Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_022_M09
(590 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase) 139 5e-33
sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase) 138 9e-33
sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reduct... 136 4e-32
sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reduct... 132 5e-31
sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reduct... 132 5e-31
sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reduct... 130 2e-30
sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 (AR... 127 2e-29
sp|O60218|AK1BA_HUMAN Aldo-keto reductase family 1 member B... 126 4e-29
sp|P50578|AK1A1_PIG Alcohol dehydrogenase [NADP+] (Aldehyde... 126 5e-29
sp|P14550|AK1A1_HUMAN Alcohol dehydrogenase [NADP+] (Aldehy... 124 2e-28
>sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 139 bits (350), Expect = 5e-33
Identities = 74/155 (47%), Positives = 103/155 (66%), Gaps = 2/155 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E+H YL +KLIE+C I
Sbjct: 147 ELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIEVHPYLTQEKLIEYCKSKGIV 206
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI + + RNLI IPKSV
Sbjct: 207 VTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPMQRNLIVIPKSV 265
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 462
+ R+AEN + + +LS ED N L + N R+CA
Sbjct: 266 TPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA 300
>sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 138 bits (348), Expect = 9e-33
Identities = 75/155 (48%), Positives = 103/155 (66%), Gaps = 2/155 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V++IG+SNFN QI+ IL+ + KP+V Q+E H YL +KLIE+C I
Sbjct: 147 QLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIV 206
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DP++ E++ KYN T Q+LI + + RNL+ IPKSV
Sbjct: 207 VTAYSPLG-SPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSV 265
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 462
+ R+AEN K + +LS+ED L + N R+CA
Sbjct: 266 TPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA 300
>sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 136 bits (342), Expect = 4e-32
Identities = 73/155 (47%), Positives = 102/155 (65%), Gaps = 2/155 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V++IG+SNFN QI+ IL+ + KP+V Q+E H YL +KLIE+C I
Sbjct: 147 QLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIV 206
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI + + RNL+ IPKSV
Sbjct: 207 VTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSV 265
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 462
+ R+AEN+K + ++S ED L + N R+CA
Sbjct: 266 TPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCA 300
>sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 132 bits (333), Expect = 5e-31
Identities = 70/155 (45%), Positives = 101/155 (65%), Gaps = 2/155 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E H YL +KLI++C I
Sbjct: 147 ELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIV 206
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DP++ ++ K+N T Q+LI + + RNL+ IPKSV
Sbjct: 207 VTAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSV 265
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 462
+ R+AEN K + +LS +D L + N R+CA
Sbjct: 266 TPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA 300
>sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reductase) (20-alpha-hydroxysteroid
dehydrogenase) (20-alpha-HSD)
Length = 315
Score = 132 bits (333), Expect = 5e-31
Identities = 71/155 (45%), Positives = 100/155 (64%), Gaps = 2/155 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V++IG+SNFN Q++ IL+ + KP+V Q+E H YL +KLI++C I
Sbjct: 146 ELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIV 205
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DP++ ++ KYN T Q+LI + + RNLI IPKSV
Sbjct: 206 VTAYSPLG-SPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSV 264
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 462
+ R+AEN + + +L ED N L + + R CA
Sbjct: 265 TPERIAENFQVFDFELDKEDMNTLLSYNRDWRACA 299
>sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 130 bits (328), Expect = 2e-30
Identities = 71/154 (46%), Positives = 99/154 (64%), Gaps = 2/154 (1%)
