Planaria EST Database

DrC_00176

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_00176
         (1400 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q26609|HXK_SCHMA  Hexokinase                                   489   e-137
sp|P52789|HXK2_HUMAN  Hexokinase, type II (HK II) (Muscle fo...   357   5e-98
sp|P05708|HXK1_RAT  Hexokinase, type I (HK I) (Brain form he...   356   1e-97
sp|O08528|HXK2_MOUSE  Hexokinase type II (HK II)                  352   2e-96
sp|P17710|HXK1_MOUSE  Hexokinase type I (HK I) (Hexokinase, ...   352   2e-96
sp|P27881|HXK2_RAT  Hexokinase type II (HK II)                    351   3e-96
sp|Q9NFT7|HXK2_DROME  Hexokinase type 2                           347   5e-95
sp|P35557|HXK4_HUMAN  Hexokinase D (Hexokinase type IV) (HK ...   345   2e-94
sp|P27595|HXK1_BOVIN  Hexokinase type I (HK I) (Brain form h...   345   2e-94
sp|P17712|HXK4_RAT  Hexokinase D (Hexokinase type IV) (HK IV...   343   7e-94

>sp|Q26609|HXK_SCHMA Hexokinase
          Length = 451

 Score =  489 bits (1258), Expect = e-137
 Identities = 248/422 (58%), Positives = 311/422 (73%), Gaps = 1/422 (0%)
 Frame = +1

Query: 1    DLKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTN 180
            DL   DYE I   + E+M  GL  +T++ +S+KMFPSYVTK P G E G FLALDLGGTN
Sbjct: 20   DLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLALDLGGTN 79

Query: 181  YRVLLVTLR-QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKL 357
            YRVL VTL  + + P I+E  Y IP +KM+G G ELF YIA+TL+DF++ + ++     L
Sbjct: 80   YRVLSVTLEGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLENNGMKDKKFDL 139

Query: 358  GFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQNLNVKCVAVVNDTV 537
            GFTFSFPC Q  L+ A LVRWTKGF+A   EG +VA LLQ  ++K+ LNVKCVAVVNDTV
Sbjct: 140  GFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKRELNVKCVAVVNDTV 199

Query: 538  GTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDG 717
            GTL SCAL+DPKC VG+IVGTGTN +YIE   +VE    D      V+IN EWGAFG+ G
Sbjct: 200  GTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELM--DGVKEPEVVINTEWGAFGEKG 257

Query: 718  CLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSL 897
             LD +RT++DK +D  SLHP +Q++EKM SGMYLGE+VR +++ L+++KILFRG+ P+ L
Sbjct: 258  ELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKILFRGDLPERL 317

Query: 898  EASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFY 1077
            +   S  T+YL++VERDP HLLY T YMLT+D +VP  E  D  IVR  CE V  RAA+ 
Sbjct: 318  KVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVRYACEMVVKRAAYL 377

Query: 1078 IGTGIACLLNRINKKEVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFVLKLSEDGSG 1257
             G GIAC+L RIN+ EVTVG+DGSL+KFH KF ERMTD+V +LK +N +F L+LSEDGSG
Sbjct: 378  AGAGIACILRRINRSEVTVGVDGSLYKFHPKFCERMTDMVDKLKPKNTRFCLRLSEDGSG 437

Query: 1258 KG 1263
            KG
Sbjct: 438  KG 439

>sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle form hexokinase)
          Length = 917

 Score =  357 bits (916), Expect = 5e-98
 Identities = 197/418 (47%), Positives = 276/418 (66%), Gaps = 10/418 (2%)
 Frame = +1

Query: 40   LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
            ++  M RGLS  TH  A VKM P+YV   P G E+G FLALDLGGTN+RVLLV +R  + 
Sbjct: 491  MKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKW 550

Query: 220  PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
              ++  N  YAIP++ M G G+ELFD+I + ++DF++   ++   + LGFTFSFPC Q +
Sbjct: 551  GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610

