Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_003_C07
(917 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26609|HXK_SCHMA Hexokinase 347 3e-95
sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form he... 282 1e-75
sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle fo... 280 5e-75
sp|P27881|HXK2_RAT Hexokinase type II (HK II) 277 3e-74
sp|O08528|HXK2_MOUSE Hexokinase type II (HK II) 277 3e-74
sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, ... 276 6e-74
sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form h... 269 7e-72
sp|P52790|HXK3_HUMAN Hexokinase type III (HK III) 267 3e-71
sp|P27926|HXK3_RAT Hexokinase type III (HK III) 264 2e-70
sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK ... 260 3e-69
>sp|Q26609|HXK_SCHMA Hexokinase
Length = 451
Score = 347 bits (890), Expect = 3e-95
Identities = 177/303 (58%), Positives = 222/303 (73%), Gaps = 1/303 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLR-QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIKI 184
FLALDLGGTNYRVL VTL + + P I+E Y IP +KM+G G ELF YIA+TL DF++
Sbjct: 70 FLALDLGGTNYRVLSVTLEGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLEN 129
Query: 185 HQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQNLNV 364
+ ++ LGFTFSFPC Q L+ A LVRWTKGF+A EG +VA LLQ ++K+ LNV
Sbjct: 130 NGMKDKKFDLGFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKRELNV 189
Query: 365 KCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIIN 544
KCVAVVNDTVGTL SCAL+DPKC VG+IVGTGTN +YIE +VE D V+IN
Sbjct: 190 KCVAVVNDTVGTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELM--DGVKEPEVVIN 247
Query: 545 MEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKI 724
EWGAFG+ G LD +RT++DK +D SLHP +Q++EKM SGMYLGE+VR +++ L+++KI
Sbjct: 248 TEWGAFGEKGELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKI 307
Query: 725 LFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVC 904
LFRG+ P+ L+ S T+YL++VERDP HLLY T YMLT+D +VP E D IVR C
Sbjct: 308 LFRGDLPERLKVRNSLLTRYLTDVERDPAHLLYNTHYMLTDDLHVPVVEPIDNRIVRYAC 367
Query: 905 EKV 913
E V
Sbjct: 368 EMV 370
>sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form hexokinase)
Length = 918
Score = 282 bits (721), Expect = 1e-75
Identities = 150/306 (49%), Positives = 206/306 (67%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVLLV +R +K ++ N Y+IP + M G G+ELFD+I + DF+
Sbjct: 528 FLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLD 587
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNL 358
I+ + LGFTFSFPC Q NL +L+ WTKGF A+DCEG DVA+LL++A+ + +
Sbjct: 588 YMGIKGPRMPLGFTFSFPCHQTNLDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEF 647
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +CA ++P C +G+IVGTGTNA Y+E+++ VE E G +
Sbjct: 648 DLDVVAVVNDTVGTMMTCAYEEPTCEIGLIVGTGTNACYMEEMKNVE-MVEGNQG--QMC 704
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
INMEWGAFGD+GCLD RT +DK++DE SL+ +Q FEKM SGMYLGEIVR +L+D +
Sbjct: 705 INMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKK 764
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
LFRG+ + L+ G F TK+LS++E D LL + + N D+ +V+
Sbjct: 765 GFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTC---DDSILVKT 821
Query: 899 VCEKVA 916
VC V+
Sbjct: 822 VCGVVS 827
Score = 235 bits (599), Expect = 1e-61
Identities = 119/269 (44%), Positives = 177/269 (65%), Gaps = 3/269 (1%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLR--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIK 181
F+ALDLGG+++R+L V + +N+ ++ Y P++ + G G +LFD++A L DF++
