Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_006_B03
(539 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31226|SAX_RANCA Saxiphilin precursor (SAX) 67 3e-11
sp|O08710|THYG_MOUSE Thyroglobulin precursor 59 6e-09
sp|P01267|THYG_BOVIN Thyroglobulin precursor 59 8e-09
sp|P06882|THYG_RAT Thyroglobulin precursor 57 2e-08
sp|P01266|THYG_HUMAN Thyroglobulin precursor 56 5e-08
sp|P81439|EQST_ACTEQ Equistatin 53 5e-07
sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2) 52 9e-07
sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonido... 52 1e-06
sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonect... 45 1e-04
sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonect... 44 2e-04
>sp|P31226|SAX_RANCA Saxiphilin precursor (SAX)
Length = 844
Score = 67.0 bits (162), Expect = 3e-11
Identities = 48/153 (31%), Positives = 72/153 (47%), Gaps = 13/153 (8%)
Frame = -2
Query: 475 NNDQCNVGLICDEVCKEDNNAPKCFKRHLDARRLIKSGAMDVTFPFCEDTGMYKPVQCVG 296
+ D N+ I E + + KC K A + + P C++ G Y+P QC G
Sbjct: 87 SKDPYNLKPIIAEPYSSNRDLQKCLKERQQA---LAKKMIGHYIPQCDEKGNYQPQQCHG 143
Query: 295 AA--CWCVDDSGDEIKGYITGIEKSYGKTC------KCAKDKHEY--SQRKIIGRFF-HC 149
+ CWCV+ G++I G T ++ TC KC K++ K++GRF C
Sbjct: 144 STGHCWCVNAMGEKISGTNTPPGQTRA-TCERHELPKCLKERQVALGGDEKVLGRFVPQC 202
Query: 148 DHLGNYEKVQCHGSVCY--CADSSGKKIPTSPT 56
D GNYE Q HGS Y C ++ G++I + T
Sbjct: 203 DEKGNYEPQQFHGSTGYSWCVNAIGEEIAGTKT 235
>sp|O08710|THYG_MOUSE Thyroglobulin precursor
Length = 2766
Score = 59.3 bits (142), Expect = 6e-09
Identities = 40/113 (35%), Positives = 52/113 (46%), Gaps = 8/113 (7%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEY----SQR 176
P C G Y+ +QC CWCVD G E+ G + T KC K + + S +
Sbjct: 618 PSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPT-KCEKQRAQMQSLASAQ 676
Query: 175 KIIGRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIP-TSPTVHIA-ECDSL 29
FF C G + VQC S CYC D+ G+ IP T TV A +C S+
Sbjct: 677 PAGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIPGTQSTVGEAKQCPSV 729
Score = 56.6 bits (135), Expect = 4e-08
Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 13/104 (12%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKI 170
P C + G ++ VQC G +CWCVD G E+ G + G+ C + QR +
Sbjct: 51 PQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPG-----SRQLGRPTVCLSFCQLHKQRIL 105
Query: 169 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 71
+G + + C GNY VQC C+C D+ G ++
Sbjct: 106 LGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEV 149
Score = 43.9 bits (102), Expect = 2e-04
Identities = 36/119 (30%), Positives = 51/119 (42%), Gaps = 5/119 (4%)
Frame = -2
Query: 364 GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEY 185
G D+ P C TG Y Q G WCVD + E T C K +
Sbjct: 1100 GPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVNTNGSAQCPGLCDVLKSR-AL 1158
Query: 184 SQRKIIGRFFHCDHL-GNYEKVQC---HGSVCYCADSSGKKIPTSPTVHI-AECDSLKC 23
S++ +G C+ L G + VQC GS C+C SG+++P + V C+S +C
Sbjct: 1159 SRKVGLGYSPVCEALDGAFSPVQCDLAQGS-CWCVLGSGEEVPGTRVVGTQPACESPQC 1216
Score = 42.7 bits (99), Expect = 6e-04
Identities = 33/133 (24%), Positives = 47/133 (35%), Gaps = 42/133 (31%)
Frame = -2
Query: 343 PFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKI 170
P C+D+G Y PVQC CWCVD G E+ G + G+ +C + ++R +
