Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_009_D10
(873 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26609|HXK_SCHMA Hexokinase 331 1e-90
sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle fo... 295 9e-80
sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form he... 293 4e-79
sp|O08528|HXK2_MOUSE Hexokinase type II (HK II) 291 2e-78
sp|P27881|HXK2_RAT Hexokinase type II (HK II) 290 3e-78
sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, ... 289 8e-78
sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form h... 279 8e-75
sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK ... 278 1e-74
sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV... 277 2e-74
sp|P52792|HXK4_MOUSE Hexokinase D (Hexokinase type IV) (HK ... 274 2e-73
>sp|Q26609|HXK_SCHMA Hexokinase
Length = 451
Score = 331 bits (849), Expect = 1e-90
Identities = 167/286 (58%), Positives = 214/286 (74%), Gaps = 1/286 (0%)
Frame = +3
Query: 12 ENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR-QNEKP 188
E+M GL +T++ +S+KMFPSYVTK P G E G FLALDLGGTNYRVL VTL + + P
Sbjct: 35 ESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLALDLGGTNYRVLSVTLEGKGKSP 94
Query: 189 DIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINLSK 368
I+E Y IP +KM+G G ELF YIA+TL+DF++ + ++ LGFTFSFPC Q L+
Sbjct: 95 RIQERTYCIPAEKMSGSGTELFKYIAETLADFLENNGMKDKKFDLGFTFSFPCVQKGLTH 154
Query: 369 ALLVRWTKGFTASDCEGQDVAALLQNAINKQNLNVKCVAVVNDTVGTLTSCALQDPKCGV 548
A LVRWTKGF+A EG +VA LLQ ++K+ LNVKCVAVVNDTVGTL SCAL+DPKC V
Sbjct: 155 ATLVRWTKGFSADGVEGHNVAELLQTELDKRELNVKCVAVVNDTVGTLASCALEDPKCAV 214
Query: 549 GVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKLLDE 728
G+IVGTGTN +YIE +VE D V+IN EWGAFG+ G LD +RT++DK +D
Sbjct: 215 GLIVGTGTNVAYIEDSSKVELM--DGVKEPEVVINTEWGAFGEKGELDCWRTQFDKSMDI 272
Query: 729 QSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
SLHP +Q++EKM SGMYLGE+VR +++ L+++KILFRG+ P+ L+
Sbjct: 273 DSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKILFRGDLPERLK 318
>sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle form hexokinase)
Length = 917
Score = 295 bits (756), Expect = 9e-80
Identities = 150/290 (51%), Positives = 207/290 (71%), Gaps = 3/290 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
++ M RGLS TH A VKM P+YV P G E+G FLALDLGGTN+RVLLV +R +
Sbjct: 491 MKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKW 550
Query: 186 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 359
++ N YAIP++ M G G+ELFD+I + ++DF++ ++ + LGFTFSFPC Q +
Sbjct: 551 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610
Query: 360 LSKALLVRWTKGFTASDCEGQDVAALLQNAIN-KQNLNVKCVAVVNDTVGTLTSCALQDP 536
L +++L++WTKGF AS CEG+DV LL+ AI+ ++ ++ VAVVNDTVGT+ +C +DP
Sbjct: 611 LDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDP 670
Query: 537 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 716
C VG+IVGTG+NA Y+E++ VE E + G + +NMEWGAFGD+GCLD +RT++D
Sbjct: 671 HCEVGLIVGTGSNACYMEEMRNVE-LVEGEEG--RMCVNMEWGAFGDNGCLDDFRTEFDV 727
Query: 717 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+
Sbjct: 728 AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLK 777
Score = 275 bits (704), Expect = 9e-74
Identities = 138/282 (48%), Positives = 198/282 (70%), Gaps = 3/282 (1%)
Frame = +3
Query: 12 ENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQN--EK 185
+ M +GL A TH A+VKM P++V P G E G+FLALDLGGTN+RVL V + N +K
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 186 PDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINLS 365
+++ YAIP+D M G G +LFD+IA+ L++F+ QI+ + LGFTFSFPC Q L
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 366 KALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPKC 542
++ LV WTKGF +S EG+DV AL++ AI ++ + ++ VAVVNDTVGT+ +C D C
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNC 224
Query: 543 GVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKLL 722
