Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_E08
(762 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O09110|MP2K3_MOUSE Dual specificity mitogen-activated pr... 201 2e-51
sp|P46734|MP2K3_HUMAN Dual specificity mitogen-activated pr... 199 9e-51
sp|P70236|MP2K6_MOUSE Dual specificity mitogen-activated pr... 195 1e-49
sp|P52564|MP2K6_HUMAN Dual specificity mitogen-activated pr... 194 2e-49
sp|P47809|MP2K4_MOUSE Dual specificity mitogen-activated pr... 186 8e-47
sp|Q07192|MP2K2_XENLA Dual specificity mitogen-activated pr... 186 8e-47
sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activated pr... 186 8e-47
sp|Q20347|YR62_CAEEL Putative serine/threonine-protein kina... 168 1e-41
sp|P08018|PBS2_YEAST Polymyxin B resistance protein kinase 150 3e-36
sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activated pr... 150 4e-36
>sp|O09110|MP2K3_MOUSE Dual specificity mitogen-activated protein kinase kinase 3 (MAP
kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
Length = 347
Score = 201 bits (511), Expect = 2e-51
Identities = 109/211 (51%), Positives = 145/211 (68%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+D+SLDKFY KV+EK N IPE +L I +V ALE+LH +L VIHRDVKPSN LI+K
Sbjct: 143 MDTSLDKFYRKVLEK--NMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINK 200
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G VK+CDFGISG L++S+AKT + G +PY+APERINP+ + GY+++SDVWSLG++++E
Sbjct: 201 EGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIE 260
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYET 539
+AI +FPY W + F QLK VV + P LPAD +S +F SQCL K ++R SY
Sbjct: 261 MAILRFPYESWGTPFQQLKQVV-EEPSPQLPADQ-FSPEFVDFTSQCLRKNPAERMSYLE 318
Query: 540 LIKHGMLTPFKDDKYLAESKKQFAEYVKQIL 632
L++H T K K A +VK+IL
Sbjct: 319 LMEHPFFTLHK------TKKTDIAAFVKEIL 343
>sp|P46734|MP2K3_HUMAN Dual specificity mitogen-activated protein kinase kinase 3 (MAP
kinase kinase 3) (MAPKK 3) (MAPK/ERK kinase 3)
Length = 347
Score = 199 bits (505), Expect = 9e-51
Identities = 107/211 (50%), Positives = 145/211 (68%), Gaps = 1/211 (0%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+D+SLDKFY KV++K N IPE +L I +V ALE+LH +L VIHRDVKPSN LI+K
Sbjct: 143 MDTSLDKFYRKVLDK--NMTIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINK 200
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G VK+CDFGISG L++S+AKT + G +PY+APERINP+ + GY+++SDVWSLG++++E
Sbjct: 201 EGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIE 260
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYET 539
+AI +FPY W + F QLK VV + P LPAD +S +F +QCL K ++R SY
Sbjct: 261 MAILRFPYESWGTPFQQLKQVV-EEPSPQLPADR-FSPEFVDFTAQCLRKNPAERMSYLE 318
Query: 540 LIKHGMLTPFKDDKYLAESKKQFAEYVKQIL 632
L++H T K K A +VK+IL
Sbjct: 319 LMEHPFFTLHK------TKKTDIAAFVKEIL 343
>sp|P70236|MP2K6_MOUSE Dual specificity mitogen-activated protein kinase kinase 6 (MAP
kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length = 334
Score = 195 bits (495), Expect = 1e-49
Identities = 108/212 (50%), Positives = 145/212 (68%), Gaps = 2/212 (0%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+D+SLDKFY +VI+K IPE +L I +V ALE+LH +L VIHRDVKPSN LI+
Sbjct: 132 MDTSLDKFYKQVIDKGQT--IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINT 189
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ + GYS++SD+WSLG++++E
Sbjct: 190 LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE 249
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYET 539
LAI +FPY W + F QLK VV + P LPAD +D V +F SQCL K +R +Y
Sbjct: 250 LAILRFPYDSWGTPFQQLKQVV-EEPSPQLPADKFSADFV-DFTSQCLKKNSKERPTYPE 307
Query: 540 LIKHGMLTPFKDDKYLAESK-KQFAEYVKQIL 632
L++H T + ESK A +VK IL