Sbjct: 119 PQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYG-----TRQQGRPTRCPRSCEIRNRRLL 173
Query: 169 IG----RFFHCDHLGNYEKVQCH------------------------------------G 110
G C G + VQC
Sbjct: 174 HGVGDRSPPQCTADGEFMPVQCKFVNTTDMMIFDLIHNYNRFPDAFVTFSSFRGRFPEVS 233
Query: 109 SVCYCADSSGKKI 71
CYCADS G+++
Sbjct: 234 GYCYCADSQGREL 246
Score = 40.8 bits (94), Expect = 0.002
Identities = 36/129 (27%), Positives = 55/129 (42%), Gaps = 16/129 (12%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK---TCKCAKDKHEYSQ 179
P C G ++PVQC CWCVD G+ I G + + C+ ++ S
Sbjct: 1030 PQCNMIGGWEPVQCHAGTGQCWCVDGRGEFIPGSLMSRSSQMPQCPTNCELSRASGLISA 1089
Query: 178 RKIIGRFFH----------CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAECDS 32
K G + C G Y + Q G+ +C D +SG+ +P + T A+C
Sbjct: 1090 WKQAGPQRNPGPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVN-TNGSAQCPG 1148
Query: 31 LKCDKRKNK 5
L CD K++
Sbjct: 1149 L-CDVLKSR 1156
Score = 38.1 bits (87), Expect = 0.014
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 2/65 (3%)
Frame = -2
Query: 343 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKH-EYSQRKI 170
P C G Y+ VQC CWCVD G E+ G + G+ CA D+ +++
Sbjct: 318 PRCHRDGHYQTVQCQTEGMCWCVDAQGREVPG-----TRQQGQPPSCAADQSCALERQQA 372
Query: 169 IGRFF 155
+ RF+
Sbjct: 373 LSRFY 377
Score = 31.6 bits (70), Expect = 1.3
Identities = 11/29 (37%), Positives = 19/29 (65%), Gaps = 1/29 (3%)
Frame = -2
Query: 151 CDHLGNYEKVQCHGS-VCYCADSSGKKIP 68
C G+Y+ VQC +C+C D+ G+++P
Sbjct: 320 CHRDGHYQTVQCQTEGMCWCVDAQGREVP 348
>sp|P01267|THYG_BOVIN Thyroglobulin precursor
Length = 2769
Score = 58.9 bits (141), Expect = 8e-09
Identities = 32/100 (32%), Positives = 42/100 (42%), Gaps = 8/100 (8%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKIIG 164
P C G Y+ VQC CWCVD G E+ G + C +K + ++G
Sbjct: 617 PACTAEGSYEEVQCFAGDCWCVDAQGRELAG---SRVRGGRPRCPTECEKQRARMQSLLG 673
Query: 163 R--------FFHCDHLGNYEKVQCHGSVCYCADSSGKKIP 68
C GN+ VQC S CYC D+ G+ IP
Sbjct: 674 SQPAGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQPIP 713
Score = 50.8 bits (120), Expect = 2e-06
Identities = 29/104 (27%), Positives = 46/104 (44%), Gaps = 13/104 (12%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKI 170
P C + G ++ VQC GA+CWCVD G E+ G + G+ C Q+ +
Sbjct: 50 PQCAEDGSFQTVQCGKDGASCWCVDADGREVPG-----SRQPGRPAACLSFCQLQKQQIL 104
Query: 169 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 71
+ + + C G+Y VQC C+C D+ G ++
Sbjct: 105 LSSYINSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEV 148
Score = 42.4 bits (98), Expect = 7e-04
Identities = 33/133 (24%), Positives = 47/133 (35%), Gaps = 42/133 (31%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKI 170
P C+D+G Y PVQC CWCVD G E+ G + G+ +C + ++R +
Sbjct: 118 PQCQDSGDYSPVQCDLRRRQCWCVDAEGMEVYG-----TRQQGRPARCPRSCEIRNRRLL 172
Query: 169 IG----RFFHCDHLGNYEKVQCH------------------------------------G 110
G C G + VQC
Sbjct: 173 HGVGDRSPPQCSPDGAFRPVQCKLVNTTDMMIFDLVHSYSRFPDAFVTFSSFRSRFPEVS 232
Query: 109 SVCYCADSSGKKI 71
CYCADS G+++
Sbjct: 233 GYCYCADSQGREL 245
Score = 42.4 bits (98), Expect = 7e-04
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCV-GAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRK 173
P C G Y+ QC G CWCVD G EI G + G+ CA+D+ S+R+
Sbjct: 317 PSCHPDGEYQAAQCQQGGPCWCVDSRGQEIPG-----TRQRGEPPSCAEDQSCPSERR 369
