Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00582 (554 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P31226|SAX_RANCA Saxiphilin precursor (SAX) 65 1e-10 sp|P01267|THYG_BOVIN Thyroglobulin precursor 59 1e-08 sp|O08710|THYG_MOUSE Thyroglobulin precursor 57 2e-08 sp|P06882|THYG_RAT Thyroglobulin precursor 57 3e-08 sp|P01266|THYG_HUMAN Thyroglobulin precursor 55 9e-08 sp|P81439|EQST_ACTEQ Equistatin 52 7e-07 sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2) 52 1e-06 sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonido... 51 2e-06 sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonect... 45 2e-04 sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonect... 44 2e-04
>sp|P31226|SAX_RANCA Saxiphilin precursor (SAX) Length = 844 Score = 65.1 bits (157), Expect = 1e-10 Identities = 47/153 (30%), Positives = 71/153 (46%), Gaps = 13/153 (8%) Frame = +3 Query: 72 NNDQCNVGLICDEVCKEDNNAPKCFKRHLDARRLIKSGAMDVTFPFCEDTGMYKPVQCVG 251 + D N+ I E + + KC K A + + P C++ G Y+P QC G Sbjct: 87 SKDPYNLKPIIAEPYSSNRDLQKCLKERQQA---LAKKMIGHYIPQCDEKGNYQPQQCHG 143 Query: 252 AA--CWCVDDSGDEIKGYITGIEKSYGKTCN------CAKDKHEY--SQRKIIGRFF-HC 398 + CWCV+ G++I G T ++ TC C K++ K++GRF C Sbjct: 144 STGHCWCVNAMGEKISGTNTPPGQTRA-TCERHELPKCLKERQVALGGDEKVLGRFVPQC 202 Query: 399 DHLGNYEKVQCHGSVCY--CADSSGKKIPTSPT 491 D GNYE Q HGS Y C ++ G++I + T Sbjct: 203 DEKGNYEPQQFHGSTGYSWCVNAIGEEIAGTKT 235
Score = 48.1 bits (113), Expect = 1e-05 Identities = 27/71 (38%), Positives = 38/71 (53%), Gaps = 9/71 (12%) Frame = +3 Query: 339 CAKDKHEYSQRKIIGRFF-HCDHLGNYEKVQCHGSV--CYCADSSGKKI-----PTSPTV 494 C K++ + +K+IG + CD GNY+ QCHGS C+C ++ G+KI P T Sbjct: 110 CLKERQQALAKKMIGHYIPQCDEKGNYQPQQCHGSTGHCWCVNAMGEKISGTNTPPGQTR 169 Query: 495 HIAERDSL-KC 524 ER L KC Sbjct: 170 ATCERHELPKC 180
>sp|P01267|THYG_BOVIN Thyroglobulin precursor Length = 2769 Score = 58.5 bits (140), Expect = 1e-08 Identities = 32/100 (32%), Positives = 42/100 (42%), Gaps = 8/100 (8%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 383 P C G Y+ VQC CWCVD G E+ G + C +K + ++G Sbjct: 617 PACTAEGSYEEVQCFAGDCWCVDAQGRELAG---SRVRGGRPRCPTECEKQRARMQSLLG 673 Query: 384 R--------FFHCDHLGNYEKVQCHGSVCYCADSSGKKIP 479 C GN+ VQC S CYC D+ G+ IP Sbjct: 674 SQPAGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQPIP 713
Score = 50.4 bits (119), Expect = 3e-06 Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 13/104 (12%) Frame = +3 Query: 204 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 377 P C + G ++ VQC GA+CWCVD G E+ G + G+ C Q+ + Sbjct: 50 PQCAEDGSFQTVQCGKDGASCWCVDADGREVPG-----SRQPGRPAACLSFCQLQKQQIL 104 Query: 378 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 476 + + + C G+Y VQC C+C D+ G ++ Sbjct: 105 LSSYINSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEV 148
Score = 42.7 bits (99), Expect = 6e-04 Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 1/58 (1%) Frame = +3 Query: 204 PFCEDTGMYKPVQCV-GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRK 374 P C G Y+ QC G CWCVD G EI G + G+ +CA+D+ S+R+ Sbjct: 317 PSCHPDGEYQAAQCQQGGPCWCVDSRGQEIPG-----TRQRGEPPSCAEDQSCPSERR 369
Score = 41.6 bits (96), Expect = 0.001 Identities = 33/133 (24%), Positives = 46/133 (34%), Gaps = 42/133 (31%) Frame = +3 Query: 204 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 377 P C+D+G Y PVQC CWCVD G E+ G + G+ C + ++R + Sbjct: 118 PQCQDSGDYSPVQCDLRRRQCWCVDAEGMEVYG-----TRQQGRPARCPRSCEIRNRRLL 172 Query: 378 IG----RFFHCDHLGNYEKVQCH------------------------------------G 437 G C G + VQC Sbjct: 173 HGVGDRSPPQCSPDGAFRPVQCKLVNTTDMMIFDLVHSYSRFPDAFVTFSSFRSRFPEVS 232 Query: 438 SVCYCADSSGKKI 476 CYCADS G+++ Sbjct: 233 GYCYCADSQGREL 245
