Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_028_H08
(898 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 129 8e-30
sp|P27636|CDC15_YEAST Cell division control protein 15 124 5e-28
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 123 6e-28
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 122 1e-27
sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinas... 122 1e-27
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 122 2e-27
sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 122 2e-27
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 121 3e-27
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 120 5e-27
sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 120 5e-27
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
signal-regulating kinase 1) (ASK-1)
Length = 1374
Score = 129 bits (325), Expect = 8e-30
Identities = 85/209 (40%), Positives = 122/209 (58%), Gaps = 7/209 (3%)
Frame = +1
Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIQKNKFKPLPLT--TIKQYTKEILKG 408
+ ++NIV+Y G+ I IFME + G SL + ++K+ PL TI YTK+IL+G
Sbjct: 732 LKHKNIVQYLGSFSENGFIKIFMEQVPGGSL-SALLRSKWGPLKDNEQTIGFYTKQILEG 790
Query: 409 LKFLHEQNIIHRDIKSAXXXXXXXXXXXX-ADFGTSRFLNVISKYHKKTFCGTANYMSPE 585
LK+LH+ I+HRDIK +DFGTS+ L I+ +TF GT YM+PE
Sbjct: 791 LKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPC-TETFTGTLQYMAPE 849
Query: 586 VMKDEP--YGCSADIWSLGATVFEMATGHPPYHEMID-NAVIFKIGSER-KIEFPSNMPD 753
++ P YG +ADIWSLG T+ EMATG PP++E+ + A +FK+G + E P +M
Sbjct: 850 IIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSA 909
Query: 754 DIKGFLNLMIIAKPENRSTADSLLNCEFL 840
+ K F+ P+ R+ A+ LL EFL
Sbjct: 910 EAKAFILKCFEPDPDKRACANDLLVDEFL 938
>sp|P27636|CDC15_YEAST Cell division control protein 15
Length = 974
Score = 124 bits (310), Expect = 5e-28
Identities = 71/203 (34%), Positives = 109/203 (53%)
Frame = +1
Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIQKNKFKPLPLTTIKQYTKEILKGLK 414
+N+ NIVKY G +R +++I +E+ SL + I ++ L K Y + L GLK
Sbjct: 77 LNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSS-TGLSENESKTYVTQTLLGLK 135
Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLNVISKYHKKTFCGTANYMSPEVMK 594
+LH + +IHRDIK+A ADFG S +N + T GT N+M+PE++
Sbjct: 136 YLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSAL----TLAGTLNWMAPEILG 191
Query: 595 DEPYGCSADIWSLGATVFEMATGHPPYHEMIDNAVIFKIGSERKIEFPSNMPDDIKGFLN 774
+ +DIWSLGATV EM T +PPYH + D + + + ++ PS+ + +K FL+
Sbjct: 192 NRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYP-PSSFSEPLKDFLS 250
Query: 775 LMIIAKPENRSTADSLLNCEFLN 843
+ R TAD LL ++N
Sbjct: 251 KCFVKNMYKRPTADQLLKHVWIN 273
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 123 bits (309), Expect = 6e-28
Identities = 83/228 (36%), Positives = 120/228 (52%), Gaps = 5/228 (2%)
Frame = +1
Query: 169 DDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRN-LEKIF-IFMEFIDGKSLFQKIQ 342
D KE E I + + +E IV+Y+G +R+ EKI IFME++ G S+ K Q
Sbjct: 398 DSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKILTIFMEYMPGGSV--KDQ 454
Query: 343 KNKFKPLPLTTIKQYTKEILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFL 522
+ L + ++YT++IL+G+ +LH I+HRDIK A DFG S+ L
Sbjct: 455 LKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL 514
Query: 523 NVI--SKYHKKTFCGTANYMSPEVMKDEPYGCSADIWSLGATVFEMATGHPPYHEMIDNA 696
I S ++ GT +MSPEV+ E YG AD+WSLG TV EM T PP+ E A
Sbjct: 515 QTICMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574
Query: 697 VIFKIGSE-RKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEF 837
IFKI ++ + PS++ + + FL I + R +A+ LL F
Sbjct: 575 AIFKIATQPTNPQLPSHISEHGRDFLR-RIFVEARQRPSAEELLTHHF 621
