DrC_01125
- Cluster detail
- GO Category : Not Available
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01125 (898 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 129 8e-30 sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 122 2e-27 sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinas... 122 2e-27 sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 121 3e-27 sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 120 5e-27 sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 120 7e-27 sp|P27636|CDC15_YEAST Cell division control protein 15 120 7e-27 sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 119 1e-26 sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 118 2e-26 sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 118 2e-26
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal-regulating kinase 1) (ASK-1) Length = 1374 Score = 129 bits (325), Expect = 8e-30 Identities = 84/209 (40%), Positives = 123/209 (58%), Gaps = 7/209 (3%) Frame = +1 Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIKKNKFKPLPLT--TIKQHTKQILKG 408 + ++NIV+Y G+ I IFME + G SL + ++K+ PL TI +TKQIL+G Sbjct: 732 LKHKNIVQYLGSFSENGFIKIFMEQVPGGSL-SALLRSKWGPLKDNEQTIGFYTKQILEG 790 Query: 409 LKFLHEQNIIHRDIKSAXXXXXXXXXXXX-ADFGTSRFLKAISKYHKKTFCGTAKYISPE 585 LK+LH+ I+HRDIK +DFGTS+ L I+ +TF GT +Y++PE Sbjct: 791 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPC-TETFTGTLQYMAPE 849 Query: 586 VMKNEP--YGCSADIWSLGATVFEMATGHPPYHEMID-NAVIFKIGSER-KIEFPSNMPD 753 ++ P YG +ADIWSLG T+ EMATG PP++E+ + A +FK+G + E P +M Sbjct: 850 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSA 909 Query: 754 DIKGFLNLMIIAKPENRSTADSLLNCEFL 840 + K F+ P+ R+ A+ LL EFL Sbjct: 910 EAKAFILKCFEPDPDKRACANDLLVDEFL 938
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 122 bits (305), Expect = 2e-27 Identities = 81/228 (35%), Positives = 122/228 (53%), Gaps = 5/228 (2%) Frame = +1 Query: 169 DDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRN-LEKIF-IFMEFIDGKSLFQKIK 342 D KE E I + + +E IV+Y+G +R+ EKI IFME++ G S+ ++K Sbjct: 398 DSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLK 456 Query: 343 KNKFKPLPLTTIKQHTKQILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFL 522 + L + +++T+QIL+G+ +LH I+HRDIK A DFG S+ L Sbjct: 457 A--YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL 514 Query: 523 KAI--SKYHKKTFCGTAKYISPEVMKNEPYGCSADIWSLGATVFEMATGHPPYHEMIDNA 696 + I S ++ GT ++SPEV+ E YG AD+WSLG TV EM T PP+ E A Sbjct: 515 QTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574 Query: 697 VIFKIGSE-RKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEF 837 IFKI ++ + PS++ + + FL I + R +A+ LL F Sbjct: 575 AIFKIATQPTNPQLPSHISEHGRDFLR-RIFVEARQRPSAEELLTHHF 621
>sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6 Length = 1011 Score = 122 bits (305), Expect = 2e-27 Identities = 79/209 (37%), Positives = 121/209 (57%), Gaps = 7/209 (3%) Frame = +1 Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIKKNKFKPLP--LTTIKQHTKQILKG 408 + ++NIV+Y G+ + IFME + G SL + ++ + PL +TI +T+QIL+G Sbjct: 423 LRHKNIVRYLGSASQGGYLKIFMEEVPGGSL-SSLLRSVWGPLKDNESTISFYTRQILQG 481 Query: 409 LKFLHEQNIIHRDIKSAXXXXXXXXXXXX-ADFGTSRFLKAISKYHKKTFCGTAKYISPE 585 L +LH+ +I+HRDIK +DFGTS+ L I+ +TF GT +Y++PE Sbjct: 482 LGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC-TETFTGTLQYMAPE 540 Query: 586 VMKNEP--YGCSADIWSLGATVFEMATGHPPYHEM-IDNAVIFKIGSER-KIEFPSNMPD 753 ++ P YG +ADIWSLG TV EMATG PP+HE+ A +F++G + PS++ Sbjct: 541 IIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSA 600 Query: 754 DIKGFLNLMIIAKPENRSTADSLLNCEFL 840 + + FL P R++A +LL FL Sbjct: 601 EAQAFLLRTFEPDPRLRASAQTLLGDPFL 629
