Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_008_M08
(842 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89... 74 7e-13
sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth musc... 60 8e-09
sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth musc... 53 1e-06
sp|Q05623|MYBPH_CHICK Myosin-binding protein H (MyBP-H) (H-... 53 1e-06
sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth musc... 50 1e-05
sp|Q7TPD3|ROBO2_MOUSE Roundabout homolog 2 precursor 50 1e-05
sp|P16092|FGFR1_MOUSE Basic fibroblast growth factor recept... 49 2e-05
sp|P21804|FGFR1_CHICK Basic fibroblast growth factor recept... 49 2e-05
sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor recept... 49 2e-05
sp|Q04589|FGFR1_RAT Basic fibroblast growth factor receptor... 49 2e-05
>sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89 (Uncoordinated protein 89)
Length = 8081
Score = 73.6 bits (179), Expect = 7e-13
Identities = 69/243 (28%), Positives = 110/243 (45%), Gaps = 7/243 (2%)
Frame = +2
Query: 95 ESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTV 274
E + AP LE++ TVN +PIRLS +V SV W KDG PL +R S
Sbjct: 5376 EKRREYAPKINPPLEDK-TVNGGQPIRLSCKVDAIP--RASVVWYKDGLPLRADSRTSIQ 5432
Query: 275 FER-GYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYV 451
+E G L I S EED G Y CVA + G ++ + +P+ +V
Sbjct: 5433 YEEDGTATLAINDSTEEDIGAYRCVATNAHGTINTSCSVNVKVPKQEVK----------- 5481
Query: 452 QQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQ 631
+ + P+F+K L ++ ++G L+ V D + W++NGQ
Sbjct: 5482 -------------KEGEEPFFTKGLV-DLWADRGDSFTLKCAVT--GDPFPEIKWYRNGQ 5525
Query: 632 SMSMGSRFNAIFDR---GYCALDILYTYPEDDGVYTCVAKNSQGEAE---SSHSQITCIP 793
+ G R + + G C+L + + D+G+Y C A+N+ G+A+ ++H Q+
Sbjct: 5526 LLRNGPR--TVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQATAHVQMALGK 5583
Query: 794 DEK 802
EK
Sbjct: 5584 TEK 5586
Score = 59.7 bits (143), Expect = 1e-08
Identities = 69/259 (26%), Positives = 107/259 (41%), Gaps = 6/259 (2%)
Frame = +2
Query: 47 VASFNKSKGHGVQSQYESKEFEAPHFLSNL-ENEITVNEEEPIRLSSQVSPAGDNSLSVE 223
V F + GH S+ + + P F L + I V + I +P + VE
Sbjct: 5256 VCEFQQGAGHDDGSRDDLRY--PPRFNVPLWDRRIPVGDPMFIECHVDANPTAE----VE 5309
Query: 224 WLKDGRPL--LTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRV 397
W KDG+ + T + G + I+ E D GVY+CVA ++ GQ ++ AT +V
Sbjct: 5310 WFKDGKKIEHTAHTEIRNTVD-GACRIKIIPFEESDIGVYMCVAVNELGQAETQ-ATYQV 5367
Query: 398 IPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETI 577
+ + E + + PP K TVN G P+ L
Sbjct: 5368 ----------------EILEHVEEEKRREYAPKINPPLEDK------TVNGGQPIRLSCK 5405
Query: 578 VD--PRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNS 748
VD PR +V W+K+G + SR + ++ G L I + ED G Y CVA N+
Sbjct: 5406 VDAIPR----ASVVWYKDGLPLRADSRTSIQYEEDGTATLAINDSTEEDIGAYRCVATNA 5461
Query: 749 QGEAESSHSQITCIPDEKI 805
G +S S +P +++
Sbjct: 5462 HGTINTSCSVNVKVPKQEV 5480
Score = 53.9 bits (128), Expect = 5e-07
Identities = 64/232 (27%), Positives = 97/232 (41%), Gaps = 5/232 (2%)
Frame = +2
Query: 80 VQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGT 259
V Q KE E P F L ++ + + L V+ GD ++W ++G+ L G
Sbjct: 5475 VPKQEVKKEGEEPFFTKGLV-DLWADRGDSFTLKCAVT--GDPFPEIKWYRNGQLLRNGP 5531
Query: 260 RFSTVFER---GYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVN 430
R TV E G L + S D G+Y C A++ G+ ++ AT V
Sbjct: 5532 R--TVIETSPDGSCSLTVNESTMSDEGIYRCEAENAHGKAKTQ-ATAHV----------- 5577
Query: 431 FIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTV 610
Q +P K + +PP F +L S+++V+ G + LE V + +V
Sbjct: 5578 ----QMALGKTEKP----KMDEGKPPKFILEL-SDMSVSLGNVIDLECKVTGLPN--PSV 5626
Query: 611 DWHKNGQSMSMGSRFNAIFD--RGYCALDILYTYPEDDGVYTCVAKNSQGEA 760
W K+G + SRF + +G L I D+G Y CVA N G A
Sbjct: 5627 KWSKDGGPLIEDSRFEWSNEASKGVYQLRIKNATVHDEGTYRCVATNENGSA 5678
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/231 (28%), Positives = 95/231 (41%), Gaps = 8/231 (3%)
Frame = +2
Query: 116 PHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTV----FER 283
P + LE+++ V+ PI+L + S + +V+W K+G+ L G T+ +
Sbjct: 4588 PKIIKGLEDQV-VSIGSPIKLEIETS---GSPKTVKWYKNGKEL-PGAAAKTIKIQKIDD 4642
Query: 284 GYVVLDILYSIEEDSGVY-VCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQD 460
VL+I S+ ED+G Y V VA N S TV E K+
Sbjct: 4643 NKYVLEIPSSVVEDTGDYKVEVANEAGSANSSGKITV----EPKIT-------------- 4684
Query: 461 QNEPQHLDKHESSQPPYFSKDLQS-NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSM 637
F K L+ +IT + +ET PR V W+KNGQ +
Sbjct: 4685 -----------------FLKPLKDQSITEGENAEFSVETNTKPR-----IVKWYKNGQEI 4722
Query: 638 SMGSRF--NAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 784
SRF D Y L I +D Y V +N+ GEAESS +Q+T
Sbjct: 4723 KPNSRFIIEQKTDTKY-QLVIKNAVRDDADTYKIVLENTAGEAESS-AQLT 4771
