Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_N01
(825 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 224 2e-58
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 224 2e-58
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 222 1e-57
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 217 4e-56
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 207 3e-53
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 202 9e-52
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 183 6e-46
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 181 2e-45
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 169 1e-41
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 162 1e-39
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 224 bits (572), Expect = 2e-58
Identities = 100/207 (48%), Positives = 133/207 (64%)
Frame = +1
Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKIVIPDF 384
S D+INYIN NTTWQAG S + + G LP++ G+S I +P+
Sbjct: 27 SDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGT--VLGGPNLPERVGFSEDINLPES 83
Query: 385 FDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCG 564
FD+R QWS+C I ++RDQ +CGSCWA A ++DR CIH+NG + +S +DLL+CCG
Sbjct: 84 FDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCG 143
Query: 565 SMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDSP 744
CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 144 IQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGD 203
Query: 745 TPQCVEKCQSGYSKSYKDDKYFGQNSY 825
TP+C + C++GYS SYK+DK++G SY
Sbjct: 204 TPKCNKMCEAGYSTSYKEDKHYGYTSY 230
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 224 bits (571), Expect = 2e-58
Identities = 103/208 (49%), Positives = 133/208 (63%), Gaps = 1/208 (0%)
Frame = +1
Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381
S DLINYIN NTTWQAG S + + G + PK LP + + I +P+
Sbjct: 27 SDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPK---LPGRVAFGEDIDLPE 82
Query: 382 FFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561
FD+R QWS+C I ++RDQ +CGSCWA A I+DR CIH+NG + +S +DLL+CC
Sbjct: 83 TFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCC 142
Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 741
G CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 143 GIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEG 202
Query: 742 PTPQCVEKCQSGYSKSYKDDKYFGQNSY 825
TP+C + C++GYS SYK+DK+FG SY
Sbjct: 203 DTPRCNKSCEAGYSPSYKEDKHFGYTSY 230
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 222 bits (565), Expect = 1e-57
Identities = 99/208 (47%), Positives = 136/208 (65%), Gaps = 1/208 (0%)
Frame = +1
Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381
S +L+N++N NTTW+AG S + + G + PK LPQ+ ++ +V+P+
Sbjct: 27 SDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGPK---LPQRDAFAADVVLPE 82
Query: 382 FFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561
FD+R QW +C I E+RDQ +CGSCWA A I+DR CIHSNG + +S +D+L+CC
Sbjct: 83 SFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCC 142
Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 741
G CG+GCNGG AW +W G+V+GG YNSH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 742 PTPQCVEKCQSGYSKSYKDDKYFGQNSY 825
TP+C + C+ GYS SYK+DK+FG +SY
Sbjct: 203 DTPKCNKTCEPGYSPSYKEDKHFGCSSY 230
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 217 bits (552), Expect = 4e-56
Identities = 98/208 (47%), Positives = 131/208 (62%), Gaps = 1/208 (0%)
Frame = +1
Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381
S +L+NY+N NTTWQAG S + + G PK PQ+ ++ + +P
Sbjct: 27 SDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKP---PQRVMFTEDLKLPA 82
Query: 382 FFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561
FD+R QW C I E+RDQ +CGSCWA A I+DR CIH+N ++ +S +DLL+CC
Sbjct: 83 SFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCC 142
Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 741
GSMCG+GCNGG AW +W G+V+GG Y SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 742 PTPQCVEKCQSGYSKSYKDDKYFGQNSY 825
TP+C + C+ GYS +YK DK++G NSY
Sbjct: 203 DTPKCSKICEPGYSPTYKQDKHYGYNSY 230
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 207 bits (527), Expect = 3e-53
Identities = 96/209 (45%), Positives = 131/209 (62%), Gaps = 2/209 (0%)
Frame = +1
Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 381
S DL+N+IN + NTT +AG S + + G PK+ P++ ++ + +PD
Sbjct: 27 SSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFLGGPKA---PERVDFAEDMDLPD 82
Query: 382 FFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 561
FD+R QW +C I E+RDQ +CGSCWA A I+DR C+H+N + +S +DLLSCC
Sbjct: 83 TFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCC 142
Query: 562 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGD- 738
G CG GCNGG AW+YW G+V+GG Y+SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEG 202
Query: 739 SPTPQCVEKCQSGYSKSYKDDKYFGQNSY 825
TP+C C+ GYS SYK+DK++G SY
Sbjct: 203 GETPRCSRHCEPGYSPSYKEDKHYGITSY 231
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 202 bits (514), Expect = 9e-52
