Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_G15
(800 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase) 219 5e-57
sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reduct... 218 2e-56
sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase) 217 3e-56
sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reduct... 216 6e-56
sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reduct... 213 6e-55
sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reduct... 201 3e-51
sp|Q95JH6|AK1C1_MACFU Aldo-keto reductase family 1 member C... 196 5e-50
sp|Q95JH7|AK1C1_MACFA Aldo-keto reductase family 1 member C... 195 1e-49
sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 (AR... 194 2e-49
sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 (AR... 194 2e-49
>sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 219 bits (559), Expect = 5e-57
Identities = 118/244 (48%), Positives = 155/244 (63%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179
LFI SKLW H +VK + TL +LKLDYLDLYLIHWP KPG + FP
Sbjct: 73 LFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKDPFPLDGDGNVV 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
DE D V TW+ ME+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E+H YL
Sbjct: 133 PDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLIE+C I VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI
Sbjct: 193 QEKLIEYCKSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ + RNLI IPKSV+ R+AEN + + +LS ED N L + N R+CA H +YP
Sbjct: 252 FPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCALMSCASHKDYP 311
Query: 714 FYED 725
F+E+
Sbjct: 312 FHEE 315
>sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 218 bits (554), Expect = 2e-56
Identities = 116/244 (47%), Positives = 155/244 (63%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179
LFI SKLW FH +VK F++TLS+L+LDYLDLYLIHWP KPG + FP
Sbjct: 73 LFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVI 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
+ D V TW ME+LVD G V++IG+SNFN QI+ IL+ + KP+V Q+E H YL
Sbjct: 133 PSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLIE+C I VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI
Sbjct: 193 QEKLIEYCHSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ + RNL+ IPKSV+ R+AEN+K + ++S ED L + N R+CA H +YP
Sbjct: 252 FPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYP 311
Query: 714 FYED 725
F+ +
Sbjct: 312 FHAE 315
>sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 217 bits (552), Expect = 3e-56
Identities = 117/244 (47%), Positives = 155/244 (63%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179
LFI SKLW FH +VK ++TLS+L+LDYLDLYLIHWP KPG + FP
Sbjct: 73 LFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVI 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
+ D V TW ME+LVD G V++IG+SNFN QI+ IL+ + KP+V Q+E H YL
Sbjct: 133 PSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLIE+C I VTAYSPLG +PDRP A + L DP++ E++ KYN T Q+LI
Sbjct: 193 QEKLIEYCHCKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ + RNL+ IPKSV+ R+AEN K + +LS+ED L + N R+CA H +YP
Sbjct: 252 FPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYP 311
Query: 714 FYED 725
F+ +
Sbjct: 312 FHAE 315
>sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reductase) (20-alpha-hydroxysteroid
dehydrogenase) (20-alpha-HSD)
Length = 315
Score = 216 bits (550), Expect = 6e-56
Identities = 115/244 (47%), Positives = 155/244 (63%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPG-NIFPAPDKFKDE 179
LFI SKLW +H ++VK ++TLS+LKLDYLDLYLIHWP KPG + FP +
Sbjct: 72 LFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVI 131
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
E D V TW ME+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E H YL
Sbjct: 132 PSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLT 191
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLI++C I VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI
Sbjct: 192 QEKLIQYCNSKGIVVTAYSPLG-SPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIR 250
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ + RNLI IPKSV+ R+AEN + + +L ED N L + + R CA H +YP
Sbjct: 251 FPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYP 310
Query: 714 FYED 725
F+E+
Sbjct: 311 FHEE 314
>sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 213 bits (541), Expect = 6e-55
Identities = 111/244 (45%), Positives = 155/244 (63%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179
LFI SKLW +H +VK ++TLS+LKLDYLDLYLIHWP KPG FP +
Sbjct: 73 LFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVV 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
+ +++ TW ME+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E H YL
Sbjct: 133 PSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLI++C I VTAYSPLG +PDRP A + L DP++ ++ K+N T Q+LI
Sbjct: 193 QEKLIQYCQSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ + RNL+ IPKSV+ R+AEN K + +LS +D L + N R+CA H +YP
Sbjct: 252 FPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYP 311
Query: 714 FYED 725
F+E+
Sbjct: 312 FHEE 315
>sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 201 bits (510), Expect = 3e-51
Identities = 110/244 (45%), Positives = 150/244 (61%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179
LFI SKLW H +VK ++TL++LKLDYLDLYLIHWP K G+ FP
