Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_B16
(477 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-acti... 77 2e-14
sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2 64 1e-10
sp|Q9JK15|CENA2_RAT Centaurin-alpha 2 62 7e-10
sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2 60 3e-09
sp|Q7TQG1|PLEA6_MOUSE Pleckstrin homology domain-containing... 42 6e-04
sp|Q9Y2H5|PLEA6_HUMAN Pleckstrin homology domain-containing... 40 0.002
sp|Q9H4M7|PLEA4_HUMAN Pleckstrin homology domain-containing... 37 0.023
sp|P60669|PLEA4_RAT Pleckstrin homology domain-containing p... 37 0.023
sp|Q8VC98|PLEA4_MOUSE Pleckstrin homology domain-containing... 37 0.023
sp|P14375|ZRAR_ECOLI Transcriptional regulatory protein zraR 34 0.15
>sp|O75689|CENA1_HUMAN Centaurin-alpha 1 (Putative MAPK-activating protein PM25)
Length = 374
Score = 77.0 bits (188), Expect = 2e-14
Identities = 48/156 (30%), Positives = 81/156 (51%), Gaps = 5/156 (3%)
Frame = +2
Query: 5 RTDA-DPKRNLRLDRINATF----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNT 169
R DA +PK ++++ +NATF I +P L +++ + S R+I++
Sbjct: 165 RNDAKEPKAVMKIEHLNATFQPAKIGHPHG--------LQVTYLKDN--STRNIFIYHED 214
Query: 170 PEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQW 349
+++VDW+ +R A+F G A++ +L L+ + G+M KTG + TE +
Sbjct: 215 GKEIVDWFNALRAARFHYLQVAFPG----ASDADLVPKLSRNYLKEGYMEKTGPKQTEGF 270
Query: 350 QKRWCVLLGRRLLYSSGPLSPCGRGEIVIGERSRGY 457
+KRW + RRL+Y PL RGE+ IG + GY
Sbjct: 271 RKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGY 306
>sp|Q9NPF8|CENA2_HUMAN Centaurin-alpha 2
Length = 381
Score = 64.3 bits (155), Expect = 1e-10
Identities = 48/160 (30%), Positives = 77/160 (48%), Gaps = 6/160 (3%)
Frame = +2
Query: 2 KRTDADPKRNLRLDRINATF----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNT 169
K PK + + +NATF I +P L I++ R + R++++ +
Sbjct: 168 KEQGKSPKAVISIKDLNATFQTEKIGHPHG--------LQITYRR--DGHTRNLFVYHES 217
Query: 170 PEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQW 349
+++VDW+ +R A R Y+ E E EL LT + G+M KTG + E +
Sbjct: 218 GKEIVDWFNALRAA----RLQYLKMAFPELPESELVPFLTRNYLKQGFMEKTGPKQKEPF 273
Query: 350 QKRWCVL--LGRRLLYSSGPLSPCGRGEIVIGERSRGYGA 463
+KRW L RRLLY PL +G++ +G + +GY A
Sbjct: 274 KKRWFALDCHERRLLYYKNPLDAFEQGQVFLGNKEQGYEA 313
>sp|Q9JK15|CENA2_RAT Centaurin-alpha 2
Length = 376
Score = 62.0 bits (149), Expect = 7e-10
Identities = 45/158 (28%), Positives = 77/158 (48%), Gaps = 6/158 (3%)
Frame = +2
Query: 2 KRTDADPKRNLRLDRINATF----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNT 169
K PK + + +NATF I +P L I++ ++E R++++ ++
Sbjct: 167 KEEGKTPKAIINIKDLNATFQTEKIGHPHG--------LQITY--RKEGQTRNLFVYHDS 216
Query: 170 PEDLVDWYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQW 349
+++VDW+ +R A R Y+ + E EL +T + G+M KTG + E +
Sbjct: 217 GKEIVDWFNALRAA----RLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPF 272
Query: 350 QKRWCVL--LGRRLLYSSGPLSPCGRGEIVIGERSRGY 457
+KRW L RRLLY PL +G++ +G +GY
Sbjct: 273 KKRWFALDPQERRLLYYKNPLDAFEQGQVFLGSNEQGY 310
>sp|Q8R2V5|CENA2_MOUSE Centaurin-alpha 2
Length = 381
Score = 59.7 bits (143), Expect = 3e-09
Identities = 44/152 (28%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Frame = +2
Query: 20 PKRNLRLDRINATF----IENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPEDLVD 187
PK + + +NATF I +P L I++ ++E R++++ ++ +++VD
Sbjct: 174 PKAVISIKDLNATFQTEKIGHPHG--------LQITY--RKEGHTRNLFVYHDSGKEIVD 223
Query: 188 WYQTIRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCV 367
