Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_005_G15
(987 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26609|HXK_SCHMA Hexokinase 376 e-104
sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle fo... 313 6e-85
sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form he... 311 2e-84
sp|O08528|HXK2_MOUSE Hexokinase type II (HK II) 308 1e-83
sp|P27881|HXK2_RAT Hexokinase type II (HK II) 308 2e-83
sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, ... 306 4e-83
sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK ... 300 3e-81
sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV... 299 9e-81
sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form h... 296 5e-80
sp|P52792|HXK4_MOUSE Hexokinase D (Hexokinase type IV) (HK ... 296 8e-80
>sp|Q26609|HXK_SCHMA Hexokinase
Length = 451
Score = 376 bits (965), Expect = e-104
Identities = 191/330 (57%), Positives = 242/330 (73%), Gaps = 1/330 (0%)
Frame = +1
Query: 1 DLKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTN 180
DL DYE I + E+M GL +T++ +S+KMFPSYVTK P G E G FLALDLGGTN
Sbjct: 20 DLSVVDYEEICDRMGESMRLGLQKSTNEKSSIKMFPSYVTKTPNGTETGNFLALDLGGTN 79
Query: 181 YRVLLVTLR-QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKL 357
YRVL VTL + + P I+E Y IP +KM+G G ELF YIA+TL+DF++ + ++ L
Sbjct: 80 YRVLSVTLEGKGKSPRIQERTYCIPAEKMSGSGTELFKYIAETLADFLENNGMKDKKFDL 139
Query: 358 GFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQNLNVKCVAVVNDTV 537
GFTFSFPC Q L+ A LVRWTKGF+A EG +VA LLQ ++K+ LNVKCVAVVNDTV
Sbjct: 140 GFTFSFPCVQKGLTHATLVRWTKGFSADGVEGHNVAELLQTELDKRELNVKCVAVVNDTV 199
Query: 538 GTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDG 717
GTL SCAL+DPKC VG+IVGTGTN +YIE +VE D V+IN EWGAFG+ G
Sbjct: 200 GTLASCALEDPKCAVGLIVGTGTNVAYIEDSSKVELM--DGVKEPEVVINTEWGAFGEKG 257
Query: 718 CLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSL 897
LD +RT++DK +D SLHP +Q++EKM SGMYLGE+VR +++ L+++KILFRG+ P+ L
Sbjct: 258 ELDCWRTQFDKSMDIDSLHPGKQLYEKMVSGMYLGELVRHIIVYLVEQKILFRGDLPERL 317
Query: 898 EASGSFHTKYLSEVERDPPHLLYCTSYMLT 987
+ S T+YL++VERDP HLLY T YMLT
Sbjct: 318 KVRNSLLTRYLTDVERDPAHLLYNTHYMLT 347
>sp|P52789|HXK2_HUMAN Hexokinase, type II (HK II) (Muscle form hexokinase)
Length = 917
Score = 313 bits (801), Expect = 6e-85
Identities = 158/306 (51%), Positives = 218/306 (71%), Gaps = 3/306 (0%)
Frame = +1
Query: 40 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
++ M RGLS TH A VKM P+YV P G E+G FLALDLGGTN+RVLLV +R +
Sbjct: 491 MKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKW 550
Query: 220 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
++ N YAIP++ M G G+ELFD+I + ++DF++ ++ + LGFTFSFPC Q +
Sbjct: 551 GGVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610
Query: 394 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
L +++L++WTKGF AS CEG+DV LL+ AI++ + ++ VAVVNDTVGT+ +C +DP
Sbjct: 611 LDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGFEDP 670
Query: 571 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
C VG+IVGTG+NA Y+E++ VE E + G + +NMEWGAFGD+GCLD +RT++D
Sbjct: 671 HCEVGLIVGTGSNACYMEEMRNVE-LVEGEEG--RMCVNMEWGAFGDNGCLDDFRTEFDV 727
Query: 751 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+ G F TK+L
Sbjct: 728 AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFL 787
Query: 931 SEVERD 948
S++E D
Sbjct: 788 SQIESD 793
Score = 287 bits (734), Expect = 4e-77
Identities = 145/302 (48%), Positives = 209/302 (69%), Gaps = 3/302 (0%)
Frame = +1
Query: 46 ENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQN--EK 219
+ M +GL A TH A+VKM P++V P G E G+FLALDLGGTN+RVL V + N +K
