Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_024_G24
(444 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 81 1e-15
sp|P53351|PLK2_MOUSE Serine/threonine-protein kinase PLK2 (... 80 2e-15
sp|Q9NYY3|PLK2_HUMAN Serine/threonine-protein kinase PLK2 (... 80 2e-15
sp|Q9R012|PLK2_RAT Serine/threonine-protein kinase PLK2 (Po... 80 2e-15
sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinas... 80 3e-15
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 79 3e-15
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 79 6e-15
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 77 1e-14
sp|Q61083|M3K2_MOUSE Mitogen-activated protein kinase kinas... 77 2e-14
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 76 3e-14
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
signal-regulating kinase 1) (ASK-1)
Length = 1374
Score = 80.9 bits (198), Expect = 1e-15
Identities = 46/99 (46%), Positives = 62/99 (62%), Gaps = 3/99 (3%)
Frame = +1
Query: 157 TIKQHTKQILKGLEFLHEQDIIHRDIK-SAXXXXXXXXXXXXADFGTSRFLRAISKYHKK 333
TI +TKQIL+GL++LH+ I+HRDIK +DFGTS+ L I+ +
Sbjct: 779 TIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPC-TE 837
Query: 334 TFCGTAIYISPEVMQSEP--YGCSADIWSLGATVFEMAT 444
TF GT Y++PE++ P YG +ADIWSLG T+ EMAT
Sbjct: 838 TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMAT 876
>sp|P53351|PLK2_MOUSE Serine/threonine-protein kinase PLK2 (Polo-like kinase 1) (PLK-2)
(Serine/threonine-protein kinase SNK) (Serum inducible
kinase)
Length = 682
Score = 80.5 bits (197), Expect = 2e-15
Identities = 34/93 (36%), Positives = 58/93 (62%)
Frame = +1
Query: 160 IKQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAISKYHKKTF 339
++ + +QI+ GL++LHEQ+I+HRD+K DFG + L + ++ ++T
Sbjct: 179 VRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL-EHRRRTI 237
Query: 340 CGTAIYISPEVMQSEPYGCSADIWSLGATVFEM 438
CGT Y+SPEV+ + +GC +DIW+LG ++ M
Sbjct: 238 CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTM 270
>sp|Q9NYY3|PLK2_HUMAN Serine/threonine-protein kinase PLK2 (Polo-like kinase 1) (PLK-2)
(Serine/threonine-protein kinase SNK) (Serum inducible
kinase)
Length = 685
Score = 80.5 bits (197), Expect = 2e-15
Identities = 34/93 (36%), Positives = 58/93 (62%)
Frame = +1
Query: 160 IKQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAISKYHKKTF 339
++ + +QI+ GL++LHEQ+I+HRD+K DFG + L + ++ ++T
Sbjct: 182 VRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL-EHRRRTI 240
Query: 340 CGTAIYISPEVMQSEPYGCSADIWSLGATVFEM 438
CGT Y+SPEV+ + +GC +DIW+LG ++ M
Sbjct: 241 CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTM 273
>sp|Q9R012|PLK2_RAT Serine/threonine-protein kinase PLK2 (Polo-like kinase 1) (PLK-2)
(Serine/threonine-protein kinase SNK) (Serum inducible
kinase)
Length = 682
Score = 80.5 bits (197), Expect = 2e-15
Identities = 34/93 (36%), Positives = 58/93 (62%)
Frame = +1
Query: 160 IKQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAISKYHKKTF 339
++ + +QI+ GL++LHEQ+I+HRD+K DFG + L + ++ ++T
Sbjct: 179 VRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPL-EHRRRTI 237
Query: 340 CGTAIYISPEVMQSEPYGCSADIWSLGATVFEM 438
CGT Y+SPEV+ + +GC +DIW+LG ++ M
Sbjct: 238 CGTPNYLSPEVLNKQGHGCESDIWALGCVMYTM 270
>sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6
Length = 1011
Score = 79.7 bits (195), Expect = 3e-15
Identities = 46/100 (46%), Positives = 62/100 (62%), Gaps = 3/100 (3%)
Frame = +1
