Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_001_J22
(414 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31226|SAX_RANCA Saxiphilin precursor (SAX) 62 5e-10
sp|P01267|THYG_BOVIN Thyroglobulin precursor 59 5e-09
sp|O08710|THYG_MOUSE Thyroglobulin precursor 57 1e-08
sp|P06882|THYG_RAT Thyroglobulin precursor 57 1e-08
sp|P01266|THYG_HUMAN Thyroglobulin precursor 55 4e-08
sp|P81439|EQST_ACTEQ Equistatin 52 4e-07
sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2) 52 6e-07
sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonido... 51 8e-07
sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonect... 44 1e-04
sp|Q5RD69|TICN3_PONPY Testican-3 precursor (SPARC/osteonect... 44 1e-04
>sp|P31226|SAX_RANCA Saxiphilin precursor (SAX)
Length = 844
Score = 62.0 bits (149), Expect = 5e-10
Identities = 39/109 (35%), Positives = 57/109 (52%), Gaps = 13/109 (11%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCN------CAKDKHE 219
P C++ G Y+P QC G+ CWCV+ G++I G T ++ TC C K++
Sbjct: 128 PQCDEKGNYQPQQCHGSTGHCWCVNAMGEKISGTNTPPGQTRA-TCERHELPKCLKERQV 186
Query: 220 Y--SQRKIIGRFF-HCDHLGNYEKVQCHGSVCY--CADSSGKKIPTSPT 351
K++GRF CD GNYE Q HGS Y C ++ G++I + T
Sbjct: 187 ALGGDEKVLGRFVPQCDEKGNYEPQQFHGSTGYSWCVNAIGEEIAGTKT 235
Score = 48.1 bits (113), Expect = 7e-06
Identities = 27/71 (38%), Positives = 38/71 (53%), Gaps = 9/71 (12%)
Frame = +1
Query: 199 CAKDKHEYSQRKIIGRFF-HCDHLGNYEKVQCHGSV--CYCADSSGKKI-----PTSPTV 354
C K++ + +K+IG + CD GNY+ QCHGS C+C ++ G+KI P T
Sbjct: 110 CLKERQQALAKKMIGHYIPQCDEKGNYQPQQCHGSTGHCWCVNAMGEKISGTNTPPGQTR 169
Query: 355 HIAERDSL-KC 384
ER L KC
Sbjct: 170 ATCERHELPKC 180
>sp|P01267|THYG_BOVIN Thyroglobulin precursor
Length = 2769
Score = 58.5 bits (140), Expect = 5e-09
Identities = 32/100 (32%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 243
P C G Y+ VQC CWCVD G E+ G + C +K + ++G
Sbjct: 617 PACTAEGSYEEVQCFAGDCWCVDAQGRELAG---SRVRGGRPRCPTECEKQRARMQSLLG 673
Query: 244 R--------FFHCDHLGNYEKVQCHGSVCYCADSSGKKIP 339
C GN+ VQC S CYC D+ G+ IP
Sbjct: 674 SQPAGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQPIP 713
Score = 50.4 bits (119), Expect = 1e-06
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 13/104 (12%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 237
P C + G ++ VQC GA+CWCVD G E+ G + G+ C Q+ +
Sbjct: 50 PQCAEDGSFQTVQCGKDGASCWCVDADGREVPG-----SRQPGRPAACLSFCQLQKQQIL 104
Query: 238 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 336
+ + + C G+Y VQC C+C D+ G ++
Sbjct: 105 LSSYINSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEV 148
Score = 42.7 bits (99), Expect = 3e-04
Identities = 22/58 (37%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCV-GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRK 234
P C G Y+ QC G CWCVD G EI G + G+ +CA+D+ S+R+
Sbjct: 317 PSCHPDGEYQAAQCQQGGPCWCVDSRGQEIPG-----TRQRGEPPSCAEDQSCPSERR 369
Score = 41.6 bits (96), Expect = 6e-04
Identities = 33/133 (24%), Positives = 46/133 (34%), Gaps = 42/133 (31%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 237
P C+D+G Y PVQC CWCVD G E+ G + G+ C + ++R +
Sbjct: 118 PQCQDSGDYSPVQCDLRRRQCWCVDAEGMEVYG-----TRQQGRPARCPRSCEIRNRRLL 172
Query: 238 IG----RFFHCDHLGNYEKVQCH------------------------------------G 297
G C G + VQC
Sbjct: 173 HGVGDRSPPQCSPDGAFRPVQCKLVNTTDMMIFDLVHSYSRFPDAFVTFSSFRSRFPEVS 232
Query: 298 SVCYCADSSGKKI 336
CYCADS G+++
