DrC_01105
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01105 (923 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-acti... 135 2e-31 sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 110 6e-24 sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 105 2e-22 sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 105 2e-22 sp|Q7TQG1|PLEA6_MOUSE Pleckstrin homology domain-containing... 43 0.001 sp|P60669|PLEA4_RAT Pleckstrin homology domain-containing p... 42 0.002 sp|Q9H4M7|PLEA4_HUMAN Pleckstrin homology domain-containing... 42 0.002 sp|Q8VC98|PLEA4_MOUSE Pleckstrin homology domain-containing... 42 0.002 sp|Q9Y2H5|PLEA6_HUMAN Pleckstrin homology domain-containing... 41 0.005 sp|P79114|MYO10_BOVIN Myosin-10 (Myosin X) 39 0.027
>sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-activating protein PM25) Length = 374 Score = 135 bits (339), Expect = 2e-31 Identities = 86/293 (29%), Positives = 146/293 (49%), Gaps = 4/293 (1%) Frame = +1 Query: 13 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLLKKRCKDKNIYNA 192 +P FY P + ++LR +I AKY+ ++F E PY + G L KR +D + + Sbjct: 89 VPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLS 148 Query: 193 RFFRLSISDITFNYFIKETDADPKRNLRLDRINATF----IENPDSRARIPDELLMISFF 360 R F L+ + YF + +PK ++++ +NATF I +P L +++ Sbjct: 149 RKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHG--------LQVTYL 200 Query: 361 RQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDIT 540 + + S R+I++ +++VDW+ +R A+F Y+ A++ +L L+ + Sbjct: 201 K--DNSTRNIFIYHEDGKEIVDWFNALRAARFH----YLQVAFPGASDADLVPKLSRNYL 254 Query: 541 MSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVIGERSRGYGAVLSSPP 720 G+M KTG + TE ++KRW + RRL+Y PL +GE+ IG + GY + PP Sbjct: 255 KEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPP 314 Query: 721 NARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTEMSVREMA 879 + + +TI TP R +LFA ++E D E W+ D M +E A Sbjct: 315 STQGHHWPHG-ITIVTPDRKFLFACETESDQRE-WVAAFQKAVDRPMLPQEYA 365
>sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 Length = 381 Score = 110 bits (275), Expect = 6e-24 Identities = 83/290 (28%), Positives = 142/290 (48%), Gaps = 6/290 (2%) Frame = +1 Query: 13 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLLKKRCKDKNIYNA 192 +P FY +P AN +L+ +I AKY+ ++F + + + + + G L KR +D + + Sbjct: 93 VPAFYYIPQANDCLVLKEQWIRAKYERREF-MADGETISLPGNREGFLWKRGRDNSQFLR 151 Query: 193 RFFRLSISDITFNYFIKETDADPKRNLRLDRINATF----IENPDSRARIPDELLMISFF 360 R F L + YF KE PK + + +NATF I +P L I++ Sbjct: 152 RKFVLLAREGLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHG--------LQITYR 203 Query: 361 RQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDIT 540 R + R++++ + +++VDW+ +R A R Y+ E E EL LT + Sbjct: 204 R--DGHTRNLFVYHESGKEIVDWFNALRAA----RLQYLKMAFPELPESELVPFLTRNYL 257 Query: 541 MSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLSPCGKGEIVIGERSRGYGAVLSS 714 G+M KTG + E ++KRW L RRLLY PL +G++ +G + +GY A Sbjct: 258 KQGFMEKTGPKQKEPFKKRWFALDCHERRLLYYKNPLDAFEQGQVFLGNKEQGYEAYEDL 317 Query: 715 PPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTEMS 864 P R ++ LTI TP R ++ SE + ++WL+ + + + ++ Sbjct: 318 PKGIRGNRW-KAGLTIVTPERRFVLTCPSEKE-QQEWLESLRGVLSSPLT 365
>sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 Length = 376 Score = 105 bits (262), Expect = 2e-22 Identities = 80/290 (27%), Positives = 140/290 (48%), Gaps = 6/290 (2%) Frame = +1 Query: 13 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSVKEVDRPYITNQKLGLLKKRCKDKNIYNA 192 +P FY +P A+ +L+ +I AKY+ ++F ++ P + G L KR +D + + Sbjct: 93 VPTFYYVPQASDCLVLKEQWIRAKYERQEFMAEKAVSP--PGDREGFLWKRGRDNSQFLR 150 Query: 193 RFFRLSISDITFNYFIKETDADPKRNLRLDRINATF----IENPDSRARIPDELLMISFF 360 R F L + Y+ KE PK + + +NATF I +P L I++ Sbjct: 151 RRFVLLSREGLLKYYTKEEGKTPKAIINIKDLNATFQTEKIGHPHG--------LQITY- 201 Query: 361 RQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDIT 540 ++E R++++ ++ +++VDW+ +R A R Y+ + E EL +T + Sbjct: 202 -RKEGQTRNLFVYHDSGKEIVDWFNALRAA----RLQYLKLAFPDLPESELVPLITRNYL 256 Query: 541 MSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLSPCGKGEIVIGERSRGYGAVLSS 714 G+M KTG + E ++KRW L RRLLY PL +G++ +G +GY Sbjct: 257 KQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFEQGQVFLGSNEQGYEVWEGL 316 Query: 715 PPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTEMS 864 P R + LT+ TP R ++F +E + E WL+ + + + +S Sbjct: 317 PQGIRGNRW-KVGLTVITPERKFVFTCPTEKEQRE-WLESLRGVLSSPLS 364
>sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 Length = 381 Score = 105 bits (261), Expect = 2e-22 Identities = 83/292 (28%), Positives = 140/292 (47%), Gaps = 8/292 (2%) Frame = +1 Query: 13 LPIFYRLPNANGPEILRRSFIIAKYQLKQFSV--KEVDRPYITNQKLGLLKKRCKDKNIY 186 +P FY +P AN +L+ +I AKY+ ++F+ K V P + G L KR +D + Sbjct: 93 VPAFYYVPQANDCLVLKEQWIRAKYERQEFTAIDKAVSHP---GNREGFLWKRGRDNAQF 149 Query: 187 NARFFRLSISDITFNYFIKETDADPKRNLRLDRINATF----IENPDSRARIPDELLMIS 354 R F L + Y+ KE PK + + +NATF I +P L I+ Sbjct: 150 LRRRFVLLSREGLLKYYTKEEGKAPKAVISIKDLNATFQTEKIGHPHG--------LQIT 201 Query: 355 FFRQEEASWRHIYLKSNTPEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLD 534 + ++E R++++ ++ +++VDW+ +R A R Y+ + E EL +T + Sbjct: 202 Y--RKEGHTRNLFVYHDSGKEIVDWFNALRAA----RLQYLKLAFPDLPESELVPLITRN 255 Query: 535 ITMSGWMYKTGSQLTEQWQKRWCVL--LGRRLLYSSGPLSPCGKGEIVIGERSRGYGAVL 708 G+M KTG + E ++KRW L RRLLY PL G++ +G +GY Sbjct: 256 YLKQGFMEKTGPKHREPFKKRWFALDPQERRLLYYKNPLDAFELGQVFLGSNEQGYEVWE 315 Query: 709 SSPPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTEMS 864 P R ++ LT+ TP R ++F +E + E WL+ + + + +S Sbjct: 316 DLPKGIRGNRW-KAGLTVITPERKFIFTCPTEKEQRE-WLESLRGVLSSPLS 365
>sp|Q7TQG1|PLEA6_MOUSE Pleckstrin homology domain-containing protein family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) Length = 1173 Score = 42.7 bits (99), Expect = 0.001 Identities = 37/141 (26%), Positives = 62/141 (43%) Frame = +1 Query: 439 IRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGR 618 IR + S +A + G A+ ++ R+ +T +GW+YK S +QW KRW VL+ R Sbjct: 33 IRATRTSRKA---IAFGKRAHSMK--RNPNAPVTKAGWLYKQASSGVKQWNKRWFVLVDR 87 Query: 619 RLLYSSGPLSPCGKGEIVIGERSRGYGAVLSSPPNARSVMTDQSPLTIKTPSRDYLFAVD 798 L Y G I + S AV S +R ++T Y F+ + Sbjct: 88 CLFYYKDEKQESILGSIPL--LSFRVAAVQPSDNISRKHTFKAEHAGVRT----YFFSAE 141 Query: 799 SEGDVAEKWLKCINDLADTEM 861 S + E W++ + + A ++ Sbjct: 142 SP-EEQEAWIQAMGEAARVQI 161
>sp|P60669|PLEA4_RAT Pleckstrin homology domain-containing protein family A member 4 (Phosphoinositol 3-phosphate binding protein 1) (PEPP-1) Length = 779 Score = 42.4 bits (98), Expect = 0.002 Identities = 33/119 (27%), Positives = 49/119 (41%), Gaps = 3/119 (2%) Frame = +1 Query: 511 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVI---GE 681 L RD L + + GW++K S W++RW VL G L Y G +++ Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSV 106 Query: 682 RSRGYGAVLSSPPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTE 858 R G GA P R T + P R Y+ A D+ D+ WL+ + + E Sbjct: 107 RPDGPGA----PRGRRFTFTAEHP-----GMRTYVLAADTLEDL-RGWLRALGKASRAE 155
