DrC_00906
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00906 (974 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 282 9e-76 sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 280 4e-75 sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 279 7e-75 sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 273 5e-73 sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 259 8e-69 sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 255 1e-67 sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 233 6e-61 sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 230 4e-60 sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 229 9e-60 sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 223 6e-58
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light chain; Cathepsin B heavy chain] Length = 339 Score = 282 bits (722), Expect = 9e-76 Identities = 132/257 (51%), Positives = 167/257 (64%), Gaps = 1/257 (0%) Frame = +1 Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381 S DLINYIN NTTWQAG S + + G + PK LP + + I +P+ Sbjct: 27 SDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPK---LPGRVAFGEDIDLPE 82 Query: 382 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561 FD+R QWS+C I ++RDQ +CGSCWA A I+DR CIH+NG + +S +DLL+CC Sbjct: 83 TFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCC 142 Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 741 G CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+ Sbjct: 143 GIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEG 202 Query: 742 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 921 TP+C + C++GYS SYK+DK+FG SYSVS +V+EI EI NGPVE F VF DF Y Sbjct: 203 DTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTY 262 Query: 922 KHGVYQHTYGPLLGGHA 972 K GVY+H G ++GGHA Sbjct: 263 KSGVYKHEAGDMMGGHA 279
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin B heavy chain] Length = 335 Score = 280 bits (716), Expect = 4e-75 Identities = 127/257 (49%), Positives = 170/257 (66%), Gaps = 1/257 (0%) Frame = +1 Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381 S +L+N++N NTTW+AG S + + G + PK LPQ+ ++ +V+P+ Sbjct: 27 SDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGPK---LPQRDAFAADVVLPE 82 Query: 382 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561 FD+R QW +C I E+RDQ +CGSCWA A I+DR CIHSNG + +S +D+L+CC Sbjct: 83 SFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCC 142 Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 741 G CG+GCNGG AW +W G+V+GG YNSH GC+ Y PPC HHV G P C+G+ Sbjct: 143 GGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEG 202 Query: 742 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 921 TP+C + C+ GYS SYK+DK+FG +SYSV+ N +EI EI NGPVE F+V+ DF Y Sbjct: 203 DTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLY 262 Query: 922 KHGVYQHTYGPLLGGHA 972 K GVYQH G ++GGHA Sbjct: 263 KSGVYQHVSGEIMGGHA 279
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B light chain; Cathepsin B heavy chain] Length = 339 Score = 279 bits (714), Expect = 7e-75 Identities = 128/256 (50%), Positives = 166/256 (64%) Frame = +1 Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKIVIPDF 384 S D+INYIN NTTWQAG S + + G LP++ G+S I +P+ Sbjct: 27 SDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGT--VLGGPNLPERVGFSEDINLPES 83 Query: 385 FDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCG 564 FD+R QWS+C I ++RDQ +CGSCWA A ++DR CIH+NG + +S +DLL+CCG Sbjct: 84 FDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCG 143 Query: 565 SMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDSP 744 CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+ Sbjct: 144 IQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGD 203 Query: 745 TPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYK 924 TP+C + C++GYS SYK+DK++G SYSVS + +EI EI NGPVE F VF DF YK Sbjct: 204 TPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYK 263 Query: 925 HGVYQHTYGPLLGGHA 972 GVY+H G ++GGHA Sbjct: 264 SGVYKHEAGDVMGGHA 279