Frame = +1
Query: 7 LVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQV 180
LVD G V+SIG+SNFN QI+ IL+ + KP+V Q+E H YL +KLI++C I V
Sbjct: 148 LVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIQYCHSKGIVV 207
Query: 181 TAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSVS 360
TAYSPLG +PDRP A + L DP++ ++ K+ T Q+LI + + RNL+ IPKSV+
Sbjct: 208 TAYSPLG-SPDRPWAKPEDPSLLEDPRIKAIADKHKKTTAQVLIRFPMQRNLVVIPKSVT 266
Query: 361 SHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 462
R+AEN + + +LS ED L + N R+CA
Sbjct: 267 PARIAENFQVFDFELSSEDMTTLLSYNRNWRVCA 300
>sp|P45377|ALD2_MOUSE Aldose reductase-related protein 2 (AR) (Aldehyde reductase)
(Fibroblast growth factor regulated protein) (FR-1
protein)
Length = 316
Score = 127 bits (319), Expect = 2e-29
Identities = 69/161 (42%), Positives = 102/161 (63%), Gaps = 3/161 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V+++G+SNFN QI+ +L+ + KP QVE H YL +KLI++C I
Sbjct: 147 ELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIS 206
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DPK+ E++ K+ T Q+LI + + RN++ IPKSV
Sbjct: 207 VTAYSPLG-SPDRPSAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIRFHIQRNVVVIPKSV 265
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMC-APQYLN 477
+ R+ ENI+ + +LSDE+ + + N R C P+ +N
Sbjct: 266 TPSRIQENIQVFDFQLSDEEMATILSFNRNWRACLLPETVN 306
>sp|O60218|AK1BA_HUMAN Aldo-keto reductase family 1 member B10 (Aldose reductase-like)
(ARL-1) (Small intestine reductase) (SI reductase)
(Aldose reductase-related protein) (ARP) (hARP)
Length = 316
Score = 126 bits (317), Expect = 4e-29
Identities = 68/154 (44%), Positives = 98/154 (63%), Gaps = 2/154 (1%)
Frame = +1
Query: 4 KLVDSGKVRSIGLSNFNIKQIQNILDH--CRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQ 177
+LVD G V+++G+SNF+ QI+ +L+ + KP QVE H YL +KLI++C I
Sbjct: 147 ELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGIT 206
Query: 178 VTAYSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSV 357
VTAYSPLG +PDRP A + L DPK+ E++ K+ T Q+LI + + RN+I IPKSV
Sbjct: 207 VTAYSPLG-SPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSV 265
Query: 358 SSHRLAENIKALEIKLSDEDFNELDNLKINNRMC 459
+ R+ ENI+ + KLSDE+ + + N R C
Sbjct: 266 TPARIVENIQVFDFKLSDEEMATILSFNRNWRAC 299
>sp|P50578|AK1A1_PIG Alcohol dehydrogenase [NADP+] (Aldehyde reductase) (Aldo-keto
reductase family 1 member A1)
Length = 325
Score = 126 bits (316), Expect = 5e-29
Identities = 67/153 (43%), Positives = 94/153 (61%)
Frame = +1
Query: 7 LVDSGKVRSIGLSNFNIKQIQNILDHCRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQVTA 186
LV G VR++GLSNF+ +QI ++L ++P+VLQVE H YL +LI C ++VTA
Sbjct: 150 LVAKGLVRALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTA 209
Query: 187 YSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSVSSH 366
YSPLG + DR E L +P V L++KYN +P QIL+ + V R +ICIPKSV+
Sbjct: 210 YSPLGSS-DRAWRDPNEPVLLEEPVVQALAEKYNRSPAQILLRWQVQRKVICIPKSVTPS 268
Query: 367 RLAENIKALEIKLSDEDFNELDNLKINNRMCAP 465
R+ +NI+ + S E+ +LD L N R P
Sbjct: 269 RIPQNIQVFDFTFSPEEMKQLDALNKNLRFIVP 301
>sp|P14550|AK1A1_HUMAN Alcohol dehydrogenase [NADP+] (Aldehyde reductase) (Aldo-keto
reductase family 1 member A1)
Length = 325
Score = 124 bits (310), Expect = 2e-28
Identities = 66/153 (43%), Positives = 94/153 (61%)
Frame = +1
Query: 7 LVDSGKVRSIGLSNFNIKQIQNILDHCRIKPSVLQVEIHVYLPNKKLIEFCWKNDIQVTA 186
LV G V+++GLSNFN +QI +IL ++P+VLQVE H YL +LI C ++VTA
Sbjct: 150 LVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTA 209
Query: 187 YSPLGGAPDRPGAVEGEARPLTDPKVVELSKKYNATPGQILINYIVHRNLICIPKSVSSH 366
YSPLG + DR E L +P V+ L++KY +P QIL+ + V R +ICIPKS++
Sbjct: 210 YSPLGSS-DRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPS 268
Query: 367 RLAENIKALEIKLSDEDFNELDNLKINNRMCAP 465
R+ +NIK + S E+ +L+ L N R P
Sbjct: 269 RILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,100,368
Number of Sequences: 369166
Number of extensions: 1301541
Number of successful extensions: 3737
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3484
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3622
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4455160255
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)