Sbjct: 45 KEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLWVKVTDNGLQK 104
Query: 220 PDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQINLS 399
+++ YAIP+D M G G +LFD+IA+ L++F+ QI+ + LGFTFSFPC Q L
Sbjct: 105 VEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKDKKLPLGFTFSFPCHQTKLD 164
Query: 400 KALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCALQDPKC 576
++ LV WTKGF +S EG+DV AL++ AI ++ + ++ VAVVNDTVGT+ +C D C
Sbjct: 165 ESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDHNC 224
Query: 577 GVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDKLL 756
+G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT++D+ +
Sbjct: 225 EIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGSLNDIRTEFDQEI 281
Query: 757 DEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYLSE 936
D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF G+ L +G F TK +S+
Sbjct: 282 DMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELLFGGKLSPELLNTGRFETKDISD 341
Query: 937 VE 942
+E
Sbjct: 342 IE 343
>sp|P05708|HXK1_RAT Hexokinase, type I (HK I) (Brain form hexokinase)
Length = 918
Score = 311 bits (796), Expect = 2e-84
Identities = 161/311 (51%), Positives = 215/311 (69%), Gaps = 3/311 (0%)
Frame = +1
Query: 40 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
L M GL T+ A+VKM PS+V +P G E G FLALDLGGTN+RVLLV +R +K
Sbjct: 491 LRTEMEMGLRKETNSKATVKMLPSFVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 220 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
++ N Y+IP + M G G+ELFD+I +SDF+ I+ + LGFTFSFPC Q N
Sbjct: 551 RTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCHQTN 610
Query: 394 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
L +L+ WTKGF A+DCEG DVA+LL++A+ + + ++ VAVVNDTVGT+ +CA ++P
Sbjct: 611 LDCGILISWTKGFKATDCEGHDVASLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 670
Query: 571 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
C +G+IVGTGTNA Y+E+++ VE E G + INMEWGAFGD+GCLD RT +DK
Sbjct: 671 TCEIGLIVGTGTNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDK 727
Query: 751 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
++DE SL+ +Q FEKM SGMYLGEIVR +L+D + LFRG+ + L+ G F TK+L
Sbjct: 728 VVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFL 787
Query: 931 SEVERDPPHLL 963
S++E D LL
Sbjct: 788 SQIESDRLALL 798
Score = 266 bits (679), Expect = 9e-71
Identities = 135/311 (43%), Positives = 202/311 (64%), Gaps = 3/311 (0%)
Frame = +1
Query: 25 NIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTL 204
+I+ ++ M GLS + ASVKM P++V +P G E+G F+ALDLGG+++R+L V +
Sbjct: 38 DILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 97
Query: 205 R--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFP 378
+N+ ++ Y P++ + G G +LFD++A L DF++ +I+ + +GFTFSFP
Sbjct: 98 NHEKNQNVSMESEIYDTPENIVHGSGTQLFDHVADCLGDFMEKKKIKDKKLPVGFTFSFP 157
Query: 379 CSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSC 555
C Q + +A+L+ WTK F AS EG DV LL AI K+ + + VAVVNDTVGT+ +C
Sbjct: 158 CRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTC 217
Query: 556 ALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYR 735
D +C VG+I+GTGTNA Y+E++ ++ D+ + IN EWGAFGDDG L+ R
Sbjct: 218 GYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIR 274
Query: 736 TKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSF 915
T++D+ LD SL+P +Q+FEKM SGMY+GE+VRL+L+ + +LF G L G F
Sbjct: 275 TEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKEGLLFEGRITPELLTRGKF 334
Query: 916 HTKYLSEVERD 948
+T +S +E+D
Sbjct: 335 NTSDVSAIEKD 345
>sp|O08528|HXK2_MOUSE Hexokinase type II (HK II)
Length = 917
Score = 308 bits (790), Expect = 1e-83