Sbjct: 80 FIALDLGGSSFRILRVQVNHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFME 139
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NL 358
+I+ + +GFTFSFPC Q + +A+L+ WTK F AS EG DV LL AI K+ +
Sbjct: 140 KKKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
+ VAVVNDTVGT+ +C D +C VG+I+GTGTNA Y+E++ ++ D+ +
Sbjct: 200 DANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---C 256
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
IN EWGAFGDDG L+ RT++D+ LD SL+P +Q+FEKM SGMY+GE+VRL+L+ +
Sbjct: 257 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 316
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERD 805
+LF G L G F+T +S +E+D
Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKD 345
>sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle form hexokinase)
Length = 917
Score = 280 bits (715), Expect = 5e-75
Identities = 149/306 (48%), Positives = 208/306 (67%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVLLV +R + ++ N YAIP++ M G G+ELFD+I + + DF++
Sbjct: 528 FLALDLGGTNFRVLLVRVRNGKWGGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLE 587
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNL 358
++ + LGFTFSFPC Q +L +++L++WTKGF AS CEG+DV LL+ AI++ +
Sbjct: 588 YMGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEF 647
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +C +DP C VG+IVGTG+NA Y+E++ VE E + G +
Sbjct: 648 DLDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVE-LVEGEEG--RMC 704
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
+NMEWGAFGD+GCLD +RT++D +DE SL+P +Q FEKM SGMYLGEIVR +L+D R
Sbjct: 705 VNMEWGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
+LFRG + L+ G F TK+LS++E D LL + + D+ IV+
Sbjct: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTC---DDSIIVKE 821
Query: 899 VCEKVA 916
VC VA
Sbjct: 822 VCTVVA 827
Score = 253 bits (647), Expect = 4e-67
Identities = 134/306 (43%), Positives = 201/306 (65%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVL V + N +K +++ YAIP+D M G G +LFD+IA+ L +F+
Sbjct: 80 FLALDLGGTNFRVLWVKVTDNGLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMD 139
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NL 358
QI+ + LGFTFSFPC Q L ++ LV WTKGF +S EG+DV AL++ AI ++ +
Sbjct: 140 KLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDF 199
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +C D C +G+IVGTG+NA Y+E++ ++ D+ +
Sbjct: 200 DIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---C 256
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
INMEWGAFGDDG L+ RT++D+ +D SL+P +Q+FEKM SGMY+GE+VRL+L+ +
Sbjct: 257 INMEWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKE 316
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
++LF G+ L +G F TK +S++E + + ++ + PT ++D
Sbjct: 317 ELLFGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLD-PT--QEDCVATHR 373
Query: 899 VCEKVA 916
+C+ V+
Sbjct: 374 ICQIVS 379
>sp|P27881|HXK2_RAT Hexokinase type II (HK II)
Length = 917
Score = 277 bits (709), Expect = 3e-74
Identities = 147/306 (48%), Positives = 206/306 (67%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVLLV +R ++ ++ N Y+IP++ M G GEELFD+I + + DF++
Sbjct: 528 FLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLE 587
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNL 358
++ + LGFTFSFPC Q +L +++L++WTKGF AS CEG+DV LL+ AI++ +
Sbjct: 588 YMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEF 647
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +C +DP C VG+IVGTG+NA Y+E++ VE ++ +
Sbjct: 648 DLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---C 704
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