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS) [Contains: Cathepsin B light chain; Cathepsin B heavy chain] Length = 339 Score = 273 bits (698), Expect = 5e-73 Identities = 125/257 (48%), Positives = 165/257 (64%), Gaps = 1/257 (0%) Frame = +1 Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381 S +L+NY+N NTTWQAG S + + G PK PQ+ ++ + +P Sbjct: 27 SDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKP---PQRVMFTEDLKLPA 82 Query: 382 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561 FD+R QW C I E+RDQ +CGSCWA A I+DR CIH+N ++ +S +DLL+CC Sbjct: 83 SFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCC 142 Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 741 GSMCG+GCNGG AW +W G+V+GG Y SH GC+ Y PPC HHV G P C+G+ Sbjct: 143 GSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG 202 Query: 742 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 921 TP+C + C+ GYS +YK DK++G NSYSVS + ++I EI NGPVE F+V+ DF Y Sbjct: 203 DTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLY 262 Query: 922 KHGVYQHTYGPLLGGHA 972 K GVYQH G ++GGHA Sbjct: 263 KSGVYQHVTGEMMGGHA 279
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light chain; Cathepsin B heavy chain] Length = 340 Score = 259 bits (662), Expect = 8e-69 Identities = 122/258 (47%), Positives = 164/258 (63%), Gaps = 2/258 (0%) Frame = +1 Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381 S DL+N+IN + NTT +AG S + + G PK+ P++ ++ + +PD Sbjct: 27 SSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFLGGPKA---PERVDFAEDMDLPD 82 Query: 382 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561 FD+R QW +C I+E+RDQ +CGSCWA A I+DR C+H+N + +S +DLLSCC Sbjct: 83 TFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCC 142 Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGD- 738 G CG GCNGG AW+YW G+V+GG Y+SH GC+ Y PPC HHV G P C+G+ Sbjct: 143 GFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEG 202 Query: 739 SPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEY 918 TP+C C+ GYS SYK+DK++G SY V ++ +EI EI NGPVE F V++DF Sbjct: 203 GETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLM 262 Query: 919 YKHGVYQHTYGPLLGGHA 972 YK GVYQH G +GGHA Sbjct: 263 YKSGVYQHVSGEQVGGHA 280
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31) Length = 342 Score = 255 bits (652), Expect = 1e-67 Identities = 120/260 (46%), Positives = 159/260 (61%), Gaps = 4/260 (1%) Frame = +1 Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSL---RLPQKYGYSNKIVI 375 S ++I++IN + W+A ++RF S + R ++G RK + R P + + I Sbjct: 31 SDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKRNRRPTVDHHDLNVEI 90 Query: 376 PDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLS 555 P FDSR +W HCK I+++RDQS CGSCWA A +TDR CI S G +S DL+S Sbjct: 91 PSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLIS 150 Query: 556 CCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSG 735 CC CG+GC GG AW YWV GIVTGG +H GCQ YPFP C HH G YP C Sbjct: 151 CCKD-CGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGT 209 Query: 736 DS-PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDF 912 TPQC + CQ GY Y+ DK++G SY+V N + IQ +I++ GPVEA F+V++DF Sbjct: 210 KIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDF 269 Query: 913 EYYKHGVYQHTYGPLLGGHA 972 YK G+Y+H G ++GGHA Sbjct: 270 LNYKSGIYRHVTGSIVGGHA 289
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31) Length = 340 Score = 233 bits (594), Expect = 6e-61 Identities = 125/291 (42%), Positives = 162/291 (55%), Gaps = 4/291 (1%) Frame = +1 Query: 112 LILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKSNSE 291 LI L ++KNE K++ L S D+I+YIN N W+A +NRF S + Sbjct: 11 LITFLEAHISVKNE--KFEPL----------SDDIISYINEHPNAGWRAEKSNRFHSLDD 58 Query: 292 FRNVLGLRKTPKSLRLPQKYGYSNK---IVIPDFFDSRTQWSHCKYINEVRDQSNCGSCW 462 R +G R+ LR ++ + + IP FDSR +W CK I +RDQS CGSCW Sbjct: 59 ARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCW 118 Query: 463 AVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYWVNFGIVT 642 + A ++DR CI S G +S DLL+CC S CG GC GG AW YWV GIVT Sbjct: 119 SFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCES-CGLGCEGGILGPAWDYWVKEGIVT 177 Query: 643 GGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS-PTPQCVEKCQSGYSKSYKDDKYFGQN 819 +H GC+ YPFP C HH G YP C TP+C + CQ Y Y DK+ G++ Sbjct: 178 ASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKS 237 Query: 820 SYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYKHGVYQHTYGPLLGGHA 972 SY+V + + IQ EI+ GPVEA F V++DF YK G+Y+H G LGGHA Sbjct: 238 SYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHA 288