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/226 (25%), Positives = 93/226 (41%), Gaps = 3/226 (1%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTR--FSTV 274
+E EAP F+ L+ V + +P L +V G V+W KDG P+ +
Sbjct: 3575 EEIEAPLFVQGLK-PYEVEQGKPAELVVRVE--GKPEPEVKWFKDGVPIAIDNQHVIEKK 3631
Query: 275 FERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQ 454
E G L I + D G Y C A +K+G++++ + E K+ + + +
Sbjct: 3632 GENGSHTLVIKDTNNADFGKYTCQATNKAGKDET-------VGELKIP------KYSFEK 3678
Query: 455 QDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQS 634
Q E + P F + L+ V +G V LE V+ + + + KN Q
Sbjct: 3679 QTAEEVK----------PLFIEPLKETFAV-EGDTVVLECKVNKESH--PQIKFFKNDQP 3725
Query: 635 MSMGSRFN-AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
+ +G + + G L I ED G Y C A N G+A ++
Sbjct: 3726 VEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTN 3771
Score = 48.5 bits (114), Expect = 2e-05
Identities = 53/226 (23%), Positives = 92/226 (40%), Gaps = 6/226 (2%)
Frame = +2
Query: 110 EAPHFLSNLENEITVNEEEPIRLSSQV--SPAGDNSLSVEWLKDGRPLLTGTRFS-TVFE 280
+ P F + ++ E +P++L +V SP + + W KDG + R ++
Sbjct: 5699 QPPRFTLKM-GDVRTTEGQPLKLECKVDASPLPE----MVWYKDGAIVTPSDRIQISLSP 5753
Query: 281 RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSN-PATVRVIPEAKVDNNVNFIENQYVQQ 457
G L I + +D G+Y +A + SG Q ATV+ +P
Sbjct: 5754 DGVATLLIPSCVYDDDGIYRVIATNPSGTAQDKGTATVKKLPR---------------DS 5798
Query: 458 DQNEPQHLDKHESSQPPYFSKDLQS-NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQS 634
D ++++ P + L++ I Q + + DP+ T+ W K+G+
Sbjct: 5799 GARRSADRDVFDANKAPKLMEPLENIRIPEKQSFRLRCKFSGDPKP----TIKWFKDGER 5854
Query: 635 MSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
+ R I G C L + +D G Y CVA+N+ G A +S
Sbjct: 5855 VFPYGRLQLIESPDGVCELVVDSATRQDAGGYRCVAENTYGSARTS 5900
Score = 47.8 bits (112), Expect = 4e-05
Identities = 57/230 (24%), Positives = 94/230 (40%), Gaps = 9/230 (3%)
Frame = +2
Query: 98 SKEFEAPHFLSNL-ENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTR--FS 268
++ E P F+ L E+ +NE + V+ G SVEWLKDG+P+ T + +
Sbjct: 3280 TQSLEKPTFVRELVTTEVKINETATL----SVTVKGVPDPSVEWLKDGQPVQTDSSHVIA 3335
Query: 269 TVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQY 448
V G + I + EDSG Y C A + +G EAK + N ++N
Sbjct: 3336 KVEGSGSYSITIKDARLEDSGKYACRATNPAG-------------EAKTEANFAVVKNLV 3382
Query: 449 VQQDQNEPQHLDKHESSQPPYFSKDLQS-NITVNQGGPVHLETIVDPRNDFTLTVDWHKN 625
PP F + L + + + ++ + P +V+W K+
Sbjct: 3383 ------------------PPEFVEKLSPLEVKEKESTTLSVKVVGTPEP----SVEWFKD 3420
Query: 626 GQSMSMGS-----RFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEA 760
+S+ + + A+ G +L I D G+Y+C A+N GEA
Sbjct: 3421 DTPISIDNVHVIQKQTAV---GSFSLTINDARQGDVGIYSCRARNEAGEA 3467
Score = 47.8 bits (112), Expect = 4e-05
Identities = 58/229 (25%), Positives = 101/229 (44%), Gaps = 7/229 (3%)
Frame = +2
Query: 95 ESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFST- 271
++ E P F+ L+ V E + + L +V+ ++ +++ K+ +P+ G
Sbjct: 3679 QTAEEVKPLFIEPLKETFAV-EGDTVVLECKVNK--ESHPQIKFFKNDQPVEIGQHMQLE 3735
Query: 272 VFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYV 451
V E G + L I + +ED G Y C A + +G+ +N A +++ AKV+ +V Q
Sbjct: 3736 VLEDGNIKLTIQNAKKEDVGAYRCEAVNVAGKANTN-ADLKIQFAAKVEEHVTDESGQLE 3794
Query: 452 QQDQNE---PQHLDKHESSQ-PPYFSKDLQS-NITVNQGGPVHLETIVDPRNDFTLTVDW 616
+ Q E K ++ + P F + L+S +T Q + + +PR + W
Sbjct: 3795 EIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAILKCKVKGEPRP----KIKW 3850
Query: 617 HKNGQSMSMGSRFNAIF-DRGYCALDILYTYPEDDGVYTCVAKNSQGEA 760
K G+ + M +R A D G L D G Y C A+N G A
Sbjct: 3851 TKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSA 3899
Score = 47.4 bits (111), Expect = 5e-05
Identities = 59/252 (23%), Positives = 103/252 (40%), Gaps = 7/252 (2%)
Frame = +2
Query: 32 DQFNHVASFNKSKGHGVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNS 211
D ++ A S G + + + EAP F L+ + +V E+E I++ +V G ++
Sbjct: 3161 DIVSYKAIATNSIGTATSTSKITTKVEAPVFEQGLK-KTSVKEKEEIKMEVKV---GGSA 3216
Query: 212 LSVEWLKDGRPLLTGTRFSTVF--ERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPA 385
VEW KD +P+ E G L + + D+G Y A + +G +S+
Sbjct: 3217 PDVEWFKDDKPVSEDGNHEMKKNPETGVFTLVVKQAATTDAGKYTAKASNPAGTAESSA- 3275
Query: 386 TVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDL-QSNITVNQGGP- 559
EA+V +S + P F ++L + + +N+
Sbjct: 3276 ------EAEVT------------------------QSLEKPTFVRELVTTEVKINETATL 3305
Query: 560 -VHLETIVDPRNDFTLTVDWHKNGQSMSMGSR--FNAIFDRGYCALDILYTYPEDDGVYT 730
V ++ + DP +V+W K+GQ + S + G ++ I ED G Y
Sbjct: 3306 SVTVKGVPDP------SVEWLKDGQPVQTDSSHVIAKVEGSGSYSITIKDARLEDSGKYA 3359
Query: 731 CVAKNSQGEAES 766
C A N GEA++
Sbjct: 3360 CRATNPAGEAKT 3371
Score = 47.4 bits (111), Expect = 5e-05