Sbjct: 308 LMQHPFFT-------VHESKAADVASFVKLIL 332
>sp|P52564|MP2K6_HUMAN Dual specificity mitogen-activated protein kinase kinase 6 (MAP
kinase kinase 6) (MAPKK 6) (MAPK/ERK kinase 6) (SAPKK3)
Length = 334
Score = 194 bits (494), Expect = 2e-49
Identities = 108/212 (50%), Positives = 145/212 (68%), Gaps = 2/212 (0%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+D+SLDKFY +VI+K IPE +L I +V ALE+LH +L VIHRDVKPSN LI+
Sbjct: 132 MDTSLDKFYKQVIDKGQT--IPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA 189
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G+VK+CDFGISG L++S+AKT + G +PY+APERINP+ + GYS++SD+WSLG++++E
Sbjct: 190 LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIE 249
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYET 539
LAI +FPY W + F QLK VV + P LPAD ++ V +F SQCL K +R +Y
Sbjct: 250 LAILRFPYDSWGTPFQQLKQVV-EEPSPQLPADKFSAEFV-DFTSQCLKKNSKERPTYPE 307
Query: 540 LIKHGMLTPFKDDKYLAESK-KQFAEYVKQIL 632
L++H T L ESK A +VK IL
Sbjct: 308 LMQHPFFT-------LHESKGTDVASFVKLIL 332
>sp|P47809|MP2K4_MOUSE Dual specificity mitogen-activated protein kinase kinase 4 (MAP
kinase kinase 4) (MAPKK 4) (MAPK/ERK kinase 4)
(JNK-activating kinase 1) (C-JUN N-terminal kinase
kinase 1) (JNK kinase 1) (JNKK 1) (SAPK/ERK kinase 1)
(SEK1)
Length = 397
Score = 186 bits (471), Expect = 8e-47
Identities = 92/194 (47%), Positives = 131/194 (67%), Gaps = 3/194 (1%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+ +S DKFY K + + IPE +L IT V AL +L L++IHRD+KPSN L+D+
Sbjct: 179 MSTSFDKFY-KYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDR 237
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G +K+CDFGISG L++S+AKT + G +PY+APERI+P S GY +RSDVWSLG+++ E
Sbjct: 238 SGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYE 297
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASY 533
LA +FPY +WNS+FDQL VV D PP L + +S + NF++ CL K +S R Y
Sbjct: 298 LATGRFPYPKWNSVFDQLTQVVKGD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKY 356
Query: 534 ETLIKHGMLTPFKD 575
+ L+KH + +++
Sbjct: 357 KELLKHPFILMYEE 370
>sp|Q07192|MP2K2_XENLA Dual specificity mitogen-activated protein kinase kinase 2 (MAP
kinase kinase 2) (MAPKK 2) (MAPK-ERK kinase 2)
Length = 446
Score = 186 bits (471), Expect = 8e-47
Identities = 98/211 (46%), Positives = 136/211 (64%), Gaps = 3/211 (1%)
Frame = +3
Query: 9 SSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGG 188
+S DKFY K + + IPE +L IT V AL +L L++IHRD+KPSN L+D G
Sbjct: 230 TSFDKFY-KYVYSFLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDTNG 288
Query: 189 RVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLELA 365
+K+CDFGISG L++S+AKT + G +PY+APERI+P S GY +RSDVWSLG+++ ELA
Sbjct: 289 NIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA 348
Query: 366 IRKFPYSRWNSLFDQLKDVVASDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASYET 539
+FPY +WNS+FDQL VV D PP L + +S + +F++QCL K +S R Y+
Sbjct: 349 TGRFPYPKWNSVFDQLTQVVKGD-PPQLSNSEEREFSPSFTSFVNQCLTKDESKRPKYKE 407
Query: 540 LIKHGMLTPFKDDKYLAESKKQFAEYVKQIL 632
L+KH + ++ E A YV +IL
Sbjct: 408 LLKHPFILMYE------ERTVDVAGYVGKIL 432
>sp|P45985|MP2K4_HUMAN Dual specificity mitogen-activated protein kinase kinase 4 (MAP
kinase kinase 4) (JNK-activating kinase 1) (c-Jun
N-terminal kinase kinase 1) (JNKK) (SAPK/ERK kinase 1)
(SEK1)
Length = 399
Score = 186 bits (471), Expect = 8e-47
Identities = 92/194 (47%), Positives = 131/194 (67%), Gaps = 3/194 (1%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+ +S DKFY K + + IPE +L IT V AL +L L++IHRD+KPSN L+D+
Sbjct: 181 MSTSFDKFY-KYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDR 239
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G +K+CDFGISG L++S+AKT + G +PY+APERI+P S GY +RSDVWSLG+++ E
