Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_023_J16
(864 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 273 5e-73
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 271 2e-72
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 270 4e-72
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 264 3e-70
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 251 2e-66
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 246 6e-65
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 224 3e-58
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 222 9e-58
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 220 5e-57
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 214 3e-55
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 273 bits (698), Expect = 5e-73
Identities = 128/253 (50%), Positives = 163/253 (64%), Gaps = 1/253 (0%)
Frame = +1
Query: 109 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 285
S DLINYIN NTTWQAG S + + G + PK LP + + I +P+
Sbjct: 27 SDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPK---LPGRVAFGEDIDLPE 82
Query: 286 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 465
FD+R QWS+C I ++RDQ +CGSCWA A I+DR CIH+NG + +S +DLL+CC
Sbjct: 83 TFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCC 142
Query: 466 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 645
G CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 143 GIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEG 202
Query: 646 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 825
TP+C + C++GYS SYK+DK+FG SYSVS +V+EI EI NGPVE F VF DF Y
Sbjct: 203 DTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTY 262
Query: 826 KHGVYQHTYGPLL 864
K GVY+H G ++
Sbjct: 263 KSGVYKHEAGDMM 275
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 271 bits (692), Expect = 2e-72
Identities = 123/253 (48%), Positives = 166/253 (65%), Gaps = 1/253 (0%)
Frame = +1
Query: 109 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 285
S +L+N++N NTTW+AG S + + G + PK LPQ+ ++ +V+P+
Sbjct: 27 SDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGPK---LPQRDAFAADVVLPE 82
Query: 286 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 465
FD+R QW +C I E+RDQ +CGSCWA A I+DR CIHSNG + +S +D+L+CC
Sbjct: 83 SFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCC 142
Query: 466 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 645
G CG+GCNGG AW +W G+V+GG YNSH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 646 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 825
TP+C + C+ GYS SYK+DK+FG +SYSV+ N +EI EI NGPVE F+V+ DF Y
Sbjct: 203 DTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLY 262
Query: 826 KHGVYQHTYGPLL 864
K GVYQH G ++
Sbjct: 263 KSGVYQHVSGEIM 275
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 270 bits (690), Expect = 4e-72
Identities = 124/252 (49%), Positives = 162/252 (64%)
Frame = +1
Query: 109 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKIVIPDF 288
S D+INYIN NTTWQAG S + + G LP++ G+S I +P+
Sbjct: 27 SDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGT--VLGGPNLPERVGFSEDINLPES 83
Query: 289 FDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCG 468
FD+R QWS+C I ++RDQ +CGSCWA A ++DR CIH+NG + +S +DLL+CCG
Sbjct: 84 FDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCG 143
Query: 469 SMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDSP 648
CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 144 IQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGD 203
Query: 649 TPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYK 828
TP+C + C++GYS SYK+DK++G SYSVS + +EI EI NGPVE F VF DF YK
Sbjct: 204 TPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYK 263
Query: 829 HGVYQHTYGPLL 864
GVY+H G ++
Sbjct: 264 SGVYKHEAGDVM 275
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 264 bits (674), Expect = 3e-70
Identities = 121/253 (47%), Positives = 161/253 (63%), Gaps = 1/253 (0%)
Frame = +1
Query: 109 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 285
S +L+NY+N NTTWQAG S + + G PK PQ+ ++ + +P
Sbjct: 27 SDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKP---PQRVMFTEDLKLPA 82
Query: 286 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 465
FD+R QW C I E+RDQ +CGSCWA A I+DR CIH+N ++ +S +DLL+CC
Sbjct: 83 SFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCC 142
Query: 466 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 645
GSMCG+GCNGG AW +W G+V+GG Y SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 646 PTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYY 825
TP+C + C+ GYS +YK DK++G NSYSVS + ++I EI NGPVE F+V+ DF Y
Sbjct: 203 DTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLY 262
Query: 826 KHGVYQHTYGPLL 864
K GVYQH G ++
Sbjct: 263 KSGVYQHVTGEMM 275
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 251 bits (640), Expect = 2e-66
Identities = 118/251 (47%), Positives = 159/251 (63%), Gaps = 2/251 (0%)
Frame = +1
Query: 109 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 285
S DL+N+IN + NTT +AG S + + G PK+ P++ ++ + +PD
Sbjct: 27 SSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFLGGPKA---PERVDFAEDMDLPD 82
Query: 286 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 465
FD+R QW +C I+E+RDQ +CGSCWA A I+DR C+H+N + +S +DLLSCC
Sbjct: 83 TFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCC 142
Query: 466 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGD- 642
G CG GCNGG AW+YW G+V+GG Y+SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEG 202
Query: 643 SPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEY 822
TP+C C+ GYS SYK+DK++G SY V ++ +EI EI NGPVE F V++DF
Sbjct: 203 GETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLM 262
Query: 823 YKHGVYQHTYG 855
YK GVYQH G
