Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_015_N07
(827 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26609|HXK_SCHMA Hexokinase 270 3e-72
sp|Q9NFT7|HXK2_DROME Hexokinase type 2 184 3e-46
sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form he... 181 2e-45
sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle fo... 181 2e-45
sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, ... 180 5e-45
sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form h... 177 4e-44
sp|O08528|HXK2_MOUSE Hexokinase type II (HK II) 176 7e-44
sp|P27881|HXK2_RAT Hexokinase type II (HK II) 176 7e-44
sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK ... 174 2e-43
sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV... 174 3e-43
>sp|Q26609|HXK_SCHMA Hexokinase
Length = 451
Score = 270 bits (691), Expect = 3e-72
Identities = 134/230 (58%), Positives = 171/230 (74%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTGTN +YIE +VE D V+IN EWGAFG+ G LD +RT++DK
Sbjct: 212 CAVGLIVGTGTNVAYIEDSSKVELM--DGVKEPEVVINTEWGAFGEKGELDCWRTQFDKS 269
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+D SLHP +Q++EKM SGMYLGE+VR +++ L+++KILFRG+ P+ L+ S T+YL+
Sbjct: 270 MDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKILFRGDLPERLKVRNSLLTRYLT 329
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
+VERDP HLLY T YMLT+D +VP E D IVR CE V RAA+ G GIAC+L RI
Sbjct: 330 DVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVRYACEMVVKRAAYLAGAGIACILRRI 389
Query: 541 NKKEVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFVLKLSEDGSGKG 690
N+ EVTVG+DGSL+KFH KF ERMTD+V +LK +N +F L+LSEDGSGKG
Sbjct: 390 NRSEVTVGVDGSLYKFHPKFCERMTDMVDKLKPKNTRFCLRLSEDGSGKG 439
>sp|Q9NFT7|HXK2_DROME Hexokinase type 2
Length = 486
Score = 184 bits (466), Expect = 3e-46
Identities = 95/231 (41%), Positives = 147/231 (63%), Gaps = 1/231 (0%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVE-YVIINMEWGAFGDDGCLDKYRTKYDK 177
C +G+IVGTG+NA Y+EK E F +T + +IIN EWGAFGD+G L+ RT YDK
Sbjct: 242 CRIGLIVGTGSNACYVEKTVNAECFEGYQTSPKPSMIINCEWGAFGDNGVLEFVRTSYDK 301
Query: 178 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 357
+D+ + +P +Q FEK SGMY+GE+VRLV+ D+I + +F G + ++ SF T Y+
Sbjct: 302 AVDKVTPNPGKQTFEKCISGMYMGELVRLVITDMIAKGFMFHGIISEKIQERWSFKTAYI 361
Query: 358 SEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNR 537
S+VE D P + +L+E + +E D +R +CE V++R+A G+ ++N+
Sbjct: 362 SDVESDAPGEYRNCNKVLSE-LGILGCQEPDKEALRYICEAVSSRSAKLCACGLVTIINK 420
Query: 538 INKKEVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFVLKLSEDGSGKG 690
+N EV +GIDGS+++FH K+ + + + +L +KF L +SEDGSG+G
Sbjct: 421 MNINEVAIGIDGSVYRFHPKYHDMLQYHMKKLLKPGVKFELVVSEDGSGRG 471
>sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form hexokinase)
Length = 918
Score = 181 bits (460), Expect = 2e-45
Identities = 106/237 (44%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C +G+IVGTGTNA Y+E+++ VE E G + INMEWGAFGD+GCLD RT +DK+
Sbjct: 672 CEIGLIVGTGTNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDKV 728
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE SL+ +Q FEKM SGMYLGEIVR +L+D + LFRG+ + L+ G F TK+LS
Sbjct: 729 VDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLS 788
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D LL + + N D+ +V+ VC V+ RAA G G+A ++ +I
Sbjct: 789 QIESDRLALLQVRAILQQLGLNSTC---DDSILVKTVCGVVSKRAAQLCGAGMAAVVEKI 845
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
+ VTVG+DG+L+K H F M V +L + + F+ LSEDGSGKG
Sbjct: 846 RENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFL--LSEDGSGKG 900
Score = 155 bits (392), Expect = 1e-37
Identities = 89/237 (37%), Positives = 140/237 (59%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+I+GTGTNA Y+E++ ++ D+ + IN EWGAFGDDG L+ RT++D+
