Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_J22
(847 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O09110|MP2K3_MOUSE Dual specificity mitogen-activated pr... 251 2e-66
sp|P46734|MP2K3_HUMAN Dual specificity mitogen-activated pr... 248 1e-65
sp|P70236|MP2K6_MOUSE Dual specificity mitogen-activated pr... 248 2e-65
sp|P52564|MP2K6_HUMAN Dual specificity mitogen-activated pr... 248 2e-65
sp|P47809|MP2K4_MOUSE Dual specificity mitogen-activated pr... 236 5e-62
sp|Q07192|MP2K2_XENLA Dual specificity mitogen-activated pr... 236 5e-62
sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activated pr... 236 5e-62
sp|Q20347|YR62_CAEEL Putative serine/threonine-protein kina... 206 9e-53
sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activated pr... 181 3e-45
sp|Q23977|HEP_DROME Dual specificity mitogen-activated prot... 176 9e-44
>sp|O09110|MP2K3_MOUSE Dual specificity mitogen-activated protein kinase kinase 3 (MAP
kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
Length = 347
Score = 251 bits (640), Expect = 2e-66
Identities = 133/248 (53%), Positives = 174/248 (70%), Gaps = 1/248 (0%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
RLL DL+I+MR+ C Y V YGA+F+ GDVWICMEL+D+SLDKFY KV+EK N IPE
Sbjct: 106 RLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEK--NMKIPE 163
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L I +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT
Sbjct: 164 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 223
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERINP+ + GY+++SDVWSLG++++E+AI +FPY W + F QLK VV
Sbjct: 224 DAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV- 282
Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESKKQF 718
+ P LPAD +S +F SQCL K ++R SY L++H T K K
Sbjct: 283 EEPSPQLPADQ-FSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHK------TKKTDI 335
Query: 719 AEYVKQIL 742
A +VK+IL
Sbjct: 336 AAFVKEIL 343
>sp|P46734|MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (MAP
kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
Length = 347
Score = 248 bits (634), Expect = 1e-65
Identities = 131/248 (52%), Positives = 174/248 (70%), Gaps = 1/248 (0%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
RLL DL+I+MR+ C Y V YGA+F+ GDVWICMEL+D+SLDKFY KV++K N IPE
Sbjct: 106 RLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLDK--NMTIPE 163
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L I +V ALE+LH +L VIHRDVKPSN LI+K G VK+CDFGISG L++S+AKT
Sbjct: 164 DILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTM 223
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERINP+ + GY+++SDVWSLG++++E+AI +FPY W + F QLK VV
Sbjct: 224 DAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVV- 282
Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESKKQF 718
+ P LPAD +S +F +QCL K ++R SY L++H T K K
Sbjct: 283 EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHK------TKKTDI 335
Query: 719 AEYVKQIL 742
A +VK+IL
Sbjct: 336 AAFVKEIL 343
>sp|P70236|MP2K6_MOUSE Dual specificity mitogen-activated protein kinase kinase 6 (MAP
kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length = 334
Score = 248 bits (633), Expect = 2e-65
Identities = 132/249 (53%), Positives = 175/249 (70%), Gaps = 2/249 (0%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
RLL DL++SMR+ CP+ V YGA+F+ GDVWICMEL+D+SLDKFY +VI+K IPE
Sbjct: 95 RLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT--IPE 152
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L I +V ALE+LH +L VIHRDVKPSN LI+ G+VK+CDFGISG L++S+AKT
Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTI 212
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERINP+ + GYS++SD+WSLG++++ELAI +FPY W + F QLK VV
Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV- 271
Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESK-KQ 715
+ P LPAD +D V +F SQCL K +R +Y L++H T + ESK
Sbjct: 272 EEPSPQLPADKFSADFV-DFTSQCLKKNSKERPTYPELMQHPFFT-------VHESKAAD 323