Identities = 58/234 (24%), Positives = 103/234 (44%), Gaps = 9/234 (3%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEP-IRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVF 277
+E +AP F + L T+ +P ++ + P G+ S++WLKDG L + +
Sbjct: 5920 REGKAPGFTTPL----TIRRAKPGDSVTFECLPFGNPFPSIKWLKDGLELFSDEKIKMEA 5975
Query: 278 E----RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQ 445
+ ++ D+ + E G + CVA ++ G T E ++ + I ++
Sbjct: 5976 AADGTQRLILSDVTFLSE---GYFRCVATNEHG-------TASTKAELVIEGD-RTIGSR 6024
Query: 446 YVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKN 625
+ + EP+ P + L N+++++G V E IV T TV W+K+
Sbjct: 6025 PLPEVNGEPEECK-------PRIRRGLY-NMSIHEGNVV--EMIVCATGIPTPTVKWYKD 6074
Query: 626 GQSM----SMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHS 775
GQ + G R +RG L I+ P+D+G Y+ A N G A++ S
Sbjct: 6075 GQEIVGDGPDGKRVIFTDERGIHHLVIVNASPDDEGEYSLEATNKLGSAKTEGS 6128
Score = 45.1 bits (105), Expect = 3e-04
Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 1/104 (0%)
Frame = +2
Query: 116 PHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYVV 295
P+F+ L N+ T + +P+R+ +V G+ ++W+K+ RP++ +R V + Y+
Sbjct: 6507 PNFIQPLVNK-TFSSAQPMRMDVRVD--GEPFPELKWMKEWRPIVESSRIKFVQDGPYLC 6563
Query: 296 LDILYS-IEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNN 424
I+ + DSG+Y CVA + +GQ + TV V EA+ D N
Sbjct: 6564 SLIINDPMWRDSGIYSCVAVNDAGQ-ATTSCTVTV--EAEGDYN 6604
Score = 42.7 bits (99), Expect = 0.001
Identities = 51/222 (22%), Positives = 87/222 (39%), Gaps = 2/222 (0%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE 280
KE P F++ L ++ E + I +V G + WL D +PL F ++
Sbjct: 643 KEAAPPAFVTKLRDK-ECKEGDVIDFECEVE--GWPEPELVWLVDDQPLRPSHDFRLQYD 699
Query: 281 RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQD 460
L+I + +D+GVY K+ N IE++
Sbjct: 700 GQTAKLEIRDAQPDDTGVYT----------------------VKIQNEFGSIESKAELFV 737
Query: 461 QNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIV--DPRNDFTLTVDWHKNGQS 634
Q +P DK+ + P F ++ + ++G V ++++ DP + + W NG+
Sbjct: 738 QADP---DKNHVA--PEFQATIEY-VECDEGEEVRFKSVITGDPNPE----IIWFINGKP 787
Query: 635 MSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEA 760
+S + I + G C L I DG+ TC N G A
Sbjct: 788 LSESEKVKFISEDGICILTIKDVTRHFDGMVTCQGSNRLGSA 829
Score = 40.0 bits (92), Expect = 0.008
Identities = 51/230 (22%), Positives = 90/230 (39%), Gaps = 5/230 (2%)
Frame = +2
Query: 101 KEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE 280
K+ E P F +N+++ V E E ++ ++ V G SV W +G P+ + +
Sbjct: 2362 KKTEVPKFTTNMDDR-QVKEGEDVKFTANVE--GYPEPSVAWTLNGEPVSKHPNITVTDK 2418
Query: 281 RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSN-PATVRVIPEAKVDNNVNFIENQYVQQ 457
G ++I E +G C A + G + + V+ + +A
Sbjct: 2419 DGEHTIEISAVTPEQAGELSCEATNPVGSKKRDVQLAVKKVGDA---------------- 2462
Query: 458 DQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLE---TIVDPRNDFTLTVDWHKNG 628
P F+K+L+ + + +G ++ IV P+ T W K+G
Sbjct: 2463 ----------------PTFAKNLEDRL-ITEGELTLMDAKLNIVKPKPKIT----WLKDG 2501
Query: 629 QSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESSHS 775
++ + + + G L IL T ED G T A++ G AE S S
Sbjct: 2502 VEITSDGHYKIVEEEDGSLKLSILQTKLEDKGRITIKAESEFGVAECSAS 2551
Score = 39.3 bits (90), Expect = 0.014
Identities = 49/246 (19%), Positives = 99/246 (40%), Gaps = 10/246 (4%)
Frame = +2
Query: 110 EAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGY 289
E P FL L N V ++ +V GD S+ W + + +L ++ V +
Sbjct: 2752 EPPDFLEWLSN---VRARTGTKVVHKVVFTGDPKPSLTWYINNKEILNSDLYTIVTDDKT 2808
Query: 290 VVLDI-LYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQN 466
L I ++ + G +C A++ +G+ + + ++ ++V D
Sbjct: 2809 STLTINSFNPDVHVGEIICKAENDAGEVSCTANMITYTSDMFSESESEAQAEEFVGDDLT 2868
Query: 467 EPQHL--DKHESSQPPYFSKDLQS--NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQS 634
E + L + H + P K + + +G E +V + W K+G+
Sbjct: 2869 EDESLREEMHRTPTPVMAPKFITKIKDTKAKKGHSAVFECVVPDTKG--VCCKWLKDGKE 2926
Query: 635 MSMGSRFNA---IFDRGYCALDILY--TYPEDDGVYTCVAKNSQGEAESSHSQITCIPDE 799
+ + +R G+ +++ PED G YTC+ +N+ G+ ++ + +T I E
Sbjct: 2927 IELIARIRVQTRTGPEGHITQELVLDNVTPEDAGKYTCIVENTAGK-DTCEATLTVI--E 2983
Query: 800 KIVSKS 817
+ KS
Sbjct: 2984 SLEKKS 2989
Score = 36.6 bits (83), Expect = 0.089
Identities = 49/173 (28%), Positives = 75/173 (43%), Gaps = 9/173 (5%)
Frame = +2
Query: 350 KSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQH---LDKHESSQPPYFSK 520
K++ G + N + VIP+A D+ + + +D N L ++ P K
Sbjct: 4535 KAQPGSDGDNKPQL-VIPDAGDDDAAEY-KVVLTDEDGNTADSSCALTVKLPAKEPKIIK 4592
Query: 521 DLQSNITVNQGGPVHLE--TIVDPRNDFTLTVDWHKNGQSMSMGS----RFNAIFDRGYC 682
L+ + V+ G P+ LE T P+ TV W+KNG+ + + + I D Y
Sbjct: 4593 GLEDQV-VSIGSPIKLEIETSGSPK-----TVKWYKNGKELPGAAAKTIKIQKIDDNKY- 4645
