Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_I01
(701 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 209 4e-54
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 208 1e-53
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 206 4e-53
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 201 2e-51
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 193 3e-49
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 189 5e-48
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 172 8e-43
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 167 2e-41
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 159 9e-39
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 150 2e-36
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 209 bits (533), Expect = 4e-54
Identities = 94/196 (47%), Positives = 124/196 (63%)
Frame = +2
Query: 113 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKIVIPDF 292
S D+INYIN NTTWQAG S + + G LP++ G+S I +P+
Sbjct: 27 SDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGT--VLGGPNLPERVGFSEDINLPES 83
Query: 293 FDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCG 472
FD+R QWS+C I ++RDQ +CGSCWA A ++DR CIH+NG + +S +DLL+CCG
Sbjct: 84 FDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCG 143
Query: 473 SMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDSP 652
CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 144 IQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGD 203
Query: 653 TPQCVEKCQSGYSKSY 700
TP+C + C++GYS SY
Sbjct: 204 TPKCNKMCEAGYSTSY 219
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 208 bits (530), Expect = 1e-53
Identities = 96/197 (48%), Positives = 124/197 (62%), Gaps = 1/197 (0%)
Frame = +2
Query: 113 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 289
S DLINYIN NTTWQAG S + + G + PK LP + + I +P+
Sbjct: 27 SDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPK---LPGRVAFGEDIDLPE 82
Query: 290 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 469
FD+R QWS+C I ++RDQ +CGSCWA A I+DR CIH+NG + +S +DLL+CC
Sbjct: 83 TFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCC 142
Query: 470 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 649
G CG+GCNGG AW +W G+V+GG YNSH GC Y PPC HHV G P C+G+
Sbjct: 143 GIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEG 202
Query: 650 PTPQCVEKCQSGYSKSY 700
TP+C + C++GYS SY
Sbjct: 203 DTPRCNKSCEAGYSPSY 219
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 206 bits (525), Expect = 4e-53
Identities = 92/197 (46%), Positives = 126/197 (63%), Gaps = 1/197 (0%)
Frame = +2
Query: 113 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 289
S +L+N++N NTTW+AG S + + G + PK LPQ+ ++ +V+P+
Sbjct: 27 SDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGPK---LPQRDAFAADVVLPE 82
Query: 290 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 469
FD+R QW +C I E+RDQ +CGSCWA A I+DR CIHSNG + +S +D+L+CC
Sbjct: 83 SFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCC 142
Query: 470 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 649
G CG+GCNGG AW +W G+V+GG YNSH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 650 PTPQCVEKCQSGYSKSY 700
TP+C + C+ GYS SY
Sbjct: 203 DTPKCNKTCEPGYSPSY 219
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 201 bits (510), Expect = 2e-51
Identities = 91/197 (46%), Positives = 122/197 (61%), Gaps = 1/197 (0%)
Frame = +2
Query: 113 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 289
S +L+NY+N NTTWQAG S + + G PK PQ+ ++ + +P
Sbjct: 27 SDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKP---PQRVMFTEDLKLPA 82
Query: 290 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 469
FD+R QW C I E+RDQ +CGSCWA A I+DR CIH+N ++ +S +DLL+CC
Sbjct: 83 SFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCC 142
Query: 470 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGDS 649
GSMCG+GCNGG AW +W G+V+GG Y SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEG 202
Query: 650 PTPQCVEKCQSGYSKSY 700
TP+C + C+ GYS +Y
Sbjct: 203 DTPKCSKICEPGYSPTY 219
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 193 bits (491), Expect = 3e-49
Identities = 90/198 (45%), Positives = 123/198 (62%), Gaps = 2/198 (1%)
Frame = +2
Query: 113 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLG-LRKTPKSLRLPQKYGYSNKIVIPD 289
S DL+N+IN + NTT +AG S + + G PK+ P++ ++ + +PD
Sbjct: 27 SSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFLGGPKA---PERVDFAEDMDLPD 82
Query: 290 FFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCC 469
FD+R QW +C I+E+RDQ +CGSCWA A I+DR C+H+N + +S +DLLSCC
Sbjct: 83 TFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCC 142
Query: 470 GSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSGD- 646
G CG GCNGG AW+YW G+V+GG Y+SH GC+ Y PPC HHV G P C+G+
Sbjct: 143 GFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEG 202
Query: 647 SPTPQCVEKCQSGYSKSY 700
TP+C C+ GYS SY
