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITC 191
+ W NGQ + + + G L I PED G YTC+A+N+ G+ S S
Sbjct: 545 ITWLLNGQPIQYA---RSTCEAGVAELHIQDALPEDHGTYTCLAENALGQV--SCSAWVT 599
Query: 192 IPDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDE 371
+ ++K KS + + AP F +GL D+ + +
Sbjct: 600 VHEKKSSRKSE-----------------------YLLPVAPSKPTAPIFLQGLSDLKVMD 636
Query: 372 GNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVV 551
G+ + + +P ++W N E+ F GT + L +
Sbjct: 637 GSQVTMTVQVSGNPPPEVIWLHNGNEIQESEDFHFEQRGTQHSLWIQEVFPEDTGTYTCE 696
Query: 552 ATNPLGQQSSECVLTVNSINNYAQ 623
A N G+ ++ VLTV ++ Q
Sbjct: 697 AWNSAGEVRTQAVLTVQEPHDGTQ 720
Score = 49.3 bits (116), Expect = 1e-05
Identities = 46/187 (24%), Positives = 80/187 (42%), Gaps = 11/187 (5%)
Frame = +3
Query: 195 PDEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQ 353
PDE +L +S +LKK +++ ++N H + ++ AP F + LQ
Sbjct: 1055 PDE------NLKSASKEELKK---DVKNDVNCKRGHAGTTDNEKRSESQGTAPAFKQKLQ 1105
Query: 354 DVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGK 533
DV + EG + S P A I+W++N + + + +G++ + + + +
Sbjct: 1106 DVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKTTKFIILSQEGSLCSVSIEKALPEDR 1165
Query: 534 HNIRVVATNPLGQQSSECVLTVN----SINNYAQDLKHIAPENPYKKMASLKKVEVTPEL 701
+ VA N GQ C +TV+ S N A ++K P+ +SL V T
Sbjct: 1166 GLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPEMKSRRPK------SSLPPVLGTESD 1219
Query: 702 TTALHKP 722
T KP
Sbjct: 1220 ATVKKKP 1226
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/56 (39%), Positives = 33/56 (58%), Gaps = 1/56 (1%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDRG-YCALDILYTYPEDDGVYTCVAKNSQGEAESS 173
T+ W NG+++ ++F + G C++ I PED G+Y CVAKN G+AE S
Sbjct: 1128 TIIWTLNGKTLKT-TKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182
Score = 38.9 bits (89), Expect = 0.017
Identities = 20/68 (29%), Positives = 39/68 (57%), Gaps = 1/68 (1%)
Frame = +3
Query: 252 KKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 428
+K ES +E+++ AF +E+ P F K ++D+ + EG+AA+F I +P +V
Sbjct: 1784 EKLES--EEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVV 1841
Query: 429 WSINNEEV 452
W +++ +
Sbjct: 1842 WFKDDQSI 1849
Score = 38.1 bits (87), Expect = 0.029
Identities = 22/52 (42%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEA 164
V W K+ QS+ F +D G C+L I +DD YTC A NS GEA
Sbjct: 1840 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1891
Score = 35.8 bits (81), Expect = 0.14
Identities = 42/172 (24%), Positives = 68/172 (39%), Gaps = 4/172 (2%)
Frame = +3
Query: 198 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGN 377
D K+V+ SH++++S+S + D+ TE AP F +++ I EG
Sbjct: 3 DVKLVASSHISKTSLS--------VDPSRVDSMPLTE------APAFILPPRNLCIKEGA 48
Query: 378 AAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCD----GTINYLELTRCTEIGKHNIR 545
AKF + +P + W N + + S +F D GT + L + E +
Sbjct: 49 TAKFEGRVRGYPEPQVTWHRNGQPITSG--GRFLLDCGIRGTFS-LVIHAVHEEDRGKYT 105
Query: 546 VVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPEL 701
ATN G + LTV ++A+ L S VE P +
Sbjct: 106 CEATNGSGARQVTVELTVE--GSFAKQLGQPVVSKTLGDRFSASAVETRPSI 155
Score = 35.8 bits (81), Expect = 0.14
Identities = 23/93 (24%), Positives = 39/93 (41%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITC 191
V W K + +R + G L+I +D GVYTC+ N G+A S
Sbjct: 192 VTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS------ 245
Query: 192 IPDEKIVSKSHLNESSISQLKKFESNIQEEIND 290