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKIVSKSHLNESSIS 841
L+I + ED G Y N G A SS +IT P KI L + SI+
Sbjct: 4646 VLEIPSSVVEDTGDYKVEVANEAGSANSS-GKITVEP--KITFLKPLKDQSIT 4695
Score = 36.6 bits (83), Expect = 0.089
Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 1/114 (0%)
Frame = +2
Query: 431 FIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTV 610
F +N Y QN L + P +K T + P+ ++ VD + +
Sbjct: 6487 FAKNDYGDAQQNIMVDLATRPNFIQPLVNK------TFSSAQPMRMDVRVD--GEPFPEL 6538
Query: 611 DWHKNGQSMSMGSRFNAIFDRGY-CALDILYTYPEDDGVYTCVAKNSQGEAESS 769
W K + + SR + D Y C+L I D G+Y+CVA N G+A +S
Sbjct: 6539 KWMKEWRPIVESSRIKFVQDGPYLCSLIINDPMWRDSGIYSCVAVNDAGQATTS 6592
Score = 33.5 bits (75), Expect = 0.76
Identities = 44/184 (23%), Positives = 65/184 (35%), Gaps = 1/184 (0%)
Frame = +2
Query: 218 VEWLKDGRPLLTGTRFSTVF-ERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVR 394
+ W KD L R + E G+ + I D+G Y C+A ++ GQ S A R
Sbjct: 579 ITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQ-ASTSAFFR 637
Query: 395 VIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLET 574
V+ K + PP F L+ +G + E
Sbjct: 638 VLKVEK---------------------------EAAPPAFVTKLRDK-ECKEGDVIDFEC 669
Query: 575 IVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQG 754
V+ + L W + Q + F +D L+I P+D GVYT +N G
Sbjct: 670 EVEGWPEPELV--WLVDDQPLRPSHDFRLQYDGQTAKLEIRDAQPDDTGVYTVKIQNEFG 727
Query: 755 EAES 766
ES
Sbjct: 728 SIES 731
Score = 33.1 bits (74), Expect = 0.99
Identities = 23/81 (28%), Positives = 36/81 (44%), Gaps = 3/81 (3%)
Frame = +2
Query: 533 NITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSM---GSRFNAIFDRGYCALDILYT 703
++ V + PV L+ V+ + W+KNGQ + G +F + G +L I +
Sbjct: 4976 DVDVEEPQPVELKVKVE---GIPKVIKWYKNGQELKPDADGFKFEEKPESGEFSLTIPSS 5032
Query: 704 YPEDDGVYTCVAKNSQGEAES 766
D G Y V N +GE S
Sbjct: 5033 KKSDGGAYRVVLGNDKGEVYS 5053
Score = 31.2 bits (69), Expect = 3.7
Identities = 17/55 (30%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Frame = +2
Query: 608 VDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
+ W+K+ + R D G+ A+ I D G YTC+A N G+A +S
Sbjct: 579 ITWYKDDVQLHEDERHTFYSDEDGFFAMTIDPVQVTDTGRYTCMATNEYGQASTS 633
>sp|P11799|MYLK_CHICK Myosin light chain kinase, smooth muscle and non-muscle isozymes
(MLCK) [Contains: Telokin]
Length = 1906
Score = 60.1 bits (144), Expect = 8e-09
Identities = 63/238 (26%), Positives = 98/238 (41%), Gaps = 2/238 (0%)
Frame = +2
Query: 77 GVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTG 256
G+ Q+ES+ + +E + I+ S+VS G VEW K+G P+ TG
Sbjct: 426 GIPPQFESRP-----------QSLEASEGQEIKFKSKVS--GKPKPDVEWFKEGVPIKTG 472
Query: 257 TRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFI 436
E G L + + DSG Y C A + G Q++ + + + KV+
Sbjct: 473 EGIQIYEEDGTHCLWLKKACLGDSGSYSCAAFNPRG--QTSTSWLLTVKRPKVE------ 524
Query: 437 ENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVD--PRNDFTLTV 610
P FS L+ TV++G L+ V P + T
Sbjct: 525 --------------------EVAPCFSSVLK-GCTVSEGQDFVLQCYVGGVPVPEIT--- 560
Query: 611 DWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 784
W N Q + ++ F+ G L + PEDDG+YTC+A+N+ G A S +Q+T
Sbjct: 561 -WLLNEQPIQYA---HSTFEAGVAKLTVQDALPEDDGIYTCLAENNAGRASCS-AQVT 613
Score = 49.7 bits (117), Expect = 1e-05
Identities = 59/234 (25%), Positives = 96/234 (41%), Gaps = 3/234 (1%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYV 292
AP F S L+ TV+E + L V G + WL + +P+ + FE G
Sbjct: 527 APCFSSVLKG-CTVSEGQDFVLQCYVG--GVPVPEITWLLNEQPIQYA---HSTFEAGVA 580
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQNQ-SNPATVRVIPEAKVDNNVNFIENQYVQQDQNE 469
L + ++ ED G+Y C+A++ +G+ S TV+ +K + E
Sbjct: 581 KLTVQDALPEDDGIYTCLAENNAGRASCSAQVTVKEKKSSK----------------KAE 624
Query: 470 PQHLDKHESSQPPYFSKDLQSNITVNQGGPVHL--ETIVDPRNDFTLTVDWHKNGQSMSM 643
K + P F K L +++ V G V + E +P + + W NG+ +
Sbjct: 625 GTQAAKLNKTFAPIFLKGL-TDLKVMDGSQVIMTVEVSANPCPE----IIWLHNGKEIQE 679
Query: 644 GSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPDEKI 805
F+ +L I +PED G YTC A N GE ++ + P + I
Sbjct: 680 TEDFHFEKKGNEYSLYIQEVFPEDTGKYTCEAWNELGETQTQATLTVQEPQDGI 733
Score = 49.3 bits (116), Expect = 1e-05
Identities = 55/229 (24%), Positives = 80/229 (34%), Gaps = 23/229 (10%)
Frame = +2
Query: 218 VEWLKDGRPLLTGTRFSTVFE-RGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVR 394
+ W ++G PL G + RG L I E DSG Y C A + G Q TV
Sbjct: 59 ITWYRNGHPLPEGDHYVVDHSIRGIFSLVIKGVQEGDSGKYTCEAANDGGVRQ---VTVE 115
Query: 395 VIPEAKVDNNVNFIENQYVQQDQNEP---------QHLDKHESSQPPYFSKDLQSNITVN 547
+ E N ++ + P +H PP F+ + + V
Sbjct: 116 LTVEG------NSLKKYSLPSSAKTPGGRLSVPPVEHRPSIWGESPPKFATK-PNRVVVR 168
Query: 548 QGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVY 727