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 121 bits (303), Expect = 3e-27 Identities = 78/228 (34%), Positives = 121/228 (53%), Gaps = 5/228 (2%) Frame = +1 Query: 169 DDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRNLEK--IFIFMEFIDGKSLFQKIK 342 D KE E I + + +E IV+Y+G +R+ + + IFME++ G S+ ++K Sbjct: 398 DSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLK 456 Query: 343 KNKFKPLPLTTIKQHTKQILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFL 522 + L + +++T+QIL+G+ +LH I+HRDIK A DFG S+ L Sbjct: 457 A--YGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL 514 Query: 523 KAI--SKYHKKTFCGTAKYISPEVMKNEPYGCSADIWSLGATVFEMATGHPPYHEMIDNA 696 + I S ++ GT ++SPEV+ E YG AD+WSLG TV EM T PP+ E A Sbjct: 515 QTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574 Query: 697 VIFKIGSE-RKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEF 837 IFKI ++ + PS++ + + FL I + R +A+ LL F Sbjct: 575 AIFKIATQPTNPQLPSHISEHGRDFLR-RIFVEARQRPSAEELLTHHF 621
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) Length = 618 Score = 120 bits (301), Expect = 5e-27 Identities = 81/239 (33%), Positives = 129/239 (53%), Gaps = 6/239 (2%) Frame = +1 Query: 145 AMKTIE-NVDDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRNLEK--IFIFMEFID 315 A+K ++ + D KE E I + F++ E IV+Y+G +R+ ++ + IFME++ Sbjct: 382 AVKQVQFDPDSPETSKEVNALECEIQLLKNFLH-ERIVQYYGCLRDPQEKTLSIFMEYMP 440 Query: 316 GKSLFQKIKKNKFKPLPLTTIKQHTKQILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXX 495 G S+ ++K + L +++T+QIL+G+ +LH I+HRDIK A Sbjct: 441 GGSIKDQLKA--YGALTENGTRKYTRQILEGVHYLHSNMILHRDIKGANILRDSTGNVKL 498 Query: 496 ADFGTSRFLKAI--SKYHKKTFCGTAKYISPEVMKNEPYGCSADIWSLGATVFEMATGHP 669 DFG S+ L+ I S K+ GT ++SPEV+ + YG ADIWS+ TV EM T P Sbjct: 499 GDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGQGYGRKADIWSVACTVVEMLTEKP 558 Query: 670 PYHEMIDNAVIFKIGSE-RKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEFLN 843 P+ E A IFKI ++ + P ++ D + FL I + + R +AD LL F++ Sbjct: 559 PWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLK-RIFVEAKLRPSADELLRHMFVH 616
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 120 bits (300), Expect = 7e-27 Identities = 73/205 (35%), Positives = 111/205 (54%), Gaps = 3/205 (1%) Frame = +1 Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIKKNKFKPLPLTTIKQHTKQILKGLK 414 +++ NIV+Y G VR + + I MEF+ G S+ ++K F P I +TKQ+L GL+ Sbjct: 128 LSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEK--FGSFPEPVIIMYTKQLLLGLE 185 Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLKAISKYH-KKTFCGTAKYISPEVM 591 +LH I+HRDIK A ADFG S+ + ++ + K+ GT +++PEV+ Sbjct: 186 YLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVI 245 Query: 592 KNEPYGCSADIWSLGATVFEMATGHPPYHEMIDN-AVIFKIG-SERKIEFPSNMPDDIKG 765 + SADIWS+G TV EMATG PP+ E A + IG ++ P ++ + K Sbjct: 246 LQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKD 305 Query: 766 FLNLMIIAKPENRSTADSLLNCEFL 840 FL + +P R +A LL F+ Sbjct: 306 FLMKCLHKEPSLRLSATELLQHPFV 330
>sp|P27636|CDC15_YEAST Cell division control protein 15 Length = 974 Score = 120 bits (300), Expect = 7e-27 Identities = 69/203 (33%), Positives = 108/203 (53%) Frame = +1 Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIKKNKFKPLPLTTIKQHTKQILKGLK 414 +N+ NIVKY G +R +++I +E+ SL + I ++ L K + Q L GLK Sbjct: 77 LNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSS-TGLSENESKTYVTQTLLGLK 135 Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLKAISKYHKKTFCGTAKYISPEVMK 594 +LH + +IHRDIK+A ADFG S + + + T GT +++PE++ Sbjct: 136 YLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSAL----TLAGTLNWMAPEILG 191 Query: 595 NEPYGCSADIWSLGATVFEMATGHPPYHEMIDNAVIFKIGSERKIEFPSNMPDDIKGFLN 774 N +DIWSLGATV EM T +PPYH + D + + + ++ PS+ + +K FL+ Sbjct: 192 NRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLS 250 Query: 775 LMIIAKPENRSTADSLLNCEFLN 843 + R TAD LL ++N Sbjct: 251 KCFVKNMYKRPTADQLLKHVWIN 273