Identities = 96/211 (45%), Positives = 122/211 (57%), Gaps = 4/211 (1%)
Frame = +1
Query: 205 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSL---RLPQKYGYSNKIVI 375
S ++I++IN + W+A ++RF S + R ++G RK + R P + + I
Sbjct: 31 SDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKRNRRPTVDHHDLNVEI 90
Query: 376 PDFFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLS 555
P FDSR +W HCK I ++RDQS CGSCWA A +TDR CI S G +S DL+S
Sbjct: 91 PSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLIS 150
Query: 556 CCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSG 735
CC CG+GC GG AW YWV GIVTGG +H GCQ YPFP C HH G YP C
Sbjct: 151 CCKD-CGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGT 209
Query: 736 D-SPTPQCVEKCQSGYSKSYKDDKYFGQNSY 825
TPQC + CQ GY Y+ DK++G SY
Sbjct: 210 KIYKTPQCKQTCQKGYKTPYEQDKHYGDESY 240
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 183 bits (464), Expect = 6e-46
Identities = 101/242 (41%), Positives = 130/242 (53%), Gaps = 4/242 (1%)
Frame = +1
Query: 112 LILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKSNSE 291
LI L ++KNE K++ L S D+I+YIN N W+A +NRF S +
Sbjct: 11 LITFLEAHISVKNE--KFEPL----------SDDIISYINEHPNAGWRAEKSNRFHSLDD 58
Query: 292 FRNVLGLRKTPKSLRLPQKYGYSNK---IVIPDFFDSRTQWSHCKYIDEVRDQSNCGSCW 462
R +G R+ LR ++ + + IP FDSR +W CK I +RDQS CGSCW
Sbjct: 59 ARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCW 118
Query: 463 AVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYWVNFGIVT 642
+ A ++DR CI S G +S DLL+CC S CG GC GG AW YWV GIVT
Sbjct: 119 SFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCES-CGLGCEGGILGPAWDYWVKEGIVT 177
Query: 643 GGPYNSHQGCQDYPFPPCSHHVIGPYPNC-SGDSPTPQCVEKCQSGYSKSYKDDKYFGQN 819
+H GC+ YPFP C HH G YP C S TP+C + CQ Y Y DK+ G++
Sbjct: 178 ASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHRGKS 237
Query: 820 SY 825
SY
Sbjct: 238 SY 239
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 181 bits (460), Expect = 2e-45
Identities = 102/258 (39%), Positives = 142/258 (55%), Gaps = 10/258 (3%)
Frame = +1
Query: 82 KLIRMWRCFVLILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAG 261
K + C V+ + N+++ K++ L DLI+Y+N N W A
Sbjct: 2 KTLLFLSCIVVAAYCACNDNLESVLDKYRNREIDSEAAELDGDDLIDYVNENQNL-WTAK 60
Query: 262 PTNRFKS----NSEFR-NVLGLRKTPKSLRLPQKYGYSNKIV--IPDFFDSRTQWSHCKY 420
RF S N + + ++G+ S++ Q + + IP+ FDSR W C
Sbjct: 61 KQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDLDIPESFDSRDNWPKCDS 120
Query: 421 IDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSD 600
I +RDQS+CGSCWA A ++DR CI S+G +Q +S DLLSCC S CG GCNGG
Sbjct: 121 IKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDLLSCCKS-CGFGCNGGDP 179
Query: 601 HAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGP-YPNCSGD-SPTPQCVEKCQS 774
AAW+YWV GIVTG Y ++ GC+ YPFPPC HH + C D PTP+C +KC S
Sbjct: 180 LAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDLYPTPKCEKKCVS 239
Query: 775 GYS-KSYKDDKYFGQNSY 825
Y+ K+Y +DK+FG ++Y
Sbjct: 240 DYTDKTYSEDKFFGASAY 257
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 169 bits (427), Expect = 1e-41
Identities = 96/226 (42%), Positives = 122/226 (53%), Gaps = 16/226 (7%)
Frame = +1
Query: 196 ALSSFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKI-- 369
AL+ LI+Y+N A W AG V+ K K L + KY +K
Sbjct: 26 ALTGQALIDYVNS-AQKLWTAG-----------HQVIPKEKITKKL-MDVKYLVPHKDED 72
Query: 370 --------VIPDFFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQ 525
IPD FD+R QW +C I+ +RDQS+CGSCWA AA I+DR CI SNG +
Sbjct: 73 IVATEVSDAIPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVN 132
Query: 526 PRISDKDLLSCCGSM--CGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCS 699
+S +DLLSCC M CG GC GG AWK+WV G+VTGG Y + GC+ Y PC
Sbjct: 133 TLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCG 192
Query: 700 HHVIG-PYPNCSGDS-PTPQCVEKCQS--GYSKSYKDDKYFGQNSY 825
V G +P C D+ PTP+CV+ C S Y+ Y DK+FG +Y
Sbjct: 193 ETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAY 238
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 162 bits (409), Expect = 1e-39
Identities = 78/151 (51%), Positives = 95/151 (62%)
Frame = +1
Query: 373 IPDFFDSRTQWSHCKYIDEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLL 552
+P FDSRTQWS CK I +RDQ+ CGSCWA A I+DR CI + G QP IS DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 553 SCCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCS 732
SCCGS CG GC GG A ++W + G+VTGG Y+ GC+ YP PC+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 733 GDSPTPQCVEKCQSGYSKSYKDDKYFGQNSY 825
+S TP C CQSGYS +Y DK+FG ++Y
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAY 227
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,653,422
Number of Sequences: 369166
Number of extensions: 2067949
Number of successful extensions: 5354
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4970
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5215
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7956112725
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)