+ I N S + + K S++++E+ +
Sbjct: 246 -AELSIQGLDSANRSFVRETKATNSDVRKEVTN 277
Score = 33.9 bits (76), Expect = 0.54
Identities = 40/196 (20%), Positives = 65/196 (33%), Gaps = 2/196 (1%)
Frame = +3
Query: 72 DRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSISQL 251
D G L +L D G Y+C A N+QG+ S + + +L
Sbjct: 466 DAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTL------------------QVERL 507
Query: 252 KKFESNIQEEINDAFRHTEVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVW 431
E AP F L+D + EG ++ P I W
Sbjct: 508 AVMEV--------------------APSFSSVLKDCAVIEGQDFVLQCSVRGTPVPRITW 547
Query: 432 SINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVN--S 605
+N + + + C+ + L + +A N LGQ S +TV+
Sbjct: 548 LLNGQPI---QYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTVHEKK 604
Query: 606 INNYAQDLKHIAPENP 653
+ ++ L +AP P
Sbjct: 605 SSRKSEYLLPVAPSKP 620
Score = 31.2 bits (69), Expect = 3.5
Identities = 23/102 (22%), Positives = 37/102 (36%), Gaps = 1/102 (0%)
Frame = +3
Query: 306 EVQEEDEAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEV-VSDSVNKFYC 482
E Q + P+F+ Q + E KF + P+ + W + V + + Y
Sbjct: 406 EGQRDSAFPKFESKPQSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYE 465
Query: 483 DGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECVLTVNSI 608
D +YL L + A+N GQ S L V +
Sbjct: 466 DAGSHYLCLLKARTRDSGTYSCTASNAQGQVSCSWTLQVERL 507
>sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth muscle (MLCK) [Contains: Telokin]
Length = 1176
Score = 49.7 bits (117), Expect = 1e-05
Identities = 26/65 (40%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDRG-YCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQI 185
T+ W NG+++ ++F + G C++ I PED G+Y CVAKNS G+AESS
Sbjct: 386 TITWTLNGKTLKT-TKFIVLSQEGSLCSVSIEKALPEDRGLYKCVAKNSAGQAESSCQVT 444
Query: 186 TCIPD 200
+PD
Sbjct: 445 VDVPD 449
Score = 45.8 bits (107), Expect = 1e-04
Identities = 39/170 (22%), Positives = 72/170 (42%), Gaps = 13/170 (7%)
Frame = +3
Query: 252 KKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQDVIIDEGNAAKFIINIYSH 410
++ + I+ ++N H + ++ AP F++ LQD+ + EG + S
Sbjct: 323 EELKKEIKNDVNCKKGHAGATDSEKRPESRGTAPTFEEKLQDLHVAEGQKLLLQCRVSSD 382
Query: 411 PRANIVWSINNEEVVSDSVNKFYCDGTINYLELTRCTEIGKHNIRVVATNPLGQQSSECV 590
P A I W++N + + + +G++ + + + + + VA N GQ S C
Sbjct: 383 PPATITWTLNGKTLKTTKFIVLSQEGSLCSVSIEKALPEDRGLYKCVAKNSAGQAESSCQ 442
Query: 591 LTVN------SINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKP 722
+TV+ S N A ++K P+ +SL V T T KP
Sbjct: 443 VTVDVPDAPTSENAKAPEMKARRPK------SSLPPVLGTESDATVKKKP 486
Score = 38.1 bits (87), Expect = 0.029
Identities = 22/52 (42%), Positives = 27/52 (51%), Gaps = 1/52 (1%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEA 164
V W K+ QS+ F +D G C+L I +DD YTC A NS GEA
Sbjct: 1100 VVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEA 1151
Score = 37.7 bits (86), Expect = 0.037
Identities = 20/68 (29%), Positives = 38/68 (55%), Gaps = 1/68 (1%)
Frame = +3
Query: 252 KKFESNIQEEINDAFRHTEVQEEDEA-PRFDKGLQDVIIDEGNAAKFIINIYSHPRANIV 428
+K ES E+++ AF +E+ P F K ++D+ + EG+AA+F I +P +V
Sbjct: 1045 EKLES---EDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVV 1101
Query: 429 WSINNEEV 452
W +++ +
Sbjct: 1102 WFKDDQSI 1109
>sp|P13592|NCA12_HUMAN Neural cell adhesion molecule 1, 120 kDa isoform precursor (N-CAM
120) (NCAM-120) (CD56 antigen)
Length = 761