+G + R +T W K + RFN G L+I D G+Y
Sbjct: 169 EGQTGRFSCKITGRPQPQVT--WTKGDIHLQQNERFNMFEKTGIQYLEIQNVQLADAGIY 226
Query: 728 TCVAKNSQGEAESS-------------HSQITCIPDEKIVSKSHLNESS 835
TC NS G+A S H+Q C+P + + E+S
Sbjct: 227 TCTVVNSAGKASVSAELTVQGPDKTDTHAQPLCMPPKPTTLATKAIENS 275
Score = 46.6 bits (109), Expect = 9e-05
Identities = 38/135 (28%), Positives = 61/135 (45%), Gaps = 1/135 (0%)
Frame = +2
Query: 359 SGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNI 538
SG+ S + I KV+N E+ ++++ E H+ PYF+K + ++
Sbjct: 1757 SGRKASGSSPTSPINADKVEN-----EDAFLEEVAEEKPHVK-------PYFTKTIL-DM 1803
Query: 539 TVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYCALDILYTYPED 715
V +G + ++ D V W+K+ Q + F +D G C+L I +D
Sbjct: 1804 EVVEGSAARFDCKIEGYPD--PEVMWYKDDQPVKESRHFQIDYDEEGNCSLTISEVCGDD 1861
Query: 716 DGVYTCVAKNSQGEA 760
D YTC A NS GEA
Sbjct: 1862 DAKYTCKAVNSLGEA 1876
Score = 39.3 bits (90), Expect = 0.014
Identities = 56/255 (21%), Positives = 95/255 (37%)
Frame = +2
Query: 59 NKSKGHGVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDG 238
+ K G Q+ +K F AP FL L ++ V + + ++ +VS + + WL +G
Sbjct: 619 SSKKAEGTQAAKLNKTF-APIFLKGL-TDLKVMDGSQVIMTVEVS--ANPCPEIIWLHNG 674
Query: 239 RPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVD 418
+ + F + L I ED+G Y C A ++ G+ Q+ AT+ V
Sbjct: 675 KEIQETEDFHFEKKGNEYSLYIQEVFPEDTGKYTCEAWNELGETQTQ-ATLTV------- 726
Query: 419 NNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDF 598
EPQ + QP + SK Q + DP
Sbjct: 727 ---------------QEPQ-----DGIQPWFISKPRSVTAAAGQNVLISCAIAGDPFP-- 764
Query: 599 TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQ 778
TV W K+GQ ++ G+ + + L + G Y +N GE Q
Sbjct: 765 --TVHWFKDGQEITPGTGCEILQNEDIFTLILRNVQSRHAGQYEIQLRNQVGECS---CQ 819
Query: 779 ITCIPDEKIVSKSHL 823
++ + E S++ +
Sbjct: 820 VSLMLRESSASRAEM 834
Score = 36.6 bits (83), Expect = 0.089
Identities = 24/86 (27%), Positives = 42/86 (48%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCA 685
P F++ LQ + V G + L+ + +D +V W + +++ + C+
Sbjct: 1084 PSFTEKLQ-DAKVADGEKLVLQCRIS--SDPPASVSWTLDSKAIKSSKSIVISQEGTLCS 1140
Query: 686 LDILYTYPEDDGVYTCVAKNSQGEAE 763
L I PED G Y C+A+N+ G+AE
Sbjct: 1141 LTIEKVMPEDGGEYKCIAENAAGKAE 1166
Score = 35.4 bits (80), Expect = 0.20
Identities = 34/136 (25%), Positives = 59/136 (43%), Gaps = 3/136 (2%)
Frame = +2
Query: 371 QSNPA-TVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVN 547
Q NP+ T +V P ++ N + V++++ EP + PP F QS + +
Sbjct: 391 QENPSLTGQVSPRSRETENRAGVRKS-VKEEKREPLGI-------PPQFESRPQS-LEAS 441
Query: 548 QGGPVHLETIVD--PRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDG 721
+G + ++ V P+ D V+W K G + G + G L + D G
Sbjct: 442 EGQEIKFKSKVSGKPKPD----VEWFKEGVPIKTGEGIQIYEEDGTHCLWLKKACLGDSG 497
Query: 722 VYTCVAKNSQGEAESS 769
Y+C A N +G+ +S
Sbjct: 498 SYSCAAFNPRGQTSTS 513
Score = 31.6 bits (70), Expect = 2.9
Identities = 23/85 (27%), Positives = 38/85 (44%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYV 292
AP F L+ + V + E + L ++S D SV W D + + + E
Sbjct: 1083 APSFTEKLQ-DAKVADGEKLVLQCRIS--SDPPASVSWTLDSKAIKSSKSIVISQEGTLC 1139
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQ 367
L I + ED G Y C+A++ +G+
Sbjct: 1140 SLTIEKVMPEDGGEYKCIAENAAGK 1164
>sp|Q28824|MYLK_BOVIN Myosin light chain kinase, smooth muscle (MLCK) [Contains: Telokin]
Length = 1176
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/98 (35%), Positives = 54/98 (55%), Gaps = 1/98 (1%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRG-YC 682
P F + LQ ++ V +G + L+ V +D T+ W NG+++ ++F + G C
Sbjct: 356 PTFEEKLQ-DLHVAEGQKLLLQCRVS--SDPPATITWTLNGKTLKT-TKFIVLSQEGSLC 411
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEAESSHSQITCIPD 796
++ I PED G+Y CVAKNS G+AESS +PD
Sbjct: 412 SVSIEKALPEDRGLYKCVAKNSAGQAESSCQVTVDVPD 449
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/126 (29%), Positives = 63/126 (50%), Gaps = 4/126 (3%)
Frame = +2
Query: 59 NKSKGHGVQSQYESKEFE---APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWL 229
N KGH + E + AP F L+ ++ V E + + L +VS D ++ W
Sbjct: 334 NCKKGHAGATDSEKRPESRGTAPTFEEKLQ-DLHVAEGQKLLLQCRVS--SDPPATITWT 390
Query: 230 KDGRPLLTGTRFSTVFERGYVV-LDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPE 406
+G+ L T T+F + + G + + I ++ ED G+Y CVAK+ +GQ +S+ +P+
Sbjct: 391 LNGKTLKT-TKFIVLSQEGSLCSVSIEKALPEDRGLYKCVAKNSAGQAESSCQVTVDVPD 449
Query: 407 AKVDNN 424
A N
Sbjct: 450 APTSEN 455
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYC 682
PYFSK ++ ++ V +G + ++ D V W K+ QS+ F +D G C
Sbjct: 1069 PYFSKTIR-DLEVVEGSAARFDCKIEGYPD--PEVVWFKDDQSIRESRHFQIDYDEDGNC 1125
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEA 760
+L I +DD YTC A NS GEA
Sbjct: 1126 SLIISDVCGDDDAKYTCKAVNSLGEA 1151