Query: 394  LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
            L +++L++WTKGF AS CEG+DV  LL+ AI++ +  ++  VAVVNDTVGT+ +C  +DP
Sbjct: 611  LDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDP 670

Query: 571  KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
             C VG+IVGTG+NA Y+E++  VE   E + G   + +NMEWGAFGD+GCLD +RT++D 
Sbjct: 671  HCEVGLIVGTGSNACYMEEMRNVE-LVEGEEG--RMCVNMEWGAFGDNGCLDDFRTEFDV 727

Query: 751  LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
             +DE SL+P +Q FEKM SGMYLGEIVR +L+D   R +LFRG   + L+  G F TK+L
Sbjct: 728  AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFL 787

Query: 931  SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 1110
            S++E D   LL   + +             D+ IV+ VC  VA RAA   G G+A +++R
Sbjct: 788  SQIESDCLALLQVRAILQHLGLESTC---DDSIIVKEVCTVVARRAAQLCGAGMAAVVDR 844

Query: 1111 INKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 1263
            I +       +VTVG+DG+L+K H  F + M + V  L  + ++ F+   SEDGSGKG
Sbjct: 845  IRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL--QSEDGSGKG 900


 Score =  323 bits (828), Expect = 7e-88
 Identities = 179/416 (43%), Positives = 267/416 (64%), Gaps = 10/416 (2%)
 Frame = +1

Query: 46   ENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQN--EK 219
            + M +GL A TH  A+VKM P++V   P G E G+FLALDLGGTN+RVL V +  N  +K
Sbjct: 45   KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104

Query: 220  PDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINLS 399
             +++   YAIP+D M G G +LFD+IA+ L++F+   QI+   + LGFTFSFPC Q  L 
Sbjct: 105  VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164

Query: 400  KALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPKC 576
            ++ LV WTKGF +S  EG+DV AL++ AI ++ + ++  VAVVNDTVGT+ +C   D  C
Sbjct: 165  ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNC 224

Query: 577  GVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKLL 756
             +G+IVGTG+NA Y+E++  ++    D+  +    INMEWGAFGDDG L+  RT++D+ +
Sbjct: 225  EIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGSLNDIRTEFDQEI 281

Query: 757  DEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLSE 936
            D  SL+P +Q+FEKM SGMY+GE+VRL+L+ +   ++LF G+    L  +G F TK +S+
Sbjct: 282  DMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISD 341

Query: 937  VERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI- 1113
            +E +   +      ++    + PT  ++D      +C+ V+ R+A      +A +L RI 
Sbjct: 342  IEGEKDGIRKAREVLMRLGLD-PT--QEDCVATHRICQIVSTRSASLCAATLAAVLQRIK 398

Query: 1114 -NKKE----VTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGSGKG 1263
             NK E     T+G+DGS++K H  F +R+   V +L    +++F+   SEDGSGKG
Sbjct: 399  ENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFL--RSEDGSGKG 452

>sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form hexokinase)
          Length = 918

 Score =  356 bits (913), Expect = 1e-97
 Identities = 197/418 (47%), Positives = 269/418 (64%), Gaps = 10/418 (2%)
 Frame = +1

Query: 40   LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
            L   M  GL   T+  A+VKM PS+V  +P G E G FLALDLGGTN+RVLLV +R  +K
Sbjct: 491  LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550

Query: 220  PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
              ++  N  Y+IP + M G G+ELFD+I   +SDF+    I+   + LGFTFSFPC Q N
Sbjct: 551  RTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTN 610

Query: 394  LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
            L   +L+ WTKGF A+DCEG DVA+LL++A+ + +  ++  VAVVNDTVGT+ +CA ++P
Sbjct: 611  LDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 670

Query: 571  KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
             C +G+IVGTGTNA Y+E+++ VE   E   G   + INMEWGAFGD+GCLD  RT +DK
Sbjct: 671  TCEIGLIVGTGTNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDK 727