Identities = 155/306 (50%), Positives = 216/306 (70%), Gaps = 3/306 (0%)
Frame = +1
Query: 40 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
++ M +GLS TH+ A VKM P+YV P G E+G FLALDLGGTN+RVLLV +R ++
Sbjct: 491 MKVEMEQGLSKETHEAAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKR 550
Query: 220 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
++ N Y+IP++ M G GEELFD+I + ++DF++ ++ + LGFTFSFPC Q +
Sbjct: 551 RGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610
Query: 394 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
L +++L++WTKGF AS CEG+DV LL+ AI + + ++ VAVVNDTVGT+ +C +DP
Sbjct: 611 LDQSILLKWTKGFKASGCEGEDVVTLLKEAIRRREEFDLDVVAVVNDTVGTMMTCGYEDP 670
Query: 571 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
C VG+IVGTG+NA Y+E++ VE ++ + +NMEWGAFGD+GCLD RT +D
Sbjct: 671 HCEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---CVNMEWGAFGDNGCLDDLRTVFDV 727
Query: 751 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+ G F TK+L
Sbjct: 728 AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFL 787
Query: 931 SEVERD 948
S++E D
Sbjct: 788 SQIESD 793
Score = 290 bits (742), Expect = 4e-78
Identities = 146/310 (47%), Positives = 213/310 (68%), Gaps = 3/310 (0%)
Frame = +1
Query: 28 IMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR 207
I + M +GL A TH A+VKM P++V P G E G+FLALDLGGTN+RVL V +
Sbjct: 39 ISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVT 98
Query: 208 QN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPC 381
N ++ +++ YAIP+D M G G +LFD+IA+ L++F+ QI++ + LGFTFSFPC
Sbjct: 99 DNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPC 158
Query: 382 SQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCA 558
Q L ++ LV WTKGF +S EG+DV L++ AI ++ + ++ VAVVNDTVGT+ +C
Sbjct: 159 HQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCG 218
Query: 559 LQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRT 738
D C +G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT
Sbjct: 219 YDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGTLNDIRT 275
Query: 739 KYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFH 918
++D+ +D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF+G+ L +GSF
Sbjct: 276 EFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFE 335
Query: 919 TKYLSEVERD 948
TK +S++E D
Sbjct: 336 TKDVSDIEDD 345
>sp|P27881|HXK2_RAT Hexokinase type II (HK II)
Length = 917
Score = 308 bits (788), Expect = 2e-83
Identities = 155/306 (50%), Positives = 216/306 (70%), Gaps = 3/306 (0%)
Frame = +1
Query: 40 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
++ M +GLS TH A VKM P+YV P G E+G FLALDLGGTN+RVLLV +R ++
Sbjct: 491 MKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKR 550
Query: 220 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
++ N Y+IP++ M G GEELFD+I + ++DF++ ++ + LGFTFSFPC Q +
Sbjct: 551 RGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNS 610
Query: 394 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
L +++L++WTKGF AS CEG+DV LL+ AI++ + ++ VAVVNDTVGT+ +C +DP
Sbjct: 611 LDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDP 670
Query: 571 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
C VG+IVGTG+NA Y+E++ VE ++ + +NMEWGAFGD+GCLD RT +D
Sbjct: 671 HCEVGLIVGTGSNACYMEEMRNVELVDGEEGRM---CVNMEWGAFGDNGCLDDLRTVFDV 727
Query: 751 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
+DE SL+P +Q FEKM SGMYLGEIVR +L+D R +LFRG + L+ G F TK+L
Sbjct: 728 AVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFL 787
Query: 931 SEVERD 948
S++E D
Sbjct: 788 SQIESD 793
Score = 291 bits (744), Expect = 3e-78