Sbjct: 240 SGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYE 299
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPAL--PADSVYSDTVRNFISQCLVKKDSDRASY 533
LA +FPY +WNS+FDQL VV D PP L + +S + NF++ CL K +S R Y
Sbjct: 300 LATGRFPYPKWNSVFDQLTQVVKGD-PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKY 358
Query: 534 ETLIKHGMLTPFKD 575
+ L+KH + +++
Sbjct: 359 KELLKHPFILMYEE 372
>sp|Q20347|YR62_CAEEL Putative serine/threonine-protein kinase F42G10.2
Length = 363
Score = 168 bits (426), Expect = 1e-41
Identities = 94/184 (51%), Positives = 119/184 (64%), Gaps = 4/184 (2%)
Frame = +3
Query: 3 LDSSLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDK 182
+D S+D Y +V N+ + E ++ +IT C V AL+YL +EL++IHRDVKPSN L+D
Sbjct: 146 MDISMDLLYKRVYMV-KNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDG 204
Query: 183 GGRVKVCDFGISGDLINSMAKT-NVGSQPYLAPERINPDRSGAGYSIRSDVWSLGLSVLE 359
G VK+CDFGI G L S AKT + G QPYLAPERI S Y +RSDVWSLG+++ E
Sbjct: 205 TGAVKLCDFGICGQLEESFAKTHDAGCQPYLAPERIT---SSDKYDVRSDVWSLGITLYE 261
Query: 360 LAIRKFPYSRWNSLFDQLKDVVASDTPPALPADS---VYSDTVRNFISQCLVKKDSDRAS 530
+A KFPY WNSLFDQ+ VV+ D PP L DS YS + FI+ CL K R
Sbjct: 262 IATGKFPYQEWNSLFDQIATVVSGD-PPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPK 320
Query: 531 YETL 542
Y+TL
Sbjct: 321 YDTL 324
>sp|P08018|PBS2_YEAST Polymyxin B resistance protein kinase
Length = 668
Score = 150 bits (380), Expect = 3e-36
Identities = 91/214 (42%), Positives = 132/214 (61%), Gaps = 7/214 (3%)
Frame = +3
Query: 12 SLDKFYHKVIEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKG-G 188
SLDK Y E I E LA+I V+ L+ L + +IHRDVKP+N L G
Sbjct: 442 SLDKIYD---ESSEIGGIDEPQLAFIANAVIHGLKELKEQHNIIHRDVKPTNILCSANQG 498
Query: 189 RVKVCDFGISGDLINSMAKTNVGSQPYLAPERI---NPDRSGAGYSIRSDVWSLGLSVLE 359
VK+CDFG+SG+L+ S+AKTN+G Q Y+APERI NPDR A Y+++SD+WSLGLS+LE
Sbjct: 499 TVKLCDFGVSGNLVASLAKTNIGCQSYMAPERIKSLNPDR--ATYTVQSDIWSLGLSILE 556
Query: 360 LAIRKFPY--SRWNSLFDQLKDVVASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASY 533
+A+ ++PY ++++F QL +V PP LP+D SD ++F+S CL K R +Y
Sbjct: 557 MALGRYPYPPETYDNIFSQLSAIV-DGPPPRLPSDKFSSD-AQDFVSLCLQKIPERRPTY 614
Query: 534 ETLIKHGMLTPFKD-DKYLAESKKQFAEYVKQIL 632
L +H L +++ D +++E + E +IL
Sbjct: 615 AALTEHPWLVKYRNQDVHMSEYITERLERRNKIL 648
>sp|O14733|MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 (MAP
kinase kinase 7) (MAPKK 7) (MAPK/ERK kinase 7)
(JNK-activating kinase 2) (c-Jun N-terminal kinase
kinase 2) (JNK kinase 2) (JNKK 2)
Length = 419
Score = 150 bits (379), Expect = 4e-36
Identities = 79/180 (43%), Positives = 114/180 (63%), Gaps = 2/180 (1%)
Frame = +3
Query: 39 IEKDSNAFIPERLLAYITFCVVTALEYLHRELRVIHRDVKPSNTLIDKGGRVKVCDFGIS 218
++K IPER+L +T +V AL YL + VIHRDVKPSN L+D+ G++K+CDFGIS
Sbjct: 206 LKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGIS 265
Query: 219 GDLINSMAKT-NVGSQPYLAPERIN-PDRSGAGYSIRSDVWSLGLSVLELAIRKFPYSRW 392
G L++S AKT + G Y+APERI+ PD + Y IR+DVWSLG+S++ELA +FPY
Sbjct: 266 GRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNC 325
Query: 393 NSLFDQLKDVVASDTPPALPADSVYSDTVRNFISQCLVKKDSDRASYETLIKHGMLTPFK 572
+ F+ L V+ + PP LP +S ++F+ CL K R Y L++H + ++
Sbjct: 326 KTDFEVLTKVL-QEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYE 384
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,477,328
Number of Sequences: 369166
Number of extensions: 1702660
Number of successful extensions: 7426
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6068
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6317
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7018522000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)