Score = 40.4 bits (93), Expect = 0.003
Identities = 29/120 (24%), Positives = 43/120 (35%), Gaps = 20/120 (16%)
Frame = -2
Query: 409 KCFKRHLDARRLIKS--GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGI 236
+C K+ + L+ S + P C G + PVQC + C+CVD G I G
Sbjct: 660 ECEKQRARMQSLLGSQPAGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQP----IPGT 715
Query: 235 EKSYGKTCKCAKDKHEYSQRKIIGR------------------FFHCDHLGNYEKVQCHG 110
+ G+ KC ++R +G C G + VQC G
Sbjct: 716 RSALGEPKKCPSPCQLQAERAFLGTVRTLVSNPSTLPALSSIYIPQCSASGQWSPVQCDG 775
Score = 40.0 bits (92), Expect = 0.004
Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 5/50 (10%)
Frame = -2
Query: 151 CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTV---HIAECDSLKCDK 17
CD G +E VQCH + C+C D G+ +PTS T I +C + C++
Sbjct: 1031 CDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLTARSRQIPQCPT-SCER 1079
Score = 38.9 bits (89), Expect = 0.008
Identities = 32/121 (26%), Positives = 52/121 (42%), Gaps = 16/121 (13%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGK---TCKCAKDKHEYSQ 179
P C+ G ++PVQC A CWCVD G+ + +T + + +C+ + S
Sbjct: 1029 PQCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLTARSRQIPQCPTSCERLRASGLLSS 1088
Query: 178 RKIIGRFFH----------CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAECDS 32
K G C G + ++Q + +C D +SG+ +P T A+C S
Sbjct: 1089 WKQAGVQAEPSPKDLFIPTCLETGEFARLQASEAGTWCVDPASGEGVPPG-TNSSAQCPS 1147
Query: 31 L 29
L
Sbjct: 1148 L 1148
Score = 36.6 bits (83), Expect = 0.040
Identities = 33/121 (27%), Positives = 49/121 (40%), Gaps = 10/121 (8%)
Frame = -2
Query: 355 DVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAK-----DKH 191
D+ P C +TG + +Q A WCVD + E G+ + +C
Sbjct: 1102 DLFIPTCLETGEFARLQASEAGTWCVDPASGE------GVPPGTNSSAQCPSLCEVLQSG 1155
Query: 190 EYSQRKIIGRFFHC-DHLGNYEKVQC---HGSVCYCADSSGKKIP-TSPTVHIAECDSLK 26
S+R G C G + VQC GS C+C SG+++P T C+S +
Sbjct: 1156 VPSRRTSPGYSPACRAEDGGFSPVQCDPAQGS-CWCVLGSGEEVPGTRVAGSQPACESPQ 1214
Query: 25 C 23
C
Sbjct: 1215 C 1215
Score = 33.9 bits (76), Expect = 0.26
Identities = 12/30 (40%), Positives = 19/30 (63%)
Frame = -2
Query: 151 CDHLGNYEKVQCHGSVCYCADSSGKKIPTS 62
C G+YE+VQC C+C D+ G+++ S
Sbjct: 619 CTAEGSYEEVQCFAGDCWCVDAQGRELAGS 648
Score = 31.6 bits (70), Expect = 1.3
Identities = 13/29 (44%), Positives = 17/29 (58%), Gaps = 1/29 (3%)
Frame = -2
Query: 151 CDHLGNYEKVQCH-GSVCYCADSSGKKIP 68
C G Y+ QC G C+C DS G++IP
Sbjct: 319 CHPDGEYQAAQCQQGGPCWCVDSRGQEIP 347
>sp|P06882|THYG_RAT Thyroglobulin precursor
Length = 2768
Score = 57.4 bits (137), Expect = 2e-08
Identities = 31/100 (31%), Positives = 46/100 (46%), Gaps = 8/100 (8%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKIIG 164
P C G Y+ +QC CWCV+ G E++G + + + + C +K + + G
Sbjct: 618 PSCTAEGSYEDIQCYAGECWCVNSQGKEVEG--SRVSGGHPR-CPTKCEKQRAQMQNLAG 674
Query: 163 ------RFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIP 68
FF C G + VQC S CYC D+ G+ IP
Sbjct: 675 AQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIP 714
Score = 55.5 bits (132), Expect = 8e-08
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 13/108 (12%)
Frame = -2
Query: 355 DVTFPFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYS 182
D P C + G ++ VQC G +CWCVD G E+ G + G+ C +