Sbjct: 233 GYCYCADSQGREL 245
Score = 39.7 bits (91), Expect = 0.002
Identities = 16/34 (47%), Positives = 21/34 (61%), Gaps = 2/34 (5%)
Frame = +1
Query: 256 CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 351
CD G +E VQCH + C+C D G+ +PTS T
Sbjct: 1031 CDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLT 1064
Score = 38.1 bits (87), Expect = 0.007
Identities = 24/96 (25%), Positives = 33/96 (34%), Gaps = 18/96 (18%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 243
P C G + PVQC + C+CVD G I G + G+ C ++R +G
Sbjct: 684 PACTSKGNFLPVQCFNSECYCVDTEGQP----IPGTRSALGEPKKCPSPCQLQAERAFLG 739
Query: 244 R------------------FFHCDHLGNYEKVQCHG 297
C G + VQC G
Sbjct: 740 TVRTLVSNPSTLPALSSIYIPQCSASGQWSPVQCDG 775
Score = 35.4 bits (80), Expect = 0.046
Identities = 27/108 (25%), Positives = 45/108 (41%), Gaps = 16/108 (14%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK---TCNCAKDKHEYSQ 228
P C+ G ++PVQC A CWCVD G+ + +T + + +C + S
Sbjct: 1029 PQCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLTARSRQIPQCPTSCERLRASGLLSS 1088
Query: 229 RKIIGRFFH----------CDHLGNYEKVQCHGSVCYCAD-SSGKKIP 339
K G C G + ++Q + +C D +SG+ +P
Sbjct: 1089 WKQAGVQAEPSPKDLFIPTCLETGEFARLQASEAGTWCVDPASGEGVP 1136
Score = 35.0 bits (79), Expect = 0.060
Identities = 29/105 (27%), Positives = 42/105 (40%), Gaps = 9/105 (8%)
Frame = +1
Query: 52 DVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAK-----DKH 216
D+ P C +TG + +Q A WCVD + E G+ + C
Sbjct: 1102 DLFIPTCLETGEFARLQASEAGTWCVDPASGE------GVPPGTNSSAQCPSLCEVLQSG 1155
Query: 217 EYSQRKIIGRFFHC-DHLGNYEKVQC---HGSVCYCADSSGKKIP 339
S+R G C G + VQC GS C+C SG+++P
Sbjct: 1156 VPSRRTSPGYSPACRAEDGGFSPVQCDPAQGS-CWCVLGSGEEVP 1199
Score = 33.9 bits (76), Expect = 0.13
Identities = 12/30 (40%), Positives = 19/30 (63%)
Frame = +1
Query: 256 CDHLGNYEKVQCHGSVCYCADSSGKKIPTS 345
C G+YE+VQC C+C D+ G+++ S
Sbjct: 619 CTAEGSYEEVQCFAGDCWCVDAQGRELAGS 648
Score = 33.1 bits (74), Expect = 0.23
Identities = 16/34 (47%), Positives = 21/34 (61%), Gaps = 3/34 (8%)
Frame = +1
Query: 64 PFCE-DTGMYKPVQCVGA--ACWCVDDSGDEIKG 156
P C + G + PVQC A +CWCV SG+E+ G
Sbjct: 1167 PACRAEDGGFSPVQCDPAQGSCWCVLGSGEEVPG 1200
Score = 31.6 bits (70), Expect = 0.66
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 1/29 (3%)
Frame = +1
Query: 256 CDHLGNYEKVQCH-GSVCYCADSSGKKIP 339
C G Y+ QC G C+C DS G++IP
Sbjct: 319 CHPDGEYQAAQCQQGGPCWCVDSRGQEIP 347
>sp|O08710|THYG_MOUSE Thyroglobulin precursor
Length = 2766
Score = 57.4 bits (137), Expect = 1e-08
Identities = 38/114 (33%), Positives = 50/114 (43%), Gaps = 7/114 (6%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEY----SQR 231
P C G Y+ +QC CWCVD G E+ G + T C K + + S +
Sbjct: 618 PSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPT-KCEKQRAQMQSLASAQ 676
Query: 232 KIIGRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIP-TSPTVHIAERDSLKC 384
FF C G + VQC S CYC D+ G+ IP T TV A++ C
Sbjct: 677 PAGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIPGTQSTVGEAKQCPSVC 730
Score = 56.2 bits (134), Expect = 3e-08
Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 13/104 (12%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 237
P C + G ++ VQC G +CWCVD G E+ G + G+ C + QR +
Sbjct: 51 PQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPG-----SRQLGRPTVCLSFCQLHKQRIL 105
Query: 238 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 336
+G + + C GNY VQC C+C D+ G ++