Query: 751  LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
            ++DE SL+  +Q FEKM SGMYLGEIVR +L+D   +  LFRG+  + L+  G F TK+L
Sbjct: 728  VVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFL 787

Query: 931  SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 1110
            S++E D   LL   + +     N       D+ +V+ VC  V+ RAA   G G+A ++ +
Sbjct: 788  SQIESDRLALLQVRAILQQLGLNSTC---DDSILVKTVCGVVSKRAAQLCGAGMAAVVEK 844

Query: 1111 INKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 1263
            I +        VTVG+DG+L+K H  F   M   V +L  +  + F+  LSEDGSGKG
Sbjct: 845  IRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFL--LSEDGSGKG 900


 Score =  300 bits (768), Expect = 7e-81
 Identities = 166/423 (39%), Positives = 258/423 (60%), Gaps = 10/423 (2%)
 Frame = +1

Query: 25   NIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTL 204
            +I+   ++ M  GLS   +  ASVKM P++V  +P G E+G F+ALDLGG+++R+L V +
Sbjct: 38   DILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 97

Query: 205  R--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFP 378
               +N+   ++   Y  P++ + G G +LFD++A  L DF++  +I+   + +GFTFSFP
Sbjct: 98   NHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFP 157

Query: 379  CSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSC 555
            C Q  + +A+L+ WTK F AS  EG DV  LL  AI K+ + +   VAVVNDTVGT+ +C
Sbjct: 158  CRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTC 217

Query: 556  ALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYR 735
               D +C VG+I+GTGTNA Y+E++  ++    D+  +    IN EWGAFGDDG L+  R
Sbjct: 218  GYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIR 274

Query: 736  TKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSF 915
            T++D+ LD  SL+P +Q+FEKM SGMY+GE+VRL+L+ +    +LF G     L   G F
Sbjct: 275  TEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKF 334

Query: 916  HTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIA 1095
            +T  +S +E+D   +      +LT     P+  + D   V+ +C  V+ R+A  +   + 
Sbjct: 335  NTSDVSAIEKDKEGIQNAKE-ILTRLGVEPS--DVDCVSVQHICTIVSFRSANLVAATLG 391

Query: 1096 CLLNRIN------KKEVTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGS 1254
             +LNR+       +   TVG+DGSL+K H ++  R    + +L  + +++F+  LSE G+
Sbjct: 392  AILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFL--LSESGT 449

Query: 1255 GKG 1263
            GKG
Sbjct: 450  GKG 452

>sp|O08528|HXK2_MOUSE Hexokinase type II (HK II)
          Length = 917

 Score =  352 bits (902), Expect = 2e-96
 Identities = 193/418 (46%), Positives = 274/418 (65%), Gaps = 10/418 (2%)
 Frame = +1

Query: 40   LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
            ++  M +GLS  TH+ A VKM P+YV   P G E+G FLALDLGGTN+RVLLV +R  ++
Sbjct: 491  MKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKR 550

Query: 220  PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
              ++  N  Y+IP++ M G GEELFD+I + ++DF++   ++   + LGFTFSFPC Q +
Sbjct: 551  RGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610

Query: 394  LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
            L +++L++WTKGF AS CEG+DV  LL+ AI + +  ++  VAVVNDTVGT+ +C  +DP
Sbjct: 611  LDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYEDP 670

Query: 571  KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
             C VG+IVGTG+NA Y+E++  VE    ++  +    +NMEWGAFGD+GCLD  RT +D 
Sbjct: 671  HCEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---CVNMEWGAFGDNGCLDDLRTVFDV 727

Query: 751  LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
             +DE SL+P +Q FEKM SGMYLGEIVR +L+D   R +LFRG   + L+  G F TK+L
Sbjct: 728  AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFL 787

Query: 931  SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 1110
            S++E D   LL   + +             D+ IV+ VC  VA RAA   G G+A ++++
Sbjct: 788  SQIESDCLALLQVRAILRHLGLESTC---DDSIIVKEVCTVVARRAAQLCGAGMAAVVDK 844

