Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00790 (509 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9Z0J0|NPC2_MOUSE Epididymal secretory protein E1 precur... 85 1e-16 sp|O97763|NPC2_PIG Epididymal secretory protein E1 precurso... 84 2e-16 sp|P61917|NPC2_PANTR Epididymal secretory protein E1 precur... 83 3e-16 sp|P79345|NPC2_BOVIN Epididymal secretory protein E1 precur... 82 6e-16 sp|Q9DGJ3|NPC2_BRARE Epididymal secretory protein E1 precur... 77 3e-14 sp|Q28895|NPC2_CANFA Epididymal secretory protein E1 precur... 68 1e-11 sp|Q9VQ62|NPC2_DROME Hypothetical protein NPC2 precursor (N... 67 2e-11 sp|Q25481|ES16_MANSE Ecdysteroid regulated 16 kDa protein p... 55 7e-08 sp|P27236|DCP_SALTY Peptidyl-dipeptidase dcp (Dipeptidyl ca... 29 5.6 sp|Q25158|OPSC2_HEMSA Compound eye opsin BCRH2 29 7.3
>sp|Q9Z0J0|NPC2_MOUSE Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (mE1) Length = 149 Score = 84.7 bits (208), Expect = 1e-16 Identities = 43/143 (30%), Positives = 68/143 (47%) Frame = +1 Query: 10 ILGLSFINISLTEPTIYKDCGSKKGIVQSVEITPCSTQPCQLKKGTKPQITIKYKSNENX 189 IL L+ + S EP +KDCGSK G+++ V ++PC T PCQL KG + I + S Sbjct: 8 ILLLALVAASQAEPLHFKDCGSKVGVIKEVNVSPCPTDPCQLHKGQSYSVNITFTSGTQS 67 Query: 190 XXXXXXXXXXXXIFNLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTI 369 +PF +P+ D + S Y N + + YPS+++ + Sbjct: 68 QNSTALVHGILEGIRVPFPIPEPDGCKSGINCPIQKDKVYS-YLNKLPVKNEYPSIKLVV 126 Query: 370 TWELIDADGNDIVCVQMPTSIVS 438 W+L D N++ C ++P I S Sbjct: 127 EWKLEDDKKNNLFCWEIPVQITS 149
>sp|O97763|NPC2_PIG Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (16 kDa secretory protein) Length = 149 Score = 84.0 bits (206), Expect = 2e-16 Identities = 42/134 (31%), Positives = 64/134 (47%) Frame = +1 Query: 37 SLTEPTIYKDCGSKKGIVQSVEITPCSTQPCQLKKGTKPQITIKYKSNENXXXXXXXXXX 216 +L EP ++DCGS G+++ V + PC TQPCQL KG + + + SN Sbjct: 17 ALAEPVHFRDCGSGVGVIKEVNVNPCPTQPCQLHKGQSYSVNVTFTSNTQSKGSKAVVHG 76 Query: 217 XXXIFNLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTITWELIDADG 396 +PF +PD D QT S Y N + + YPS+++ + W+L D + Sbjct: 77 IVMGVPIPFPIPDPDGCKSGINCPIQKDQTYS-YLNKLPVKAEYPSIKLVVEWKLQDDND 135 Query: 397 NDIVCVQMPTSIVS 438 + C Q+P I S Sbjct: 136 QCLFCWQIPVQIES 149
