Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_E15
(871 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 282 7e-76
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 280 4e-75
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 279 6e-75
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 273 5e-73
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 259 7e-69
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 255 1e-67
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 233 5e-61
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 229 7e-60
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 228 2e-59
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 223 5e-58
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 282 bits (722), Expect = 7e-76
Identities = 132/257 (51%), Positives = 167/257 (64%), Gaps = 1/257 (0%)
Frame = +3
Query: 102 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 278
S DLINYIN NTTWQAG S + + G + PK LP + + I +P+
Sbjct: 27 SDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPK---LPGRVAFGEDIDLPE 82
Query: 279 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 458
FD+R QWS+C I ++RDQ +CGSCWA A I+DR CIH+NG + +S +DLL+CC
Sbjct: 83 TFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCC 142
Query: 459 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 638
G CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 143 GIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEG 202
Query: 639 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 818
TP+C + C++GYS SYK+DK+FG SYSVS +V+EI EI NGPVE F VF DF Y
Sbjct: 203 DTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTY 262
Query: 819 KHGVYQHTYGPLLGGHA 869
K GVY+H G ++GGHA
Sbjct: 263 KSGVYKHEAGDMMGGHA 279
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 280 bits (716), Expect = 4e-75
Identities = 127/257 (49%), Positives = 170/257 (66%), Gaps = 1/257 (0%)
Frame = +3
Query: 102 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 278
S +L+N++N NTTW+AG S + + G + PK LPQ+ ++ +V+P+
Sbjct: 27 SDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGPK---LPQRDAFAADVVLPE 82
Query: 279 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 458
FD+R QW +C I E+RDQ +CGSCWA A I+DR CIHSNG + +S +D+L+CC
Sbjct: 83 SFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCC 142
Query: 459 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 638
G CG+GCNGG AW +W G+V+GG YNSH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 639 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 818
TP+C + C+ GYS SYK+DK+FG +SYSV+ N +EI EI NGPVE F+V+ DF Y
Sbjct: 203 DTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLY 262
Query: 819 KHGVYQHTYGPLLGGHA 869
K GVYQH G ++GGHA
Sbjct: 263 KSGVYQHVSGEIMGGHA 279
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 279 bits (714), Expect = 6e-75
Identities = 128/256 (50%), Positives = 166/256 (64%)
Frame = +3
Query: 102 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKIVIPDF 281
S D+INYIN NTTWQAG S + + G LP++ G+S I +P+
Sbjct: 27 SDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGT--VLGGPNLPERVGFSEDINLPES 83
Query: 282 FDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCG 461
FD+R QWS+C I ++RDQ +CGSCWA A ++DR CIH+NG + +S +DLL+CCG
Sbjct: 84 FDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCG 143
Query: 462 SMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDSP 641
CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 144 IQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGD 203
Query: 642 TPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYK 821
TP+C + C++GYS SYK+DK++G SYSVS + +EI EI NGPVE F VF DF YK
Sbjct: 204 TPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYK 263
Query: 822 HGVYQHTYGPLLGGHA 869
GVY+H G ++GGHA
Sbjct: 264 SGVYKHEAGDVMGGHA 279
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 273 bits (698), Expect = 5e-73
Identities = 125/257 (48%), Positives = 165/257 (64%), Gaps = 1/257 (0%)
Frame = +3
Query: 102 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 278
S +L+NY+N NTTWQAG S + + G PK PQ+ ++ + +P
Sbjct: 27 SDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKP---PQRVMFTEDLKLPA 82
Query: 279 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 458
FD+R QW C I E+RDQ +CGSCWA A I+DR CIH+N ++ +S +DLL+CC
Sbjct: 83 SFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCC 142
Query: 459 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 638
GSMCG+GCNGG AW +W G+V+GG Y SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 639 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 818
TP+C + C+ GYS +YK DK++G NSYSVS + ++I EI NGPVE F+V+ DF Y
Sbjct: 203 DTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLY 262
Query: 819 KHGVYQHTYGPLLGGHA 869
K GVYQH G ++GGHA
Sbjct: 263 KSGVYQHVTGEMMGGHA 279
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 259 bits (662), Expect = 7e-69
Identities = 122/258 (47%), Positives = 164/258 (63%), Gaps = 2/258 (0%)
Frame = +3
Query: 102 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 278
S DL+N+IN + NTT +AG S + + G PK+ P++ ++ + +PD
Sbjct: 27 SSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFLGGPKA---PERVDFAEDMDLPD 82
Query: 279 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 458
FD+R QW +C I+E+RDQ +CGSCWA A I+DR C+H+N + +S +DLLSCC
Sbjct: 83 TFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCC 142
Query: 459 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGD- 635
G CG GCNGG AW+YW G+V+GG Y+SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEG 202
Query: 636 SPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEY 815
TP+C C+ GYS SYK+DK++G SY V ++ +EI EI NGPVE F V++DF
Sbjct: 203 GETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLM 262