+NMEWGAFGD+GCLD RT +D +DE SL+P +Q FEKM SGMYLGEIVR +L+D R
Sbjct: 705 VNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
+LFRG + L+ G F TK+LS++E D LL + + D+ IV+
Sbjct: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTC---DDSIIVKE 821
Query: 899 VCEKVA 916
VC VA
Sbjct: 822 VCTVVA 827
Score = 256 bits (654), Expect = 6e-68
Identities = 129/269 (47%), Positives = 189/269 (70%), Gaps = 3/269 (1%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVL V + N ++ +++ YAIP+D M G G +LFD+IA+ L +F+
Sbjct: 80 FLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMD 139
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NL 358
QI++ + LGFTFSFPC Q L ++ LV WTKGF +S EG+DV L++ AI ++ +
Sbjct: 140 KLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDF 199
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +C D C +G+IVGTG+NA Y+E++ ++ D+ +
Sbjct: 200 DIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---C 256
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
INMEWGAFGDDG L+ RT++D+ +D SL+P +Q+FEKM SGMY+GE+VRL+L+ +
Sbjct: 257 INMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKA 316
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERD 805
++LF+G+ L +GSF TK +S++E D
Sbjct: 317 ELLFQGKLSPELLTTGSFETKDVSDIEED 345
>sp|O08528|HXK2_MOUSE Hexokinase type II (HK II)
Length = 917
Score = 277 bits (708), Expect = 3e-74
Identities = 147/306 (48%), Positives = 205/306 (66%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVLLV +R ++ ++ N Y+IP++ M G GEELFD+I + + DF++
Sbjct: 528 FLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLE 587
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNL 358
++ + LGFTFSFPC Q +L +++L++WTKGF AS CEG+DV LL+ AI + +
Sbjct: 588 YMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEF 647
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +C +DP C VG+IVGTG+NA Y+E++ VE ++ +
Sbjct: 648 DLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---C 704
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
+NMEWGAFGD+GCLD RT +D +DE SL+P +Q FEKM SGMYLGEIVR +L+D R
Sbjct: 705 VNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKR 764
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
+LFRG + L+ G F TK+LS++E D LL + + D+ IV+
Sbjct: 765 GLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTC---DDSIIVKE 821
Query: 899 VCEKVA 916
VC VA
Sbjct: 822 VCTVVA 827
Score = 256 bits (653), Expect = 8e-68
Identities = 134/306 (43%), Positives = 202/306 (66%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVL V + N ++ +++ YAIP+D M G G +LFD+IA+ L +F+
Sbjct: 80 FLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMD 139
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NL 358
QI++ + LGFTFSFPC Q L ++ LV WTKGF +S EG+DV L++ AI ++ +
Sbjct: 140 KLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDF 199
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +C D C +G+IVGTG+NA Y+E++ ++ D+ +
Sbjct: 200 DIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---C 256
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
INMEWGAFGDDG L+ RT++D+ +D SL+P +Q+FEKM SGMY+GE+VRL+L+ +
Sbjct: 257 INMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKA 316
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
++LF+G+ L +GSF TK +S++E D + +Y + + +E D
Sbjct: 317 ELLFQGKLSPELLTTGSFETKDVSDIEDDKDGIQ--KAYQILVRLGLSPLQE-DCVATHR 373
Query: 899 VCEKVA 916
+C+ V+
Sbjct: 374 ICQIVS 379
>sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, tumor isozyme)
Length = 974
Score = 276 bits (706), Expect = 6e-74