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 122 bits (307), Expect = 1e-27
Identities = 80/228 (35%), Positives = 119/228 (52%), Gaps = 5/228 (2%)
Frame = +1
Query: 169 DDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRNLEK--IFIFMEFIDGKSLFQKIQ 342
D KE E I + + +E IV+Y+G +R+ + + IFME++ G S+ K Q
Sbjct: 398 DSPETSKEVSALECEIQLLKN-LQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSV--KDQ 454
Query: 343 KNKFKPLPLTTIKQYTKEILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFL 522
+ L + ++YT++IL+G+ +LH I+HRDIK A DFG S+ L
Sbjct: 455 LKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL 514
Query: 523 NVI--SKYHKKTFCGTANYMSPEVMKDEPYGCSADIWSLGATVFEMATGHPPYHEMIDNA 696
I S ++ GT +MSPEV+ E YG AD+WSLG TV EM T PP+ E A
Sbjct: 515 QTICMSGTGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMA 574
Query: 697 VIFKIGSE-RKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEF 837
IFKI ++ + PS++ + + FL I + R +A+ LL F
Sbjct: 575 AIFKIATQPTNPQLPSHISEHGRDFLR-RIFVEARQRPSAEELLTHHF 621
>sp|O95382|M3K6_HUMAN Mitogen-activated protein kinase kinase kinase 6
Length = 1011
Score = 122 bits (306), Expect = 1e-27
Identities = 80/209 (38%), Positives = 120/209 (57%), Gaps = 7/209 (3%)
Frame = +1
Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIQKNKFKPLP--LTTIKQYTKEILKG 408
+ ++NIV+Y G+ + IFME + G SL + ++ + PL +TI YT++IL+G
Sbjct: 423 LRHKNIVRYLGSASQGGYLKIFMEEVPGGSL-SSLLRSVWGPLKDNESTISFYTRQILQG 481
Query: 409 LKFLHEQNIIHRDIKSAXXXXXXXXXXXX-ADFGTSRFLNVISKYHKKTFCGTANYMSPE 585
L +LH+ +I+HRDIK +DFGTS+ L I+ +TF GT YM+PE
Sbjct: 482 LGYLHDNHIVHRDIKGDNVLINTFSGLLKISDFGTSKRLAGITPC-TETFTGTLQYMAPE 540
Query: 586 VMKDEP--YGCSADIWSLGATVFEMATGHPPYHEM-IDNAVIFKIGSER-KIEFPSNMPD 753
++ P YG +ADIWSLG TV EMATG PP+HE+ A +F++G + PS++
Sbjct: 541 IIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAMFQVGMYKVHPPMPSSLSA 600
Query: 754 DIKGFLNLMIIAKPENRSTADSLLNCEFL 840
+ + FL P R++A +LL FL
Sbjct: 601 EAQAFLLRTFEPDPRLRASAQTLLGDPFL 629
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 122 bits (305), Expect = 2e-27
Identities = 74/205 (36%), Positives = 111/205 (54%), Gaps = 3/205 (1%)
Frame = +1
Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIQKNKFKPLPLTTIKQYTKEILKGLK 414
+++ NIV+Y G VR + + I MEF+ G S+ ++K F P I YTK++L GL+
Sbjct: 128 LSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEK--FGSFPEPVIIMYTKQLLLGLE 185
Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLNVISKYH-KKTFCGTANYMSPEVM 591
+LH I+HRDIK A ADFG S+ + ++ + K+ GT +M+PEV+
Sbjct: 186 YLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAKSMKGTPYWMAPEVI 245
Query: 592 KDEPYGCSADIWSLGATVFEMATGHPPYHEMIDN-AVIFKIG-SERKIEFPSNMPDDIKG 765
+ SADIWS+G TV EMATG PP+ E A + IG ++ P ++ + K
Sbjct: 246 LQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHPPIPEDLSPEAKD 305
Query: 766 FLNLMIIAKPENRSTADSLLNCEFL 840
FL + +P R +A LL F+
Sbjct: 306 FLMKCLHKEPSLRLSATELLQHPFV 330
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 618
Score = 122 bits (305), Expect = 2e-27
Identities = 83/239 (34%), Positives = 127/239 (53%), Gaps = 6/239 (2%)
Frame = +1
Query: 145 AMKTIE-NVDDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRNLEK--IFIFMEFID 315
A+K ++ + D KE E I + F++ E IV+Y+G +R+ ++ + IFME++
Sbjct: 382 AVKQVQFDPDSPETSKEVNALECEIQLLKNFLH-ERIVQYYGCLRDPQEKTLSIFMEYMP 440
Query: 316 GKSLFQKIQKNKFKPLPLTTIKQYTKEILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXX 495
G S+ K Q + L ++YT++IL+G+ +LH I+HRDIK A
Sbjct: 441 GGSI--KDQLKAYGALTENGTRKYTRQILEGVHYLHSNMILHRDIKGANILRDSTGNVKL 498
Query: 496 ADFGTSRFLNVI--SKYHKKTFCGTANYMSPEVMKDEPYGCSADIWSLGATVFEMATGHP 669