Query: 716 FAEYVKQIL 742
A +VK IL
Sbjct: 324 VASFVKLIL 332
>sp|P52564|MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (MAP
kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length = 334
Score = 248 bits (633), Expect = 2e-65
Identities = 133/249 (53%), Positives = 175/249 (70%), Gaps = 2/249 (0%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
RLL DL+ISMR+ CP+ V YGA+F+ GDVWICMEL+D+SLDKFY +VI+K IPE
Sbjct: 95 RLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQT--IPE 152
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L I +V ALE+LH +L VIHRDVKPSN LI+ G+VK+CDFGISG L++S+AKT
Sbjct: 153 DILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTI 212
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERINP+ + GYS++SD+WSLG++++ELAI +FPY W + F QLK VV
Sbjct: 213 DAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVV- 271
Query: 539 SDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESK-KQ 715
+ P LPAD ++ V +F SQCL K +R +Y L++H T L ESK
Sbjct: 272 EEPSPQLPADKFSAEFV-DFTSQCLKKNSKERPTYPELMQHPFFT-------LHESKGTD 323
Query: 716 FAEYVKQIL 742
A +VK IL
Sbjct: 324 VASFVKLIL 332
>sp|P47809|MP2K4_MOUSE Dual specificity mitogen-activated protein kinase kinase 4 (MAP
kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4)
(JNK-activating kinase 1) (C-JUN N-terminal kinase
kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1)
(SEK1)
Length = 397
Score = 236 bits (603), Expect = 5e-62
Identities = 115/231 (49%), Positives = 161/231 (69%), Gaps = 3/231 (1%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
+LL DL++ MRS+ CPY+V YGA+F+ GD WICMEL+ +S DKFY K + + IPE
Sbjct: 142 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFY-KYVYSVLDDVIPE 200
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L IT V AL +L L++IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT
Sbjct: 201 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTR 260
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERI+P S GY +RSDVWSLG+++ ELA +FPY +WNS+FDQL VV
Sbjct: 261 DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 320
Query: 539 SDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKD 685
D PP L + +S + NF++ CL K +S R Y+ L+KH + +++
Sbjct: 321 GD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE 370
>sp|Q07192|MP2K2_XENLA Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (MAPK-ERK kinase 2)
Length = 446
Score = 236 bits (603), Expect = 5e-62
Identities = 121/250 (48%), Positives = 167/250 (66%), Gaps = 3/250 (1%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
+LL DL++ MRS+ CPY+V YGA+F+ GD WICMEL+ +S DKFY K + + IPE
Sbjct: 191 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMATSFDKFY-KYVYSFLDDVIPE 249
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L IT V AL +L L++IHRD+KPSN L+D G +K+CDFGISG L++S+AKT
Sbjct: 250 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDTNGNIKLCDFGISGQLVDSIAKTR 309
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERI+P S GY +RSDVWSLG+++ ELA +FPY +WNS+FDQL VV
Sbjct: 310 DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 369
Query: 539 SDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDKYLAESKK 712
D PP L + +S + +F++QCL K +S R Y+ L+KH + ++ E
Sbjct: 370 GD-PPQLSNSEEREFSPSFTSFVNQCLTKDESKRPKYKELLKHPFILMYE------ERTV 422
Query: 713 QFAEYVKQIL 742
A YV +IL
Sbjct: 423 DVAGYVGKIL 432
>sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (MAP
kinase kinase 4) (JNK-activating kinase 1) (c-Jun
N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1)
(SEK1)
Length = 399
Score = 236 bits (603), Expect = 5e-62
Identities = 115/231 (49%), Positives = 161/231 (69%), Gaps = 3/231 (1%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
+LL DL++ MRS+ CPY+V YGA+F+ GD WICMEL+ +S DKFY K + + IPE
Sbjct: 144 QLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFY-KYVYSVLDDVIPE 202
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
+L IT V AL +L L++IHRD+KPSN L+D+ G +K+CDFGISG L++S+AKT