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis NPK1-related protein kinase 1) Length = 666 Score = 119 bits (297), Expect = 1e-26 Identities = 72/205 (35%), Positives = 111/205 (54%), Gaps = 3/205 (1%) Frame = +1 Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIKKNKFKPLPLTTIKQHTKQILKGLK 414 +++ NIV+Y G VR + + I +EF+ G S+ ++K F P P + ++ +T+Q+L GL+ Sbjct: 129 LSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEK--FGPFPESVVRTYTRQLLLGLE 186 Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLKAISKY-HKKTFCGTAKYISPEVM 591 +LH I+HRDIK A ADFG S+ + ++ K+ GT +++PEV+ Sbjct: 187 YLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVI 246 Query: 592 KNEPYGCSADIWSLGATVFEMATGHPPYHEMI-DNAVIFKIGSERK-IEFPSNMPDDIKG 765 + SADIWS+G TV EM TG P+ + + A IF IG+ + P + D K Sbjct: 247 LQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKD 306 Query: 766 FLNLMIIAKPENRSTADSLLNCEFL 840 FL + P R TA LL F+ Sbjct: 307 FLLKCLQEVPNLRPTASELLKHPFV 331
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis NPK1-related protein kinase 2) Length = 651 Score = 118 bits (296), Expect = 2e-26 Identities = 72/205 (35%), Positives = 110/205 (53%), Gaps = 3/205 (1%) Frame = +1 Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIKKNKFKPLPLTTIKQHTKQILKGLK 414 +++ NIV+Y G VR E + I +EF+ G S+ ++K F P + ++ +T Q+L GL+ Sbjct: 128 LSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEK--FGAFPESVVRTYTNQLLLGLE 185 Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLKAISKYH-KKTFCGTAKYISPEVM 591 +LH I+HRDIK A ADFG S+ + ++ K+ GT +++PEV+ Sbjct: 186 YLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVI 245 Query: 592 KNEPYGCSADIWSLGATVFEMATGHPPYHEMI-DNAVIFKIGSERK-IEFPSNMPDDIKG 765 + SADIWS+G TV EM TG P+ + + A IF IG+ + P N+ D Sbjct: 246 LQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISSDAND 305 Query: 766 FLNLMIIAKPENRSTADSLLNCEFL 840 FL + +P R TA LL F+ Sbjct: 306 FLLKCLQQEPNLRPTASELLKHPFV 330
>sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 Length = 738 Score = 118 bits (296), Expect = 2e-26 Identities = 78/233 (33%), Positives = 118/233 (50%), Gaps = 2/233 (0%) Frame = +1 Query: 151 KTIENVDDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRNLEKIFIFMEFIDGKSLF 330 KT +N+ +K + +N +E +++ENIV Y+GA + + IF+E++ G S+ Sbjct: 509 KTNQNIH----RKMVDALQHEMNLLKE-LHHENIVTYYGASQEGGNLNIFLEYVPGGSVS 563 Query: 331 QKIKKNKFKPLPLTTIKQHTKQILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXXADFGT 510 + N + P + I T+QIL G+ +LH++NIIHRDIK A DFG Sbjct: 564 SML--NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGI 621 Query: 511 SRFLKAISKYHKK--TFCGTAKYISPEVMKNEPYGCSADIWSLGATVFEMATGHPPYHEM 684 S+ L ++K K + G+ ++SPEV+K ADIWS G V EM TG P+ + Sbjct: 622 SKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDF 681 Query: 685 IDNAVIFKIGSERKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEFLN 843 IFKIG+ E PS + K FL + R +A LL +L+ Sbjct: 682 SQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWLD 734
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,552,546
Number of Sequences: 369166
Number of extensions: 1400599
Number of successful extensions: 7393
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5387
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5642
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9030416440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
