Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_H20
(413 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase) 70 2e-12
sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase) 66 2e-11
sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reduct... 66 3e-11
sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reduct... 65 5e-11
sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reduct... 65 5e-11
sp|Q9DCT1|AK1E1_MOUSE Aldo-keto reductase family 1 member E1 61 1e-09
sp|P70694|DHB5_MOUSE Estradiol 17 beta-dehydrogenase 5 (17-... 59 3e-09
sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reduct... 59 3e-09
sp|P51652|AKC1H_RAT Aldo-keto reductase family 1 member C18... 57 1e-08
sp|P50578|AK1A1_PIG Alcohol dehydrogenase [NADP+] (Aldehyde... 57 1e-08
>sp|P80276|ALDR_PIG Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 69.7 bits (169), Expect = 2e-12
Identities = 34/75 (45%), Positives = 47/75 (62%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
YN T Q+LI + + RNLI IPKSV+ R+AEN + + +LS ED N L + N R+CA
Sbjct: 241 YNKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCA 300
Query: 294 PQIFKLHHNYPFYED 338
H +YPF+E+
Sbjct: 301 LMSCASHKDYPFHEE 315
Score = 30.4 bits (67), Expect = 1.5
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Frame = +1
Query: 16 AYSPLGGAPDRPGAVEGEARPLTDPKV----VELSKNIMQHLVKF 138
AYSPLG +PDRP A + L DP++ + +K Q L++F
Sbjct: 209 AYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRF 252
>sp|P07943|ALDR_RAT Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 66.2 bits (160), Expect = 2e-11
Identities = 32/75 (42%), Positives = 46/75 (61%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
YN T Q+LI + + RNL+ IPKSV+ R+AEN K + +LS+ED L + N R+CA
Sbjct: 241 YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA 300
Query: 294 PQIFKLHHNYPFYED 338
H +YPF+ +
Sbjct: 301 LMSCAKHKDYPFHAE 315
Score = 32.3 bits (72), Expect = 0.39
Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 4/45 (8%)
Frame = +1
Query: 16 AYSPLGGAPDRPGAVEGEARPLTDPKVVEL----SKNIMQHLVKF 138
AYSPLG +PDRP A + L DP++ E+ +K Q L++F
Sbjct: 209 AYSPLG-SPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRF 252
>sp|P16116|ALDR_BOVIN Aldose reductase (AR) (Aldehyde reductase) (20-alpha-hydroxysteroid
dehydrogenase) (20-alpha-HSD)
Length = 315
Score = 65.9 bits (159), Expect = 3e-11
Identities = 32/75 (42%), Positives = 45/75 (60%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
YN T Q+LI + + RNLI IPKSV+ R+AEN + + +L ED N L + + R CA
Sbjct: 240 YNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACA 299
Query: 294 PQIFKLHHNYPFYED 338
H +YPF+E+
Sbjct: 300 LVSCASHRDYPFHEE 314
Score = 30.0 bits (66), Expect = 1.9
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Frame = +1
Query: 16 AYSPLGGAPDRPGAVEGEARPLTDPKVVEL----SKNIMQHLVKF 138
AYSPLG +PDRP A + L DP++ + +K Q L++F
Sbjct: 208 AYSPLG-SPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRF 251
>sp|P45376|ALDR_MOUSE Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 65.1 bits (157), Expect = 5e-11
Identities = 31/75 (41%), Positives = 46/75 (61%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
YN T Q+LI + + RNL+ IPKSV+ R+AEN+K + ++S ED L + N R+CA
Sbjct: 241 YNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCA 300
Query: 294 PQIFKLHHNYPFYED 338
H +YPF+ +
Sbjct: 301 LMSCAKHKDYPFHAE 315
Score = 30.4 bits (67), Expect = 1.5
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Frame = +1
Query: 16 AYSPLGGAPDRPGAVEGEARPLTDPKV----VELSKNIMQHLVKF 138
AYSPLG +PDRP A + L DP++ + +K Q L++F
Sbjct: 209 AYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRF 252