Score = 39.7 bits (91), Expect = 0.005 Identities = 16/34 (47%), Positives = 21/34 (61%), Gaps = 2/34 (5%) Frame = +3 Query: 396 CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 491 CD G +E VQCH + C+C D G+ +PTS T Sbjct: 1031 CDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLT 1064
Score = 38.5 bits (88), Expect = 0.011 Identities = 28/120 (23%), Positives = 42/120 (35%), Gaps = 20/120 (16%) Frame = +3 Query: 138 KCFKRHLDARRLIKS--GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGI 311 +C K+ + L+ S + P C G + PVQC + C+CVD G I G Sbjct: 660 ECEKQRARMQSLLGSQPAGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQP----IPGT 715 Query: 312 EKSYGKTCNCAKDKHEYSQRKIIGR------------------FFHCDHLGNYEKVQCHG 437 + G+ C ++R +G C G + VQC G Sbjct: 716 RSALGEPKKCPSPCQLQAERAFLGTVRTLVSNPSTLPALSSIYIPQCSASGQWSPVQCDG 775
Score = 35.4 bits (80), Expect = 0.095 Identities = 27/108 (25%), Positives = 45/108 (41%), Gaps = 16/108 (14%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK---TCNCAKDKHEYSQ 368 P C+ G ++PVQC A CWCVD G+ + +T + + +C + S Sbjct: 1029 PQCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLTARSRQIPQCPTSCERLRASGLLSS 1088 Query: 369 RKIIGRFFH----------CDHLGNYEKVQCHGSVCYCAD-SSGKKIP 479 K G C G + ++Q + +C D +SG+ +P Sbjct: 1089 WKQAGVQAEPSPKDLFIPTCLETGEFARLQASEAGTWCVDPASGEGVP 1136
Score = 35.0 bits (79), Expect = 0.12 Identities = 29/105 (27%), Positives = 42/105 (40%), Gaps = 9/105 (8%) Frame = +3 Query: 192 DVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAK-----DKH 356 D+ P C +TG + +Q A WCVD + E G+ + C Sbjct: 1102 DLFIPTCLETGEFARLQASEAGTWCVDPASGE------GVPPGTNSSAQCPSLCEVLQSG 1155 Query: 357 EYSQRKIIGRFFHC-DHLGNYEKVQC---HGSVCYCADSSGKKIP 479 S+R G C G + VQC GS C+C SG+++P Sbjct: 1156 VPSRRTSPGYSPACRAEDGGFSPVQCDPAQGS-CWCVLGSGEEVP 1199
Score = 33.9 bits (76), Expect = 0.28 Identities = 12/30 (40%), Positives = 19/30 (63%) Frame = +3 Query: 396 CDHLGNYEKVQCHGSVCYCADSSGKKIPTS 485 C G+YE+VQC C+C D+ G+++ S Sbjct: 619 CTAEGSYEEVQCFAGDCWCVDAQGRELAGS 648
Score = 33.1 bits (74), Expect = 0.47 Identities = 16/34 (47%), Positives = 21/34 (61%), Gaps = 3/34 (8%) Frame = +3 Query: 204 PFCE-DTGMYKPVQCVGA--ACWCVDDSGDEIKG 296 P C + G + PVQC A +CWCV SG+E+ G Sbjct: 1167 PACRAEDGGFSPVQCDPAQGSCWCVLGSGEEVPG 1200
Score = 31.6 bits (70), Expect = 1.4 Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 1/29 (3%) Frame = +3 Query: 396 CDHLGNYEKVQCH-GSVCYCADSSGKKIP 479 C G Y+ QC G C+C DS G++IP Sbjct: 319 CHPDGEYQAAQCQQGGPCWCVDSRGQEIP 347
>sp|O08710|THYG_MOUSE Thyroglobulin precursor Length = 2766 Score = 57.4 bits (137), Expect = 2e-08 Identities = 38/114 (33%), Positives = 50/114 (43%), Gaps = 7/114 (6%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEY----SQR 371 P C G Y+ +QC CWCVD G E+ G + T C K + + S + Sbjct: 618 PSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPT-KCEKQRAQMQSLASAQ 676 Query: 372 KIIGRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIP-TSPTVHIAERDSLKC 524 FF C G + VQC S CYC D+ G+ IP T TV A++ C Sbjct: 677 PAGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIPGTQSTVGEAKQCPSVC 730
Score = 56.2 bits (134), Expect = 5e-08 Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 13/104 (12%) Frame = +3 Query: 204 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 377 P C + G ++ VQC G +CWCVD G E+ G + G+ C + QR + Sbjct: 51 PQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPG-----SRQLGRPTVCLSFCQLHKQRIL 105 Query: 378 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 476 +G + + C GNY VQC C+C D+ G ++ Sbjct: 106 LGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEV 149
Score = 42.7 bits (99), Expect = 6e-04 Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 4/108 (3%) Frame = +3 Query: 183 GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEY 362 G D+ P C TG Y Q G WCVD + E T C+ K + Sbjct: 1100 GPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVNTNGSAQCPGLCDVLKSR-AL 1158 Query: 363 SQRKIIGRFFHCDHL-GNYEKVQC---HGSVCYCADSSGKKIPTSPTV 494 S++ +G C+ L G + VQC GS C+C SG+++P + V Sbjct: 1159 SRKVGLGYSPVCEALDGAFSPVQCDLAQGS-CWCVLGSGEEVPGTRVV 1205
Score = 42.0 bits (97), Expect = 0.001 Identities = 33/133 (24%), Positives = 46/133 (34%), Gaps = 42/133 (31%) Frame = +3 Query: 204 PFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 377 P C+D+G Y PVQC CWCVD G E+ G + G+ C + ++R + Sbjct: 119 PQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYG-----TRQQGRPTRCPRSCEIRNRRLL 173 Query: 378 IG----RFFHCDHLGNYEKVQCH------------------------------------G 437 G C G + VQC Sbjct: 174 HGVGDRSPPQCTADGEFMPVQCKFVNTTDMMIFDLIHNYNRFPDAFVTFSSFRGRFPEVS 233 Query: 438 SVCYCADSSGKKI 476 CYCADS G+++ Sbjct: 234 GYCYCADSQGREL 246
Score = 39.7 bits (91), Expect = 0.005 Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 2/55 (3%) Frame = +3 Query: 369 RKIIGRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTVHIAERDSLKCD 527 +++ G+FF C G+YE +QC+ C+C DS GK++ S R KC+ Sbjct: 609 KQMPGKFFVPSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCE 663
Score = 38.5 bits (88), Expect = 0.011 Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 2/65 (3%) Frame = +3 Query: 204 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKH-EYSQRKI 377 P C G Y+ VQC CWCVD G E+ G + G+ +CA D+ +++ Sbjct: 318 PRCHRDGHYQTVQCQTEGMCWCVDAQGREVPG-----TRQQGQPPSCAADQSCALERQQA 372 Query: 378 IGRFF 392 + RF+ Sbjct: 373 LSRFY 377
Score = 36.6 bits (83), Expect = 0.043 Identities = 35/129 (27%), Positives = 54/129 (41%), Gaps = 16/129 (12%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK---TCNCAKDKHEYSQ 368 P C G ++PVQC CWCVD G+ I G + + C ++ S Sbjct: 1030 PQCNMIGGWEPVQCHAGTGQCWCVDGRGEFIPGSLMSRSSQMPQCPTNCELSRASGLISA 1089 Query: 369 RKIIGRFFH----------CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAERDS 515 K G + C G Y + Q G+ +C D +SG+ +P + T A+ Sbjct: 1090 WKQAGPQRNPGPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVN-TNGSAQCPG 1148 Query: 516 LKCD*IKNK 542 L CD +K++ Sbjct: 1149 L-CDVLKSR 1156
Score = 31.6 bits (70), Expect = 1.4 Identities = 11/29 (37%), Positives = 19/29 (65%), Gaps = 1/29 (3%) Frame = +3 Query: 396 CDHLGNYEKVQCHGS-VCYCADSSGKKIP 479 C G+Y+ VQC +C+C D+ G+++P Sbjct: 320 CHRDGHYQTVQCQTEGMCWCVDAQGREVP 348
>sp|P06882|THYG_RAT Thyroglobulin precursor Length = 2768 Score = 57.0 bits (136), Expect = 3e-08 Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 8/100 (8%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 383 P C G Y+ +QC CWCV+ G E++G + + + + C +K + + G Sbjct: 618 PSCTAEGSYEDIQCYAGECWCVNSQGKEVEG--SRVSGGHPR-CPTKCEKQRAQMQNLAG 674 Query: 384 ------RFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIP 479 FF C G + VQC S CYC D+ G+ IP Sbjct: 675 AQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIP 714