Sbjct: 203 EILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTR 262
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G +PY+APERI+P S GY +RSDVWSLG+++ ELA +FPY +WNS+FDQL VV
Sbjct: 263 DAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 322
Query: 539 SDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKD 685
D PP L + +S + NF++ CL K +S R Y+ L+KH + +++
Sbjct: 323 GD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEE 372
>sp|Q20347|YR62_CAEEL Putative serine/threonine-protein kinase F42G10.2
Length = 363
Score = 206 bits (523), Expect = 9e-53
Identities = 113/221 (51%), Positives = 144/221 (65%), Gaps = 4/221 (1%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
RLL + + ++S K P +V YGA+F GD WICMEL+D S+D Y +V N+ + E
Sbjct: 109 RLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRVYMV-KNSRLNE 167
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
++ +IT C V AL+YL +EL++IHRDVKPSN L+D G VK+CDFGI G L S AKT
Sbjct: 168 NVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICGQLEESFAKTH 227
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G QPYLAPERI S Y +RSDVWSLG+++ E+A KFPY WNSLFDQ+ VV+
Sbjct: 228 DAGCQPYLAPERIT---SSDKYDVRSDVWSLGITLYEIATGKFPYQEWNSLFDQIATVVS 284
Query: 539 SDTPPALPADS---VYSDTVRNFISQCLVKKDSDRASYETL 652
D PP L DS YS + FI+ CL K R Y+TL
Sbjct: 285 GD-PPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTL 324
>sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (MAP
kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7)
(JNK-activating kinase 2) (c-Jun N-terminal kinase
kinase 2) (JNK kinase 2) (JNKK 2)
Length = 419
Score = 181 bits (458), Expect = 3e-45
Identities = 96/229 (41%), Positives = 142/229 (62%), Gaps = 2/229 (0%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
R+L DL++ ++S CPY+V +G DV+I MEL+ + +K ++K IPE
Sbjct: 162 RILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEK-----LKKRMQGPIPE 216
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
R+L +T +V AL YL + VIHRDVKPSN L+D+ G++K+CDFGISG L++S AKT
Sbjct: 217 RILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTR 276
Query: 359 NVGSQPYLAPERIN-PDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVV 535
+ G Y+APERI+ PD + Y IR+DVWSLG+S++ELA +FPY + F+ L V+
Sbjct: 277 SAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVL 336
Query: 536 ASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFK 682
+ PP LP +S ++F+ CL K R Y L++H + ++
Sbjct: 337 -QEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYE 384
>sp|Q23977|HEP_DROME Dual specificity mitogen-activated protein kinase kinase
hemipterous (MAPKK)
Length = 1178
Score = 176 bits (445), Expect = 9e-44
Identities = 99/233 (42%), Positives = 138/233 (59%), Gaps = 3/233 (1%)
Frame = +2
Query: 2 RLLNDLNISMRSTKCPYVVVSYGAMFQGGDVWICMELLDSSLDKFYHKVIEKDSNAFIPE 181
R+L DL++ ++S C Y+V G + DVWICMEL+ DK K S +PE
Sbjct: 239 RILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLL-----KLSKKPVPE 293
Query: 182 RLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGISGDLINSMAKT- 358
++L +T V AL YL + VIHRDVKPSN LID+ G +K+CDFGISG L++S A T
Sbjct: 294 QILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTR 353
Query: 359 NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRWNSLFDQLKDVVA 538
+ G Y+APERI+P + Y IR+DVWSLG++++ELA + PY N+ F+ L V+
Sbjct: 354 SAGCAAYMAPERIDPKK--PKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLD 411
Query: 539 SDTPPALPADSVY--SDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFKDDK 691
S+ PP LP Y S R+F+ +CL K DR Y L+ + ++ K
Sbjct: 412 SE-PPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIRIYESAK 463
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,274,111
Number of Sequences: 369166
Number of extensions: 1980128
Number of successful extensions: 7946
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6473
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6755
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)