W+ +R A R Y+ + E EL +T + G+M KTG + E ++KRW
Sbjct: 224 WFNALRAA----RLQYLKLAFPDLPESELVPLITRNYLKQGFMEKTGPKHREPFKKRWFA 279
Query: 368 L--LGRRLLYSSGPLSPCGRGEIVIGERSRGY 457
L RRLLY PL G++ +G +GY
Sbjct: 280 LDPQERRLLYYKNPLDAFELGQVFLGSNEQGY 311
>sp|Q7TQG1|PLEA6_MOUSE Pleckstrin homology domain-containing protein family A member 6
(Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Length = 1173
Score = 42.4 bits (98), Expect = 6e-04
Identities = 23/64 (35%), Positives = 35/64 (54%)
Frame = +2
Query: 200 IRFAKFSLRAAYVVGTGDEANELELARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGR 379
IR + S +A + G A+ ++ R+ +T +GW+YK S +QW KRW VL+ R
Sbjct: 33 IRATRTSRKA---IAFGKRAHSMK--RNPNAPVTKAGWLYKQASSGVKQWNKRWFVLVDR 87
Query: 380 RLLY 391
L Y
Sbjct: 88 CLFY 91
>sp|Q9Y2H5|PLEA6_HUMAN Pleckstrin homology domain-containing protein family A member 6
(Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Length = 1048
Score = 40.4 bits (93), Expect = 0.002
Identities = 16/40 (40%), Positives = 24/40 (60%)
Frame = +2
Query: 272 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLY 391
+ R+ +T +GW++K S +QW KRW VL+ R L Y
Sbjct: 52 MKRNPNAPVTKAGWLFKQASSGVKQWNKRWFVLVDRCLFY 91
>sp|Q9H4M7|PLEA4_HUMAN Pleckstrin homology domain-containing protein family A member 4
(Phosphoinositol 3-phosphate binding protein 1) (PEPP-1)
Length = 779
Score = 37.0 bits (84), Expect = 0.023
Identities = 16/40 (40%), Positives = 22/40 (55%)
Frame = +2
Query: 272 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLY 391
L RD L + + GW++K S W++RW VL G L Y
Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFY 86
>sp|P60669|PLEA4_RAT Pleckstrin homology domain-containing protein family A member 4
(Phosphoinositol 3-phosphate binding protein 1) (PEPP-1)
Length = 779
Score = 37.0 bits (84), Expect = 0.023
Identities = 16/40 (40%), Positives = 22/40 (55%)
Frame = +2
Query: 272 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLY 391
L RD L + + GW++K S W++RW VL G L Y
Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFY 86
>sp|Q8VC98|PLEA4_MOUSE Pleckstrin homology domain-containing protein family A member 4
(Phosphoinositol 3-phosphate binding protein 1) (PEPP-1)
Length = 588
Score = 37.0 bits (84), Expect = 0.023
Identities = 16/40 (40%), Positives = 22/40 (55%)
Frame = +2
Query: 272 LARDLTLDITMSGWMYKTGSQLTEQWQKRWCVLLGRRLLY 391
L RD L + + GW++K S W++RW VL G L Y
Sbjct: 47 LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFY 86
>sp|P14375|ZRAR_ECOLI Transcriptional regulatory protein zraR
Length = 441
Score = 34.3 bits (77), Expect = 0.15
Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 5/82 (6%)
Frame = +2
Query: 44 RINATFIENPDSRARIPDELLMISFFRQEEASWRHIYLKSNTPE--DLV---DWYQTIRF 208
R+N IE P R R D L+ F Q A +K TP+ DL+ DW IR
Sbjct: 301 RLNVVAIEVPSLRQRREDIPLLAGHFLQRFAERNRKAVKGFTPQAMDLLIHYDWPGNIRE 360
Query: 209 AKFSLRAAYVVGTGDEANELEL 274
+ ++ A V+ TG+ +E EL
Sbjct: 361 LENAVERAVVLLTGEYISEREL 382
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 54,437,890
Number of Sequences: 369166
Number of extensions: 1045392
Number of successful extensions: 2332
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2277
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2324
length of database: 68,354,980
effective HSP length: 101
effective length of database: 49,696,745
effective search space used: 2832714465
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)