Planaria EST Database

DrC_01138

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_01138
         (896 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|O09110|MP2K3_MOUSE  Dual specificity mitogen-activated pr...   251   3e-66
sp|P46734|MP2K3_HUMAN  Dual specificity mitogen-activated pr...   248   1e-65
sp|P70236|MP2K6_MOUSE  Dual specificity mitogen-activated pr...   248   2e-65
sp|P52564|MP2K6_HUMAN  Dual specificity mitogen-activated pr...   248   2e-65
sp|P47809|MP2K4_MOUSE  Dual specificity mitogen-activated pr...   236   5e-62
sp|Q07192|MP2K2_XENLA  Dual specificity mitogen-activated pr...   236   5e-62
sp|P45985|MP2K4_HUMAN  Dual specificity mitogen-activated pr...   236   5e-62
sp|Q20347|YR62_CAEEL  Putative serine/threonine-protein kina...   206   9e-53
sp|O14733|MP2K7_HUMAN  Dual specificity mitogen-activated pr...   181   3e-45
sp|Q23977|HEP_DROME  Dual specificity mitogen-activated prot...   176   1e-43

>sp|O09110|MP2K3_MOUSE Dual specificity mitogen-activated protein kinase kinase 3 (MAP
           kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
          Length = 347

 Score =  251 bits (640), Expect = 3e-66
 Identities = 133/248 (53%), Positives = 174/248 (70%), Gaps = 1/248 (0%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY KV+EK  N  IPE
Sbjct: 106 RLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEK--NMKIPE 163

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT 
Sbjct: 164 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 223

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV 
Sbjct: 224 DAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV- 282

Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESKKQF 718
            +  P LPAD  +S    +F SQCL K  ++R SY  L++H   T  K        K   
Sbjct: 283 EEPSPQLPADQ-FSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHK------TKKTDI 335

Query: 719 AEYVKQIL 742
           A +VK+IL
Sbjct: 336 AAFVKEIL 343

>sp|P46734|MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (MAP
           kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
          Length = 347

 Score =  248 bits (634), Expect = 1e-65
 Identities = 131/248 (52%), Positives = 174/248 (70%), Gaps = 1/248 (0%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           RLL DL+I+MR+  C Y V  YGA+F+ GDVWICMEL+D+SLDKFY KV++K  N  IPE
Sbjct: 106 RLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDK--NMTIPE 163

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  I   +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT 
Sbjct: 164 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 223

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERINP+ +  GY+++SDVWSLG++++E+AI +FPY  W + F QLK VV 
Sbjct: 224 DAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV- 282

Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESKKQF 718
            +  P LPAD  +S    +F +QCL K  ++R SY  L++H   T  K        K   
Sbjct: 283 EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK------TKKTDI 335

Query: 719 AEYVKQIL 742
           A +VK+IL
Sbjct: 336 AAFVKEIL 343

>sp|P70236|MP2K6_MOUSE Dual specificity mitogen-activated protein kinase kinase 6 (MAP
           kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
          Length = 334

 Score =  248 bits (633), Expect = 2e-65
 Identities = 132/249 (53%), Positives = 175/249 (70%), Gaps = 2/249 (0%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           RLL DL++SMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY +VI+K     IPE
Sbjct: 95  RLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT--IPE 152

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT 
Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTI 212

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV 
Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV- 271

Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESK-KQ 715
            +  P LPAD   +D V +F SQCL K   +R +Y  L++H   T       + ESK   
Sbjct: 272 EEPSPQLPADKFSADFV-DFTSQCLKKNSKERPTYPELMQHPFFT-------VHESKAAD 323

Query: 716 FAEYVKQIL 742
            A +VK IL
Sbjct: 324 VASFVKLIL 332

>sp|P52564|MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (MAP
           kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
          Length = 334

 Score =  248 bits (633), Expect = 2e-65
 Identities = 133/249 (53%), Positives = 175/249 (70%), Gaps = 2/249 (0%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           RLL DL+ISMR+  CP+ V  YGA+F+ GDVWICMEL+D+SLDKFY +VI+K     IPE
Sbjct: 95  RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT--IPE 152

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  I   +V ALE+LH +L VIHRDVKPSN LI+  G+VK+CDFGISG L++S+AKT 
Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERINP+ +  GYS++SD+WSLG++++ELAI +FPY  W + F QLK VV 
Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV- 271

Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESK-KQ 715
            +  P LPAD   ++ V +F SQCL K   +R +Y  L++H   T       L ESK   
Sbjct: 272 EEPSPQLPADKFSAEFV-DFTSQCLKKNSKERPTYPELMQHPFFT-------LHESKGTD 323

Query: 716 FAEYVKQIL 742
            A +VK IL
Sbjct: 324 VASFVKLIL 332

>sp|P47809|MP2K4_MOUSE Dual specificity mitogen-activated protein kinase kinase 4 (MAP
           kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4)
           (JNK-activating kinase 1) (C-JUN N-terminal kinase
           kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1)
           (SEK1)
          Length = 397

 Score =  236 bits (603), Expect = 5e-62
 Identities = 115/231 (49%), Positives = 161/231 (69%), Gaps = 3/231 (1%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           +LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY K +    +  IPE
Sbjct: 142 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFY-KYVYSVLDDVIPE 200

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  IT   V AL +L   L++IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT 
Sbjct: 201 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTR 260

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV 
Sbjct: 261 DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 320

Query: 539 SDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKD 685
            D PP L    +  +S +  NF++ CL K +S R  Y+ L+KH  +  +++
Sbjct: 321 GD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE 370