Query: 816 YKHGVYQHTYGPLLGGHA 869
YK GVYQH G +GGHA
Sbjct: 263 YKSGVYQHVSGEQVGGHA 280
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 255 bits (652), Expect = 1e-67
Identities = 120/260 (46%), Positives = 159/260 (61%), Gaps = 4/260 (1%)
Frame = +3
Query: 102 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSL---RLPQKYGYSNKIVI 272
S ++I++IN + W+A ++RF S + R ++G RK + R P + + I
Sbjct: 31 SDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKRNRRPTVDHHDLNVEI 90
Query: 273 PDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLS 452
P FDSR +W HCK I+++RDQS CGSCWA A +TDR CI S G +S DL+S
Sbjct: 91 PSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLIS 150
Query: 453 CCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSG 632
CC CG+GC GG AW YWV GIVTGG +H GCQ YPFP C HH G YP C
Sbjct: 151 CCKD-CGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGT 209
Query: 633 DS-PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDF 809
TPQC + CQ GY Y+ DK++G SY+V N + IQ +I++ GPVEA F+V++DF
Sbjct: 210 KIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDF 269
Query: 810 EYYKHGVYQHTYGPLLGGHA 869
YK G+Y+H G ++GGHA
Sbjct: 270 LNYKSGIYRHVTGSIVGGHA 289
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 233 bits (594), Expect = 5e-61
Identities = 125/291 (42%), Positives = 162/291 (55%), Gaps = 4/291 (1%)
Frame = +3
Query: 9 LILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKSNSE 188
LI L ++KNE K++ L S D+I+YIN N W+A +NRF S +
Sbjct: 11 LITFLEAHISVKNE--KFEPL----------SDDIISYINEHPNAGWRAEKSNRFHSLDD 58
Query: 189 FRNVLGLRKTPKSLRLPQKYGYSNK---IVIPDFFDSRTQWSHCKYINEVRDQSNCGSCW 359
R +G R+ LR ++ + + IP FDSR +W CK I +RDQS CGSCW
Sbjct: 59 ARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCW 118
Query: 360 AVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYWVNFGIVT 539
+ A ++DR CI S G +S DLL+CC S CG GC GG AW YWV GIVT
Sbjct: 119 SFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCES-CGLGCEGGILGPAWDYWVKEGIVT 177
Query: 540 GGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS-PTPQCVEKCQSGYSKSYKDDKYFGQN 716
+H GC+ YPFP C HH G YP C TP+C + CQ Y Y DK+ G++
Sbjct: 178 ASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKS 237
Query: 717 SYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYKHGVYQHTYGPLLGGHA 869
SY+V + + IQ EI+ GPVEA F V++DF YK G+Y+H G LGGHA
Sbjct: 238 SYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHA 288
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 229 bits (584), Expect = 7e-60
Identities = 126/275 (45%), Positives = 156/275 (56%), Gaps = 16/275 (5%)
Frame = +3
Query: 93 ALSSFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKI-- 266
AL+ LI+Y+N A W AG V+ K K L + KY +K
Sbjct: 26 ALTGQALIDYVNS-AQKLWTAG-----------HQVIPKEKITKKL-MDVKYLVPHKDED 72
Query: 267 --------VIPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQ 422
IPD FD+R QW +C IN +RDQS+CGSCWA AA I+DR CI SNG +
Sbjct: 73 IVATEVSDAIPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVN 132
Query: 423 PRISDKDLLSCCGSM--CGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCS 596
+S +DLLSCC M CG GC GG AWK+WV G+VTGG Y + GC+ Y PC
Sbjct: 133 TLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCG 192
Query: 597 HHVIG-PYPNCSGDS-PTPQCVEKCQS--GYSKSYKDDKYFGQNSYSVSKNVEEIQGEIL 764
V G +P C D+ PTP+CV+ C S Y+ Y DK+FG +Y+V K VE+IQ EIL
Sbjct: 193 ETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEIL 252
Query: 765 INGPVEAGFNVFQDFEYYKHGVYQHTYGPLLGGHA 869
NGP+E F V++DF Y GVY HT G LGGHA
Sbjct: 253 TNGPIEVAFTVYEDFYQYTTGVYVHTAGASLGGHA 287
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 228 bits (581), Expect = 2e-59
Identities = 122/268 (45%), Positives = 161/268 (60%), Gaps = 10/268 (3%)
Frame = +3
Query: 96 LSSFDLINYINYVANTTWQAGPTNRFKS----NSEFR-NVLGLRKTPKSLRLPQKYGYSN 260
L DLI+Y+N N W A RF S N + + ++G+ S++ Q +
Sbjct: 41 LDGDDLIDYVNENQNL-WTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTK 99
Query: 261 KIV--IPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRIS 434
+ IP+ FDSR W C I +RDQS+CGSCWA A ++DR CI S+G +Q +S
Sbjct: 100 DLDLDIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLS 159
Query: 435 DKDLLSCCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGP 614
DLLSCC S CG GCNGG AAW+YWV GIVTG Y ++ GC+ YPFPPC HH
Sbjct: 160 ADDLLSCCKS-CGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKT 218
Query: 615 -YPNCSGD-SPTPQCVEKCQSGYS-KSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEA 785
+ C D PTP+C +KC S Y+ K+Y +DK+FG ++Y V +VE IQ E++ +GP+E
Sbjct: 219 HFDPCPHDLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEI 278
Query: 786 GFNVFQDFEYYKHGVYQHTYGPLLGGHA 869
F V++DF Y GVY HT G L GGHA
Sbjct: 279 AFEVYEDFLNYDGGVYVHTGGKLGGGHA 306
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 223 bits (568), Expect = 5e-58
Identities = 108/200 (54%), Positives = 130/200 (65%)
Frame = +3
Query: 270 IPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLL 449
+P FDSRTQWS CK I +RDQ+ CGSCWA A I+DR CI + G QP IS DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 450 SCCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCS 629
SCCGS CG GC GG A ++W + G+VTGG Y+ GC+ YP PC+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 630 GDSPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDF 809
+S TP C CQSGYS +Y DK+FG ++Y+V KN IQ EI NGPVEA F+V++DF
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256
Query: 810 EYYKHGVYQHTYGPLLGGHA 869
YK GVY+HT G LGGHA
Sbjct: 257 YKYKSGVYKHTAGKYLGGHA 276
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,745,580
Number of Sequences: 369166
Number of extensions: 2247076
Number of successful extensions: 5985
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5502
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5823
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)