Sbjct: 47 DEYVPQCSEDGSFQTVQCQNDGQSCWCVDSDGTEVPG-----SRQLGRPTACLSFCQLHK 101
Query: 181 QRKIIGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 71
QR ++ + + C GNY VQC C+C D+ G ++
Sbjct: 102 QRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEV 149
Score = 48.1 bits (113), Expect = 1e-05
Identities = 40/120 (33%), Positives = 53/120 (44%), Gaps = 6/120 (5%)
Frame = -2
Query: 364 GAMDVTFPFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEY 185
G D+ P C TG Y Q G WCVD S E G T S C K
Sbjct: 1100 GPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGE--GVPTNTNSSAQCPGLCDALKSRV 1157
Query: 184 SQRKI-IGRFFHCDHL-GNYEKVQC---HGSVCYCADSSGKKIPTSPTVHI-AECDSLKC 23
RK+ +G C+ L G + VQC GS C+C +SG+++P + V C+S +C
Sbjct: 1158 LSRKVGLGYTPVCEALDGGFSPVQCDLAQGS-CWCVLASGEEVPGTRVVGTQPACESPQC 1216
Score = 47.4 bits (111), Expect = 2e-05
Identities = 39/153 (25%), Positives = 57/153 (37%), Gaps = 46/153 (30%)
Frame = -2
Query: 391 LDARRLIKSGAMDVT----FPFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEK 230
L +R++ S ++ T P C+D+G Y PVQC CWCVD G E+ G +
Sbjct: 99 LHKQRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEVYG-----TR 153
Query: 229 SYGKTCKCAKDKHEYSQRKIIG----RFFHCDHLGNYEKVQCH----------------- 113
G+ +C + S+R + G CD G + VQC
Sbjct: 154 QQGRPTRCPRSCEIRSRRLLHGVGDKSPPQCDADGEFMPVQCKFVNTTDMMIFDLIHNYN 213
Query: 112 -------------------GSVCYCADSSGKKI 71
CYCADS G+++
Sbjct: 214 RFPDAFVTFSAFRNRFPEVSGYCYCADSQGREL 246
Score = 46.6 bits (109), Expect = 4e-05
Identities = 40/129 (31%), Positives = 56/129 (43%), Gaps = 16/129 (12%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYI-----------TGIEKSYGKTCKCA 203
P C G ++PVQC CWCVD G+ I G + T E S A
Sbjct: 1030 PQCNTIGGWEPVQCHPGTGQCWCVDGWGELIPGSLMARSSQMPQCPTSCELSRANGLISA 1089
Query: 202 KDKHEYSQRKIIGRFFH--CDHLGNYEKVQCHGSVCYCAD-SSGKKIPTSPTVHIAECDS 32
+ + + G F C G Y + Q G+ +C D SSG+ +PT+ T A+C
Sbjct: 1090 WKQAGHQRNPGPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTN-TNSSAQCPG 1148
Query: 31 LKCDKRKNK 5
L CD K++
Sbjct: 1149 L-CDALKSR 1156
Score = 41.2 bits (95), Expect = 0.002
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 1/58 (1%)
Frame = -2
Query: 343 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRK 173
P C G Y+ VQC + CWCVD G EI G + G+ CAKD+ S+R+
Sbjct: 318 PSCHRDGHYQTVQCQMERMCWCVDAQGIEIPG-----TRQQGQPLFCAKDQSCASERQ 370
Score = 39.7 bits (91), Expect = 0.005
Identities = 19/54 (35%), Positives = 29/54 (53%), Gaps = 2/54 (3%)
Frame = -2
Query: 166 GRFF--HCDHLGNYEKVQCHGSVCYCADSSGKKIPTSPTVHIAECDSLKCDKRK 11
GRFF C G+YE +QC+ C+C +S GK++ S KC+K++
Sbjct: 613 GRFFVPSCTAEGSYEDIQCYAGECWCVNSQGKEVEGSRVSGGHPRCPTKCEKQR 666
Score = 38.5 bits (88), Expect = 0.010
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 2/55 (3%)
Frame = -2
Query: 409 KCFKRHLDARRLIKSGAMDVTF--PFCEDTGMYKPVQCVGAACWCVDDSGDEIKG 251
KC K+ + L + +F P C G + PVQC + C+CVD G I G
Sbjct: 661 KCEKQRAQMQNLAGAQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIPG 715
Score = 29.6 bits (65), Expect = 4.9
Identities = 12/29 (41%), Positives = 18/29 (62%), Gaps = 1/29 (3%)
Frame = -2
Query: 151 CDHLGNYEKVQCHGS-VCYCADSSGKKIP 68
C G+Y+ VQC +C+C D+ G +IP
Sbjct: 320 CHRDGHYQTVQCQMERMCWCVDAQGIEIP 348
>sp|P01266|THYG_HUMAN Thyroglobulin precursor
Length = 2768
Score = 56.2 bits (134), Expect = 5e-08