Sbjct: 73 LFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHGSEYFPLDAAGNVI 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
+ D + TW+ ME LVD G V+SIG+SNFN QI+ IL+ + KP+V Q+E H YL
Sbjct: 133 PSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVNQIECHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLI++C I VTAYSPLG +PDRP A + L DP++ ++ K+ T Q+LI
Sbjct: 193 QEKLIQYCHSKGIVVTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIADKHKKTTAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ + RNL+ IPKSV+ R+AEN + + +LS ED L + N R+CA H +YP
Sbjct: 252 FPMQRNLVVIPKSVTPARIAENFQVFDFELSSEDMTTLLSYNRNWRVCALVSCASHKDYP 311
Query: 714 FYED 725
F+ +
Sbjct: 312 FHAE 315
>sp|Q95JH6|AK1C1_MACFU Aldo-keto reductase family 1 member C1 homolog
(20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD)
(Dihydrodiol dehydrogenase 1) (DD-1) (DD1)
Length = 323
Score = 196 bits (499), Expect = 5e-50
Identities = 104/244 (42%), Positives = 146/244 (59%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179
+F TSKLW HRPE V+ E +L NL+LDY+DLYLIH+P+S+KPG + P + K
Sbjct: 79 IFYTSKLWCNSHRPEFVRPALERSLKNLQLDYVDLYLIHFPVSLKPGEELIPKDENGKLL 138
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
D VDL ATW+ MEK D+G +SIG+SNFN +Q++ IL+ + KP QVE H YL
Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLN 198
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KL++FC DI + AYS LG ++P + L DP + L+KK+ TP I +
Sbjct: 199 QRKLLDFCKSKDIVLVAYSALGSHREKPWVDQNSPVLLEDPVLCALAKKHKRTPALIALR 258
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
Y + R ++ + KS + R+ EN+K E +L+ ED +D L N R IF NYP
Sbjct: 259 YQLQRGVVVLAKSYNEQRIRENMKVFEFQLTSEDMKAIDGLDRNIRYLTLDIFAGPPNYP 318
Query: 714 FYED 725
F ++
Sbjct: 319 FSDE 322
>sp|Q95JH7|AK1C1_MACFA Aldo-keto reductase family 1 member C1 homolog
(20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD)
(Dihydrodiol dehydrogenase 1) (DD-1) (DD1)
Length = 323
Score = 195 bits (495), Expect = 1e-49
Identities = 103/244 (42%), Positives = 146/244 (59%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179
+F TSKLW HRPE V+ E +L NL+LDY+DLYLIH+P+S+KPG + P + K
Sbjct: 79 IFYTSKLWCNSHRPEFVRPALERSLKNLQLDYVDLYLIHFPVSLKPGEELIPKDENGKLL 138
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
D VDL ATW+ MEK D+G +SIG+SNFN +Q++ IL+ + KP QVE H YL
Sbjct: 139 FDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYLN 198
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KL++FC DI + A+S LG ++P + L DP + L+KK+ TP I +
Sbjct: 199 QRKLLDFCKSKDIVLVAFSALGSHREKPWVDQNSPVLLEDPVLCALAKKHKRTPALIALR 258
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
Y + R ++ + KS + R+ EN+K E +L+ ED +D L N R IF NYP
Sbjct: 259 YQLQRGVVVLAKSYNEQRIRENMKVFEFQLTSEDMKAIDGLDRNIRYLTLDIFAGPPNYP 318
Query: 714 FYED 725
F ++
Sbjct: 319 FSDE 322
>sp|P21300|ALD1_MOUSE Aldose reductase-related protein 1 (AR) (Aldehyde reductase) (VAS
deferens androgen-dependent protein) (MVDP) (Aldo-keto
reductase family 1 member B7)
Length = 316
Score = 194 bits (494), Expect = 2e-49
Identities = 103/244 (42%), Positives = 151/244 (61%), Gaps = 3/244 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179
LFI SKLW F +VK F+ TLS+LKLDYLDLYL+HWP + GN + P +K K
Sbjct: 73 LFIVSKLWATFFEKSLVKKAFQNTLSDLKLDYLDLYLVHWPQGFQAGNALLPKDNKGKVL 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
+ + + W+ ME+LVD G V+++G+SNFN QI+ +L+ + KP Q+E H YL
Sbjct: 133 LSKSTFLDAWEAMEELVDQGLVKALGISNFNHFQIERLLNKPGLKHKPVTNQIESHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLI++C I VTAYSPLG +PDRP A + + PK+ E++ K+ T Q+LI
Sbjct: 193 QEKLIQYCQSKGIAVTAYSPLG-SPDRPYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCAPQIFKLHHNYP 713
+ V RN++ IPKSV+ R+ EN++ + +LS+ED + + N R C + +YP
Sbjct: 252 FHVQRNVVVIPKSVTPSRIQENLQVFDFQLSEEDMAAILSFNRNWRACDLLDARTEEDYP 311
Query: 714 FYED 725
F+E+
Sbjct: 312 FHEE 315
>sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 (AR) (Aldehyde reductase)
(Fibroblast growth factor regulated protein) (FR-1
protein)
Length = 316
Score = 194 bits (493), Expect = 2e-49
Identities = 103/242 (42%), Positives = 152/242 (62%), Gaps = 4/242 (1%)
Frame = +3
Query: 3 LFITSKLWNAFHRPEVVKTGFEETLSNLKLDYLDLYLIHWPISIKPGN-IFPAPDKFKDE 179
LFI SKLW +++K F++TL++LKLDYLDLYLIHWP ++PG +FP D+ +
Sbjct: 73 LFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGKELFPKDDQGRIL 132
Query: 180 VDEVDLVATWKEMEKLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLP 353
+ + W+ ME+LVD G V+++G+SNFN QI+ +L+ + KP QVE H YL
Sbjct: 133 TSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLT 192
Query: 354 NKKLIEFCWKNDIQVTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILIN 533
+KLI++C I VTAYSPLG +PDRP A + L DPK+ E++ K+ T Q+LI
Sbjct: 193 QEKLIQYCHSKGISVTAYSPLG-SPDRPSAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIR 251
Query: 534 YIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMC-APQIFKLHHNY 710
+ + RN++ IPKSV+ R+ ENI+ + +LSDE+ + + N R C P+ + Y
Sbjct: 252 FHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLLPETVNM-EEY 310
Query: 711 PF 716
P+
Sbjct: 311 PY 312
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,585,013
Number of Sequences: 369166
Number of extensions: 1901475
Number of successful extensions: 5606
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5152
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5389
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7570361805
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)