Identities = 147/306 (48%), Positives = 204/306 (66%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVLLV +R +K ++ N Y+IP + M G G+ELFD+I + DF+
Sbjct: 584 FLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLD 643
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNL 358
I+ + LGFTFSFPC Q +L +L+ WTKGF A+DC G DVA LL++A+ + +
Sbjct: 644 YMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEF 703
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +CA ++P C +G+IVGTG+NA Y+E+++ VE E G +
Sbjct: 704 DLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVE-MVEGNQG--QMC 760
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
INMEWGAFGD+GCLD RT +DK++DE SL+ +Q FEKM SGMYLGEIVR +L+D +
Sbjct: 761 INMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKK 820
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
LFRG+ + L+ G F TK+LS++E D LL + + N D+ +V+
Sbjct: 821 GFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTC---DDSILVKT 877
Query: 899 VCEKVA 916
VC V+
Sbjct: 878 VCGVVS 883
Score = 233 bits (593), Expect = 7e-61
Identities = 117/269 (43%), Positives = 175/269 (65%), Gaps = 3/269 (1%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
F+ALDLGG+++R+L V + + ++ + Y P++ + G G +LFD++A+ L DF++
Sbjct: 136 FIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 195
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NL 358
+I+ + +GFTFSFPC Q + +A+L+ WTK F AS EG DV LL AI K+ +
Sbjct: 196 KRKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDY 255
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
+ VAVVNDTVGT+ +C D +C VG+I+GTGTNA Y+E++ ++ D+ +
Sbjct: 256 DANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---C 312
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
IN EWGAFGDDG L+ RT++D+ LD SL+P +Q+FEKM SGMY+GE+VRL+L+ +
Sbjct: 313 INTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKE 372
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERD 805
+LF G L G F T ++ +E D
Sbjct: 373 SLLFEGRITPELLTRGKFTTSDVAAIETD 401
>sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form hexokinase)
Length = 918
Score = 269 bits (688), Expect = 7e-72
Identities = 143/306 (46%), Positives = 199/306 (65%), Gaps = 3/306 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLFDFIK 181
FLALDLGGTN+RVLLV +R +K ++ N Y IP + M G GEELFD+I + DF+
Sbjct: 528 FLALDLGGTNFRVLLVKIRSGKKSTVEMHNKIYRIPIEIMQGTGEELFDHIVSCISDFLD 587
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNL 358
I+ + LGFTFSFPC Q +L +L+ WTKGF A+DC G DV LL++A+ + +
Sbjct: 588 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAVKRREEF 647
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
++ VAVVNDTVGT+ +CA ++P C VG+IVGTG+NA Y+E+++ VE ++ +
Sbjct: 648 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGNQ---RQMC 704
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
INMEWGAFGD+GC D RT +DK++DE SL+ Q FE M SG+YLGEIVR +L+D +
Sbjct: 705 INMEWGAFGDNGCSDDIRTDFDKVVDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKK 764
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRA 898
LFRG+ + L+ G F TK+LS++E D LL + + N D+ +V+
Sbjct: 765 GFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTC---DDSILVKT 821
Query: 899 VCEKVA 916
VC V+
Sbjct: 822 VCGVVS 827
Score = 209 bits (532), Expect = 9e-54
Identities = 111/269 (41%), Positives = 164/269 (60%), Gaps = 3/269 (1%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLR--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIK 181
F+ALDLGG+++R+L V + QN ++ Y P++ M G G +LFD++ + L DF++
Sbjct: 80 FIALDLGGSSFRILRVQVNHEQNRPVHMESEVYDTPENIMHGSGSQLFDHVLECLGDFME 139
Query: 182 IHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NL 358