Score = 55.1 bits (131), Expect = 1e-07 Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 13/108 (12%) Frame = +3 Query: 192 DVTFPFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYS 365 D P C + G ++ VQC G +CWCVD G E+ G + G+ C + Sbjct: 47 DEYVPQCSEDGSFQTVQCQNDGQSCWCVDSDGTEVPG-----SRQLGRPTACLSFCQLHK 101 Query: 366 QRKIIGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 476 QR ++ + + C GNY VQC C+C D+ G ++ Sbjct: 102 QRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEV 149
Score = 46.6 bits (109), Expect = 4e-05 Identities = 39/153 (25%), Positives = 56/153 (36%), Gaps = 46/153 (30%) Frame = +3 Query: 156 LDARRLIKSGAMDVT----FPFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEK 317 L +R++ S ++ T P C+D+G Y PVQC CWCVD G E+ G + Sbjct: 99 LHKQRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEVYG-----TR 153 Query: 318 SYGKTCNCAKDKHEYSQRKIIG----RFFHCDHLGNYEKVQCH----------------- 434 G+ C + S+R + G CD G + VQC Sbjct: 154 QQGRPTRCPRSCEIRSRRLLHGVGDKSPPQCDADGEFMPVQCKFVNTTDMMIFDLIHNYN 213 Query: 435 -------------------GSVCYCADSSGKKI 476 CYCADS G+++ Sbjct: 214 RFPDAFVTFSAFRNRFPEVSGYCYCADSQGREL 246
Score = 45.8 bits (107), Expect = 7e-05 Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 5/109 (4%) Frame = +3 Query: 183 GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEY 362 G D+ P C TG Y Q G WCVD S E G T S C K Sbjct: 1100 GPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGE--GVPTNTNSSAQCPGLCDALKSRV 1157 Query: 363 SQRKI-IGRFFHCDHL-GNYEKVQC---HGSVCYCADSSGKKIPTSPTV 494 RK+ +G C+ L G + VQC GS C+C +SG+++P + V Sbjct: 1158 LSRKVGLGYTPVCEALDGGFSPVQCDLAQGS-CWCVLASGEEVPGTRVV 1205
Score = 42.4 bits (98), Expect = 8e-04 Identities = 39/129 (30%), Positives = 56/129 (43%), Gaps = 16/129 (12%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYI-----------TGIEKSYGKTCNCA 344 P C G ++PVQC CWCVD G+ I G + T E S A Sbjct: 1030 PQCNTIGGWEPVQCHPGTGQCWCVDGWGELIPGSLMARSSQMPQCPTSCELSRANGLISA 1089 Query: 345 KDKHEYSQRKIIGRFFH--CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAERDS 515 + + + G F C G Y + Q G+ +C D SSG+ +PT+ T A+ Sbjct: 1090 WKQAGHQRNPGPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTN-TNSSAQCPG 1148 Query: 516 LKCD*IKNK 542 L CD +K++ Sbjct: 1149 L-CDALKSR 1156
Score = 41.2 bits (95), Expect = 0.002 Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 1/58 (1%) Frame = +3 Query: 204 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRK 374 P C G Y+ VQC + CWCVD G EI G + G+ CAKD+ S+R+ Sbjct: 318 PSCHRDGHYQTVQCQMERMCWCVDAQGIEIPG-----TRQQGQPLFCAKDQSCASERQ 370
Score = 39.7 bits (91), Expect = 0.005 Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 2/51 (3%) Frame = +3 Query: 381 GRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTVHIAERDSLKCD 527 GRFF C G+YE +QC+ C+C +S GK++ S R KC+ Sbjct: 613 GRFFVPSCTAEGSYEDIQCYAGECWCVNSQGKEVEGSRVSGGHPRCPTKCE 663
Score = 38.5 bits (88), Expect = 0.011 Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%) Frame = +3 Query: 138 KCFKRHLDARRLIKSGAMDVTF--PFCEDTGMYKPVQCVGAACWCVDDSGDEIKG 296 KC K+ + L + +F P C G + PVQC + C+CVD G I G Sbjct: 661 KCEKQRAQMQNLAGAQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIPG 715
Score = 29.6 bits (65), Expect = 5.2 Identities = 12/29 (41%), Positives = 18/29 (62%), Gaps = 1/29 (3%) Frame = +3 Query: 396 CDHLGNYEKVQCHGS-VCYCADSSGKKIP 479 C G+Y+ VQC +C+C D+ G +IP Sbjct: 320 CHRDGHYQTVQCQMERMCWCVDAQGIEIP 348