Score = 45.8 bits (107), Expect = 1e-04
Identities = 76/325 (23%), Positives = 117/325 (36%), Gaps = 58/325 (17%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNA-IFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS---- 173
T+ W K+G+ + IF L I D+ Y C+A+N GE +++
Sbjct: 244 TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLK 303
Query: 174 --------------------HSQITC------IP------------------DEKIVSKS 221
+TC IP D +V +S
Sbjct: 304 VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363
Query: 222 HLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQDVIIDEGNA 380
H SS++ LK + E +T Q+ AP+ +G V EGN
Sbjct: 364 HARVSSLT-LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQ 421
Query: 381 AKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNIRVVA 554
++++P A I W + + + S + + K Y + +YLE+T +E N A
Sbjct: 422 VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
Query: 555 TNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKPKATA 734
N +GQ+S E +L + I PY A ++ E PE T + K A
Sbjct: 482 VNRIGQESLEFIL----VQADTPSSPSIDQVEPYSSTAQVQFDE--PEATGGVPILKYKA 535
Query: 735 EKIVKIERNVEVNARHAKTADIKEA 809
E R V H+K D KEA
Sbjct: 536 E-----WRAVGEEVWHSKWYDAKEA 555
>sp|P13591|NCA11_HUMAN Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140) (CD56 antigen)
Length = 848
Score = 45.8 bits (107), Expect = 1e-04
Identities = 76/325 (23%), Positives = 117/325 (36%), Gaps = 58/325 (17%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNA-IFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS---- 173
T+ W K+G+ + IF L I D+ Y C+A+N GE +++
Sbjct: 244 TMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLK 303
Query: 174 --------------------HSQITC------IP------------------DEKIVSKS 221
+TC IP D +V +S
Sbjct: 304 VFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKTLDGHMVVRS 363
Query: 222 HLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQDVIIDEGNA 380
H SS++ LK + E +T Q+ AP+ +G V EGN
Sbjct: 364 HARVSSLT-LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVAVYTWEGNQ 421
Query: 381 AKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIGKHNIRVVA 554
++++P A I W + + + S + + K Y + +YLE+T +E N A
Sbjct: 422 VNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTA 481
Query: 555 TNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTALHKPKATA 734
N +GQ+S E +L + I PY A ++ E PE T + K A
Sbjct: 482 VNRIGQESLEFIL----VQADTPSSPSIDQVEPYSSTAQVQFDE--PEATGGVPILKYKA 535
Query: 735 EKIVKIERNVEVNARHAKTADIKEA 809
E R V H+K D KEA
Sbjct: 536 E-----WRAVGEEVWHSKWYDAKEA 555
>sp|O70468|MYPC3_MOUSE Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein,
cardiac muscle isoform)
Length = 1270
Score = 45.1 bits (105), Expect = 2e-04
Identities = 21/52 (40%), Positives = 27/52 (51%)
Frame = +3
Query: 12 VDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAE 167
+ W KNG + +RF +G L+I P D GVY C A N QGEA+
Sbjct: 1208 ISWFKNGLDLGEDARFRMFCKQGVLTLEIRKPCPYDGGVYVCRATNLQGEAQ 1259
Score = 30.8 bits (68), Expect = 4.6
Identities = 24/92 (26%), Positives = 37/92 (40%)
Frame = +3
Query: 324 EAPRFDKGLQDVIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVNKFYCDGTINYL 503
EAP F + L + I G A + P+ I W N ++ D+ + +C + L
Sbjct: 1175 EAPSFTQPLANRSIIAGYNAILCCAVRGSPKPKISWFKNGLDLGEDARFRMFCKQGVLTL 1234
Query: 504 ELTRCTEIGKHNIRVVATNPLGQQSSECVLTV 599
E+ + ATN G+ EC L V
Sbjct: 1235 EIRKPCPYDGGVYVCRATNLQGEAQCECRLEV 1266