+G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+ +
Sbjct: 225 EIGLIVGTGSNACYMEEMRHIDMVEGDE---GRMCINMEWGAFGDDGSLNDIRTEFDQEI 281
Query: 723 DEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGE 848
D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF G+
Sbjct: 282 DMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGK 323
>sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form hexokinase)
Length = 918
Score = 293 bits (750), Expect = 4e-79
Identities = 151/290 (52%), Positives = 202/290 (69%), Gaps = 3/290 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
L M GL T+ A+VKM PS+V +P G E G FLALDLGGTN+RVLLV +R +K
Sbjct: 491 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 186 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 359
++ N Y+IP + M G G+ELFD+I +SDF+ I+ + LGFTFSFPC Q N
Sbjct: 551 RTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTN 610
Query: 360 LSKALLVRWTKGFTASDCEGQDVAALLQNAI-NKQNLNVKCVAVVNDTVGTLTSCALQDP 536
L +L+ WTKGF A+DCEG DVA+LL++A+ ++ ++ VAVVNDTVGT+ +CA ++P
Sbjct: 611 LDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 670
Query: 537 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 716
C +G+IVGTGTNA Y+E+++ VE E G + INMEWGAFGD+GCLD RT +DK
Sbjct: 671 TCEIGLIVGTGTNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDK 727
Query: 717 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
++DE SL+ +Q FEKM SGMYLGEIVR +L+D + LFRG+ + L+
Sbjct: 728 VVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Score = 253 bits (646), Expect = 5e-67
Identities = 127/282 (45%), Positives = 188/282 (66%), Gaps = 3/282 (1%)
Frame = +3
Query: 9 EENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR--QNE 182
++ M GLS + ASVKM P++V +P G E+G F+ALDLGG+++R+L V + +N+
Sbjct: 44 KKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKNQ 103
Query: 183 KPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINL 362
++ Y P++ + G G +LFD++A L DF++ +I+ + +GFTFSFPC Q +
Sbjct: 104 NVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFPCRQSKI 163
Query: 363 SKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPK 539
+A+L+ WTK F AS EG DV LL AI K+ + + VAVVNDTVGT+ +C D +
Sbjct: 164 DEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQ 223
Query: 540 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 719
C VG+I+GTGTNA Y+E++ ++ D+ + IN EWGAFGDDG L+ RT++D+
Sbjct: 224 CEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIRTEFDRE 280
Query: 720 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRG 845
LD SL+P +Q+FEKM SGMY+GE+VRL+L+ + +LF G
Sbjct: 281 LDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEG 322
>sp|O08528|HXK2_MOUSE Hexokinase type II (HK II)
Length = 917
Score = 291 bits (745), Expect = 2e-78
Identities = 147/290 (50%), Positives = 205/290 (70%), Gaps = 3/290 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
++ M +GLS TH+ A VKM P+YV P G E+G FLALDLGGTN+RVLLV +R ++
Sbjct: 491 MKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKR 550
Query: 186 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 359
++ N Y+IP++ M G GEELFD+I + ++DF++ ++ + LGFTFSFPC Q +
Sbjct: 551 RGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610
Query: 360 LSKALLVRWTKGFTASDCEGQDVAALLQNAI-NKQNLNVKCVAVVNDTVGTLTSCALQDP 536
L +++L++WTKGF AS CEG+DV LL+ AI ++ ++ VAVVNDTVGT+ +C +DP
Sbjct: 611 LDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYEDP 670
Query: 537 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 716
C VG+IVGTG+NA Y+E++ VE ++ + +NMEWGAFGD+GCLD RT +D
Sbjct: 671 HCEVGLIVGTGSNACYMEEMRNVELVDGEE---GRMCVNMEWGAFGDNGCLDDLRTVFDV 727
Query: 717 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+
Sbjct: 728 AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLK 777
Score = 274 bits (701), Expect = 2e-73
Identities = 136/282 (48%), Positives = 199/282 (70%), Gaps = 3/282 (1%)
Frame = +3
Query: 12 ENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQN--EK 185