>sp|Q05623|MYBPH_CHICK Myosin-binding protein H (MyBP-H) (H-protein) (86 kDa protein)
Length = 537
Score = 52.8 bits (125), Expect = 1e-06
Identities = 32/105 (30%), Positives = 53/105 (50%)
Frame = +2
Query: 446 YVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKN 625
++++ +PQ + + + +PP F++ L T +G HL V R + W KN
Sbjct: 424 HIKKTVYQPQKIPERDMMEPPKFTQPLTDRATT-RGYSTHLFCSV--RGFPQPKIIWMKN 480
Query: 626 GQSMSMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEA 760
+ ++ A+ ++G C+L+I P D GVYTC A N GEA
Sbjct: 481 KMEIREDPKYIAMIEQGVCSLEIRKPSPFDAGVYTCKAVNPLGEA 525
>sp|Q15746|MYLK_HUMAN Myosin light chain kinase, smooth muscle and non-muscle isozymes
(MLCK) [Contains: Telokin (Kinase related protein)
(KRP)]
Length = 1914
Score = 49.7 bits (117), Expect = 1e-05
Identities = 58/224 (25%), Positives = 86/224 (38%), Gaps = 4/224 (1%)
Frame = +2
Query: 110 EAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE-RG 286
EAP F+ N + + E + +V G V W ++G+P+ +G RF RG
Sbjct: 31 EAPAFILPPRN-LCIKEGATAKFEGRVR--GYPEPQVTWHRNGQPITSGGRFLLDCGIRG 87
Query: 287 YVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQN 466
L I EED G Y C A + SG Q TV + E + D+
Sbjct: 88 TFSLVIHAVHEEDRGKYTCEATNGSGARQ---VTVELTVEGSFAKQLGQPVVSKTLGDRF 144
Query: 467 EPQHLDKHES---SQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSM 637
++ S PP F+ L + V +G + R +T W K +
Sbjct: 145 SASAVETRPSIWGECPPKFATKL-GRVVVKEGQMGRFSCKITGRPQPQVT--WLKGNVPL 201
Query: 638 SMGSRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
+R + G L+I +D GVYTC+ N G+A S
Sbjct: 202 QPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGKASMS 245
Score = 49.3 bits (116), Expect = 1e-05
Identities = 43/155 (27%), Positives = 74/155 (47%), Gaps = 14/155 (9%)
Frame = +2
Query: 347 AKSKSGQNQSNPA-TVRVIPEAKVDNNVNFIENQYVQQDQNEPQHL----------DKHE 493
A++ + PA T++ + AK D N+ + +++D + +K
Sbjct: 1032 AETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRS 1091
Query: 494 SSQ--PPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIF 667
SQ P F + LQ ++ V +G + L+ V +D T+ W NG+++ ++F +
Sbjct: 1092 ESQGTAPAFKQKLQ-DVHVAEGKKLLLQCQVS--SDPPATIIWTLNGKTLKT-TKFIILS 1147
Query: 668 DRG-YCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
G C++ I PED G+Y CVAKN G+AE S
Sbjct: 1148 QEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECS 1182
Score = 48.9 bits (115), Expect = 2e-05
Identities = 58/220 (26%), Positives = 91/220 (41%), Gaps = 2/220 (0%)
Frame = +2
Query: 113 APHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYV 292
AP F S L++ + ++ + Q S G + WL +G+P+ + E G
Sbjct: 513 APSFSSVLKDCAVIEGQDFVL---QCSVRGTPVPRITWLLNGQPIQYAR---STCEAGVA 566
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEP 472
L I ++ ED G Y C+A++ GQ S A V V + ++ +
Sbjct: 567 ELHIQDALPEDHGTYTCLAENALGQ-VSCSAWVTV----------------HEKKSSRKS 609
Query: 473 QHLDKHESSQP--PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMG 646
++L S+P P F + L S++ V G V + V + V W NG +
Sbjct: 610 EYLLPVAPSKPTAPIFLQGL-SDLKVMDGSQVTMTVQVS--GNPPPEVIWLHNGNEIQES 666
Query: 647 SRFNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAES 766
F+ +L I +PED G YTC A NS GE +
Sbjct: 667 EDFHFEQRGTQHSLWIQEVFPEDTGTYTCEAWNSAGEVRT 706
Score = 43.9 bits (102), Expect = 6e-04
Identities = 30/86 (34%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Frame = +2
Query: 506 PYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDR-GYC 682
PYFSK ++ ++ V +G + ++ D V W K+ QS+ F +D G C
Sbjct: 1809 PYFSKTIR-DLEVVEGSAARFDCKIEGYPD--PEVVWFKDDQSIRESRHFQIDYDEDGNC 1865
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEA 760
+L I +DD YTC A NS GEA
Sbjct: 1866 SLIISDVCGDDDAKYTCKAVNSLGEA 1891
Score = 42.7 bits (99), Expect = 0.001
Identities = 58/255 (22%), Positives = 99/255 (38%), Gaps = 19/255 (7%)
Frame = +2
Query: 59 NKSKGHGVQSQYESK---EFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWL 229
N +GH + E + + AP F L+ ++ V E + + L QVS D ++ W
Sbjct: 1076 NCKRGHAGTTDNEKRSESQGTAPAFKQKLQ-DVHVAEGKKLLLQCQVS--SDPPATIIWT 1132
Query: 230 KDGRPLLTGTRFSTVFERGYVV-LDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPE 406
+G+ L T T+F + + G + + I ++ ED G+Y CVAK+ +GQ + + + +
Sbjct: 1133 LNGKTLKT-TKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQV--TVDD 1189
Query: 407 AKVDNNVNFIENQYVQQDQNEPQHLDKH---------------ESSQPPYFSKDLQSNIT 541
A N E + + + P L +++ PP + +
Sbjct: 1190 APASENTKAPEMKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQ-FPEDQK 1248
Query: 542 VNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILYTYPEDDG 721
V G V L V T T W K + + L IL E G
Sbjct: 1249 VRAGESVELFGKVTGTQPITCT--WMKFRKQIQESEHMKVENSENGSKLTILAARQEHCG 1306
Query: 722 VYTCVAKNSQGEAES 766
YT + +N G ++
Sbjct: 1307 CYTLLVENKLGSRQA 1321