Query: 1111 INKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 1263
            I +       +VTVG+DG+L+K H  F + M + V  L  + ++ F+   SEDGSGKG
Sbjct: 845  IRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFL--ESEDGSGKG 900


 Score =  325 bits (834), Expect = 1e-88
 Identities = 180/422 (42%), Positives = 270/422 (63%), Gaps = 10/422 (2%)
 Frame = +1

Query: 28   IMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR 207
            I     + M +GL A TH  A+VKM P++V   P G E G+FLALDLGGTN+RVL V + 
Sbjct: 39   ISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVT 98

Query: 208  QN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPC 381
             N  ++ +++   YAIP+D M G G +LFD+IA+ L++F+   QI++  + LGFTFSFPC
Sbjct: 99   DNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPC 158

Query: 382  SQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCA 558
             Q  L ++ LV WTKGF +S  EG+DV  L++ AI ++ + ++  VAVVNDTVGT+ +C 
Sbjct: 159  HQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCG 218

Query: 559  LQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRT 738
              D  C +G+IVGTG+NA Y+E++  ++    D+  +    INMEWGAFGDDG L+  RT
Sbjct: 219  YDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGTLNDIRT 275

Query: 739  KYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFH 918
            ++D+ +D  SL+P +Q+FEKM SGMY+GE+VRL+L+ +   ++LF+G+    L  +GSF 
Sbjct: 276  EFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFE 335

Query: 919  TKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIAC 1098
            TK +S++E D   +    +Y +     +   +E D      +C+ V+ R+A      +A 
Sbjct: 336  TKDVSDIEDDKDGIQ--KAYQILVRLGLSPLQE-DCVATHRICQIVSTRSASLCAATLAA 392

Query: 1099 LLNRI--NKKE----VTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSG 1257
            +L RI  NK E     T+G+DGS++K H  F +R+   V +L  + +++F+   SEDGSG
Sbjct: 393  VLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFL--RSEDGSG 450

Query: 1258 KG 1263
            KG
Sbjct: 451  KG 452

>sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, tumor isozyme)
          Length = 974

 Score =  352 bits (902), Expect = 2e-96
 Identities = 195/418 (46%), Positives = 267/418 (63%), Gaps = 10/418 (2%)
 Frame = +1

Query: 40   LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
            L   M  GL   T+  A+VKM PSYV  +P G E G FLALDLGGTN+RVLLV +R  +K
Sbjct: 547  LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 606

Query: 220  PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
              ++  N  Y+IP + M G G+ELFD+I   +SDF+    I+   + LGFTFSFPC Q +
Sbjct: 607  RTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTS 666

Query: 394  LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
            L   +L+ WTKGF A+DC G DVA LL++A+ + +  ++  VAVVNDTVGT+ +CA ++P
Sbjct: 667  LDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 726

Query: 571  KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
             C +G+IVGTG+NA Y+E+++ VE   E   G   + INMEWGAFGD+GCLD  RT +DK
Sbjct: 727  SCEIGLIVGTGSNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDK 783

Query: 751  LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
            ++DE SL+  +Q FEKM SGMYLGEIVR +L+D   +  LFRG+  + L+  G F TK+L
Sbjct: 784  VVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFL 843

Query: 931  SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 1110
            S++E D   LL   + +     N       D+ +V+ VC  V+ RAA   G G+A ++ +
Sbjct: 844  SQIESDRLALLQVRAILQQLGLNSTC---DDSILVKTVCGVVSKRAAQLCGAGMAAVVQK 900

Query: 1111 INKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 1263
            I +        VTVG+DG+L+K H  F   M   V +L  +  + F+  LSEDGSGKG
Sbjct: 901  IRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFL--LSEDGSGKG 956


 Score =  299 bits (766), Expect = 1e-80
 Identities = 166/423 (39%), Positives = 256/423 (60%), Gaps = 10/423 (2%)
 Frame = +1