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine protease-related 6) Length = 379 Score = 230 bits (587), Expect = 4e-60 Identities = 127/307 (41%), Positives = 174/307 (56%), Gaps = 10/307 (3%) Frame = +1 Query: 82 KLIRMWRCFVLILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAG 261 K + C V+ + N+++ K++ L DLI+Y+N N W A Sbjct: 2 KTLLFLSCIVVAAYCACNDNLESVLDKYRNREIDSEAAELDGDDLIDYVNENQNL-WTAK 60 Query: 262 PTNRFKS----NSEFR-NVLGLRKTPKSLRLPQKYGYSNKIV--IPDFFDSRTQWSHCKY 420 RF S N + + ++G+ S++ Q + + IP+ FDSR W C Sbjct: 61 KQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDLDIPESFDSRDNWPKCDS 120 Query: 421 INEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSD 600 I +RDQS+CGSCWA A ++DR CI S+G +Q +S DLLSCC S CG GCNGG Sbjct: 121 IKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDLLSCCKS-CGFGCNGGDP 179 Query: 601 HAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGP-YPNCSGD-SPTPQCVEKCQS 774 AAW+YWV GIVTG Y ++ GC+ YPFPPC HH + C D PTP+C +KC S Sbjct: 180 LAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDLYPTPKCEKKCVS 239 Query: 775 GYS-KSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYKHGVYQHTYG 951 Y+ K+Y +DK+FG ++Y V +VE IQ E++ +GP+E F V++DF Y GVY HT G Sbjct: 240 DYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGG 299 Query: 952 PLLGGHA 972 L GGHA Sbjct: 300 KLGGGHA 306
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine protease-related 5) Length = 344 Score = 229 bits (584), Expect = 9e-60 Identities = 126/275 (45%), Positives = 156/275 (56%), Gaps = 16/275 (5%) Frame = +1 Query: 196 ALSSFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKI-- 369 AL+ LI+Y+N A W AG V+ K K L + KY +K Sbjct: 26 ALTGQALIDYVNS-AQKLWTAG-----------HQVIPKEKITKKL-MDVKYLVPHKDED 72 Query: 370 --------VIPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQ 525 IPD FD+R QW +C IN +RDQS+CGSCWA AA I+DR CI SNG + Sbjct: 73 IVATEVSDAIPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVN 132 Query: 526 PRISDKDLLSCCGSM--CGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCS 699 +S +DLLSCC M CG GC GG AWK+WV G+VTGG Y + GC+ Y PC Sbjct: 133 TLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCG 192 Query: 700 HHVIG-PYPNCSGDS-PTPQCVEKCQS--GYSKSYKDDKYFGQNSYSVSKNVEEIQGEIL 867 V G +P C D+ PTP+CV+ C S Y+ Y DK+FG +Y+V K VE+IQ EIL Sbjct: 193 ETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEIL 252 Query: 868 INGPVEAGFNVFQDFEYYKHGVYQHTYGPLLGGHA 972 NGP+E F V++DF Y GVY HT G LGGHA Sbjct: 253 TNGPIEVAFTVYEDFYQYTTGVYVHTAGASLGGHA 287
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor Length = 329 Score = 223 bits (568), Expect = 6e-58 Identities = 108/200 (54%), Positives = 130/200 (65%) Frame = +1 Query: 373 IPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLL 552 +P FDSRTQWS CK I +RDQ+ CGSCWA A I+DR CI + G QP IS DLL Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144 Query: 553 SCCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCS 732 SCCGS CG GC GG A ++W + G+VTGG Y+ GC+ YP PC+ NC Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197 Query: 733 GDSPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDF 912 +S TP C CQSGYS +Y DK+FG ++Y+V KN IQ EI NGPVEA F+V++DF Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256 Query: 913 EYYKHGVYQHTYGPLLGGHA 972 YK GVY+HT G LGGHA Sbjct: 257 YKYKSGVYKHTAGKYLGGHA 276
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,192,299
Number of Sequences: 369166
Number of extensions: 2396673
Number of successful extensions: 6389
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5880
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6227
length of database: 68,354,980
effective HSP length: 111
effective length of database: 47,849,395
effective search space used: 10191921135
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