Query: 154 TTIKQHTKQILKGLEFLHEQDIIHRDIK-SAXXXXXXXXXXXXADFGTSRFLRAISKYHK 330
+TI +T+QIL+GL +LH+ I+HRDIK +DFGTS+ L I+
Sbjct: 469 STISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC-T 527
Query: 331 KTFCGTAIYISPEVMQSEP--YGCSADIWSLGATVFEMAT 444
+TF GT Y++PE++ P YG +ADIWSLG TV EMAT
Sbjct: 528 ETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMAT 567
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 79.3 bits (194), Expect = 3e-15
Identities = 41/96 (42%), Positives = 57/96 (59%), Gaps = 2/96 (2%)
Frame = +1
Query: 163 KQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAI--SKYHKKT 336
+++T+QIL+G+ +LH I+HRDIK A DFG S+ L+ I S ++
Sbjct: 467 RKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRS 526
Query: 337 FCGTAIYISPEVMQSEPYGCSADIWSLGATVFEMAT 444
GT ++SPEV+ E YG AD+WSLG TV EM T
Sbjct: 527 VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT 562
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 78.6 bits (192), Expect = 6e-15
Identities = 41/96 (42%), Positives = 57/96 (59%), Gaps = 2/96 (2%)
Frame = +1
Query: 163 KQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAI--SKYHKKT 336
+++T+QIL+G+ +LH I+HRDIK A DFG S+ L+ I S ++
Sbjct: 467 RKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRS 526
Query: 337 FCGTAIYISPEVMQSEPYGCSADIWSLGATVFEMAT 444
GT ++SPEV+ E YG AD+WSLG TV EM T
Sbjct: 527 VTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLT 562
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 77.4 bits (189), Expect = 1e-14
Identities = 40/102 (39%), Positives = 59/102 (57%), Gaps = 1/102 (0%)
Frame = +1
Query: 142 PLPLTTIKQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAISK 321
P P + ++ +T+Q+L GLE+LH I+HRDIK A ADFG S+ + ++
Sbjct: 168 PFPESVVRTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELAT 227
Query: 322 Y-HKKTFCGTAIYISPEVMQSEPYGCSADIWSLGATVFEMAT 444
K+ GT +++PEV+ + SADIWS+G TV EM T
Sbjct: 228 MTGAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVT 269
>sp|Q61083|M3K2_MOUSE Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 619
Score = 77.0 bits (188), Expect = 2e-14
Identities = 41/96 (42%), Positives = 56/96 (58%), Gaps = 2/96 (2%)
Frame = +1
Query: 163 KQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAI--SKYHKKT 336
+++T+QIL+G+ +LH I+HRDIK A DFG S+ L+ I S K+
Sbjct: 461 RKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKS 520
Query: 337 FCGTAIYISPEVMQSEPYGCSADIWSLGATVFEMAT 444
GT ++SPEV+ E YG ADIWS+ TV EM T
Sbjct: 521 VTGTPYWMSPEVISGEGYGRKADIWSVACTVVEMLT 556
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 76.3 bits (186), Expect = 3e-14
Identities = 42/100 (42%), Positives = 58/100 (58%), Gaps = 1/100 (1%)
Frame = +1
Query: 148 PLTTIKQHTKQILKGLEFLHEQDIIHRDIKSAXXXXXXXXXXXXADFGTSRFLRAISKYH 327
P I +TKQ+L GLE+LH I+HRDIK A ADFG S+ + ++ +
Sbjct: 169 PEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVN 228
Query: 328 -KKTFCGTAIYISPEVMQSEPYGCSADIWSLGATVFEMAT 444
K+ GT +++PEV+ + SADIWS+G TV EMAT
Sbjct: 229 GAKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMAT 268
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,494,792
Number of Sequences: 369166
Number of extensions: 523128
Number of successful extensions: 4448
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3115
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3255
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2344429560
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)