Query: 25   NIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTL 204
            +I+   ++ M  GLS   +  ASVKM P++V  +P G E+G F+ALDLGG+++R+L V +
Sbjct: 94   DILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 153

Query: 205  RQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFP 378
               +  ++   +  Y  P++ + G G +LFD++A+ L DF++  +I+   + +GFTFSFP
Sbjct: 154  NHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFP 213

Query: 379  CSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSC 555
            C Q  + +A+L+ WTK F AS  EG DV  LL  AI K+ + +   VAVVNDTVGT+ +C
Sbjct: 214  CRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTC 273

Query: 556  ALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYR 735
               D +C VG+I+GTGTNA Y+E++  ++    D+  +    IN EWGAFGDDG L+  R
Sbjct: 274  GYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIR 330

Query: 736  TKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSF 915
            T++D+ LD  SL+P +Q+FEKM SGMY+GE+VRL+L+ +    +LF G     L   G F
Sbjct: 331  TEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKF 390

Query: 916  HTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIA 1095
             T  ++ +E D   +      +LT     P+ +  D   V+ VC  V+ R+A  +   + 
Sbjct: 391  TTSDVAAIETDKEGVQNAKE-ILTRLGVEPSHD--DCVSVQHVCTIVSFRSANLVAATLG 447

Query: 1096 CLLNRIN------KKEVTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGS 1254
             +LNR+       +   TVG+DGSL+K H ++  R    + +L  + +++F+  LSE GS
Sbjct: 448  AILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFL--LSESGS 505

Query: 1255 GKG 1263
            GKG
Sbjct: 506  GKG 508

>sp|P27881|HXK2_RAT Hexokinase type II (HK II)
          Length = 917

 Score =  351 bits (900), Expect = 3e-96
 Identities = 193/418 (46%), Positives = 274/418 (65%), Gaps = 10/418 (2%)
 Frame = +1

Query: 40   LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
            ++  M +GLS  TH  A VKM P+YV   P G E+G FLALDLGGTN+RVLLV +R  ++
Sbjct: 491  MKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKR 550

Query: 220  PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
              ++  N  Y+IP++ M G GEELFD+I + ++DF++   ++   + LGFTFSFPC Q +
Sbjct: 551  RGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610

Query: 394  LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
            L +++L++WTKGF AS CEG+DV  LL+ AI++ +  ++  VAVVNDTVGT+ +C  +DP
Sbjct: 611  LDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDP 670

Query: 571  KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
             C VG+IVGTG+NA Y+E++  VE    ++  +    +NMEWGAFGD+GCLD  RT +D 
Sbjct: 671  HCEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---CVNMEWGAFGDNGCLDDLRTVFDV 727

Query: 751  LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
             +DE SL+P +Q FEKM SGMYLGEIVR +L+D   R +LFRG   + L+  G F TK+L
Sbjct: 728  AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFL 787

Query: 931  SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 1110
            S++E D   LL   + +             D+ IV+ VC  VA RAA   G G+A ++++
Sbjct: 788  SQIESDCLALLQVRAILRHLGLESTC---DDSIIVKEVCTVVARRAAQLCGAGMAAVVDK 844

Query: 1111 INKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 1263
            I +       +VTVG+DG+L+K H  F + M + V  L  + ++ F+   SEDGSGKG
Sbjct: 845  IRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFL--ESEDGSGKG 900


 Score =  325 bits (834), Expect = 1e-88
 Identities = 179/422 (42%), Positives = 269/422 (63%), Gaps = 10/422 (2%)
 Frame = +1

Query: 28   IMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR 207
            I     + M +GL A TH  A+VKM P++V   P G E G+FLALDLGGTN+RVL V + 
Sbjct: 39   ISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVT 98

Query: 208  QN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPC 381
             N  ++ +++   YAIP+D M G G +LFD+IA+ L++F+   QI++  + LGFTFSFPC
Sbjct: 99   DNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPC 158