Identities = 32/102 (31%), Positives = 44/102 (43%), Gaps = 10/102 (9%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKD--KHEYSQRKI 170
P C G Y+ VQC CWCV+ G E+ G + G +C D K + +
Sbjct: 618 PSCTTEGSYEDVQCFSGECWCVNSWGKELPG-----SRVRGGQPRCPTDCEKQRARMQSL 672
Query: 169 IGR--------FFHCDHLGNYEKVQCHGSVCYCADSSGKKIP 68
+G C G++ VQC S CYC D+ G+ IP
Sbjct: 673 MGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIP 714
Score = 45.8 bits (107), Expect = 7e-05
Identities = 27/104 (25%), Positives = 45/104 (43%), Gaps = 13/104 (12%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCV--GAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKI 170
P C + G ++ VQC G +CWCV +G E+ G + G+ C Q+ +
Sbjct: 50 PQCAEDGSFQTVQCQNDGRSCWCVGANGSEVLG-----SRQPGRPVACLSFCQLQKQQIL 104
Query: 169 IGRFFH---------CDHLGNYEKVQC--HGSVCYCADSSGKKI 71
+ + + C G+Y VQC C+C D+ G ++
Sbjct: 105 LSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEV 148
Score = 45.8 bits (107), Expect = 7e-05
Identities = 37/118 (31%), Positives = 53/118 (44%), Gaps = 7/118 (5%)
Frame = -2
Query: 355 DVTFPFCEDTGMYKPVQCVGAACWCVDD-SGDEIKGYITGIEKSYGKTCKCAKDKHEYSQ 179
D+ P C +TG Y +Q GA WCVD SG+E++ G S C K
Sbjct: 1102 DLFVPACLETGEYARLQASGAGTWCVDPASGEELR---PGSSSSAQCPSLCNVLKSGVLS 1158
Query: 178 RKIIGRFFHCDHL--GNYEKVQC---HGSVCYCADSSGKKIP-TSPTVHIAECDSLKC 23
R++ + G + VQC GS C+C SG+++P T T C+S +C
Sbjct: 1159 RRVSPGYVPACRAEDGGFSPVQCDQAQGS-CWCVMDSGEEVPGTRVTGGQPACESPRC 1215
Score = 43.9 bits (102), Expect = 2e-04
Identities = 37/136 (27%), Positives = 57/136 (41%), Gaps = 17/136 (12%)
Frame = -2
Query: 385 ARRLIKSGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITG--------- 239
A L++SG P C+ G ++PVQC CWCVD+ G I G +T
Sbjct: 1018 ASALLRSGPY---MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCP 1074
Query: 238 --IEKSYG----KTCKCAKDKHEYSQRKIIGRFFHCDHLGNYEKVQCHGSVCYCADSSGK 77
EKS + K A+ + S + + C G Y ++Q G+ +C D +
Sbjct: 1075 TTCEKSRTSGLLSSWKQARSQENPSPKDLF--VPACLETGEYARLQASGAGTWCVDPASG 1132
Query: 76 KIPTSPTVHIAECDSL 29
+ + A+C SL
Sbjct: 1133 EELRPGSSSSAQCPSL 1148
Score = 43.5 bits (101), Expect = 3e-04
Identities = 30/102 (29%), Positives = 47/102 (46%), Gaps = 10/102 (9%)
Frame = -2
Query: 391 LDARRLIKSGAMDVT----FPFCEDTGMYKPVQC--VGAACWCVDDSGDEIKGYITGIEK 230
L ++++ SG ++ T P C+D+G Y PVQC CWCVD G E+ G +
Sbjct: 98 LQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYG-----TR 152
Query: 229 SYGKTCKCAKDKHEYSQRKIIG----RFFHCDHLGNYEKVQC 116
G+ +C + ++R + G C G + VQC
Sbjct: 153 QLGRPKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPVQC 194
Score = 39.3 bits (90), Expect = 0.006
Identities = 24/92 (26%), Positives = 34/92 (36%), Gaps = 14/92 (15%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRKIIG 164
P C G + PVQC + C+CVD G I G + I K C + R +
Sbjct: 685 PACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAIGKPKKCPTPCQLQSEQAFLRTVQA 744
Query: 163 RFFH--------------CDHLGNYEKVQCHG 110
+ C G + +VQC+G
Sbjct: 745 LLSNSSMLPTLSDTYIPQCSTDGQWRQVQCNG 776
Score = 38.1 bits (87), Expect = 0.014
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 5/52 (9%)
Frame = -2
Query: 151 CDHLGNYEKVQCHGSV--CYCADSSGKKIP---TSPTVHIAECDSLKCDKRK 11
CD G++E VQCH C+C D G IP T+ ++ I +C + C+K +
Sbjct: 1031 CDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPT-TCEKSR 1081