>sp|Q07192|MP2K2_XENLA Dual specificity mitogen-activated protein kinase kinase 2 (MAP
           kinase kinase 2) (MAPKK 2) (MAPK-ERK kinase 2)
          Length = 446

 Score =  236 bits (603), Expect = 5e-62
 Identities = 121/250 (48%), Positives = 167/250 (66%), Gaps = 3/250 (1%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           +LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY K +    +  IPE
Sbjct: 191 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMATSFDKFY-KYVYSFLDDVIPE 249

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  IT   V AL +L   L++IHRD+KPSN L+D  G +K+CDFGISG L++S+AKT 
Sbjct: 250 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDTNGNIKLCDFGISGQLVDSIAKTR 309

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV 
Sbjct: 310 DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 369

Query: 539 SDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESKK 712
            D PP L    +  +S +  +F++QCL K +S R  Y+ L+KH  +  ++      E   
Sbjct: 370 GD-PPQLSNSEEREFSPSFTSFVNQCLTKDESKRPKYKELLKHPFILMYE------ERTV 422

Query: 713 QFAEYVKQIL 742
             A YV +IL
Sbjct: 423 DVAGYVGKIL 432

>sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (MAP
           kinase kinase 4) (JNK-activating kinase 1) (c-Jun
           N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1)
           (SEK1)
          Length = 399

 Score =  236 bits (603), Expect = 5e-62
 Identities = 115/231 (49%), Positives = 161/231 (69%), Gaps = 3/231 (1%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           +LL DL++ MRS+ CPY+V  YGA+F+ GD WICMEL+ +S DKFY K +    +  IPE
Sbjct: 144 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFY-KYVYSVLDDVIPE 202

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            +L  IT   V AL +L   L++IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT 
Sbjct: 203 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTR 262

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G +PY+APERI+P  S  GY +RSDVWSLG+++ ELA  +FPY +WNS+FDQL  VV 
Sbjct: 263 DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 322

Query: 539 SDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKD 685
            D PP L    +  +S +  NF++ CL K +S R  Y+ L+KH  +  +++
Sbjct: 323 GD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE 372

>sp|Q20347|YR62_CAEEL Putative serine/threonine-protein kinase F42G10.2
          Length = 363

 Score =  206 bits (523), Expect = 9e-53
 Identities = 113/221 (51%), Positives = 144/221 (65%), Gaps = 4/221 (1%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           RLL + +  ++S K P +V  YGA+F  GD WICMEL+D S+D  Y +V     N+ + E
Sbjct: 109 RLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMV-KNSRLNE 167

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
            ++ +IT C V AL+YL +EL++IHRDVKPSN L+D  G VK+CDFGI G L  S AKT 
Sbjct: 168 NVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTH 227

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G QPYLAPERI    S   Y +RSDVWSLG+++ E+A  KFPY  WNSLFDQ+  VV+
Sbjct: 228 DAGCQPYLAPERIT---SSDKYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVS 284

Query: 539 SDTPPALPADS---VYSDTVRNFISQCLVKKDSDRASYETL 652
            D PP L  DS    YS  +  FI+ CL K    R  Y+TL
Sbjct: 285 GD-PPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTL 324

>sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (MAP
           kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7)
           (JNK-activating kinase 2) (c-Jun N-terminal kinase
           kinase 2) (JNK kinase 2) (JNKK 2)
          Length = 419

 Score =  181 bits (458), Expect = 3e-45
 Identities = 96/229 (41%), Positives = 142/229 (62%), Gaps = 2/229 (0%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           R+L DL++ ++S  CPY+V  +G      DV+I MEL+ +  +K     ++K     IPE
Sbjct: 162 RILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEK-----LKKRMQGPIPE 216

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
           R+L  +T  +V AL YL  +  VIHRDVKPSN L+D+ G++K+CDFGISG L++S AKT 
Sbjct: 217 RILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTR 276

Query: 359 NVGSQPYLAPERIN-PDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVV 535
           + G   Y+APERI+ PD +   Y IR+DVWSLG+S++ELA  +FPY    + F+ L  V+
Sbjct: 277 SAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVL 336

Query: 536 ASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFK 682
             + PP LP    +S   ++F+  CL K    R  Y  L++H  +  ++
Sbjct: 337 -QEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYE 384

>sp|Q23977|HEP_DROME Dual specificity mitogen-activated protein kinase kinase
           hemipterous (MAPKK)
          Length = 1178

 Score =  176 bits (445), Expect = 1e-43
 Identities = 99/233 (42%), Positives = 138/233 (59%), Gaps = 3/233 (1%)
 Frame = +2

Query: 2   RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
           R+L DL++ ++S  C Y+V   G   +  DVWICMEL+    DK       K S   +PE
Sbjct: 239 RILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLL-----KLSKKPVPE 293

Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
           ++L  +T   V AL YL  +  VIHRDVKPSN LID+ G +K+CDFGISG L++S A T 
Sbjct: 294 QILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTR 353

Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
           + G   Y+APERI+P +    Y IR+DVWSLG++++ELA  + PY   N+ F+ L  V+ 
Sbjct: 354 SAGCAAYMAPERIDPKK--PKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLD 411

Query: 539 SDTPPALPADSVY--SDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDK 691
           S+ PP LP    Y  S   R+F+ +CL K   DR  Y  L+    +  ++  K
Sbjct: 412 SE-PPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAK 463

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,862,231
Number of Sequences: 369166
Number of extensions: 2028406
Number of successful extensions: 8048
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6567
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6857
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9030416440
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Cluster detail

DrC_01138

  1. Dr_sW_010_F22
  2. Dr_sW_028_J22
  3. Dr_sW_004_E08
  4. Dr_sW_020_A05