Score = 42.0 bits (97), Expect = 0.002
Identities = 56/219 (25%), Positives = 85/219 (38%), Gaps = 1/219 (0%)
Frame = +2
Query: 116 PHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFE-RGYV 292
P F S +++ V E + ++ +VS G V W +G P+ V+E G
Sbjct: 414 PKFESKPQSQ-EVKENQTVKFRCEVS--GIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSH 470
Query: 293 VLDILYSIEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEP 472
L +L + DSG Y C A + GQ S T++V A ++
Sbjct: 471 YLCLLKARTRDSGTYSCTASNAQGQ-VSCSWTLQVERLAVME------------------ 511
Query: 473 QHLDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSR 652
P FS L+ + V +G L+ V R + W NGQ +
Sbjct: 512 ---------VAPSFSSVLK-DCAVIEGQDFVLQCSV--RGTPVPRITWLLNGQPIQYA-- 557
Query: 653 FNAIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESS 769
+ + G L I PED G YTC+A+N+ G+ S
Sbjct: 558 -RSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCS 595
Score = 39.3 bits (90), Expect = 0.014
Identities = 35/119 (29%), Positives = 49/119 (41%), Gaps = 14/119 (11%)
Frame = +2
Query: 53 SFNKSKGHGVQSQYESKEFEA--------------PHFLSNLENEITVNEEEPIRLSSQV 190
SF K G V S+ F A P F + L + V E + R S ++
Sbjct: 126 SFAKQLGQPVVSKTLGDRFSASAVETRPSIWGECPPKFATKL-GRVVVKEGQMGRFSCKI 184
Query: 191 SPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQ 367
+ G V WLK PL R S + G VL+I ++D GVY C+ + SG+
Sbjct: 185 T--GRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSGK 241
Score = 32.3 bits (72), Expect = 1.7
Identities = 33/141 (23%), Positives = 52/141 (36%), Gaps = 2/141 (1%)
Frame = +2
Query: 353 SKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLD-KHESSQPPYFSKDLQ 529
S SG+ + PA R P V + N ++ + +S+ P + SK
Sbjct: 365 SPSGEERKRPAPPR--PATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKPQS 422
Query: 530 SNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIF-DRGYCALDILYTY 706
+ NQ E P+ + V W G + ++ D G L +L
Sbjct: 423 QEVKENQTVKFRCEVSGIPKPE----VAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKAR 478
Query: 707 PEDDGVYTCVAKNSQGEAESS 769
D G Y+C A N+QG+ S
Sbjct: 479 TRDSGTYSCTASNAQGQVSCS 499
Score = 30.4 bits (67), Expect = 6.4
Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 1/106 (0%)
Frame = +2
Query: 53 SFNKSKGHGVQSQYESKEFEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLK 232
S + + V + E + P F+S +T + + + +S + AGD +V WL+
Sbjct: 700 SAGEVRTQAVLTVQEPHDGTQPWFISK-PRSVTASLGQSVLISCAI--AGDPFPTVHWLR 756
Query: 233 DGRPLLTGTRFSTVFERGYVVLDILYSIEE-DSGVYVCVAKSKSGQ 367
DG+ L T V + V +L ++ +G Y + K++ G+
Sbjct: 757 DGKALCKDTGHFEVLQNEDVFTLVLKKVQPWHAGQYEILLKNRVGE 802
>sp|Q7TPD3|ROBO2_MOUSE Roundabout homolog 2 precursor
Length = 1470
Score = 49.7 bits (117), Expect = 1e-05
Identities = 50/170 (29%), Positives = 76/170 (44%), Gaps = 3/170 (1%)
Frame = +2
Query: 107 FEAPHFLSNLENEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERG 286
FE P FL N++ + EEE + QV GD +V W KD L G R+ +
Sbjct: 222 FERPTFLRRPINQVVL-EEEAVEFRCQVQ--GDPQPTVRWKKDDADLPRG-RYDI---KD 274
Query: 287 YVVLDILYSIEEDSGVYVCVAKSKSGQNQSNPA-TVRVIPEAKVDNNVNFIENQYVQQDQ 463
L I ++ D G YVC+A+++ G+ +++ TVRV P A V +Q V Q +
Sbjct: 275 DYTLRIKKAMSTDEGTYVCIAENRVGKVEASATLTVRVRPVAPPQFVVR-PRDQIVAQGR 333
Query: 464 NEPQHLDKHESSQPPYF--SKDLQSNITVNQGGPVHLETIVDPRNDFTLT 607
+ + QP F + Q+ + NQ + V P D T+T
Sbjct: 334 TVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTIT 383
Score = 41.2 bits (95), Expect = 0.004
Identities = 54/222 (24%), Positives = 90/222 (40%), Gaps = 7/222 (3%)
Frame = +2
Query: 140 NEITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTG-----TRFSTVFERGYVVLDI 304
+++ V++ EP L+ + G + ++EW KDG + T + + L I
Sbjct: 38 SDVIVSKGEPTTLNCKAE--GRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRI 95
Query: 305 LYS--IEEDSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQH 478
++ + D G YVCVA++ G+ S A++ V
Sbjct: 96 VHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVA-------------------------- 129
Query: 479 LDKHESSQPPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFN 658
L + + Q P +++ V G P LE PR T+ W K+ + + +
Sbjct: 130 LLRDDFRQNP-------TDVVVAAGEPAILEC-QPPRGHPEPTIYWKKD--KVRIDDKEE 179
Query: 659 AIFDRGYCALDILYTYPEDDGVYTCVAKNSQGEAESSHSQIT 784
I RG L I T D G+YTCV N GE +S +++T
Sbjct: 180 RISIRGG-KLMISNTRKSDAGMYTCVGTNMVGERDSDPAELT 220
Score = 37.7 bits (86), Expect = 0.040
Identities = 44/209 (21%), Positives = 78/209 (37%)
Frame = +2
Query: 143 EITVNEEEPIRLSSQVSPAGDNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEE 322
++ V EP L Q P G ++ W KD + + + RG ++ I + +
Sbjct: 141 DVVVAAGEPAILECQ-PPRGHPEPTIYWKKD--KVRIDDKEERISIRGGKLM-ISNTRKS 196
Query: 323 DSGVYVCVAKSKSGQNQSNPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQ 502