Sbjct: 106 LGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEV 149
Score = 42.7 bits (99), Expect = 3e-04
Identities = 33/108 (30%), Positives = 47/108 (43%), Gaps = 4/108 (3%)
Frame = +1
Query: 43 GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEY 222
G D+ P C TG Y Q G WCVD + E T C+ K +
Sbjct: 1100 GPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVNTNGSAQCPGLCDVLKSR-AL 1158
Query: 223 SQRKIIGRFFHCDHL-GNYEKVQC---HGSVCYCADSSGKKIPTSPTV 354
S++ +G C+ L G + VQC GS C+C SG+++P + V
Sbjct: 1159 SRKVGLGYSPVCEALDGAFSPVQCDLAQGS-CWCVLGSGEEVPGTRVV 1205
Score = 42.0 bits (97), Expect = 5e-04
Identities = 33/133 (24%), Positives = 46/133 (34%), Gaps = 42/133 (31%)
Frame = +1
Query: 64 PFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 237
P C+D+G Y PVQC CWCVD G E+ G + G+ C + ++R +
Sbjct: 119 PQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYG-----TRQQGRPTRCPRSCEIRNRRLL 173
Query: 238 IG----RFFHCDHLGNYEKVQCH------------------------------------G 297
G C G + VQC
Sbjct: 174 HGVGDRSPPQCTADGEFMPVQCKFVNTTDMMIFDLIHNYNRFPDAFVTFSSFRGRFPEVS 233
Query: 298 SVCYCADSSGKKI 336
CYCADS G+++
Sbjct: 234 GYCYCADSQGREL 246
Score = 39.7 bits (91), Expect = 0.002
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 2/55 (3%)
Frame = +1
Query: 229 RKIIGRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTVHIAERDSLKCD 387
+++ G+FF C G+YE +QC+ C+C DS GK++ S R KC+
Sbjct: 609 KQMPGKFFVPSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCE 663
Score = 38.5 bits (88), Expect = 0.005
Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 2/65 (3%)
Frame = +1
Query: 64 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKH-EYSQRKI 237
P C G Y+ VQC CWCVD G E+ G + G+ +CA D+ +++
Sbjct: 318 PRCHRDGHYQTVQCQTEGMCWCVDAQGREVPG-----TRQQGQPPSCAADQSCALERQQA 372
Query: 238 IGRFF 252
+ RF+
Sbjct: 373 LSRFY 377
Score = 36.6 bits (83), Expect = 0.021
Identities = 35/129 (27%), Positives = 54/129 (41%), Gaps = 16/129 (12%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK---TCNCAKDKHEYSQ 228
P C G ++PVQC CWCVD G+ I G + + C ++ S
Sbjct: 1030 PQCNMIGGWEPVQCHAGTGQCWCVDGRGEFIPGSLMSRSSQMPQCPTNCELSRASGLISA 1089
Query: 229 RKIIGRFFH----------CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAERDS 375
K G + C G Y + Q G+ +C D +SG+ +P + T A+
Sbjct: 1090 WKQAGPQRNPGPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVN-TNGSAQCPG 1148
Query: 376 LKCD*IKNK 402
L CD +K++
Sbjct: 1149 L-CDVLKSR 1156
Score = 31.6 bits (70), Expect = 0.66
Identities = 11/29 (37%), Positives = 19/29 (65%), Gaps = 1/29 (3%)
Frame = +1
Query: 256 CDHLGNYEKVQCHGS-VCYCADSSGKKIP 339
C G+Y+ VQC +C+C D+ G+++P
Sbjct: 320 CHRDGHYQTVQCQTEGMCWCVDAQGREVP 348
>sp|P06882|THYG_RAT Thyroglobulin precursor
Length = 2768
Score = 57.0 bits (136), Expect = 1e-08
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 8/100 (8%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 243
P C G Y+ +QC CWCV+ G E++G + + + + C +K + + G
Sbjct: 618 PSCTAEGSYEDIQCYAGECWCVNSQGKEVEG--SRVSGGHPR-CPTKCEKQRAQMQNLAG 674
Query: 244 ------RFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIP 339
FF C G + VQC S CYC D+ G+ IP
Sbjct: 675 AQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIP 714
Score = 55.1 bits (131), Expect = 6e-08
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 13/108 (12%)
Frame = +1
Query: 52 DVTFPFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYS 225