DFG S+ L I S K+ GT +MSPEV+ + YG ADIWS+ TV EM T P
Sbjct: 499 GDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVISGQGYGRKADIWSVACTVVEMLTEKP 558
Query: 670 PYHEMIDNAVIFKIGSE-RKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEFLN 843
P+ E A IFKI ++ + P ++ D + FL I + + R +AD LL F++
Sbjct: 559 PWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLK-RIFVEAKLRPSADELLRHMFVH 616
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 121 bits (303), Expect = 3e-27
Identities = 73/205 (35%), Positives = 110/205 (53%), Gaps = 3/205 (1%)
Frame = +1
Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIQKNKFKPLPLTTIKQYTKEILKGLK 414
+++ NIV+Y G VR + + I +EF+ G S+ ++K F P P + ++ YT+++L GL+
Sbjct: 129 LSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEK--FGPFPESVVRTYTRQLLLGLE 186
Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSR-FLNVISKYHKKTFCGTANYMSPEVM 591
+LH I+HRDIK A ADFG S+ + + K+ GT +M+PEV+
Sbjct: 187 YLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMTGAKSMKGTPYWMAPEVI 246
Query: 592 KDEPYGCSADIWSLGATVFEMATGHPPYHEMI-DNAVIFKIGSERK-IEFPSNMPDDIKG 765
+ SADIWS+G TV EM TG P+ + + A IF IG+ + P + D K
Sbjct: 247 LQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSSDAKD 306
Query: 766 FLNLMIIAKPENRSTADSLLNCEFL 840
FL + P R TA LL F+
Sbjct: 307 FLLKCLQEVPNLRPTASELLKHPFV 331
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 120 bits (301), Expect = 5e-27
Identities = 73/205 (35%), Positives = 110/205 (53%), Gaps = 3/205 (1%)
Frame = +1
Query: 235 INNENIVKYFGAVRNLEKIFIFMEFIDGKSLFQKIQKNKFKPLPLTTIKQYTKEILKGLK 414
+++ NIV+Y G VR E + I +EF+ G S+ ++K F P + ++ YT ++L GL+
Sbjct: 128 LSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEK--FGAFPESVVRTYTNQLLLGLE 185
Query: 415 FLHEQNIIHRDIKSAXXXXXXXXXXXXADFGTSRFLNVISKYH-KKTFCGTANYMSPEVM 591
+LH I+HRDIK A ADFG S+ + ++ K+ GT +M+PEV+
Sbjct: 186 YLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATISGAKSMKGTPYWMAPEVI 245
Query: 592 KDEPYGCSADIWSLGATVFEMATGHPPYHEMI-DNAVIFKIGSERK-IEFPSNMPDDIKG 765
+ SADIWS+G TV EM TG P+ + + A IF IG+ + P N+ D
Sbjct: 246 LQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISSDAND 305
Query: 766 FLNLMIIAKPENRSTADSLLNCEFL 840
FL + +P R TA LL F+
Sbjct: 306 FLLKCLQQEPNLRPTASELLKHPFV 330
>sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11
Length = 738
Score = 120 bits (301), Expect = 5e-27
Identities = 78/233 (33%), Positives = 120/233 (51%), Gaps = 2/233 (0%)
Frame = +1
Query: 151 KTIENVDDENVKKEAKCFEDNINRYREFINNENIVKYFGAVRNLEKIFIFMEFIDGKSLF 330
KT +N+ +K + +N +E +++ENIV Y+GA + + IF+E++ G S+
Sbjct: 509 KTNQNIH----RKMVDALQHEMNLLKE-LHHENIVTYYGASQEGGNLNIFLEYVPGGSVS 563
Query: 331 QKIQKNKFKPLPLTTIKQYTKEILKGLKFLHEQNIIHRDIKSAXXXXXXXXXXXXADFGT 510
+ N + P + I +T++IL G+ +LH++NIIHRDIK A DFG
Sbjct: 564 SML--NNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGI 621
Query: 511 SRFLNVISKYHKK--TFCGTANYMSPEVMKDEPYGCSADIWSLGATVFEMATGHPPYHEM 684
S+ L+ ++K K + G+ +MSPEV+K ADIWS G V EM TG P+ +
Sbjct: 622 SKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDF 681
Query: 685 IDNAVIFKIGSERKIEFPSNMPDDIKGFLNLMIIAKPENRSTADSLLNCEFLN 843
IFKIG+ E PS + K FL + R +A LL +L+
Sbjct: 682 SQMQAIFKIGTNTTPEIPSWATSEGKNFLRKAFELDYQYRPSALELLQHPWLD 734
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,340,944
Number of Sequences: 369166
Number of extensions: 1531479
Number of successful extensions: 7560
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5520
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5790
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9030416440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)