Sbjct: 224 CEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIRTEFDRE 280
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
LD SL+P +Q+FEKM SGMY+GE+VRL+L+ + +LF G L G F+T +S
Sbjct: 281 LDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKFNTSDVS 340
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
+E+D + +LT P+ + D V+ +C V+ R+A + + +LNR+
Sbjct: 341 AIEKDKEGIQNAKE-ILTRLGVEPS--DVDCVSVQHICTIVSFRSANLVAATLGAILNRL 397
Query: 541 N------KKEVTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGSGKG 690
+ TVG+DGSL+K H ++ R + +L + +++F+ LSE G+GKG
Sbjct: 398 RDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFL--LSESGTGKG 452
>sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle form hexokinase)
Length = 917
Score = 181 bits (459), Expect = 2e-45
Identities = 107/237 (45%), Positives = 149/237 (62%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTG+NA Y+E++ VE E + G + +NMEWGAFGD+GCLD +RT++D
Sbjct: 672 CEVGLIVGTGSNACYMEEMRNVE-LVEGEEG--RMCVNMEWGAFGDNGCLDDFRTEFDVA 728
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+ G F TK+LS
Sbjct: 729 VDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLS 788
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D LL + + D+ IV+ VC VA RAA G G+A +++RI
Sbjct: 789 QIESDCLALLQVRAILQHLGLESTC---DDSIIVKEVCTVVARRAAQLCGAGMAAVVDRI 845
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
+ +VTVG+DG+L+K H F + M + V L + ++ F+ SEDGSGKG
Sbjct: 846 RENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDVSFL--QSEDGSGKG 900
Score = 156 bits (394), Expect = 7e-38
Identities = 91/237 (38%), Positives = 145/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C +G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+
Sbjct: 224 CEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGSLNDIRTEFDQE 280
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF G+ L +G F TK +S
Sbjct: 281 IDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDIS 340
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E + + ++ + PT ++D +C+ V+ R+A +A +L RI
Sbjct: 341 DIEGEKDGIRKAREVLMRLGLD-PT--QEDCVATHRICQIVSTRSASLCAATLAAVLQRI 397
Query: 541 --NKKE----VTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGSGKG 690
NK E T+G+DGS++K H F +R+ V +L +++F+ SEDGSGKG
Sbjct: 398 KENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCDVRFL--RSEDGSGKG 452
>sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, tumor isozyme)
Length = 974
Score = 180 bits (456), Expect = 5e-45
Identities = 105/237 (44%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C +G+IVGTG+NA Y+E+++ VE E G + INMEWGAFGD+GCLD RT +DK+
Sbjct: 728 CEIGLIVGTGSNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDKV 784
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE SL+ +Q FEKM SGMYLGEIVR +L+D + LFRG+ + L+ G F TK+LS
Sbjct: 785 VDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLS 844
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D LL + + N D+ +V+ VC V+ RAA G G+A ++ +I
Sbjct: 845 QIESDRLALLQVRAILQQLGLNSTC---DDSILVKTVCGVVSKRAAQLCGAGMAAVVQKI 901
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
+ VTVG+DG+L+K H F M V +L + + F+ LSEDGSGKG
Sbjct: 902 RENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFL--LSEDGSGKG 956
Score = 154 bits (389), Expect = 3e-37
Identities = 90/237 (37%), Positives = 138/237 (58%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+I+GTGTNA Y+E++ ++ D+ + IN EWGAFGDDG L+ RT++D+
Sbjct: 280 CEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIRTEFDRE 336
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
LD SL+P +Q+FEKM SGMY+GE+VRL+L+ + +LF G L G F T ++
Sbjct: 337 LDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVA 396
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
+E D + +LT P+ + D V+ VC V+ R+A + + +LNR+