D+G+Y CV + G+ S+PA + V +
Sbjct: 197 DAGMYTCVGTNMVGERDSDPAELTVF--------------------------------ER 224
Query: 503 PPYFSKDLQSNITVNQGGPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYC 682
P + + + + + + DP+ TV W K+ + G R++ D
Sbjct: 225 PTFLRRPINQVVLEEEAVEFRCQVQGDPQP----TVRWKKDDADLPRG-RYDIKDD---Y 276
Query: 683 ALDILYTYPEDDGVYTCVAKNSQGEAESS 769
L I D+G Y C+A+N G+ E+S
Sbjct: 277 TLRIKKAMSTDEGTYVCIAENRVGKVEAS 305
Score = 32.0 bits (71), Expect = 2.2
Identities = 18/50 (36%), Positives = 26/50 (52%)
Frame = +2
Query: 218 VEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQ 367
+ WLK+G L +T+ ++G L I D+G Y CVA S SG+
Sbjct: 453 ISWLKEGFTFLGRDPRATIQDQG--TLQIKNLRISDTGTYTCVATSSSGE 500
>sp|P16092|FGFR1_MOUSE Basic fibroblast growth factor receptor 1 precursor (FGFR-1)
(bFGF-R) (MFR)
Length = 822
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/195 (22%), Positives = 79/195 (40%), Gaps = 5/195 (2%)
Frame = +2
Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQS-- 376
D+ S+ WL+DG L+ R E +++ SI DSG+Y CV S SG + +
Sbjct: 59 DDVQSINWLRDGVQLVESNRTRITGEE----VEVRDSIPADSGLYACVTSSPSGSDTTYF 114
Query: 377 NPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGG 556
+ +P ++ D++ + ++ + D +P + PY++ + ++
Sbjct: 115 SVNVSDALPSSEDDDDDDDSSSEEKETDNTKP-----NRRPVAPYWTSPEKMEKKLHAVP 169
Query: 557 PVHLETIVDPRNDF-TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727
P + T+ W KNG+ R R Y I+ P D G Y
Sbjct: 170 AAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 228
Query: 728 TCVAKNSQGEAESSH 772
TC+ +N G ++
Sbjct: 229 TCIVENEYGSINHTY 243
>sp|P21804|FGFR1_CHICK Basic fibroblast growth factor receptor 1 precursor
Length = 819
Score = 48.9 bits (115), Expect = 2e-05
Identities = 47/195 (24%), Positives = 81/195 (41%), Gaps = 5/195 (2%)
Frame = +2
Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQSNP 382
D+ S+ W++DG L R E +++ ++ EDSG+Y C+ S SG +++
Sbjct: 58 DDVQSINWVRDGVQLPENNRTRITGEE----VEVRDAVPEDSGLYACMTNSPSG-SETTY 112
Query: 383 ATVRV---IPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQG 553
+V V +P A+ D++ + ++ + D +P + P K L + V
Sbjct: 113 FSVNVSDALPSAEDDDDEDDSSSEEKEADNTKPNQAVAPYWTYPEKMEKKLHA---VPAA 169
Query: 554 GPVHLETIVDPRNDFTLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727
V + + TL W KNG+ R R Y I+ P D G Y
Sbjct: 170 KTVKFKCPSGGTPNPTLR--WLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 226
Query: 728 TCVAKNSQGEAESSH 772
TC+ +N G ++
Sbjct: 227 TCIVENKYGSINHTY 241
>sp|P11362|FGFR1_HUMAN Basic fibroblast growth factor receptor 1 precursor (FGFR-1)
(bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331
antigen)
Length = 822
Score = 48.5 bits (114), Expect = 2e-05
Identities = 43/195 (22%), Positives = 78/195 (40%), Gaps = 5/195 (2%)
Frame = +2
Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQS-- 376
D+ S+ WL+DG L R E +++ S+ DSG+Y CV S SG + +
Sbjct: 59 DDVQSINWLRDGVQLAESNRTRITGEE----VEVQDSVPADSGLYACVTSSPSGSDTTYF 114
Query: 377 NPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGG 556
+ +P ++ D++ + ++ + D +P + PY++ + ++
Sbjct: 115 SVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRM-----PVAPYWTSPEKMEKKLHAVP 169
Query: 557 PVHLETIVDPRNDF-TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727
P + T+ W KNG+ R R Y I+ P D G Y
Sbjct: 170 AAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 228
Query: 728 TCVAKNSQGEAESSH 772
TC+ +N G ++
Sbjct: 229 TCIVENEYGSINHTY 243
>sp|Q04589|FGFR1_RAT Basic fibroblast growth factor receptor 1 precursor (FGFR-1)
(bFGF-R) (MFR)
Length = 822
Score = 48.5 bits (114), Expect = 2e-05
Identities = 44/195 (22%), Positives = 79/195 (40%), Gaps = 5/195 (2%)
Frame = +2
Query: 203 DNSLSVEWLKDGRPLLTGTRFSTVFERGYVVLDILYSIEEDSGVYVCVAKSKSGQNQS-- 376
D+ S+ WL+DG L R E +++ SI DSG+Y CV S SG + +
Sbjct: 59 DDVQSINWLRDGVQLAESNRTRITGEE----VEVRDSIPADSGLYACVTNSPSGSDTTYF 114
Query: 377 NPATVRVIPEAKVDNNVNFIENQYVQQDQNEPQHLDKHESSQPPYFSKDLQSNITVNQGG 556
+ +P ++ D++ + ++ + D +P + PY++ + ++
Sbjct: 115 SVNVSDALPSSEDDDDDDDSSSEEKETDNTKP-----NRRPVAPYWTSPEKMEKKLHAVP 169
Query: 557 PVHLETIVDPRNDF-TLTVDWHKNGQSMSMGSRFNAIFDRGYCALDILY--TYPEDDGVY 727
P + + T+ W KNG+ R R Y I+ P D G Y
Sbjct: 170 AAKTVKFKCPSSGTPSPTLRWLKNGKEFKPDHRIGGYKVR-YATWSIIMDSVVPSDKGNY 228
Query: 728 TCVAKNSQGEAESSH 772
TC+ +N G ++
Sbjct: 229 TCIVENEYGSINHTY 243
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,723,095
Number of Sequences: 369166
Number of extensions: 1882506
Number of successful extensions: 6720
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5488
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6551
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8245425915
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)