Identities = 146/310 (47%), Positives = 213/310 (68%), Gaps = 3/310 (0%)
Frame = +1
Query: 28 IMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLR 207
I + M +GL A TH A+VKM P++V P G E G+FLALDLGGTN+RVL V +
Sbjct: 39 ISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVT 98
Query: 208 QN--EKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPC 381
N ++ +++ YAIP+D M G G +LFD+IA+ L++F+ QI++ + LGFTFSFPC
Sbjct: 99 DNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPC 158
Query: 382 SQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSCA 558
Q L ++ LV WTKGF +S EG+DV L++ AI ++ + ++ VAVVNDTVGT+ +C
Sbjct: 159 HQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCG 218
Query: 559 LQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRT 738
D C +G+IVGTG+NA Y+E++ ++ D+ + INMEWGAFGDDG L+ RT
Sbjct: 219 YDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRM---CINMEWGAFGDDGTLNDIRT 275
Query: 739 KYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFH 918
++D+ +D SL+P +Q+FEKM SGMY+GE+VRL+L+ + ++LF+G+ L +GSF
Sbjct: 276 EFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFE 335
Query: 919 TKYLSEVERD 948
TK +S++E D
Sbjct: 336 TKDVSDIEED 345
>sp|P17710|HXK1_MOUSE Hexokinase type I (HK I) (Hexokinase, tumor isozyme)
Length = 974
Score = 306 bits (785), Expect = 4e-83
Identities = 159/311 (51%), Positives = 213/311 (68%), Gaps = 3/311 (0%)
Frame = +1
Query: 40 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
L M GL T+ A+VKM PSYV +P G E G FLALDLGGTN+RVLLV +R +K
Sbjct: 547 LRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKK 606
Query: 220 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
++ N Y+IP + M G G+ELFD+I +SDF+ I+ + LGFTFSFPC Q +
Sbjct: 607 RTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTS 666
Query: 394 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
L +L+ WTKGF A+DC G DVA LL++A+ + + ++ VAVVNDTVGT+ +CA ++P
Sbjct: 667 LDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 726
Query: 571 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
C +G+IVGTG+NA Y+E+++ VE E G + INMEWGAFGD+GCLD RT +DK
Sbjct: 727 SCEIGLIVGTGSNACYMEEMKNVE-MVEGNQG--QMCINMEWGAFGDNGCLDDIRTDFDK 783
Query: 751 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
++DE SL+ +Q FEKM SGMYLGEIVR +L+D + LFRG+ + L+ G F TK+L
Sbjct: 784 VVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFL 843
Query: 931 SEVERDPPHLL 963
S++E D LL
Sbjct: 844 SQIESDRLALL 854
Score = 263 bits (673), Expect = 4e-70
Identities = 133/311 (42%), Positives = 200/311 (64%), Gaps = 3/311 (0%)
Frame = +1
Query: 25 NIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTL 204
+I+ ++ M GLS + ASVKM P++V +P G E+G F+ALDLGG+++R+L V +
Sbjct: 94 DILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 153
Query: 205 RQNEKPDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFP 378
+ ++ + Y P++ + G G +LFD++A+ L DF++ +I+ + +GFTFSFP
Sbjct: 154 NHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFP 213
Query: 379 CSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSC 555
C Q + +A+L+ WTK F AS EG DV LL AI K+ + + VAVVNDTVGT+ +C
Sbjct: 214 CRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTC 273
Query: 556 ALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYR 735
D +C VG+I+GTGTNA Y+E++ ++ D+ + IN EWGAFGDDG L+ R
Sbjct: 274 GYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRM---CINTEWGAFGDDGSLEDIR 330
Query: 736 TKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSF 915
T++D+ LD SL+P +Q+FEKM SGMY+GE+VRL+L+ + +LF G L G F
Sbjct: 331 TEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKF 390
Query: 916 HTKYLSEVERD 948