D P C + G ++ VQC G +CWCVD G E+ G + G+ C +
Sbjct: 47 DEYVPQCSEDGSFQTVQCQNDGQSCWCVDSDGTEVPG-----SRQLGRPTACLSFCQLHK 101
Query: 226 QRKIIGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 336
QR ++ + + C GNY VQC C+C D+ G ++
Sbjct: 102 QRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEV 149
Score = 46.6 bits (109), Expect = 2e-05
Identities = 39/153 (25%), Positives = 56/153 (36%), Gaps = 46/153 (30%)
Frame = +1
Query: 16 LDARRLIKSGAMDVT----FPFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEK 177
L +R++ S ++ T P C+D+G Y PVQC CWCVD G E+ G +
Sbjct: 99 LHKQRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEVYG-----TR 153
Query: 178 SYGKTCNCAKDKHEYSQRKIIG----RFFHCDHLGNYEKVQCH----------------- 294
G+ C + S+R + G CD G + VQC
Sbjct: 154 QQGRPTRCPRSCEIRSRRLLHGVGDKSPPQCDADGEFMPVQCKFVNTTDMMIFDLIHNYN 213
Query: 295 -------------------GSVCYCADSSGKKI 336
CYCADS G+++
Sbjct: 214 RFPDAFVTFSAFRNRFPEVSGYCYCADSQGREL 246
Score = 45.8 bits (107), Expect = 3e-05
Identities = 37/109 (33%), Positives = 48/109 (44%), Gaps = 5/109 (4%)
Frame = +1
Query: 43 GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEY 222
G D+ P C TG Y Q G WCVD S E G T S C K
Sbjct: 1100 GPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGE--GVPTNTNSSAQCPGLCDALKSRV 1157
Query: 223 SQRKI-IGRFFHCDHL-GNYEKVQC---HGSVCYCADSSGKKIPTSPTV 354
RK+ +G C+ L G + VQC GS C+C +SG+++P + V
Sbjct: 1158 LSRKVGLGYTPVCEALDGGFSPVQCDLAQGS-CWCVLASGEEVPGTRVV 1205
Score = 42.4 bits (98), Expect = 4e-04
Identities = 39/129 (30%), Positives = 56/129 (43%), Gaps = 16/129 (12%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYI-----------TGIEKSYGKTCNCA 204
P C G ++PVQC CWCVD G+ I G + T E S A
Sbjct: 1030 PQCNTIGGWEPVQCHPGTGQCWCVDGWGELIPGSLMARSSQMPQCPTSCELSRANGLISA 1089
Query: 205 KDKHEYSQRKIIGRFFH--CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAERDS 375
+ + + G F C G Y + Q G+ +C D SSG+ +PT+ T A+
Sbjct: 1090 WKQAGHQRNPGPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTN-TNSSAQCPG 1148
Query: 376 LKCD*IKNK 402
L CD +K++
Sbjct: 1149 L-CDALKSR 1156
Score = 41.2 bits (95), Expect = 8e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Frame = +1
Query: 64 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRK 234
P C G Y+ VQC + CWCVD G EI G + G+ CAKD+ S+R+
Sbjct: 318 PSCHRDGHYQTVQCQMERMCWCVDAQGIEIPG-----TRQQGQPLFCAKDQSCASERQ 370
Score = 39.7 bits (91), Expect = 0.002
Identities = 19/51 (37%), Positives = 27/51 (52%), Gaps = 2/51 (3%)
Frame = +1
Query: 241 GRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTVHIAERDSLKCD 387
GRFF C G+YE +QC+ C+C +S GK++ S R KC+
Sbjct: 613 GRFFVPSCTAEGSYEDIQCYAGECWCVNSQGKEVEGSRVSGGHPRCPTKCE 663
Score = 36.6 bits (83), Expect = 0.021
Identities = 14/31 (45%), Positives = 17/31 (54%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKG 156
P C G + PVQC + C+CVD G I G
Sbjct: 685 PTCTSEGYFLPVQCFNSECYCVDAEGQVIPG 715
Score = 29.6 bits (65), Expect = 2.5
Identities = 12/29 (41%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Frame = +1
Query: 256 CDHLGNYEKVQCHGS-VCYCADSSGKKIP 339
C G+Y+ VQC +C+C D+ G +IP
Sbjct: 320 CHRDGHYQTVQCQMERMCWCVDAQGIEIP 348
Score = 28.1 bits (61), Expect = 7.3
Identities = 8/14 (57%), Positives = 12/14 (85%)
Frame = +1
Query: 115 ACWCVDDSGDEIKG 156
+CWCVD++G E+ G
Sbjct: 898 SCWCVDEAGQELDG 911
>sp|P01266|THYG_HUMAN Thyroglobulin precursor
Length = 2768