Query: 382  SQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCA 558
             Q  L ++ LV WTKGF +S  EG+DV  L++ AI ++ + ++  VAVVNDTVGT+ +C 
Sbjct: 159  HQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCG 218

Query: 559  LQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRT 738
              D  C +G+IVGTG+NA Y+E++  ++    D+  +    INMEWGAFGDDG L+  RT
Sbjct: 219  YDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGTLNDIRT 275

Query: 739  KYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFH 918
            ++D+ +D  SL+P +Q+FEKM SGMY+GE+VRL+L+ +   ++LF+G+    L  +GSF 
Sbjct: 276  EFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFE 335

Query: 919  TKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIAC 1098
            TK +S++E D   +      ++    N     ++D      +C+ V+ R+A      +A 
Sbjct: 336  TKDVSDIEEDKDGIEKAYQILMRLGLNP---LQEDCVATHRICQIVSTRSASLCAATLAA 392

Query: 1099 LLNRI--NKKE----VTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSG 1257
            +L RI  NK E     T+G+DGS++K H  F +R+   V +L  + +++F+   SEDGSG
Sbjct: 393  VLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFL--RSEDGSG 450

Query: 1258 KG 1263
            KG
Sbjct: 451  KG 452

>sp|Q9NFT7|HXK2_DROME Hexokinase type 2
          Length = 486

 Score =  347 bits (890), Expect = 5e-95
 Identities = 180/414 (43%), Positives = 266/414 (64%), Gaps = 2/414 (0%)
 Frame = +1

Query: 28   IMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR 207
            ++  + + +  GL+  TH  A +K F S+V  LPTGKE G++LALDLGG+N+RVLLV L 
Sbjct: 59   VVERMTKEIKMGLAKDTHARAVIKCFVSHVQDLPTGKERGKYLALDLGGSNFRVLLVNLI 118

Query: 208  QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQ 387
             N   +     Y  P+  M+G G+ LFD++A+ LS+F   H +E   + LGFTFSFP  Q
Sbjct: 119  SNSDVETMSKGYNFPQTLMSGSGKALFDFLAECLSEFCHSHGLENESLALGFTFSFPLQQ 178

Query: 388  INLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQ 564
              LSK +LV WTKGF+     G++V +LLQ AI+++ +L +  VA++NDTVGTL SCA  
Sbjct: 179  QGLSKGILVAWTKGFSCEGVVGKNVVSLLQEAIDRRGDLKINTVAILNDTVGTLMSCAFY 238

Query: 565  DPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVE-YVIINMEWGAFGDDGCLDKYRTK 741
             P C +G+IVGTG+NA Y+EK    E F   +T  +  +IIN EWGAFGD+G L+  RT 
Sbjct: 239  HPNCRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTS 298

Query: 742  YDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHT 921
            YDK +D+ + +P +Q FEK  SGMY+GE+VRLV+ D+I +  +F G   + ++   SF T
Sbjct: 299  YDKAVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKT 358

Query: 922  KYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACL 1101
             Y+S+VE D P      + +L+E   +   +E D   +R +CE V++R+A     G+  +
Sbjct: 359  AYISDVESDAPGEYRNCNKVLSE-LGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTI 417

Query: 1102 LNRINKKEVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFVLKLSEDGSGKG 1263
            +N++N  EV +GIDGS+++FH K+ + +   + +L    +KF L +SEDGSG+G
Sbjct: 418  INKMNINEVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRG 471

>sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
          Length = 465

 Score =  345 bits (884), Expect = 2e-94
 Identities = 185/431 (42%), Positives = 268/431 (62%), Gaps = 11/431 (2%)
 Frame = +1

Query: 4    LKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNY 183
            L+  D + +M  +++ M RGL   TH++ASVKM P+YV   P G E G FL+LDLGGTN+
Sbjct: 25   LQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNF 84

Query: 184  RVLLVTLRQNEKPD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPI 351
            RV+LV + + E+       K   Y+IP+D MTG  E LFDYI++ +SDF+  HQ++   +
Sbjct: 85   RVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 144