Sbjct: 263 YKSGVYQHVSG 273
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 246 bits (628), Expect = 6e-65
Identities = 116/256 (45%), Positives = 155/256 (60%), Gaps = 4/256 (1%)
Frame = +1
Query: 109 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSL---RLPQKYGYSNKIVI 279
S ++I++IN + W+A ++RF S + R ++G RK + R P + + I
Sbjct: 31 SDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKRNRRPTVDHHDLNVEI 90
Query: 280 PDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLS 459
P FDSR +W HCK I+++RDQS CGSCWA A +TDR CI S G +S DL+S
Sbjct: 91 PSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLIS 150
Query: 460 CCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSG 639
CC CG+GC GG AW YWV GIVTGG +H GCQ YPFP C HH G YP C
Sbjct: 151 CCKD-CGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGT 209
Query: 640 D-SPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDF 816
TPQC + CQ GY Y+ DK++G SY+V N + IQ +I++ GPVEA F+V++DF
Sbjct: 210 KIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDF 269
Query: 817 EYYKHGVYQHTYGPLL 864
YK G+Y+H G ++
Sbjct: 270 LNYKSGIYRHVTGSIV 285
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 224 bits (570), Expect = 3e-58
Identities = 122/287 (42%), Positives = 159/287 (55%), Gaps = 4/287 (1%)
Frame = +1
Query: 16 LILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKSNSE 195
LI L ++KNE K++ L S D+I+YIN N W+A +NRF S +
Sbjct: 11 LITFLEAHISVKNE--KFEPL----------SDDIISYINEHPNAGWRAEKSNRFHSLDD 58
Query: 196 FRNVLGLRKTPKSLRLPQKYGYSNK---IVIPDFFDSRTQWSHCKYINEVRDQSNCGSCW 366
R +G R+ LR ++ + + IP FDSR +W CK I +RDQS CGSCW
Sbjct: 59 ARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCW 118
Query: 367 AVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYWVNFGIVT 546
+ A ++DR CI S G +S DLL+CC S CG GC GG AW YWV GIVT
Sbjct: 119 SFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCES-CGLGCEGGILGPAWDYWVKEGIVT 177
Query: 547 GGPYNSHQGCQDYPFPPCSHHVIGPYPNC-SGDSPTPQCVEKCQSGYSKSYKDDKYFGQN 723
+H GC+ YPFP C HH G YP C S TP+C + CQ Y Y DK+ G++
Sbjct: 178 ASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKS 237
Query: 724 SYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYKHGVYQHTYGPLL 864
SY+V + + IQ EI+ GPVEA F V++DF YK G+Y+H G L
Sbjct: 238 SYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEAL 284
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 222 bits (566), Expect = 9e-58
Identities = 122/295 (41%), Positives = 168/295 (56%), Gaps = 10/295 (3%)
Frame = +1
Query: 7 CFVLILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKS 186
C V+ + N+++ K++ L DLI+Y+N N W A RF S
Sbjct: 9 CIVVAAYCACNDNLESVLDKYRNREIDSEAAELDGDDLIDYVNENQNL-WTAKKQRRFSS 67
Query: 187 ----NSEFR-NVLGLRKTPKSLRLPQKYGYSNKIV--IPDFFDSRTQWSHCKYINEVRDQ 345
N + + ++G+ S++ Q + + IP+ FDSR W C I +RDQ
Sbjct: 68 VYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDLDIPESFDSRDNWPKCDSIKVIRDQ 127
Query: 346 SNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYW 525
S+CGSCWA A ++DR CI S+G +Q +S DLLSCC S CG GCNGG AAW+YW
Sbjct: 128 SSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDLLSCCKS-CGFGCNGGDPLAAWRYW 186
Query: 526 VNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGP-YPNCSGD-SPTPQCVEKCQSGYS-KSY 696
V GIVTG Y ++ GC+ YPFPPC HH + C D PTP+C +KC S Y+ K+Y
Sbjct: 187 VKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDLYPTPKCEKKCVSDYTDKTY 246
Query: 697 KDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDFEYYKHGVYQHTYGPL 861
+DK+FG ++Y V +VE IQ E++ +GP+E F V++DF Y GVY HT G L
Sbjct: 247 SEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGGKL 301
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 220 bits (560), Expect = 5e-57
Identities = 122/271 (45%), Positives = 152/271 (56%), Gaps = 16/271 (5%)
Frame = +1
Query: 100 ALSSFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKI-- 273
AL+ LI+Y+N A W AG V+ K K L + KY +K
Sbjct: 26 ALTGQALIDYVNS-AQKLWTAG-----------HQVIPKEKITKKL-MDVKYLVPHKDED 72
Query: 274 --------VIPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQ 429
IPD FD+R QW +C IN +RDQS+CGSCWA AA I+DR CI SNG +
Sbjct: 73 IVATEVSDAIPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVN 132
Query: 430 PRISDKDLLSCCGSM--CGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCS 603
+S +DLLSCC M CG GC GG AWK+WV G+VTGG Y + GC+ Y PC
Sbjct: 133 TLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCG 192
Query: 604 HHVIG-PYPNCSGDS-PTPQCVEKCQS--GYSKSYKDDKYFGQNSYSVSKNVEEIQGEIL 771
V G +P C D+ PTP+CV+ C S Y+ Y DK+FG +Y+V K VE+IQ EIL
Sbjct: 193 ETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEIL 252
Query: 772 INGPVEAGFNVFQDFEYYKHGVYQHTYGPLL 864
NGP+E F V++DF Y GVY HT G L
Sbjct: 253 TNGPIEVAFTVYEDFYQYTTGVYVHTAGASL 283
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 214 bits (544), Expect = 3e-55
Identities = 104/196 (53%), Positives = 126/196 (64%)
Frame = +1
Query: 277 IPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLL 456
+P FDSRTQWS CK I +RDQ+ CGSCWA A I+DR CI + G QP IS DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 457 SCCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCS 636
SCCGS CG GC GG A ++W + G+VTGG Y+ GC+ YP PC+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 637 GDSPTPQCVEKCQSGYSKSYKDDKYFGQNSYSVSKNVEEIQGEILINGPVEAGFNVFQDF 816
+S TP C CQSGYS +Y DK+FG ++Y+V KN IQ EI NGPVEA F+V++DF
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256
Query: 817 EYYKHGVYQHTYGPLL 864
YK GVY+HT G L
Sbjct: 257 YKYKSGVYKHTAGKYL 272
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 99,794,865
Number of Sequences: 369166
Number of extensions: 2245672
Number of successful extensions: 5974
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5492
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5812
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)