Score = 55.5 bits (132), Expect = 4e-08
Identities = 32/102 (31%), Positives = 43/102 (42%), Gaps = 10/102 (9%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKD--KHEYSQRKI 237
P C G Y+ VQC CWCV+ G E+ G + G C D K + +
Sbjct: 618 PSCTTEGSYEDVQCFSGECWCVNSWGKELPG-----SRVRGGQPRCPTDCEKQRARMQSL 672
Query: 238 IGR--------FFHCDHLGNYEKVQCHGSVCYCADSSGKKIP 339
+G C G++ VQC S CYC D+ G+ IP
Sbjct: 673 MGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIP 714
Score = 45.8 bits (107), Expect = 3e-05
Identities = 31/126 (24%), Positives = 55/126 (43%), Gaps = 13/126 (10%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKI 237
P C + G ++ VQC G +CWCV +G E+ G + G+ C Q+ +
Sbjct: 50 PQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLG-----SRQPGRPVACLSFCQLQKQQIL 104
Query: 238 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKIPTSPTVHIAERDSLKC 384
+ + + C G+Y VQC C+C D+ G ++ + + +R C
Sbjct: 105 LSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYGTRQLGRPKRCPRSC 164
Query: 385 D*IKNK 402
+ I+N+
Sbjct: 165 E-IRNR 169
Score = 42.7 bits (99), Expect = 3e-04
Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 10/102 (9%)
Frame = +1
Query: 16 LDARRLIKSGAMDVT----FPFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEK 177
L ++++ SG ++ T P C+D+G Y PVQC CWCVD G E+ G +
Sbjct: 98 LQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYG-----TR 152
Query: 178 SYGKTCNCAKDKHEYSQRKIIG----RFFHCDHLGNYEKVQC 291
G+ C + ++R + G C G + VQC
Sbjct: 153 QLGRPKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPVQC 194
Score = 42.4 bits (98), Expect = 4e-04
Identities = 34/101 (33%), Positives = 47/101 (46%), Gaps = 5/101 (4%)
Frame = +1
Query: 52 DVTFPFCEDTGMYKPVQCVGAACWCVDD-SGDEIKGYITGIEKSYGKTCNCAKDKHEYSQ 228
D+ P C +TG Y +Q GA WCVD SG+E++ + CN K S+
Sbjct: 1102 DLFVPACLETGEYARLQASGAGTWCVDPASGEELRPG-SSSSAQCPSLCNVLK-SGVLSR 1159
Query: 229 RKIIGRFFHC-DHLGNYEKVQC---HGSVCYCADSSGKKIP 339
R G C G + VQC GS C+C SG+++P
Sbjct: 1160 RVSPGYVPACRAEDGGFSPVQCDQAQGS-CWCVMDSGEEVP 1199
Score = 42.0 bits (97), Expect = 5e-04
Identities = 34/121 (28%), Positives = 53/121 (43%), Gaps = 16/121 (13%)
Frame = +1
Query: 22 ARRLIKSGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK-- 189
A L++SG P C+ G ++PVQC CWCVD+ G I G +T +
Sbjct: 1018 ASALLRSGPY---MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCP 1074
Query: 190 -TCNCAKD-------KHEYSQRKIIGRFFH---CDHLGNYEKVQCHGSVCYCAD-SSGKK 333
TC ++ K SQ + C G Y ++Q G+ +C D +SG++
Sbjct: 1075 TTCEKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPASGEE 1134
Query: 334 I 336
+
Sbjct: 1135 L 1135
Score = 39.7 bits (91), Expect = 0.002
Identities = 26/101 (25%), Positives = 43/101 (42%), Gaps = 4/101 (3%)
Frame = +1
Query: 64 PFCE-DTGMYKPVQCVGA--ACWCVDDSGDEIKG-YITGIEKSYGKTCNCAKDKHEYSQR 231
P C + G + PVQC A +CWCV DSG+E+ G +TG + + C + ++
Sbjct: 1167 PACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPA----CESPRCPLPFNAS 1222
Query: 232 KIIGRFFHCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTV 354
+++G C+ + C S P P +
Sbjct: 1223 EVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPGPLI 1263
Score = 38.9 bits (89), Expect = 0.004
Identities = 24/92 (26%), Positives = 34/92 (36%), Gaps = 14/92 (15%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRKIIG 243
P C G + PVQC + C+CVD G I G + I K C + R +
Sbjct: 685 PACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAIGKPKKCPTPCQLQSEQAFLRTVQA 744