Score = 37.0 bits (84), Expect = 0.031
Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Frame = -2
Query: 343 PFCEDTGMYKPVQC-VGAACWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQRK 173
P C G Y+ VQC CWCVD G E+ G + G+ CA+ + S+R+
Sbjct: 317 PSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHG-----TRQQGEPPSCAEGQSCASERQ 369
Score = 35.8 bits (81), Expect = 0.068
Identities = 14/30 (46%), Positives = 19/30 (63%)
Frame = -2
Query: 151 CDHLGNYEKVQCHGSVCYCADSSGKKIPTS 62
C G+YE VQC C+C +S GK++P S
Sbjct: 620 CTTEGSYEDVQCFSGECWCVNSWGKELPGS 649
>sp|P81439|EQST_ACTEQ Equistatin
Length = 199
Score = 52.8 bits (125), Expect = 5e-07
Identities = 39/141 (27%), Positives = 62/141 (43%), Gaps = 21/141 (14%)
Frame = -2
Query: 367 SGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCKCAKDK 194
SG + P C++TG ++ QC G+ CWCVD+ G EI G T I S C++ K
Sbjct: 14 SGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILG--TKIRGS----PDCSRRK 67
Query: 193 HEYSQRKIIGRFF----------HCDHLGNYEKVQCHGS--VCYCADSSGKKIP------ 68
+ +++ C G++++VQC S CYC D GK++
Sbjct: 68 AALTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQKG 127
Query: 67 -TSPTVHIAECDSLKCDKRKN 8
S H++ C+ + N
Sbjct: 128 RPSCERHLSPCEEARLQAHSN 148
Score = 47.4 bits (111), Expect = 2e-05
Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 9/103 (8%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGA--ACWCVDDSGDEIKGYIT----GIEKSYGKTCKCAKDKHEYS 182
P C+ G + VQC + C+CVD G E++G E+ + H S
Sbjct: 90 PSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQKGRPSCERHLSPCEEARLQAHSNS 149
Query: 181 QRKIIGRFF-HCDHLGNYEKVQCHGSV--CYCADSSGKKIPTS 62
R +G F C G+Y VQC S C+C D G K+P S
Sbjct: 150 LR--VGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPGS 190
Score = 45.1 bits (105), Expect = 1e-04
Identities = 32/103 (31%), Positives = 46/103 (44%), Gaps = 13/103 (12%)
Frame = -2
Query: 520 TCVFSSKLEEFDVCGNNDQCNVGLICDEVCKE-----DNNAPKCFKRHL----DARRLIK 368
+C +E C +N +C D+ KE P C +RHL +AR
Sbjct: 91 SCKADGSFDEVQCCASNGEC---YCVDKKGKELEGTRQKGRPSC-ERHLSPCEEARLQAH 146
Query: 367 SGAMDVTF--PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 251
S ++ V P C + G Y PVQC + CWCVD+ G ++ G
Sbjct: 147 SNSLRVGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPG 189
>sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2)
Length = 1403
Score = 52.0 bits (123), Expect = 9e-07
Identities = 34/118 (28%), Positives = 52/118 (44%), Gaps = 24/118 (20%)
Frame = -2
Query: 352 VTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKSYGKTCKCAKDKHEYSQ 179
+ P C+D G + P+QC G+ CWCVD +G E + G + G T E +Q
Sbjct: 986 IHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHE----VPGTQTPPGSTPPHCGPPPEPTQ 1041
Query: 178 --RKIIGRFF------------------HCDHLGNYEKVQCHG--SVCYCADSSGKKI 71
R + R+ CD LG++ +QCHG C+C D G+++
Sbjct: 1042 RPRTVCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREL 1099
Score = 40.4 bits (93), Expect = 0.003
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Frame = -2
Query: 205 AKDKHEYSQRKIIGRFFHCDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 56
A+ +H Y +I CD GN+ +QCHGS C+C D +G ++P + T
Sbjct: 975 AQTQHAYPGSRI--HIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQT 1024
Score = 40.4 bits (93), Expect = 0.003