>sp|P01266|THYG_HUMAN Thyroglobulin precursor Length = 2768 Score = 55.5 bits (132), Expect = 9e-08 Identities = 32/102 (31%), Positives = 43/102 (42%), Gaps = 10/102 (9%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKD--KHEYSQRKI 377 P C G Y+ VQC CWCV+ G E+ G + G C D K + + Sbjct: 618 PSCTTEGSYEDVQCFSGECWCVNSWGKELPG-----SRVRGGQPRCPTDCEKQRARMQSL 672 Query: 378 IGR--------FFHCDHLGNYEKVQCHGSVCYCADSSGKKIP 479 +G C G++ VQC S CYC D+ G+ IP Sbjct: 673 MGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIP 714
Score = 45.8 bits (107), Expect = 7e-05 Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 13/126 (10%) Frame = +3 Query: 204 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 377 P C + G ++ VQC G +CWCV +G E+ G + G+ C Q+ + Sbjct: 50 PQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLG-----SRQPGRPVACLSFCQLQKQQIL 104 Query: 378 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKIPTSPTVHIAERDSLKC 524 + + + C G+Y VQC C+C D+ G ++ + + +R C Sbjct: 105 LSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSC 164 Query: 525 D*IKNK 542 + I+N+ Sbjct: 165 E-IRNR 169
Score = 42.7 bits (99), Expect = 6e-04 Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 10/102 (9%) Frame = +3 Query: 156 LDARRLIKSGAMDVT----FPFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEK 317 L ++++ SG ++ T P C+D+G Y PVQC CWCVD G E+ G + Sbjct: 98 LQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYG-----TR 152 Query: 318 SYGKTCNCAKDKHEYSQRKIIG----RFFHCDHLGNYEKVQC 431 G+ C + ++R + G C G + VQC Sbjct: 153 QLGRPKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPVQC 194
Score = 42.4 bits (98), Expect = 8e-04 Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%) Frame = +3 Query: 192 DVTFPFCEDTGMYKPVQCVGAACWCVDD-SGDEIKGYITGIEKSYGKTCNCAKDKHEYSQ 368 D+ P C +TG Y +Q GA WCVD SG+E++ + CN K S+ Sbjct: 1102 DLFVPACLETGEYARLQASGAGTWCVDPASGEELRPG-SSSSAQCPSLCNVLK-SGVLSR 1159 Query: 369 RKIIGRFFHC-DHLGNYEKVQC---HGSVCYCADSSGKKIP 479 R G C G + VQC GS C+C SG+++P Sbjct: 1160 RVSPGYVPACRAEDGGFSPVQCDQAQGS-CWCVMDSGEEVP 1199
Score = 42.0 bits (97), Expect = 0.001 Identities = 34/121 (28%), Positives = 53/121 (43%), Gaps = 16/121 (13%) Frame = +3 Query: 162 ARRLIKSGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK-- 329 A L++SG P C+ G ++PVQC CWCVD+ G I G +T + Sbjct: 1018 ASALLRSGPY---MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCP 1074 Query: 330 -TCNCAKD-------KHEYSQRKIIGRFFH---CDHLGNYEKVQCHGSVCYCAD-SSGKK 473 TC ++ K SQ + C G Y ++Q G+ +C D +SG++ Sbjct: 1075 TTCEKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEE 1134 Query: 474 I 476 + Sbjct: 1135 L 1135
Score = 39.7 bits (91), Expect = 0.005 Identities = 26/101 (25%), Positives = 43/101 (42%), Gaps = 4/101 (3%) Frame = +3 Query: 204 PFCE-DTGMYKPVQCVGA--ACWCVDDSGDEIKG-YITGIEKSYGKTCNCAKDKHEYSQR 371 P C + G + PVQC A +CWCV DSG+E+ G +TG + + C + ++ Sbjct: 1167 PACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPA----CESPRCPLPFNAS 1222 Query: 372 KIIGRFFHCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTV 494 +++G C+ + C S P P + Sbjct: 1223 EVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPGPLI 1263
Score = 38.9 bits (89), Expect = 0.009 Identities = 24/92 (26%), Positives = 34/92 (36%), Gaps = 14/92 (15%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 383 P C G + PVQC + C+CVD G I G + I K C + R + Sbjct: 685 PACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAIGKPKKCPTPCQLQSEQAFLRTVQA 744 Query: 384 RFFH--------------CDHLGNYEKVQCHG 437 + C G + +VQC+G Sbjct: 745 LLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNG 776