>sp|P61917|NPC2_PANTR Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (EPI-1) sp|P61918|NPC2_MACFA Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (Epididymal secretory protein 14.6) (ESP14.6) sp|P61916|NPC2_HUMAN Epididymal secretory protein E1 precursor (Niemann-Pick disease type C2 protein) (hE1) Length = 151 Score = 83.2 bits (204), Expect = 3e-16 Identities = 41/140 (29%), Positives = 66/140 (47%) Frame = +1 Query: 19 LSFINISLTEPTIYKDCGSKKGIVQSVEITPCSTQPCQLKKGTKPQITIKYKSNENXXXX 198 L+ + EP +KDCGS G+++ V ++PC TQPCQL KG + + + SN Sbjct: 11 LALSTAAQAEPVQFKDCGSVDGVIKEVNVSPCPTQPCQLSKGQSYSVNVTFTSNIQSKSS 70 Query: 199 XXXXXXXXXIFNLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTITWE 378 +PF +P+ D +T S Y N + + YPS+++ + W+ Sbjct: 71 KAVVHGILMGVPVPFPIPEPDGCKSGINCPIQKDKTYS-YLNKLPVKSEYPSIKLVVEWQ 129 Query: 379 LIDADGNDIVCVQMPTSIVS 438 L D + C ++P IVS Sbjct: 130 LQDDKNQSLFCWEIPVQIVS 149
>sp|P79345|NPC2_BOVIN Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (EPV20) Length = 149 Score = 82.4 bits (202), Expect = 6e-16 Identities = 40/143 (27%), Positives = 67/143 (46%) Frame = +1 Query: 4 IVILGLSFINISLTEPTIYKDCGSKKGIVQSVEITPCSTQPCQLKKGTKPQITIKYKSNE 183 + L L+ +L EP +KDCGS G+++ V ++PC TQPC+L +G + + + SN Sbjct: 6 VAFLFLALSASALAEPVKFKDCGSWVGVIKEVNVSPCPTQPCKLHRGQSYSVNVTFTSNT 65 Query: 184 NXXXXXXXXXXXXXIFNLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRV 363 +PF +P++D +T + Y N + + YPS++V Sbjct: 66 QSQSSKAVVHGIVMGIPVPFPIPESDGCKSGIRCPIEKDKTYN-YVNKLPVKNEYPSIKV 124 Query: 364 TITWELIDADGNDIVCVQMPTSI 432 + WEL D C Q+P + Sbjct: 125 VVEWELTDDKNQRFFCWQIPIEV 147
>sp|Q9DGJ3|NPC2_BRARE Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (16.5 kDa secretory protein) Length = 149 Score = 76.6 bits (187), Expect = 3e-14 Identities = 40/140 (28%), Positives = 62/140 (44%) Frame = +1 Query: 19 LSFINISLTEPTIYKDCGSKKGIVQSVEITPCSTQPCQLKKGTKPQITIKYKSNENXXXX 198 LSF+ + +P + DCGS G V V+I PCS QPC+L KG + + + S Sbjct: 11 LSFLAYTCADPVKFVDCGSVDGKVVQVDIKPCSQQPCKLHKGQSYTVNVTFSSGVESQTS 70 Query: 199 XXXXXXXXXIFNLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTITWE 378 +PF +P +D Q Y + + YP+++V + WE Sbjct: 71 KAVVHGVLAGVPVPFPIPIDD-GCKSGIQCPIVPQKPYNYVTELPVKTEYPAIKVVVEWE 129 Query: 379 LIDADGNDIVCVQMPTSIVS 438 L D D+ C++ P IV+ Sbjct: 130 LRDDSSKDLFCIKFPVQIVN 149
>sp|Q28895|NPC2_CANFA Epididymal secretory protein E1 precursor (Niemann Pick type C2 protein homolog) (cE1) Length = 149 Score = 68.2 bits (165), Expect = 1e-11 Identities = 32/125 (25%), Positives = 57/125 (45%) Frame = +1 Query: 58 YKDCGSKKGIVQSVEITPCSTQPCQLKKGTKPQITIKYKSNENXXXXXXXXXXXXXIFNL 237 +KDCGS G+++ + + PC QPC+L KG + + + SN + Sbjct: 24 FKDCGSAVGVIKELNVNPCPAQPCKLHKGQSYSVNVTFTSNIPSQSSKAVVHGIVLGVAV 83 Query: 238 PFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTITWELIDADGNDIVCVQ 417 PF +P+ D +T S Y N + + YPS+++ + W L+ + + C + Sbjct: 84 PFPIPEADGCKSGINCPIQKDKTYS-YLNKLPVKNEYPSIKLVVQWMLLGDNNQHLFCWE 142 Query: 418 MPTSI 432 +P I Sbjct: 143 IPVQI 147