Query: 244 RFFH--------------CDHLGNYEKVQCHG 297
+ C G + +VQC+G
Sbjct: 745 LLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNG 776
Score = 37.4 bits (85), Expect = 0.012
Identities = 20/58 (34%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = +1
Query: 64 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQRK 234
P C G Y+ VQC CWCVD G E+ G + G+ +CA+ + S+R+
Sbjct: 317 PSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHG-----TRQQGEPPSCAEGQSCASERQ 369
Score = 35.8 bits (81), Expect = 0.035
Identities = 14/30 (46%), Positives = 19/30 (63%)
Frame = +1
Query: 256 CDHLGNYEKVQCHGSVCYCADSSGKKIPTS 345
C G+YE VQC C+C +S GK++P S
Sbjct: 620 CTTEGSYEDVQCFSGECWCVNSWGKELPGS 649
Score = 35.8 bits (81), Expect = 0.035
Identities = 16/34 (47%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Frame = +1
Query: 256 CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 351
CD G++E VQCH C+C D G IP S T
Sbjct: 1031 CDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLT 1064
Score = 28.5 bits (62), Expect = 5.6
Identities = 8/13 (61%), Positives = 12/13 (92%)
Frame = +1
Query: 118 CWCVDDSGDEIKG 156
CWCVD++G E++G
Sbjct: 898 CWCVDEAGQELEG 910
>sp|P81439|EQST_ACTEQ Equistatin
Length = 199
Score = 52.4 bits (124), Expect = 4e-07
Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 14/113 (12%)
Frame = +1
Query: 40 SGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCNCAKDK 213
SG + P C++TG ++ QC G+ CWCVD+ G EI G T I S +C++ K
Sbjct: 14 SGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILG--TKIRGS----PDCSRRK 67
Query: 214 HEYSQRKIIGRFF----------HCDHLGNYEKVQCHGS--VCYCADSSGKKI 336
+ +++ C G++++VQC S CYC D GK++
Sbjct: 68 AALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKEL 120
Score = 47.0 bits (110), Expect = 2e-05
Identities = 33/103 (32%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGA--ACWCVDDSGDEIKGYIT----GIEKSYGKTCNCAKDKHEYS 225
P C+ G + VQC + C+CVD G E++G E+ H S
Sbjct: 90 PSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQKGRPSCERHLSPCEEARLQAHSNS 149
Query: 226 QRKIIGRFF-HCDHLGNYEKVQCHGSV--CYCADSSGKKIPTS 345
R +G F C G+Y VQC S C+C D G K+P S
Sbjct: 150 LR--VGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPGS 190
Score = 37.7 bits (86), Expect = 0.009
Identities = 22/58 (37%), Positives = 31/58 (53%), Gaps = 8/58 (13%)
Frame = +1
Query: 7 KRHL----DARRLIKSGAMDVTF--PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 156
+RHL +AR S ++ V P C + G Y PVQC + CWCVD+ G ++ G
Sbjct: 132 ERHLSPCEEARLQAHSNSLRVGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPG 189
>sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2)
Length = 1403
Score = 51.6 bits (122), Expect = 6e-07
Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 24/118 (20%)
Frame = +1
Query: 55 VTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCNCAKDKHEYSQ 228
+ P C+D G + P+QC G+ CWCVD +G E + G + G T E +Q
Sbjct: 986 IHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHE----VPGTQTPPGSTPPHCGPPPEPTQ 1041
Query: 229 --RKIIGRFF------------------HCDHLGNYEKVQCHG--SVCYCADSSGKKI 336
R + R+ CD LG++ +QCHG C+C D G+++
Sbjct: 1042 RPRTVCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREL 1099
Score = 40.4 bits (93), Expect = 0.001
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Frame = +1
Query: 202 AKDKHEYSQRKIIGRFFHCDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 351