+I+ + +GFTFSFPC Q + +A+L+ WTK F A EG V LL AI K+ +
Sbjct: 140 KKKIKDKKLPVGFTFSFPCRQSKIDQAILITWTKRFKARGAEGNYVVKLLDKAIKKRGDY 199
Query: 359 NVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVI 538
+ VAVVNDTVGT+ C D C VG+I+GTGTNA Y+E++ +++ D +
Sbjct: 200 DANIVAVVNDTVGTMIDCGYDDQHCEVGLIIGTGTNACYMEELRQIDFGWGDD---GRMC 256
Query: 539 INMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDR 718
IN EWG GDDG L+ R ++D+ SL+P +Q FEKM SG Y+ ++VRLVL+ +
Sbjct: 257 INTEWGDLGDDGSLEDIRKEFDREFRRGSLNPGKQRFEKMVSGRYMEDVVRLVLVKMAKE 316
Query: 719 KILFRGEKPKSLEASGSFHTKYLSEVERD 805
+LF G L G F+T +S +E+D
Sbjct: 317 GLLFEGRITPELLTRGKFNTSDVSAIEKD 345
>sp|P52790|HXK3_HUMAN Hexokinase type III (HK III)
Length = 923
Score = 267 bits (683), Expect = 3e-71
Identities = 145/304 (47%), Positives = 196/304 (64%), Gaps = 1/304 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIKIH 187
FLALDLGGTN+RVLLV R I Y+IP+ G G++LFD+I + DF +
Sbjct: 538 FLALDLGGTNFRVLLV--RVTTGVQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQQKQ 595
Query: 188 QIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNV 364
+ + LGFTFSFPC Q+ L + +L+ WTKGF ASDCEGQDV +LL+ AI + Q + +
Sbjct: 596 GLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQAVEL 655
Query: 365 KCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIIN 544
VA+VNDTVGT+ SC +DP+C +G+IVGTGTNA Y+E++ V D + IN
Sbjct: 656 NVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRM---CIN 712
Query: 545 MEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKI 724
MEWGAFGDDG L T++D +D+ S++P +Q FEKM SGMYLGEIVR +LL L +
Sbjct: 713 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 772
Query: 725 LFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVC 904
LFRG++ + L+ F TK+LSE+E D L + + ED +P + DA +V VC
Sbjct: 773 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRA--ILEDLGLPLTSD-DALMVLEVC 829
Query: 905 EKVA 916
+ V+
Sbjct: 830 QAVS 833
Score = 211 bits (536), Expect = 3e-54
Identities = 117/272 (43%), Positives = 166/272 (61%), Gaps = 5/272 (1%)
Frame = +2
Query: 8 FLALDLG--GTNYRVLLVTLR--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDF 175
F+ L+LG G + RVL VTL + + + + + IP++ M G G++LFD+ A L +F
Sbjct: 91 FVVLELGATGASLRVLWVTLTGIEGHRVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSEF 150
Query: 176 IKIHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQN 355
+ + K ++LGF+FSFPC Q L ++ L+ WTKGF S EGQDV LL++AI +Q
Sbjct: 151 LDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQG 210
Query: 356 -LNVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEY 532
N+ VAVVNDTVGT+ C C VG++V TGTNA Y+E+ V ED+
Sbjct: 211 AYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDR---GR 267
Query: 533 VIINMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLI 712
V +++EWG+ DDG L T +D LD +SL+P Q FEKM G+YLGE+VRLVL L
Sbjct: 268 VCVSVEWGSLSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLA 327
Query: 713 DRKILFRGEKPKSLEASGSFHTKYLSEVERDP 808
+LF G +L + GS ++++E+E DP
Sbjct: 328 RCGVLFGGCTSPALLSQGSILLEHVAEME-DP 358
>sp|P27926|HXK3_RAT Hexokinase type III (HK III)
Length = 924
Score = 264 bits (675), Expect = 2e-70
Identities = 145/304 (47%), Positives = 193/304 (63%), Gaps = 1/304 (0%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLFDFIKIH 187
FLALDLGGTN+RVLLV + + I Y+IP+ G G++LFD+I + DF K
Sbjct: 538 FLALDLGGTNFRVLLVRVAEGSV-QITNQVYSIPEYVAQGSGQKLFDHIVDCIVDFQKRQ 596
Query: 188 QIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNV 364
+ + LGFTFSFPC Q+ L + +L+ WTKGF AS CEGQDV LL+ AI + Q + +