Query: 352  KLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVN 528
             LGFTFSFP    ++ K +L+ WTKGF AS  EG +V  LL++AI ++ +  +  VA+VN
Sbjct: 145  PLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVN 204

Query: 529  DTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFG 708
            DTV T+ SC  +D +C VG+IVGTG NA Y+E+++ VE    D+  +    +N EWGAFG
Sbjct: 205  DTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFG 261

Query: 709  DDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKP 888
            D G LD++  +YD+L+DE S +P QQ++EK+  G Y+GE+VRLVLL L+D  +LF GE  
Sbjct: 262  DSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEAS 321

Query: 889  KSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARA 1068
            + L   G+F T+++S+VE D        + + T      T    D  IVR  CE V+ RA
Sbjct: 322  EQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPST---TDCDIVRRACESVSTRA 378

Query: 1069 AFYIGTGIACLLNRINKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFV 1230
            A     G+A ++NR+ +        +TVG+DGS++K H  F ER    V +L   + +  
Sbjct: 379  AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL-TPSCEIT 437

Query: 1231 LKLSEDGSGKG 1263
               SE+GSG+G
Sbjct: 438  FIESEEGSGRG 448

>sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form hexokinase)
          Length = 918

 Score =  345 bits (884), Expect = 2e-94
 Identities = 189/418 (45%), Positives = 266/418 (63%), Gaps = 10/418 (2%)
 Frame = +1

Query: 40   LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
            L   M  GL   T+ +A+V M PS++  +P G E+G FLALDLGGTN+RVLLV +R  +K
Sbjct: 491  LRTEMEMGLRKETNSNATVNMLPSFLRSIPDGTEDGDFLALDLGGTNFRVLLVKIRSGKK 550

Query: 220  PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
              ++  N  Y IP + M G GEELFD+I   +SDF+    I+   + LGFTFSFPC Q +
Sbjct: 551  STVEMHNKIYRIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTS 610

Query: 394  LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
            L   +L+ WTKGF A+DC G DV  LL++A+ + +  ++  VAVVNDTVGT+ +CA ++P
Sbjct: 611  LDAGILITWTKGFKATDCVGHDVVTLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 670

Query: 571  KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
             C VG+IVGTG+NA Y+E+++ VE    ++     + INMEWGAFGD+GC D  RT +DK
Sbjct: 671  TCEVGLIVGTGSNACYMEEMKNVEMVEGNQ---RQMCINMEWGAFGDNGCSDDIRTDFDK 727

Query: 751  LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
            ++DE SL+   Q FE M SG+YLGEIVR +L+D   +  LFRG+  + L+  G F TK+L
Sbjct: 728  VVDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFL 787

Query: 931  SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 1110
            S++E D   LL   + +     N       D+ +V+ VC  V+ RAA   G G+A ++ +
Sbjct: 788  SQIESDRLALLQVRAILQQLGLNSTC---DDSILVKTVCGVVSKRAAQLCGAGMAAVVEK 844

Query: 1111 I------NKKEVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 1263
            I      ++  VTVG+DG+L+K H +F   M   V +L  + N+ F+  LSEDGSGKG
Sbjct: 845  IRENRGLDRLNVTVGVDGTLYKLHPQFSRIMHQTVKELSPKCNVSFL--LSEDGSGKG 900


 Score =  272 bits (696), Expect = 1e-72
 Identities = 159/423 (37%), Positives = 246/423 (58%), Gaps = 10/423 (2%)
 Frame = +1

Query: 25   NIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTL 204
            +IM+  ++ M  GLS   +  A+VKM P++V  +P G E+G F+ALDLGG+++R+L V +
Sbjct: 38   DIMNRFKKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 97

Query: 205  R--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFP 378
               QN    ++   Y  P++ M G G +LFD++ + L DF++  +I+   + +GFTFSFP
Sbjct: 98   NHEQNRPVHMESEVYDTPENIMHGSGSQLFDHVLECLGDFMEKKKIKDKKLPVGFTFSFP 157