A+ +H Y +I CD GN+ +QCHGS C+C D +G ++P + T
Sbjct: 975 AQTQHAYPGSRI--HIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQT 1024
Score = 40.4 bits (93), Expect = 0.001
Identities = 17/37 (45%), Positives = 23/37 (62%), Gaps = 2/37 (5%)
Frame = +1
Query: 52 DVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 156
D P C+D G + P+QC G + CWCVD G E++G
Sbjct: 1065 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQG 1101
>sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonidogen)
Length = 1375
Score = 51.2 bits (121), Expect = 8e-07
Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 24/134 (17%)
Frame = +1
Query: 7 KRHLDARRLIKSGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKS 180
+RH A+ + P C++ G + P+QC G+ CWCVD G E + G +
Sbjct: 944 QRHAQAQYAYPGARFHI--PQCDEQGNFLPLQCHGSTGFCWCVDPDGHE----VPGTQTP 997
Query: 181 YGKTCNCAKDKHEYSQR--KIIGRFF------------------HCDHLGNYEKVQCHG- 297
G T E +QR I R+ CD LG++ +QCHG
Sbjct: 998 PGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGK 1057
Query: 298 -SVCYCADSSGKKI 336
C+C D G+++
Sbjct: 1058 SDFCWCVDKDGREV 1071
Score = 42.4 bits (98), Expect = 4e-04
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 5/54 (9%)
Frame = +1
Query: 205 KDKHEYSQRKIIGRFFH---CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 351
+ +H +Q G FH CD GN+ +QCHGS C+C D G ++P + T
Sbjct: 943 QQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQT 996
Score = 40.8 bits (94), Expect = 0.001
Identities = 17/37 (45%), Positives = 23/37 (62%), Gaps = 2/37 (5%)
Frame = +1
Query: 52 DVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 156
D P C+D G + P+QC G + CWCVD G E++G
Sbjct: 1037 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQG 1073
>sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 44.3 bits (103), Expect = 1e-04
Identities = 17/33 (51%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 156
P C++ G YKP QC G+ CWCVD G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMG 371
Score = 37.7 bits (86), Expect = 0.009
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +1
Query: 229 RKIIGRFFH-CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTVHIAE 366
+K++G++ CD G Y+ QCHGSV C+C D G ++ S +A+
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVAD 379
>sp|Q5RD69|TICN3_PONPY Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 44.3 bits (103), Expect = 1e-04
Identities = 17/33 (51%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +1
Query: 64 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 156
P C++ G YKP QC G+ CWCVD G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMG 371
Score = 37.7 bits (86), Expect = 0.009
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +1
Query: 229 RKIIGRFFH-CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTVHIAE 366
+K++G++ CD G Y+ QCHGSV C+C D G ++ S +A+
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVAD 379
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,109,582
Number of Sequences: 369166
Number of extensions: 1063340
Number of successful extensions: 3009
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2760
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2948
length of database: 68,354,980
effective HSP length: 99
effective length of database: 50,066,215
effective search space used: 1902516170
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)