Score = 37.4 bits (85), Expect = 0.025 Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Frame = +3 Query: 204 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRK 374 P C G Y+ VQC CWCVD G E+ G + G+ +CA+ + S+R+ Sbjct: 317 PSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHG-----TRQQGEPPSCAEGQSCASERQ 369
Score = 35.8 bits (81), Expect = 0.073 Identities = 14/30 (46%), Positives = 19/30 (63%) Frame = +3 Query: 396 CDHLGNYEKVQCHGSVCYCADSSGKKIPTS 485 C G+YE VQC C+C +S GK++P S Sbjct: 620 CTTEGSYEDVQCFSGECWCVNSWGKELPGS 649
Score = 35.8 bits (81), Expect = 0.073 Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 2/34 (5%) Frame = +3 Query: 396 CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 491 CD G++E VQCH C+C D G IP S T Sbjct: 1031 CDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLT 1064
>sp|P81439|EQST_ACTEQ Equistatin Length = 199 Score = 52.4 bits (124), Expect = 7e-07 Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 14/113 (12%) Frame = +3 Query: 180 SGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCNCAKDK 353 SG + P C++TG ++ QC G+ CWCVD+ G EI G T I S +C++ K Sbjct: 14 SGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILG--TKIRGS----PDCSRRK 67 Query: 354 HEYSQRKIIGRFF----------HCDHLGNYEKVQCHGS--VCYCADSSGKKI 476 + +++ C G++++VQC S CYC D GK++ Sbjct: 68 AALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKEL 120
Score = 47.0 bits (110), Expect = 3e-05 Identities = 33/103 (32%), Positives = 44/103 (42%), Gaps = 9/103 (8%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGA--ACWCVDDSGDEIKGYIT----GIEKSYGKTCNCAKDKHEYS 365 P C+ G + VQC + C+CVD G E++G E+ H S Sbjct: 90 PSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQKGRPSCERHLSPCEEARLQAHSNS 149 Query: 366 QRKIIGRFF-HCDHLGNYEKVQCHGSV--CYCADSSGKKIPTS 485 R +G F C G+Y VQC S C+C D G K+P S Sbjct: 150 LR--VGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPGS 190
Score = 44.7 bits (104), Expect = 2e-04 Identities = 32/103 (31%), Positives = 46/103 (44%), Gaps = 13/103 (12%) Frame = +3 Query: 27 TCIFSSKLEEFDVCGNNDQCNVGLICDEVCKE-----DNNAPKCFKRHL----DARRLIK 179 +C +E C +N +C D+ KE P C +RHL +AR Sbjct: 91 SCKADGSFDEVQCCASNGEC---YCVDKKGKELEGTRQKGRPSC-ERHLSPCEEARLQAH 146 Query: 180 SGAMDVTF--PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 296 S ++ V P C + G Y PVQC + CWCVD+ G ++ G Sbjct: 147 SNSLRVGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPG 189
>sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2) Length = 1403 Score = 51.6 bits (122), Expect = 1e-06 Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 24/118 (20%) Frame = +3 Query: 195 VTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQ 368 + P C+D G + P+QC G+ CWCVD +G E + G + G T E +Q Sbjct: 986 IHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHE----VPGTQTPPGSTPPHCGPPPEPTQ 1041 Query: 369 --RKIIGRFF------------------HCDHLGNYEKVQCHG--SVCYCADSSGKKI 476 R + R+ CD LG++ +QCHG C+C D G+++ Sbjct: 1042 RPRTVCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREL 1099
Score = 40.4 bits (93), Expect = 0.003 Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%) Frame = +3 Query: 342 AKDKHEYSQRKIIGRFFHCDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 491 A+ +H Y +I CD GN+ +QCHGS C+C D +G ++P + T Sbjct: 975 AQTQHAYPGSRI--HIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQT 1024