T ++ +E D
Sbjct: 391 TTSDVAAIETD 401
>sp|P35557|HXK4_HUMAN Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 300 bits (769), Expect = 3e-81
Identities = 150/320 (46%), Positives = 216/320 (67%), Gaps = 5/320 (1%)
Frame = +1
Query: 4 LKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNY 183
L+ D + +M +++ M RGL TH++ASVKM P+YV P G E G FL+LDLGGTN+
Sbjct: 25 LQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNF 84
Query: 184 RVLLVTLRQNEKPD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPI 351
RV+LV + + E+ K Y+IP+D MTG E LFDYI++ +SDF+ HQ++ +
Sbjct: 85 RVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 144
Query: 352 KLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVN 528
LGFTFSFP ++ K +L+ WTKGF AS EG +V LL++AI ++ + + VA+VN
Sbjct: 145 PLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVN 204
Query: 529 DTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFG 708
DTV T+ SC +D +C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFG
Sbjct: 205 DTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFG 261
Query: 709 DDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKP 888
D G LD++ +YD+L+DE S +P QQ++EK+ G Y+GE+VRLVLL L+D +LF GE
Sbjct: 262 DSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEAS 321
Query: 889 KSLEASGSFHTKYLSEVERD 948
+ L G+F T+++S+VE D
Sbjct: 322 EQLRTRGAFETRFVSQVESD 341
>sp|P17712|HXK4_RAT Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 299 bits (765), Expect = 9e-81
Identities = 149/320 (46%), Positives = 215/320 (67%), Gaps = 5/320 (1%)
Frame = +1
Query: 4 LKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNY 183
L+ D + +M +++ M RGL TH++ASVKM P+YV P G E G FL+LDLGGTN+
Sbjct: 25 LQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNF 84
Query: 184 RVLLVTLRQNEKPD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPI 351
RV+LV + + E K Y+IP+D MTG E LFDYI++ +SDF+ HQ++ +
Sbjct: 85 RVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 144
Query: 352 KLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVN 528
LGFTFSFP +L K +L+ WTKGF AS EG ++ LL++AI ++ + + VA+VN
Sbjct: 145 PLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVN 204
Query: 529 DTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFG 708
DTV T+ SC +D +C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFG
Sbjct: 205 DTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFG 261
Query: 709 DDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKP 888
D G LD++ +YD+++DE S +P QQ++EK+ G Y+GE+VRLVLL L+D +LF GE
Sbjct: 262 DSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGELVRLVLLKLVDENLLFHGEAS 321
Query: 889 KSLEASGSFHTKYLSEVERD 948
+ L G+F T+++S+VE D
Sbjct: 322 EQLRTRGAFETRFVSQVESD 341
>sp|P27595|HXK1_BOVIN Hexokinase type I (HK I) (Brain form hexokinase)
Length = 918
Score = 296 bits (759), Expect = 5e-80
Identities = 152/311 (48%), Positives = 209/311 (67%), Gaps = 3/311 (0%)
Frame = +1
Query: 40 LEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTLRQNEK 219
L M GL T+ +A+V M PS++ +P G E+G FLALDLGGTN+RVLLV +R +K
Sbjct: 491 LRTEMEMGLRKETNSNATVNMLPSFLRSIPDGTEDGDFLALDLGGTNFRVLLVKIRSGKK 550
Query: 220 PDIKETN--YAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFPCSQIN 393
++ N Y IP + M G GEELFD+I +SDF+ I+ + LGFTFSFPC Q +
Sbjct: 551 STVEMHNKIYRIPIEIMQGTGEELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCQQTS 610
Query: 394 LSKALLVRWTKGFTASDCEGQDVAALLQNAINK-QNLNVKCVAVVNDTVGTLTSCALQDP 570
L +L+ WTKGF A+DC G DV LL++A+ + + ++ VAVVNDTVGT+ +CA ++P
Sbjct: 611 LDAGILITWTKGFKATDCVGHDVVTLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEP 670