Sbjct: 397 AIETDKEGVQNAKE-ILTRLGVEPSHD--DCVSVQHVCTIVSFRSANLVAATLGAILNRL 453
Query: 541 N------KKEVTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGSGKG 690
+ TVG+DGSL+K H ++ R + +L + +++F+ LSE GSGKG
Sbjct: 454 RDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFL--LSESGSGKG 508
>sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form hexokinase)
Length = 918
Score = 177 bits (448), Expect = 4e-44
Identities = 102/237 (43%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTG+NA Y+E+++ VE ++ + INMEWGAFGD+GC D RT +DK+
Sbjct: 672 CEVGLIVGTGSNACYMEEMKNVEMVEGNQ---RQMCINMEWGAFGDNGCSDDIRTDFDKV 728
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE SL+ Q FE M SG+YLGEIVR +L+D + LFRG+ + L+ G F TK+LS
Sbjct: 729 VDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLS 788
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D LL + + N D+ +V+ VC V+ RAA G G+A ++ +I
Sbjct: 789 QIESDRLALLQVRAILQQLGLNSTC---DDSILVKTVCGVVSKRAAQLCGAGMAAVVEKI 845
Query: 541 ------NKKEVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
++ VTVG+DG+L+K H +F M V +L + N+ F+ LSEDGSGKG
Sbjct: 846 RENRGLDRLNVTVGVDGTLYKLHPQFSRIMHQTVKELSPKCNVSFL--LSEDGSGKG 900
Score = 131 bits (329), Expect = 3e-30
Identities = 83/237 (35%), Positives = 132/237 (55%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+I+GTGTNA Y+E++ +++ D + IN EWG GDDG L+ R ++D+
Sbjct: 224 CEVGLIIGTGTNACYMEELRQIDFGWGDDGRM---CINTEWGDLGDDGSLEDIRKEFDRE 280
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
SL+P +Q FEKM SG Y+ ++VRLVL+ + +LF G L G F+T +S
Sbjct: 281 FRRGSLNPGKQRFEKMVSGRYMEDVVRLVLVKMAKEGLLFEGRITPELLTRGKFNTSDVS 340
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
+E+D L+ +LT V ++ D V+ VC V+ R+A + + +LNR+
Sbjct: 341 AIEKDKEG-LHNAKEILTR-LGVERSDD-DCVSVQHVCTIVSFRSANLVAATLGAILNRL 397
Query: 541 N------KKEVTVGIDGSLFKFHCKFPERMTDIVHQL-KNENIKFVLKLSEDGSGKG 690
+ TV +DGSL+K H ++ R + +L + +++F+ LSE G+GKG
Sbjct: 398 RDNKSTPRLRTTVRVDGSLYKTHPQYSRRFHKTLRRLVPDSDVRFL--LSESGTGKG 452
>sp|O08528|HXK2_MOUSE Hexokinase type II (HK II)
Length = 917
Score = 176 bits (446), Expect = 7e-44
Identities = 104/237 (43%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTG+NA Y+E++ VE ++ + +NMEWGAFGD+GCLD RT +D
Sbjct: 672 CEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---CVNMEWGAFGDNGCLDDLRTVFDVA 728
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+ G F TK+LS
Sbjct: 729 VDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLS 788
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D LL + + D+ IV+ VC VA RAA G G+A ++++I
Sbjct: 789 QIESDCLALLQVRAILRHLGLESTC---DDSIIVKEVCTVVARRAAQLCGAGMAAVVDKI 845
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
+ +VTVG+DG+L+K H F + M + V L + ++ F+ SEDGSGKG
Sbjct: 846 RENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFL--ESEDGSGKG 900
Score = 160 bits (405), Expect = 4e-39
Identities = 93/237 (39%), Positives = 147/237 (62%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C +G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+
Sbjct: 224 CEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGTLNDIRTEFDRE 280
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF+G+ L +GSF TK +S
Sbjct: 281 IDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVS 340
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D + +Y + + +E D +C+ V+ R+A +A +L RI
Sbjct: 341 DIEDDKDGIQ--KAYQILVRLGLSPLQE-DCVATHRICQIVSTRSASLCAATLAAVLWRI 397
Query: 541 --NKKE----VTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
NK E T+G+DGS++K H F +R+ V +L + +++F+ SEDGSGKG
Sbjct: 398 KENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFL--RSEDGSGKG 452
>sp|P27881|HXK2_RAT Hexokinase type II (HK II)
Length = 917
Score = 176 bits (446), Expect = 7e-44