>sp|Q9VQ62|NPC2_DROME Hypothetical protein NPC2 precursor (Niemann Pick type C2 protein homolog) Length = 148 Score = 67.4 bits (163), Expect = 2e-11 Identities = 39/127 (30%), Positives = 54/127 (42%), Gaps = 2/127 (1%) Frame = +1 Query: 58 YKDCGSKKGIVQSVEITPCSTQP--CQLKKGTKPQITIKYKSNENXXXXXXXXXXXXXIF 231 + DCGSK G V I C T C LK+ T +I + E Sbjct: 21 FSDCGSKTGKFTRVAIEGCDTTKAECILKRNTTVSFSIDFALAEEATAVKTVVHGKVLGI 80 Query: 232 NLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTITWELIDADGNDIVC 411 +PF L + D + YT ++ +L+ YP V V + WEL D DG DI+C Sbjct: 81 EMPFPLANPDACVDSGLKCPLEKDESYRYTATLPVLRSYPKVSVLVKWELQDQDGADIIC 140 Query: 412 VQMPTSI 432 V++P I Sbjct: 141 VEIPAKI 147
>sp|Q25481|ES16_MANSE Ecdysteroid regulated 16 kDa protein precursor Length = 145 Score = 55.5 bits (132), Expect = 7e-08 Identities = 35/127 (27%), Positives = 53/127 (41%), Gaps = 2/127 (1%) Frame = +1 Query: 58 YKDCGSKKGIVQSVEIT--PCSTQPCQLKKGTKPQITIKYKSNENXXXXXXXXXXXXXIF 231 Y DCGSK VQSV ++ P + + C LK+ + I+I + + Sbjct: 19 YTDCGSKLATVQSVGVSGWPENARECVLKRNSNVTISIDFSPTTDVSAITTEVHGVIMSL 78 Query: 232 NLPFSLPDNDLXXXXXXXXXXXXQTNSTYTNSIDILKYYPSVRVTITWELIDADGNDIVC 411 +PF D + Y ++ +LK YP V V + WEL D D+VC Sbjct: 79 PVPFPCRSPDACKDNGLTCPIKAGVVANYKTTLPVLKSYPKVSVDVKWEL-KKDEEDLVC 137 Query: 412 VQMPTSI 432 + +P I Sbjct: 138 ILIPARI 144
>sp|P27236|DCP_SALTY Peptidyl-dipeptidase dcp (Dipeptidyl carboxypeptidase) Length = 680 Score = 29.3 bits (64), Expect = 5.6 Identities = 13/28 (46%), Positives = 17/28 (60%) Frame = +1 Query: 313 TYTNSIDILKYYPSVRVTITWELIDADG 396 T+ DI Y+P VRV WE+ D+DG Sbjct: 380 TFVERFDIPVYHPDVRV---WEIFDSDG 404
>sp|Q25158|OPSC2_HEMSA Compound eye opsin BCRH2 Length = 377 Score = 28.9 bits (63), Expect = 7.3 Identities = 11/31 (35%), Positives = 20/31 (64%), Gaps = 1/31 (3%) Frame = -1 Query: 185 FSLDLYLIVI-CGFVPFFNWHGWVLQGVIST 96 F+L ++I I C PFF W ++L+G++ + Sbjct: 174 FALISWVIAIGCALPPFFGWGNYILEGILDS 204
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 51,044,441 Number of Sequences: 369166 Number of extensions: 905251 Number of successful extensions: 1856 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 1803 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 1848 length of database: 68,354,980 effective HSP length: 103 effective length of database: 49,327,275 effective search space used: 3255600150 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)