>sp|Q9H4M7|PLEA4_HUMAN Pleckstrin homology domain-containing protein family A member 4 (Phosphoinositol 3-phosphate binding protein 1) (PEPP-1) Length = 779 Score = 42.0 bits (97), Expect = 0.002 Identities = 33/119 (27%), Positives = 49/119 (41%), Gaps = 3/119 (2%) Frame = +1 Query: 511 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVIGE--- 681 L RD L + + GW++K S W++RW VL G L Y G +++ Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNI 106 Query: 682 RSRGYGAVLSSPPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTE 858 R G GA P R T + P R Y+ A D+ D+ WL+ + + E Sbjct: 107 RPDGPGA----PRGRRFTFTAEHP-----GMRTYVLAADTLEDL-RGWLRALGRASRAE 155
>sp|Q8VC98|PLEA4_MOUSE Pleckstrin homology domain-containing protein family A member 4 (Phosphoinositol 3-phosphate binding protein 1) (PEPP-1) Length = 588 Score = 42.0 bits (97), Expect = 0.002 Identities = 33/119 (27%), Positives = 49/119 (41%), Gaps = 3/119 (2%) Frame = +1 Query: 511 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVI---GE 681 L RD L + + GW++K S W++RW VL G L Y G +++ Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYSV 106 Query: 682 RSRGYGAVLSSPPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTE 858 R G GA P R T + P R Y+ A D+ D+ WL+ + + E Sbjct: 107 RPDGPGA----PRGRRFTFTAEHP-----GMRTYVLAADTLEDL-RGWLRALGRASRAE 155
>sp|Q9Y2H5|PLEA6_HUMAN Pleckstrin homology domain-containing protein family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3) Length = 1048 Score = 40.8 bits (94), Expect = 0.005 Identities = 30/117 (25%), Positives = 51/117 (43%) Frame = +1 Query: 511 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLYSSGPLSPCGKGEIVIGERSR 690 + R+ +T +GW++K S +QW KRW VL+ R L Y G I + S Sbjct: 52 MKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFYYKDEKEESILGSIPL--LSF 109 Query: 691 GYGAVLSSPPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDLADTEM 861 AV S +R ++T Y F+ +S + E W++ + + A ++ Sbjct: 110 RVAAVQPSDNISRKHTFKAEHAGVRT----YFFSAESP-EEQEAWIQAMGEAARVQI 161
>sp|P79114|MYO10_BOVIN Myosin-10 (Myosin X) Length = 2052 Score = 38.5 bits (88), Expect = 0.027 Identities = 31/123 (25%), Positives = 57/123 (46%), Gaps = 5/123 (4%) Frame = +1 Query: 547 GWMYKTG---SQLTEQ-WQKRWCVLLGRRLLYSSGPLSPCGKGEIVIGERSRGYGAVLSS 714 GW++K G S L+ + W+KRW VL +L+Y KG + + R ++ + Sbjct: 1211 GWLHKKGGGSSTLSRRNWKKRWFVLRQAKLMYFENDSEEKLKGTVEV----RAAKEIIDN 1266 Query: 715 PPNARSVMTDQSPLTIKTPSRDYLFAVDSEGDVAEKWLKCINDL-ADTEMSVREMADYQL 891 + ++ + I R + +S D A +W ++ + A T+ +REM D Q Sbjct: 1267 -------TSKENGIDIIMADRTFHLIAESPED-ASQWFSVLSQVHASTDQEIREMHDEQA 1318 Query: 892 HPK 900 +P+ Sbjct: 1319 NPQ 1321
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,465,425
Number of Sequences: 369166
Number of extensions: 2134752
Number of successful extensions: 4901
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4721
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4886
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9462723610
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