Query: 379  CSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSC 555
            C Q  + +A+L+ WTK F A   EG  V  LL  AI K+ + +   VAVVNDTVGT+  C
Sbjct: 158  CRQSKIDQAILITWTKRFKARGAEGNYVVKLLDKAIKKRGDYDANIVAVVNDTVGTMIDC 217

Query: 556  ALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYR 735
               D  C VG+I+GTGTNA Y+E++ +++    D      + IN EWG  GDDG L+  R
Sbjct: 218  GYDDQHCEVGLIIGTGTNACYMEELRQIDFGWGDD---GRMCINTEWGDLGDDGSLEDIR 274

Query: 736  TKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSF 915
             ++D+     SL+P +Q FEKM SG Y+ ++VRLVL+ +    +LF G     L   G F
Sbjct: 275  KEFDREFRRGSLNPGKQRFEKMVSGRYMEDVVRLVLVKMAKEGLLFEGRITPELLTRGKF 334

Query: 916  HTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIA 1095
            +T  +S +E+D    L+    +LT    V   ++ D   V+ VC  V+ R+A  +   + 
Sbjct: 335  NTSDVSAIEKDKEG-LHNAKEILTR-LGVERSDD-DCVSVQHVCTIVSFRSANLVAATLG 391

Query: 1096 CLLNRIN------KKEVTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGS 1254
             +LNR+       +   TV +DGSL+K H ++  R    + +L  + +++F+  LSE G+
Sbjct: 392  AILNRLRDNKSTPRLRTTVRVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL--LSESGT 449

Query: 1255 GKG 1263
            GKG
Sbjct: 450  GKG 452

>sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
          Length = 465

 Score =  343 bits (880), Expect = 7e-94
 Identities = 184/431 (42%), Positives = 266/431 (61%), Gaps = 11/431 (2%)
 Frame = +1

Query: 4    LKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNY 183
            L+  D + +M  +++ M RGL   TH++ASVKM P+YV   P G E G FL+LDLGGTN+
Sbjct: 25   LQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNF 84

Query: 184  RVLLVTLRQNEKPD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPI 351
            RV+LV + + E        K   Y+IP+D MTG  E LFDYI++ +SDF+  HQ++   +
Sbjct: 85   RVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 144

Query: 352  KLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVN 528
             LGFTFSFP    +L K +L+ WTKGF AS  EG ++  LL++AI ++ +  +  VA+VN
Sbjct: 145  PLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVN 204

Query: 529  DTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFG 708
            DTV T+ SC  +D +C VG+IVGTG NA Y+E+++ VE    D+  +    +N EWGAFG
Sbjct: 205  DTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFG 261

Query: 709  DDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKP 888
            D G LD++  +YD+++DE S +P QQ++EK+  G Y+GE+VRLVLL L+D  +LF GE  
Sbjct: 262  DSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEAS 321

Query: 889  KSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARA 1068
            + L   G+F T+++S+VE D        + + T           D  IVR  CE V+ RA
Sbjct: 322  EQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPSV---TDCDIVRRACESVSTRA 378

Query: 1069 AFYIGTGIACLLNRINKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFV 1230
            A     G+A ++NR+ +        +TVG+DGS++K H  F ER    V +L   N +  
Sbjct: 379  AHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL-TPNCEIT 437

Query: 1231 LKLSEDGSGKG 1263
               SE+GSG+G
Sbjct: 438  FIESEEGSGRG 448

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 153,117,605
Number of Sequences: 369166
Number of extensions: 3170628
Number of successful extensions: 8947
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8220
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 8731
length of database: 68,354,980
effective HSP length: 114
effective length of database: 47,295,190
effective search space used: 16647906880
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Cluster detail

DrC_00176

  1. Dr_sW_009_D10
  2. Dr_sW_005_G15
  3. Dr_sW_003_C07
  4. Dr_sW_015_N07