DrC_01048
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01048 (810 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase) 219 5e-57 sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reduct... 218 2e-56 sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase) 217 3e-56 sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reduct... 216 6e-56 sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reduct... 213 7e-55 sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reduct... 201 3e-51 sp|Q95JH6|AK1C1_MACFU Aldo-keto reductase family 1 member C... 196 5e-50 sp|Q95JH7|AK1C1_MACFA Aldo-keto reductase family 1 member C... 195 1e-49 sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 (AR... 194 2e-49 sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 (AR... 194 2e-49
>sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase) Length = 316 Score = 219 bits (559), Expect = 5e-57 Identities = 118/244 (48%), Positives = 155/244 (63%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179 LFI SKLW H +VK + TL +LKLDYLDLYLIHWP KPG + FP Sbjct: 73 LFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVV 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 DE D V TW+ ME+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E+H YL Sbjct: 133 PDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLIE+C I VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI Sbjct: 193 QEKLIEYCKSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + + RNLI IPKSV+ R+AEN + + +LS ED N L + N R+CA H +YP Sbjct: 252 FPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALMSCASHKDYP 311 Query: 714 FYED 725 F+E+ Sbjct: 312 FHEE 315
>sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reductase) Length = 316 Score = 218 bits (554), Expect = 2e-56 Identities = 116/244 (47%), Positives = 155/244 (63%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179 LFI SKLW FH +VK F++TLS+L+LDYLDLYLIHWP KPG + FP Sbjct: 73 LFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVI 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 + D V TW ME+LVD G V++IG+SNFN QI+ IL+ + KP+V Q+E H YL Sbjct: 133 PSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLIE+C I VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI Sbjct: 193 QEKLIEYCHSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + + RNL+ IPKSV+ R+AEN+K + ++S ED L + N R+CA H +YP Sbjct: 252 FPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYP 311 Query: 714 FYED 725 F+ + Sbjct: 312 FHAE 315
>sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase) Length = 316 Score = 217 bits (552), Expect = 3e-56 Identities = 117/244 (47%), Positives = 155/244 (63%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179 LFI SKLW FH +VK ++TLS+L+LDYLDLYLIHWP KPG + FP Sbjct: 73 LFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVI 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 + D V TW ME+LVD G V++IG+SNFN QI+ IL+ + KP+V Q+E H YL Sbjct: 133 PSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLIE+C I VTAYSPLG +PDRP A + L DP++ E++ KYN T Q+LI Sbjct: 193 QEKLIEYCHCKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + + RNL+ IPKSV+ R+AEN K + +LS+ED L + N R+CA H +YP Sbjct: 252 FPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYP 311 Query: 714 FYED 725 F+ + Sbjct: 312 FHAE 315
>sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reductase) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) Length = 315 Score = 216 bits (550), Expect = 6e-56 Identities = 115/244 (47%), Positives = 155/244 (63%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179 LFI SKLW +H ++VK ++TLS+LKLDYLDLYLIHWP KPG + FP + Sbjct: 72 LFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVI 131 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 E D V TW ME+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E H YL Sbjct: 132 PSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLT 191 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLI++C I VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI Sbjct: 192 QEKLIQYCNSKGIVVTAYSPLG-SPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIR 250 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + + RNLI IPKSV+ R+AEN + + +L ED N L + + R CA H +YP Sbjct: 251 FPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYP 310 Query: 714 FYED 725 F+E+ Sbjct: 311 FHEE 314
>sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reductase) Length = 316 Score = 213 bits (541), Expect = 7e-55 Identities = 111/244 (45%), Positives = 155/244 (63%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179 LFI SKLW +H +VK ++TLS+LKLDYLDLYLIHWP KPG FP + Sbjct: 73 LFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVV 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 + +++ TW ME+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E H YL Sbjct: 133 PSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLI++C I VTAYSPLG +PDRP A + L DP++ ++ K+N T Q+LI Sbjct: 193 QEKLIQYCQSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + + RNL+ IPKSV+ R+AEN K + +LS +D L + N R+CA H +YP Sbjct: 252 FPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYP 311 Query: 714 FYED 725 F+E+ Sbjct: 312 FHEE 315
>sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reductase) Length = 316 Score = 201 bits (510), Expect = 3e-51 Identities = 110/244 (45%), Positives = 150/244 (61%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179 LFI SKLW H +VK ++TL++LKLDYLDLYLIHWP K G+ FP Sbjct: 73 LFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHGSEYFPLDAAGNVI 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 + D + TW+ ME LVD G V+SIG+SNFN QI+ IL+ + KP+V Q+E H YL Sbjct: 133 PSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVNQIECHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLI++C I VTAYSPLG +PDRP A + L DP++ ++ K+ T Q+LI Sbjct: 193 QEKLIQYCHSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIADKHKKTTAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + + RNL+ IPKSV+ R+AEN + + +LS ED L + N R+CA H +YP Sbjct: 252 FPMQRNLVVIPKSVTPARIAENFQVFDFELSSEDMTTLLSYNRNWRVCALVSCASHKDYP 311 Query: 714 FYED 725 F+ + Sbjct: 312 FHAE 315
>sp|Q95JH6|AK1C1_MACFU Aldo-keto reductase family 1 member C1 homolog (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (Dihydrodiol dehydrogenase 1) (DD-1) (DD1) Length = 323 Score = 196 bits (499), Expect = 5e-50 Identities = 104/244 (42%), Positives = 146/244 (59%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179 +F TSKLW HRPE V+ E +L NL+LDY+DLYLIH+P+S+KPG + P + K Sbjct: 79 IFYTSKLWCNSHRPEFVRPALERSLKNLQLDYVDLYLIHFPVSLKPGEELIPKDENGKLL 138 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 D VDL ATW+ MEK D+G +SIG+SNFN +Q++ IL+ + KP QVE H YL Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLN 198 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KL++FC DI + AYS LG ++P + L DP + L+KK+ TP I + Sbjct: 199 QRKLLDFCKSKDIVLVAYSALGSHREKPWVDQNSPVLLEDPVLCALAKKHKRTPALIALR 258 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 Y + R ++ + KS + R+ EN+K E +L+ ED +D L N R IF NYP Sbjct: 259 YQLQRGVVVLAKSYNEQRIRENMKVFEFQLTSEDMKAIDGLDRNIRYLTLDIFAGPPNYP 318 Query: 714 FYED 725 F ++ Sbjct: 319 FSDE 322
>sp|Q95JH7|AK1C1_MACFA Aldo-keto reductase family 1 member C1 homolog (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (Dihydrodiol dehydrogenase 1) (DD-1) (DD1) Length = 323 Score = 195 bits (495), Expect = 1e-49 Identities = 103/244 (42%), Positives = 146/244 (59%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179 +F TSKLW HRPE V+ E +L NL+LDY+DLYLIH+P+S+KPG + P + K Sbjct: 79 IFYTSKLWCNSHRPEFVRPALERSLKNLQLDYVDLYLIHFPVSLKPGEELIPKDENGKLL 138 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 D VDL ATW+ MEK D+G +SIG+SNFN +Q++ IL+ + KP QVE H YL Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLN 198 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KL++FC DI + A+S LG ++P + L DP + L+KK+ TP I + Sbjct: 199 QRKLLDFCKSKDIVLVAFSALGSHREKPWVDQNSPVLLEDPVLCALAKKHKRTPALIALR 258 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 Y + R ++ + KS + R+ EN+K E +L+ ED +D L N R IF NYP Sbjct: 259 YQLQRGVVVLAKSYNEQRIRENMKVFEFQLTSEDMKAIDGLDRNIRYLTLDIFAGPPNYP 318 Query: 714 FYED 725 F ++ Sbjct: 319 FSDE 322
>sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 (AR) (Aldehyde reductase) (VAS deferens androgen-dependent protein) (MVDP) (Aldo-keto reductase family 1 member B7) Length = 316 Score = 194 bits (494), Expect = 2e-49 Identities = 103/244 (42%), Positives = 151/244 (61%), Gaps = 3/244 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179 LFI SKLW F +VK F+ TLS+LKLDYLDLYL+HWP + GN + P +K K Sbjct: 73 LFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAGNALLPKDNKGKVL 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 + + + W+ ME+LVD G V+++G+SNFN QI+ +L+ + KP Q+E H YL Sbjct: 133 LSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHKPVTNQIESHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLI++C I VTAYSPLG +PDRP A + + PK+ E++ K+ T Q+LI Sbjct: 193 QEKLIQYCQSKGIAVTAYSPLG-SPDRPYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713 + V RN++ IPKSV+ R+ EN++ + +LS+ED + + N R C + +YP Sbjct: 252 FHVQRNVVVIPKSVTPSRIQENLQVFDFQLSEEDMAAILSFNRNWRACDLLDARTEEDYP 311 Query: 714 FYED 725 F+E+ Sbjct: 312 FHEE 315
>sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 (AR) (Aldehyde reductase) (Fibroblast growth factor regulated protein) (FR-1 protein) Length = 316 Score = 194 bits (493), Expect = 2e-49 Identities = 103/242 (42%), Positives = 152/242 (62%), Gaps = 4/242 (1%) Frame = +3 Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179 LFI SKLW +++K F++TL++LKLDYLDLYLIHWP ++PG +FP D+ + Sbjct: 73 LFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKELFPKDDQGRIL 132 Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353 + + W+ ME+LVD G V+++G+SNFN QI+ +L+ + KP QVE H YL Sbjct: 133 TSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLT 192 Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533 +KLI++C I VTAYSPLG +PDRP A + L DPK+ E++ K+ T Q+LI Sbjct: 193 QEKLIQYCHSKGISVTAYSPLG-SPDRPSAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIR 251 Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMC-APQIFKLHHNY 710 + + RN++ IPKSV+ R+ ENI+ + +LSDE+ + + N R C P+ + Y Sbjct: 252 FHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLLPETVNM-EEY 310 Query: 711 PF 716 P+ Sbjct: 311 PY 312
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,784,644
Number of Sequences: 369166
Number of extensions: 1919509
Number of successful extensions: 5596
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5142
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5379
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