Sbjct: 203 GETPRCSRHCEPGYSPSY 220
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 189 bits (481), Expect = 5e-48
Identities = 91/200 (45%), Positives = 115/200 (57%), Gaps = 4/200 (2%)
Frame = +2
Query: 113 SFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSL---RLPQKYGYSNKIVI 283
S ++I++IN + W+A ++RF S + R ++G RK + R P + + I
Sbjct: 31 SDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKRNRRPTVDHHDLNVEI 90
Query: 284 PDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLS 463
P FDSR +W HCK I+++RDQS CGSCWA A +TDR CI S G +S DL+S
Sbjct: 91 PSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALDLIS 150
Query: 464 CCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCSG 643
CC CG+GC GG AW YWV GIVTGG +H GCQ YPFP C HH G YP C
Sbjct: 151 CCKD-CGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGT 209
Query: 644 D-SPTPQCVEKCQSGYSKSY 700
TPQC + CQ GY Y
Sbjct: 210 KIYKTPQCKQTCQKGYKTPY 229
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 172 bits (436), Expect = 8e-43
Identities = 96/231 (41%), Positives = 122/231 (52%), Gaps = 4/231 (1%)
Frame = +2
Query: 20 LILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKSNSE 199
LI L ++KNE K++ L S D+I+YIN N W+A +NRF S +
Sbjct: 11 LITFLEAHISVKNE--KFEPL----------SDDIISYINEHPNAGWRAEKSNRFHSLDD 58
Query: 200 FRNVLGLRKTPKSLRLPQKYGYSNK---IVIPDFFDSRTQWSHCKYINEVRDQSNCGSCW 370
R +G R+ LR ++ + + IP FDSR +W CK I +RDQS CGSCW
Sbjct: 59 ARIQMGARREEPDLRRKRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRDQSRCGSCW 118
Query: 371 AVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYWVNFGIVT 550
+ A ++DR CI S G +S DLL+CC S CG GC GG AW YWV GIVT
Sbjct: 119 SFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCES-CGLGCEGGILGPAWDYWVKEGIVT 177
Query: 551 GGPYNSHQGCQDYPFPPCSHHVIGPYPNC-SGDSPTPQCVEKCQSGYSKSY 700
+H GC+ YPFP C HH G YP C S TP+C + CQ Y Y
Sbjct: 178 ASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPY 228
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 167 bits (424), Expect = 2e-41
Identities = 96/240 (40%), Positives = 131/240 (54%), Gaps = 10/240 (4%)
Frame = +2
Query: 11 CFVLILILSIFPNIKNESIKWKRLTKPDIIQALSSFDLINYINYVANTTWQAGPTNRFKS 190
C V+ + N+++ K++ L DLI+Y+N N W A RF S
Sbjct: 9 CIVVAAYCACNDNLESVLDKYRNREIDSEAAELDGDDLIDYVNENQNL-WTAKKQRRFSS 67
Query: 191 ----NSEFR-NVLGLRKTPKSLRLPQKYGYSNKIV--IPDFFDSRTQWSHCKYINEVRDQ 349
N + + ++G+ S++ Q + + IP+ FDSR W C I +RDQ
Sbjct: 68 VYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDLDIPESFDSRDNWPKCDSIKVIRDQ 127
Query: 350 SNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLLSCCGSMCGEGCNGGSDHAAWKYW 529
S+CGSCWA A ++DR CI S+G +Q +S DLLSCC S CG GCNGG AAW+YW
Sbjct: 128 SSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDLLSCCKS-CGFGCNGGDPLAAWRYW 186
Query: 530 VNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGP-YPNCSGD-SPTPQCVEKCQSGYS-KSY 700
V GIVTG Y ++ GC+ YPFPPC HH + C D PTP+C +KC S Y+ K+Y
Sbjct: 187 VKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDLYPTPKCEKKCVSDYTDKTY 246
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 159 bits (401), Expect = 9e-39
Identities = 90/207 (43%), Positives = 112/207 (54%), Gaps = 14/207 (6%)
Frame = +2
Query: 104 ALSSFDLINYINYVANTTWQAGPTNRFKSNSEFRNVLGLRKTPKSLRLPQKYGYSNKI-- 277
AL+ LI+Y+N A W AG V+ K K L + KY +K
Sbjct: 26 ALTGQALIDYVNS-AQKLWTAG-----------HQVIPKEKITKKL-MDVKYLVPHKDED 72
Query: 278 --------VIPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQ 433
IPD FD+R QW +C IN +RDQS+CGSCWA AA I+DR CI SNG +
Sbjct: 73 IVATEVSDAIPDHFDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVN 132
Query: 434 PRISDKDLLSCCGSM--CGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCS 607
+S +DLLSCC M CG GC GG AWK+WV G+VTGG Y + GC+ Y PC
Sbjct: 133 TLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCG 192
Query: 608 HHVIG-PYPNCSGDS-PTPQCVEKCQS 682
V G +P C D+ PTP+CV+ C S
Sbjct: 193 ETVNGVKWPACPEDTEPTPKCVDSCTS 219
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 150 bits (380), Expect = 2e-36
Identities = 73/140 (52%), Positives = 87/140 (62%)
Frame = +2
Query: 281 IPDFFDSRTQWSHCKYINEVRDQSNCGSCWAVAATATITDRYCIHSNGNIQPRISDKDLL 460
+P FDSRTQWS CK I +RDQ+ CGSCWA A I+DR CI + G QP IS DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 461 SCCGSMCGEGCNGGSDHAAWKYWVNFGIVTGGPYNSHQGCQDYPFPPCSHHVIGPYPNCS 640
SCCGS CG GC GG A ++W + G+VTGG Y+ GC+ YP PC+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 641 GDSPTPQCVEKCQSGYSKSY 700
+S TP C CQSGYS +Y
Sbjct: 198 -ESKTPSCSMSCQSGYSTAY 216
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,751,472
Number of Sequences: 369166
Number of extensions: 1852127
Number of successful extensions: 4682
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4343
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4547
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6122130210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)