Score = 40.4 bits (93), Expect = 0.003 Identities = 17/37 (45%), Positives = 23/37 (62%), Gaps = 2/37 (5%) Frame = +3 Query: 192 DVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 296 D P C+D G + P+QC G + CWCVD G E++G Sbjct: 1065 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQG 1101
>sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonidogen) Length = 1375 Score = 51.2 bits (121), Expect = 2e-06 Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 24/134 (17%) Frame = +3 Query: 147 KRHLDARRLIKSGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKS 320 +RH A+ + P C++ G + P+QC G+ CWCVD G E + G + Sbjct: 944 QRHAQAQYAYPGARFHI--PQCDEQGNFLPLQCHGSTGFCWCVDPDGHE----VPGTQTP 997 Query: 321 YGKTCNCAKDKHEYSQR--KIIGRFF------------------HCDHLGNYEKVQCHG- 437 G T E +QR I R+ CD LG++ +QCHG Sbjct: 998 PGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGK 1057 Query: 438 -SVCYCADSSGKKI 476 C+C D G+++ Sbjct: 1058 SDFCWCVDKDGREV 1071
Score = 42.4 bits (98), Expect = 8e-04 Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 5/54 (9%) Frame = +3 Query: 345 KDKHEYSQRKIIGRFFH---CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 491 + +H +Q G FH CD GN+ +QCHGS C+C D G ++P + T Sbjct: 943 QQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQT 996
Score = 40.8 bits (94), Expect = 0.002 Identities = 17/37 (45%), Positives = 23/37 (62%), Gaps = 2/37 (5%) Frame = +3 Query: 192 DVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 296 D P C+D G + P+QC G + CWCVD G E++G Sbjct: 1037 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQG 1073
>sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3) Length = 436 Score = 44.7 bits (104), Expect = 2e-04 Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 4/79 (5%) Frame = +3 Query: 72 NNDQCNVGLICDEVCKEDNNAPKCFKR--HLDARRLIKSGAMDVTFPFCEDTGMYKPVQC 245 NN+ C C + P C ++ R+ IK + P C++ G YKP QC Sbjct: 302 NNEWC--------YCFQRQQDPPCHTELSNIQKRQGIKK-LLGQYIPLCDEDGYYKPTQC 352 Query: 246 VGAA--CWCVDDSGDEIKG 296 G+ CWCVD G+E+ G Sbjct: 353 HGSVGQCWCVDRYGNEVVG 371
Score = 37.7 bits (86), Expect = 0.019 Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%) Frame = +3 Query: 369 RKIIGRFFH-CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTVHIAE 506 +K++G++ CD G Y+ QCHGSV C+C D G ++ S +A+ Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVAD 379
>sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3) Length = 436 Score = 44.3 bits (103), Expect = 2e-04 Identities = 17/33 (51%), Positives = 22/33 (66%), Gaps = 2/33 (6%) Frame = +3 Query: 204 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 296 P C++ G YKP QC G+ CWCVD G+E+ G Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMG 371
Score = 37.7 bits (86), Expect = 0.019 Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%) Frame = +3 Query: 369 RKIIGRFFH-CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTVHIAE 506 +K++G++ CD G Y+ QCHGSV C+C D G ++ S +A+ Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVAD 379
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 64,061,871 Number of Sequences: 369166 Number of extensions: 1358760 Number of successful extensions: 3750 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 3451 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 3685 length of database: 68,354,980 effective HSP length: 104 effective length of database: 49,142,540 effective search space used: 3931403200 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)