Identities = 104/237 (43%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTG+NA Y+E++ VE ++ + +NMEWGAFGD+GCLD RT +D
Sbjct: 672 CEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---CVNMEWGAFGDNGCLDDLRTVFDVA 728
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+ G F TK+LS
Sbjct: 729 VDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLS 788
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D LL + + D+ IV+ VC VA RAA G G+A ++++I
Sbjct: 789 QIESDCLALLQVRAILRHLGLESTC---DDSIIVKEVCTVVARRAAQLCGAGMAAVVDKI 845
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
+ +VTVG+DG+L+K H F + M + V L + ++ F+ SEDGSGKG
Sbjct: 846 RENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFL--ESEDGSGKG 900
Score = 160 bits (405), Expect = 4e-39
Identities = 92/237 (38%), Positives = 146/237 (61%), Gaps = 7/237 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C +G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+
Sbjct: 224 CEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGTLNDIRTEFDRE 280
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF+G+ L +GSF TK +S
Sbjct: 281 IDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVS 340
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
++E D + ++ N ++D +C+ V+ R+A +A +L RI
Sbjct: 341 DIEEDKDGIEKAYQILMRLGLNP---LQEDCVATHRICQIVSTRSASLCAATLAAVLWRI 397
Query: 541 --NKKE----VTVGIDGSLFKFHCKFPERMTDIVHQLKNE-NIKFVLKLSEDGSGKG 690
NK E T+G+DGS++K H F +R+ V +L + +++F+ SEDGSGKG
Sbjct: 398 KENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFL--RSEDGSGKG 452
>sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 174 bits (442), Expect = 2e-43
Identities = 96/236 (40%), Positives = 140/236 (59%), Gaps = 6/236 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFGD G LD++ +YD+L
Sbjct: 220 CEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFGDSGELDEFLLEYDRL 276
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE S +P QQ++EK+ G Y+GE+VRLVLL L+D +LF GE + L G+F T+++S
Sbjct: 277 VDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVS 336
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
+VE D + + T T D IVR CE V+ RAA G+A ++NR+
Sbjct: 337 QVESDTGDRKQIYNILSTLGLRPST---TDCDIVRRACESVSTRAAHMCSAGLAGVINRM 393
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFVLKLSEDGSGKG 690
+ +TVG+DGS++K H F ER V +L + + SE+GSG+G
Sbjct: 394 RESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL-TPSCEITFIESEEGSGRG 448
>sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 174 bits (440), Expect = 3e-43
Identities = 95/236 (40%), Positives = 139/236 (58%), Gaps = 6/236 (2%)
Frame = +1
Query: 1 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 180
C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFGD G LD++ +YD++
Sbjct: 220 CEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFGDSGELDEFLLEYDRM 276
Query: 181 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLS 360
+DE S +P QQ++EK+ G Y+GE+VRLVLL L+D +LF GE + L G+F T+++S
Sbjct: 277 VDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVS 336
Query: 361 EVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVCEKVAARAAFYIGTGIACLLNRI 540
+VE D + + T D IVR CE V+ RAA G+A ++NR+
Sbjct: 337 QVESDSGDRKQIHNILSTLGLRPSV---TDCDIVRRACESVSTRAAHMCSAGLAGVINRM 393
Query: 541 NKK------EVTVGIDGSLFKFHCKFPERMTDIVHQLKNENIKFVLKLSEDGSGKG 690
+ +TVG+DGS++K H F ER V +L N + SE+GSG+G
Sbjct: 394 RESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRL-TPNCEITFIESEEGSGRG 448
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,374,316
Number of Sequences: 369166
Number of extensions: 1757111
Number of successful extensions: 5064
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4692
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4941
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)