>sp|P13590|NCAM1_CHICK Neural cell adhesion molecule 1, 180 kDa isoform precursor (N-CAM
180)
Length = 1091
Score = 45.1 bits (105), Expect = 2e-04
Identities = 57/213 (26%), Positives = 90/213 (42%), Gaps = 9/213 (4%)
Frame = +3
Query: 198 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQD 356
D +IV +SH SS++ LK+ + E +T Q+ AP+ +G
Sbjct: 356 DGRIVVRSHARVSSLT-LKEIQYTDAGEYVCTASNTIGQDSQAMYLEVQYAPKL-QGPVA 413
Query: 357 VIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIG 530
V EGN ++++P A I W + + + S + + K Y + +YLE+T +E
Sbjct: 414 VYTWEGNQVNITCEVFAYPSAVISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 473
Query: 531 KHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTA 710
N A N +GQ+SSE +L + I PY A ++ E PE T
Sbjct: 474 FGNYNCTAVNRIGQESSEFIL----VQADTPSSPSIDRVEPYSSTARVEFDE--PEATGG 527
Query: 711 LHKPKATAEKIVKIERNVEVNARHAKTADIKEA 809
+ K AE R + H++ D KEA
Sbjct: 528 VPILKYKAE-----WRALGEGEWHSRLYDAKEA 555
>sp|P13596|NCAM1_RAT Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140)
Length = 858
Score = 44.7 bits (104), Expect = 3e-04
Identities = 56/213 (26%), Positives = 89/213 (41%), Gaps = 9/213 (4%)
Frame = +3
Query: 198 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQD 356
D +V +SH SS++ LK + E +T Q+ AP+ +G
Sbjct: 367 DGHMVVRSHARVSSLT-LKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKL-QGPVA 424
Query: 357 VIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIG 530
V EGN ++++P A I W + + + S + + K Y + +YLE+T +E
Sbjct: 425 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 484
Query: 531 KHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTA 710
N A N +GQ+S E +L + I PY A ++ E PE T
Sbjct: 485 FGNYNCTAVNRIGQESLEFIL----VQADTPSSPSIDRVEPYSSTAQVQFDE--PEATGG 538
Query: 711 LHKPKATAEKIVKIERNVEVNARHAKTADIKEA 809
+ K AE +++ A H+K D KEA
Sbjct: 539 VPILKYKAE-----WKSLGEEAWHSKWYDAKEA 566
>sp|P31836|NCAM1_BOVIN Neural cell adhesion molecule 1, 140 kDa isoform precursor (N-CAM
140) (NCAM-140)
Length = 853
Score = 43.9 bits (102), Expect = 5e-04
Identities = 57/213 (26%), Positives = 87/213 (40%), Gaps = 9/213 (4%)
Frame = +3
Query: 198 DEKIVSKSHLNESSISQLKKFESNIQEEINDAFRHTEVQEEDE-------APRFDKGLQD 356
D +V +SH SS++ LK + E +T Q+ AP+ +G
Sbjct: 365 DGHMVVRSHARVSSLT-LKSIQYTDAGEYVCTASNTIGQDSQSMYLEVQYAPKL-QGPVA 422
Query: 357 VIIDEGNAAKFIINIYSHPRANIVWSINNEEVVSDSVN--KFYCDGTINYLELTRCTEIG 530
V EGN ++++P A I W + + + S + + K Y + +YLE+T +E
Sbjct: 423 VYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSEND 482
Query: 531 KHNIRVVATNPLGQQSSECVLTVNSINNYAQDLKHIAPENPYKKMASLKKVEVTPELTTA 710
N A N +GQ+S E VL + I PY A ++ E PE T
Sbjct: 483 FGNYNCTAVNRIGQESLEFVL----VQADTPSSPSIDQVEPYSSTAQVQFDE--PEATGG 536
Query: 711 LHKPKATAEKIVKIERNVEVNARHAKTADIKEA 809
+ K AE R + H+K D KEA
Sbjct: 537 VPILKYKAE-----WRAMGEEVWHSKWYDAKEA 564
Score = 33.1 bits (74), Expect = 0.92
Identities = 16/55 (29%), Positives = 25/55 (45%)
Frame = +3
Query: 9 TVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS 173
TV W K+G+ + +F L I D+ Y C+A+N GE ++S
Sbjct: 244 TVSWTKDGEQIENEEDEKYLFSDDSSELTIRKVDKNDEAEYVCIAENKAGEQDAS 298
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,415,746
Number of Sequences: 369166
Number of extensions: 1469436
Number of successful extensions: 5671
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5053
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5634
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)