Query: 571 KCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYRTKYDK 750
C VG+IVGTG+NA Y+E+++ VE ++ + INMEWGAFGD+GC D RT +DK
Sbjct: 671 TCEVGLIVGTGSNACYMEEMKNVEMVEGNQ---RQMCINMEWGAFGDNGCSDDIRTDFDK 727
Query: 751 LLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSFHTKYL 930
++DE SL+ Q FE M SG+YLGEIVR +L+D + LFRG+ + L+ G F TK+L
Sbjct: 728 VVDEYSLNSGNQRFENMISGIYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFL 787
Query: 931 SEVERDPPHLL 963
S++E D LL
Sbjct: 788 SQIESDRLALL 798
Score = 241 bits (615), Expect = 2e-63
Identities = 127/311 (40%), Positives = 190/311 (61%), Gaps = 3/311 (0%)
Frame = +1
Query: 25 NIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNYRVLLVTL 204
+IM+ ++ M GLS + A+VKM P++V +P G E+G F+ALDLGG+++R+L V +
Sbjct: 38 DIMNRFKKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQV 97
Query: 205 R--QNEKPDIKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPIKLGFTFSFP 378
QN ++ Y P++ M G G +LFD++ + L DF++ +I+ + +GFTFSFP
Sbjct: 98 NHEQNRPVHMESEVYDTPENIMHGSGSQLFDHVLECLGDFMEKKKIKDKKLPVGFTFSFP 157
Query: 379 CSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVNDTVGTLTSC 555
C Q + +A+L+ WTK F A EG V LL AI K+ + + VAVVNDTVGT+ C
Sbjct: 158 CRQSKIDQAILITWTKRFKARGAEGNYVVKLLDKAIKKRGDYDANIVAVVNDTVGTMIDC 217
Query: 556 ALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFGDDGCLDKYR 735
D C VG+I+GTGTNA Y+E++ +++ D + IN EWG GDDG L+ R
Sbjct: 218 GYDDQHCEVGLIIGTGTNACYMEELRQIDFGWGDD---GRMCINTEWGDLGDDGSLEDIR 274
Query: 736 TKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKPKSLEASGSF 915
++D+ SL+P +Q FEKM SG Y+ ++VRLVL+ + +LF G L G F
Sbjct: 275 KEFDREFRRGSLNPGKQRFEKMVSGRYMEDVVRLVLVKMAKEGLLFEGRITPELLTRGKF 334
Query: 916 HTKYLSEVERD 948
+T +S +E+D
Sbjct: 335 NTSDVSAIEKD 345
>sp|P52792|HXK4_MOUSE Hexokinase D (Hexokinase type IV) (HK IV) (HK4) (Glucokinase)
Length = 465
Score = 296 bits (757), Expect = 8e-80
Identities = 146/320 (45%), Positives = 216/320 (67%), Gaps = 5/320 (1%)
Frame = +1
Query: 4 LKFNDYENIMHLLEENMIRGLSAATHKDASVKMFPSYVTKLPTGKEEGQFLALDLGGTNY 183
L+ D + +M +++ M RGL TH++ASVKM P+YV P G E G FL+LDLGGTN+
Sbjct: 25 LQEEDLKKVMSRMQKEMDRGLKLETHQEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNF 84
Query: 184 RVLLVTLRQNEKPD----IKETNYAIPKDKMTGKGEELFDYIAKTLSDFIKIHQIEKWPI 351
RV+LV + + E K Y+IP+D MTG E LFDYI++ +SDF+ HQ++ +
Sbjct: 85 RVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKL 144
Query: 352 KLGFTFSFPCSQINLSKALLVRWTKGFTASDCEGQDVAALLQNAINKQ-NLNVKCVAVVN 528
LGFTFSFP ++ K +L+ WTKGF AS EG ++ LL++AI ++ + + VA+VN
Sbjct: 145 PLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNIVGLLRDAIKRRGDFEMDVVAMVN 204
Query: 529 DTVGTLTSCALQDPKCGVGVIVGTGTNASYIEKIERVETFTEDKTGVEYVIINMEWGAFG 708
DTV T+ SC +D +C VG+IVGTG NA Y+E+++ VE D+ + +N EWGAFG
Sbjct: 205 DTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRM---CVNTEWGAFG 261
Query: 709 DDGCLDKYRTKYDKLLDEQSLHPNQQIFEKMCSGMYLGEIVRLVLLDLIDRKILFRGEKP 888
+ G LD++ +YD+++DE S++P QQ++EK+ G Y+GE+VRLVLL L++ +LF GE
Sbjct: 262 NSGELDEFLLEYDRMVDESSVNPGQQLYEKIIGGKYMGELVRLVLLKLVEENLLFHGEAS 321
Query: 889 KSLEASGSFHTKYLSEVERD 948
+ L G+F T+++S+VE D
Sbjct: 322 EQLRTRGAFETRFVSQVESD 341
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,255,005
Number of Sequences: 369166
Number of extensions: 2479749
Number of successful extensions: 7242
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6709
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7085
length of database: 68,354,980
effective HSP length: 111
effective length of database: 47,849,395
effective search space used: 10383318715
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)