+ M +GL A TH A+VKM P++V P G E G+FLALDLGGTN+RVL V + N ++
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQR 104
Query: 186 PDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINLS 365
+++ YAIP+D M G G +LFD+IA+ L++F+ QI++ + LGFTFSFPC Q L
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLD 164
Query: 366 KALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPKC 542
++ LV WTKGF +S EG+DV L++ AI ++ + ++ VAVVNDTVGT+ +C D C
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNC 224
Query: 543 GVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKLL 722
+G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+ +
Sbjct: 225 EIGLIVGTGSNACYMEEMRHIDMVEGDE---GRMCINMEWGAFGDDGTLNDIRTEFDREI 281
Query: 723 DEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGE 848
D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF+G+
Sbjct: 282 DMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGK 323
>sp|P27881|HXK2_RAT Hexokinase type II (HK II)
Length = 917
Score = 290 bits (743), Expect = 3e-78
Identities = 147/290 (50%), Positives = 205/290 (70%), Gaps = 3/290 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
++ M +GLS TH A VKM P+YV P G E+G FLALDLGGTN+RVLLV +R ++
Sbjct: 491 MKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKR 550
Query: 186 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 359
++ N Y+IP++ M G GEELFD+I + ++DF++ ++ + LGFTFSFPC Q +
Sbjct: 551 RGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610
Query: 360 LSKALLVRWTKGFTASDCEGQDVAALLQNAIN-KQNLNVKCVAVVNDTVGTLTSCALQDP 536
L +++L++WTKGF AS CEG+DV LL+ AI+ ++ ++ VAVVNDTVGT+ +C +DP
Sbjct: 611 LDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDP 670
Query: 537 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 716
C VG+IVGTG+NA Y+E++ VE ++ + +NMEWGAFGD+GCLD RT +D
Sbjct: 671 HCEVGLIVGTGSNACYMEEMRNVELVDGEE---GRMCVNMEWGAFGDNGCLDDLRTVFDV 727
Query: 717 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+
Sbjct: 728 AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLK 777
Score = 274 bits (701), Expect = 2e-73
Identities = 136/282 (48%), Positives = 199/282 (70%), Gaps = 3/282 (1%)
Frame = +3
Query: 12 ENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQN--EK 185
+ M +GL A TH A+VKM P++V P G E G+FLALDLGGTN+RVL V + N ++
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQR 104
Query: 186 PDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINLS 365
+++ YAIP+D M G G +LFD+IA+ L++F+ QI++ + LGFTFSFPC Q L
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLD 164
Query: 366 KALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPKC 542
++ LV WTKGF +S EG+DV L++ AI ++ + ++ VAVVNDTVGT+ +C D C
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNC 224
Query: 543 GVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKLL 722
+G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+ +
Sbjct: 225 EIGLIVGTGSNACYMEEMRHIDMVEGDE---GRMCINMEWGAFGDDGTLNDIRTEFDREI 281
Query: 723 DEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGE 848
D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF+G+
Sbjct: 282 DMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGK 323
>sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, tumor isozyme)
Length = 974
Score = 289 bits (739), Expect = 8e-78
Identities = 149/290 (51%), Positives = 200/290 (68%), Gaps = 3/290 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
L M GL T+ A+VKM PSYV +P G E G FLALDLGGTN+RVLLV +R +K
Sbjct: 547 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 606
Query: 186 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 359
++ N Y+IP + M G G+ELFD+I +SDF+ I+ + LGFTFSFPC Q +
Sbjct: 607 RTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTS 666
Query: 360 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 536
L +L+ WTKGF A+DC G DVA LL++A+ + + ++ VAVVNDTVGT+ +CA ++P