>sp|P15121|ALDR_HUMAN Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 65.1 bits (157), Expect = 5e-11
Identities = 31/75 (41%), Positives = 46/75 (61%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
+N T Q+LI + + RNL+ IPKSV+ R+AEN K + +LS +D L + N R+CA
Sbjct: 241 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA 300
Query: 294 PQIFKLHHNYPFYED 338
H +YPF+E+
Sbjct: 301 LLSCTSHKDYPFHEE 315
Score = 30.0 bits (66), Expect = 1.9
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Frame = +1
Query: 16 AYSPLGGAPDRPGAVEGEARPLTDPKVVEL----SKNIMQHLVKF 138
AYSPLG +PDRP A + L DP++ + +K Q L++F
Sbjct: 209 AYSPLG-SPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRF 252
>sp|Q9DCT1|AK1E1_MOUSE Aldo-keto reductase family 1 member E1
Length = 301
Score = 60.8 bits (146), Expect = 1e-09
Identities = 29/73 (39%), Positives = 46/73 (63%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
+ +P QILI + + RNLI IPKSV+ R+ ENI+ + +L+++D EL +L N R+
Sbjct: 226 HGKSPAQILIRFQIQRNLIVIPKSVTPSRIRENIQVFDFELTEKDMEELLSLDKNLRLAT 285
Query: 294 PQIFKLHHNYPFY 332
+ H +YPF+
Sbjct: 286 FPTTENHQDYPFH 298
>sp|P70694|DHB5_MOUSE Estradiol 17 beta-dehydrogenase 5 (17-beta-HSD 5)
Length = 323
Score = 59.3 bits (142), Expect = 3e-09
Identities = 27/75 (36%), Positives = 44/75 (58%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
YN TP I + Y + R ++ + KS S R+ EN++ E +L+ ED LD+L N R +
Sbjct: 248 YNRTPALIALRYQLQRGVVVLAKSFSEKRIKENMQVFEFQLTSEDMKVLDDLNKNIRYIS 307
Query: 294 PQIFKLHHNYPFYED 338
FK H ++PF+++
Sbjct: 308 GSSFKDHPDFPFWDE 322
>sp|P15122|ALDR_RABIT Aldose reductase (AR) (Aldehyde reductase)
Length = 316
Score = 59.3 bits (142), Expect = 3e-09
Identities = 29/75 (38%), Positives = 44/75 (58%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
+ T Q+LI + + RNL+ IPKSV+ R+AEN + + +LS ED L + N R+CA
Sbjct: 241 HKKTTAQVLIRFPMQRNLVVIPKSVTPARIAENFQVFDFELSSEDMTTLLSYNRNWRVCA 300
Query: 294 PQIFKLHHNYPFYED 338
H +YPF+ +
Sbjct: 301 LVSCASHKDYPFHAE 315
Score = 30.0 bits (66), Expect = 1.9
Identities = 18/45 (40%), Positives = 26/45 (57%), Gaps = 4/45 (8%)
Frame = +1
Query: 16 AYSPLGGAPDRPGAVEGEARPLTDPKVVELS----KNIMQHLVKF 138
AYSPLG +PDRP A + L DP++ ++ K Q L++F
Sbjct: 209 AYSPLG-SPDRPWAKPEDPSLLEDPRIKAIADKHKKTTAQVLIRF 252
>sp|P51652|AKC1H_RAT Aldo-keto reductase family 1 member C18 (20-alpha-hydroxysteroid
dehydrogenase) (20-alpha-HSD) (HSD1)
Length = 323
Score = 57.4 bits (137), Expect = 1e-08
Identities = 25/75 (33%), Positives = 42/75 (56%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
Y TP I + Y + R ++ + KS + R+ EN++ + +L+ +D LDNL N R
Sbjct: 248 YKRTPALIALRYQLERGIVTLVKSFNEERIRENLQVFDFQLASDDMEILDNLDRNLRYFP 307
Query: 294 PQIFKLHHNYPFYED 338
+FK H N+PF ++
Sbjct: 308 ANMFKAHPNFPFSDE 322
>sp|P50578|AK1A1_PIG Alcohol dehydrogenase [NADP+] (Aldehyde reductase) (Aldo-keto
reductase family 1 member A1)
Length = 325
Score = 57.4 bits (137), Expect = 1e-08
Identities = 26/63 (41%), Positives = 38/63 (60%)
Frame = +3
Query: 114 YNATPGQILINYIVHRNLICIPKSVSSHRLAENIKALEIKLSDEDFNELDNLKINNRMCA 293
YN +P QIL+ + V R +ICIPKSV+ R+ +NI+ + S E+ +LD L N R
Sbjct: 241 YNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIV 300
Query: 294 PQI 302
P +
Sbjct: 301 PML 303
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,680,508
Number of Sequences: 369166
Number of extensions: 880373
Number of successful extensions: 2542
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2401
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2542
length of database: 68,354,980
effective HSP length: 99
effective length of database: 50,066,215
effective search space used: 1902516170
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)