Identities = 17/37 (45%), Positives = 23/37 (62%), Gaps = 2/37 (5%)
Frame = -2
Query: 355 DVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 251
D P C+D G + P+QC G + CWCVD G E++G
Sbjct: 1065 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQG 1101
>sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonidogen)
Length = 1375
Score = 51.6 bits (122), Expect = 1e-06
Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 24/134 (17%)
Frame = -2
Query: 400 KRHLDARRLIKSGAMDVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKGYITGIEKS 227
+RH A+ + P C++ G + P+QC G+ CWCVD G E + G +
Sbjct: 944 QRHAQAQYAYPGARFHI--PQCDEQGNFLPLQCHGSTGFCWCVDPDGHE----VPGTQTP 997
Query: 226 YGKTCKCAKDKHEYSQR--KIIGRFF------------------HCDHLGNYEKVQCHG- 110
G T E +QR I R+ CD LG++ +QCHG
Sbjct: 998 PGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGK 1057
Query: 109 -SVCYCADSSGKKI 71
C+C D G+++
Sbjct: 1058 SDFCWCVDKDGREV 1071
Score = 42.4 bits (98), Expect = 7e-04
Identities = 20/54 (37%), Positives = 29/54 (53%), Gaps = 5/54 (9%)
Frame = -2
Query: 202 KDKHEYSQRKIIGRFFH---CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPT 56
+ +H +Q G FH CD GN+ +QCHGS C+C D G ++P + T
Sbjct: 943 QQRHAQAQYAYPGARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQT 996
Score = 40.8 bits (94), Expect = 0.002
Identities = 17/37 (45%), Positives = 23/37 (62%), Gaps = 2/37 (5%)
Frame = -2
Query: 355 DVTFPFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 251
D P C+D G + P+QC G + CWCVD G E++G
Sbjct: 1037 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQG 1073
>sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 44.7 bits (104), Expect = 1e-04
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Frame = -2
Query: 475 NNDQCNVGLICDEVCKEDNNAPKCFKR--HLDARRLIKSGAMDVTFPFCEDTGMYKPVQC 302
NN+ C C + P C ++ R+ IK + P C++ G YKP QC
Sbjct: 302 NNEWC--------YCFQRQQDPPCHTELSNIQKRQGIKK-LLGQYIPLCDEDGYYKPTQC 352
Query: 301 VGAA--CWCVDDSGDEIKG 251
G+ CWCVD G+E+ G
Sbjct: 353 HGSVGQCWCVDRYGNEVVG 371
Score = 41.2 bits (95), Expect = 0.002
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 3/50 (6%)
Frame = -2
Query: 178 RKIIGRFFH-CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTVHIAEC 38
+K++G++ CD G Y+ QCHGSV C+C D G ++ S +A+C
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVADC 380
>sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 44.3 bits (103), Expect = 2e-04
Identities = 17/33 (51%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = -2
Query: 343 PFCEDTGMYKPVQCVGAA--CWCVDDSGDEIKG 251
P C++ G YKP QC G+ CWCVD G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMG 371
Score = 41.2 bits (95), Expect = 0.002
Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 3/50 (6%)
Frame = -2
Query: 178 RKIIGRFFH-CDHLGNYEKVQCHGSV--CYCADSSGKKIPTSPTVHIAEC 38
+K++G++ CD G Y+ QCHGSV C+C D G ++ S +A+C
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADC 380
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,057,014
Number of Sequences: 369166
Number of extensions: 1355103
Number of successful extensions: 3803
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3510
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3729
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 3685690500
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)