Sbjct: 667 LDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 726
Query: 537 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 716
C +G+IVGTG+NA Y+E+++ VE E G + INMEWGAFGD+GCLD RT +DK
Sbjct: 727 SCEIGLIVGTGSNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDK 783
Query: 717 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
++DE SL+ +Q FEKM SGMYLGEIVR +L+D + LFRG+ + L+
Sbjct: 784 VVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLK 833
Score = 254 bits (649), Expect = 2e-67
Identities = 126/282 (44%), Positives = 188/282 (66%), Gaps = 3/282 (1%)
Frame = +3
Query: 9 EENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEKP 188
++ M GLS + ASVKM P++V +P G E+G F+ALDLGG+++R+L V + +
Sbjct: 100 KKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQ 159
Query: 189 DIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINL 362
++ + Y P++ + G G +LFD++A+ L DF++ +I+ + +GFTFSFPC Q +
Sbjct: 160 NVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKI 219
Query: 363 SKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPK 539
+A+L+ WTK F AS EG DV LL AI K+ + + VAVVNDTVGT+ +C D +
Sbjct: 220 DEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQ 279
Query: 540 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 719
C VG+I+GTGTNA Y+E++ ++ D+ + IN EWGAFGDDG L+ RT++D+
Sbjct: 280 CEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIRTEFDRE 336
Query: 720 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRG 845
LD SL+P +Q+FEKM SGMY+GE+VRL+L+ + +LF G
Sbjct: 337 LDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEG 378
>sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form hexokinase)
Length = 918
Score = 279 bits (713), Expect = 8e-75
Identities = 142/290 (48%), Positives = 196/290 (67%), Gaps = 3/290 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
L M GL T+ +A+V M PS++ +P G E+G FLALDLGGTN+RVLLV +R +K
Sbjct: 491 LRTEMEMGLRKETNSNATVNMLPSFLRSIPDGTEDGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 186 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 359
++ N Y IP + M G GEELFD+I +SDF+ I+ + LGFTFSFPC Q +
Sbjct: 551 STVEMHNKIYRIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTS 610
Query: 360 LSKALLVRWTKGFTASDCEGQDVAALLQNAI-NKQNLNVKCVAVVNDTVGTLTSCALQDP 536
L +L+ WTKGF A+DC G DV LL++A+ ++ ++ VAVVNDTVGT+ +CA ++P
Sbjct: 611 LDAGILITWTKGFKATDCVGHDVVTLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 670
Query: 537 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 716
C VG+IVGTG+NA Y+E+++ VE ++ + INMEWGAFGD+GC D RT +DK
Sbjct: 671 TCEVGLIVGTGSNACYMEEMKNVEMVEGNQ---RQMCINMEWGAFGDNGCSDDIRTDFDK 727
Query: 717 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLE 866
++DE SL+ Q FE M SG+YLGEIVR +L+D + LFRG+ + L+
Sbjct: 728 VVDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKKGFLFRGQISEPLK 777
Score = 226 bits (576), Expect = 6e-59
Identities = 118/282 (41%), Positives = 175/282 (62%), Gaps = 3/282 (1%)
Frame = +3
Query: 9 EENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR--QNE 182
++ M GLS + A+VKM P++V +P G E+G F+ALDLGG+++R+L V + QN
Sbjct: 44 KKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEQNR 103
Query: 183 KPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINL 362
++ Y P++ M G G +LFD++ + L DF++ +I+ + +GFTFSFPC Q +
Sbjct: 104 PVHMESEVYDTPENIMHGSGSQLFDHVLECLGDFMEKKKIKDKKLPVGFTFSFPCRQSKI 163
Query: 363 SKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPK 539
+A+L+ WTK F A EG V LL AI K+ + + VAVVNDTVGT+ C D
Sbjct: 164 DQAILITWTKRFKARGAEGNYVVKLLDKAIKKRGDYDANIVAVVNDTVGTMIDCGYDDQH 223
Query: 540 CGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKL 719
C VG+I+GTGTNA Y+E++ +++ D + IN EWG GDDG L+ R ++D+
Sbjct: 224 CEVGLIIGTGTNACYMEELRQIDFGWGDD---GRMCINTEWGDLGDDGSLEDIRKEFDRE 280
Query: 720 LDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRG 845
SL+P +Q FEKM SG Y+ ++VRLVL+ + +LF G
Sbjct: 281 FRRGSLNPGKQRFEKMVSGRYMEDVVRLVLVKMAKEGLLFEG 322
>sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 278 bits (712), Expect = 1e-74
Identities = 140/291 (48%), Positives = 198/291 (68%), Gaps = 5/291 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
+++ M RGL TH++ASVKM P+YV P G E G FL+LDLGGTN+RV+LV + + E+
Sbjct: 37 MQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEE 96
Query: 186 PD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQ 353
K Y+IP+D MTG E LFDYI++ +SDF+ HQ++ + LGFTFSFP
Sbjct: 97 GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRH 156
Query: 354 INLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQ 530
++ K +L+ WTKGF AS EG +V LL++AI ++ + + VA+VNDTV T+ SC +
Sbjct: 157 EDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYE 216
Query: 531 DPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKY 710
D +C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFGD G LD++ +Y
Sbjct: 217 DHQCEVGMIVGTGCNACYMEEMQNVELVEGDE---GRMCVNTEWGAFGDSGELDEFLLEY 273
Query: 711 DKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSL 863
D+L+DE S +P QQ++EK+ G Y+GE+VRLVLL L+D +LF GE + L
Sbjct: 274 DRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQL 324
>sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 277 bits (709), Expect = 2e-74
Identities = 139/291 (47%), Positives = 197/291 (67%), Gaps = 5/291 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
+++ M RGL TH++ASVKM P+YV P G E G FL+LDLGGTN+RV+LV + + E
Sbjct: 37 MQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEA 96
Query: 186 PD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQ 353
K Y+IP+D MTG E LFDYI++ +SDF+ HQ++ + LGFTFSFP
Sbjct: 97 GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRH 156
Query: 354 INLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQ 530
+L K +L+ WTKGF AS EG ++ LL++AI ++ + + VA+VNDTV T+ SC +
Sbjct: 157 EDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYE 216
Query: 531 DPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKY 710
D +C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFGD G LD++ +Y
Sbjct: 217 DRQCEVGMIVGTGCNACYMEEMQNVELVEGDE---GRMCVNTEWGAFGDSGELDEFLLEY 273
Query: 711 DKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSL 863
D+++DE S +P QQ++EK+ G Y+GE+VRLVLL L+D +LF GE + L
Sbjct: 274 DRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEASEQL 324
>sp|P52792|HXK4_MOUSE Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 274 bits (701), Expect = 2e-73
Identities = 136/291 (46%), Positives = 198/291 (68%), Gaps = 5/291 (1%)
Frame = +3
Query: 6 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 185
+++ M RGL TH++ASVKM P+YV P G E G FL+LDLGGTN+RV+LV + + E
Sbjct: 37 MQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEA 96
Query: 186 PD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQ 353
K Y+IP+D MTG E LFDYI++ +SDF+ HQ++ + LGFTFSFP
Sbjct: 97 GQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRH 156
Query: 354 INLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQ 530
++ K +L+ WTKGF AS EG ++ LL++AI ++ + + VA+VNDTV T+ SC +
Sbjct: 157 EDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYE 216
Query: 531 DPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKY 710
D +C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFG+ G LD++ +Y
Sbjct: 217 DRQCEVGMIVGTGCNACYMEEMQNVELVEGDE---GRMCVNTEWGAFGNSGELDEFLLEY 273
Query: 711 DKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSL 863
D+++DE S++P QQ++EK+ G Y+GE+VRLVLL L++ +LF GE + L
Sbjct: 274 DRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEASEQL 324
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,578,612
Number of Sequences: 369166
Number of extensions: 2158590
Number of successful extensions: 6235
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5788
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6079
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)