Sbjct: 597 GLSGQSLPLGFTFSFPCKQLGLDQGILLNWTKGFNASGCEGQDVVYLLREAIRRRQAVEL 656
Query: 365 KCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIIN 544
VA+VNDTVGT+ SC DP C +G+IVGTGTNA Y+E++ V + D ++ IN
Sbjct: 657 NVVAIVNDTVGTMMSCGYDDPCCEMGLIVGTGTNACYMEELRNVASVPGDSG---HMCIN 713
Query: 545 MEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKI 724
MEWGAFGDDG L T +D +D+ S++P +Q FEKM SGMYLGEIVR +LL L +
Sbjct: 714 MEWGAFGDDGSLSMLGTCFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 773
Query: 725 LFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIVRAVC 904
LFRG+K + L+ F TK+LSE+E D L + + ED + T DA +V VC
Sbjct: 774 LFRGQKTQCLQTRDIFKTKFLSEIESDSLALRQVRA--ILEDLGL-TLTSDDALMVLEVC 830
Query: 905 EKVA 916
+ V+
Sbjct: 831 QAVS 834
Score = 209 bits (533), Expect = 7e-54
Identities = 120/307 (39%), Positives = 178/307 (57%), Gaps = 5/307 (1%)
Frame = +2
Query: 8 FLALDLG--GTNYRVLLVTLRQNEKPDI--KETNYAIPKDKMTGKGEELFDYIAKTLFDF 175
FL L+LG G + RVL VTL ++ + + + IP++ + G G++LFD+ A+ L +F
Sbjct: 91 FLVLELGATGASLRVLWVTLTGTKEHSVETRSQEFVIPQEVILGAGQQLFDFAARCLSEF 150
Query: 176 IKIHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ- 352
+ + +E +KLGF FSFPC Q L K+ L+ WTKGF S EGQDV LL++AI +Q
Sbjct: 151 LDAYPVENQGLKLGFNFSFPCHQTGLDKSTLISWTKGFRCSGVEGQDVVQLLRDAIQRQG 210
Query: 353 NLNVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEY 532
N+ VA+VNDTVGT+ C L C VG+IV TGTNA Y+E+ V ED+
Sbjct: 211 TYNIDVVAMVNDTVGTMMGCELGTRPCEVGLIVDTGTNACYMEEARHVAALDEDR---GR 267
Query: 533 VIINMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLI 712
+++EWG+F D+ L T +D LD +SL P Q FEKM G+YLGE+VRLVL+ L
Sbjct: 268 TCVSIEWGSFYDEEALGPVLTTFDDALDHESLVPGAQRFEKMIGGLYLGELVRLVLVHLS 327
Query: 713 DRKILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIV 892
+LF G +L + S ++++++E + + + + + + DA +V
Sbjct: 328 QHGVLFGGCASPALLSQNSILLEHVAKMEDPATGIAHVHTVLQGLGLSP---QASDAELV 384
Query: 893 RAVCEKV 913
+ VC V
Sbjct: 385 QRVCMAV 391
>sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 260 bits (665), Expect = 3e-69
Identities = 137/308 (44%), Positives = 197/308 (63%), Gaps = 5/308 (1%)
Frame = +2
Query: 8 FLALDLGGTNYRVLLVTLRQNEKPD----IKETNYAIPKDKMTGKGEELFDYIAKTLFDF 175
FL+LDLGGTN+RV+LV + + E+ K Y+IP+D MTG E LFDYI++ + DF
Sbjct: 74 FLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 133
Query: 176 IKIHQIEKWPIKLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ- 352
+ HQ++ + LGFTFSFP ++ K +L+ WTKGF AS EG +V LL++AI ++
Sbjct: 134 LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRG 193
Query: 353 NLNVKCVAVVNDTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEY 532
+ + VA+VNDTV T+ SC +D +C VG+IVGTG NA Y+E+++ VE D+ +
Sbjct: 194 DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM-- 251
Query: 533 VIINMEWGAFGDDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLI 712
+N EWGAFGD G LD++ +YD+L+DE S +P QQ++EK+ G Y+GE+VRLVLL L+
Sbjct: 252 -CVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLV 310
Query: 713 DRKILFRGEKPKSLEASGSFHTKYLSEVERDPPHLLYCTSYMLTEDFNVPTFEEKDAAIV 892
D +LF GE + L G+F T+++S+VE D + + T T D IV
Sbjct: 311 DENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPST---TDCDIV 367
Query: 893 RAVCEKVA 916
R CE V+
Sbjct: 368 RRACESVS 375
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,659,807
Number of Sequences: 369166
Number of extensions: 2253120
Number of successful extensions: 6795
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6267
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6643
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9366655350
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)