Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_01037 (359 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P83917|CBX1_MOUSE Chromobox protein homolog 1 (Heterochr... 119 2e-27 sp|Q61686|CBX5_MOUSE Chromobox protein homolog 5 (Heterochr... 111 4e-25 sp|P45973|CBX5_HUMAN Chromobox protein homolog 5 (Heterochr... 110 1e-24 sp|Q5R6X7|CBX3_PONPY Chromobox protein homolog 3 (Heterochr... 108 3e-24 sp|P23198|CBX3_MOUSE Chromobox protein homolog 3 (Heterochr... 108 3e-24 sp|Q13185|CBX3_HUMAN Chromobox protein homolog 3 (Heterochr... 106 1e-23 sp|P29227|HP1_DROVI Heterochromatin protein 1 (HP1) 89 4e-18 sp|P05205|HP1_DROME Heterochromatin protein 1 (HP1) (Nonhis... 86 3e-17 sp|P40381|SWI6_SCHPO Chromatin-associated swi6 protein 33 0.15 sp|P47134|BIR1_YEAST Protein BIR1 30 2.2
>sp|P83917|CBX1_MOUSE Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) sp|P83916|CBX1_HUMAN Chromobox protein homolog 1 (Heterochromatin protein 1 homolog beta) (HP1 beta) (Modifier 1 protein) (M31) (Heterochromatin protein p25) (HP1Hsbeta) (p25beta) Length = 185 Score = 119 bits (298), Expect = 2e-27 Identities = 54/81 (66%), Positives = 70/81 (86%) Frame = +3 Query: 30 EKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVV 209 +K K ++ + +GF+RGLE ++IIGATDS+GELMFL+KWKNS+EADLVPA+EANVKCPQVV Sbjct: 101 KKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVV 160 Query: 210 IKFYEERLTWHTPTNATTNEK 272 I FYEERLTWH+ + ++K Sbjct: 161 ISFYEERLTWHSYPSEDDDKK 181
Score = 35.8 bits (81), Expect = 0.031 Identities = 14/52 (26%), Positives = 28/52 (53%) Frame = +3 Query: 87 DKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVVIKFYEERLTWH 242 +K++ G++ +L+KWK + D E N+ CP ++ +F + + T H Sbjct: 24 EKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAH 75
>sp|Q61686|CBX5_MOUSE Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) Length = 191 Score = 111 bits (278), Expect = 4e-25 Identities = 54/88 (61%), Positives = 71/88 (80%), Gaps = 1/88 (1%) Frame = +3 Query: 21 KTEEKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCP 200 K+++K + + ++GF RGLE +KIIGATDS G+LMFL+KWK+++EADLV A+EANVKCP Sbjct: 102 KSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCP 161 Query: 201 QVVIKFYEERLTWHT-PTNATTNEKVSS 281 Q+VI FYEERLTWH P +A EK S+ Sbjct: 162 QIVIAFYEERLTWHAYPEDAENKEKESA 189
Score = 32.0 bits (71), Expect = 0.45 Identities = 15/62 (24%), Positives = 29/62 (46%) Frame = +3 Query: 87 DKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVVIKFYEERLTWHTPTNATTN 266 +K++ G++ +L+KWK E E N+ CP+++ +F ++ N Sbjct: 23 EKVLDRRMVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPR 82 Query: 267 EK 272 EK Sbjct: 83 EK 84
>sp|P45973|CBX5_HUMAN Chromobox protein homolog 5 (Heterochromatin protein 1 homolog alpha) (HP1 alpha) (Antigen p25) Length = 191 Score = 110 bits (275), Expect = 1e-24 Identities = 53/85 (62%), Positives = 69/85 (81%), Gaps = 1/85 (1%) Frame = +3 Query: 21 KTEEKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCP 200 K+++K + + ++GF RGLE +KIIGATDS G+LMFL+KWK+++EADLV A+EANVKCP Sbjct: 102 KSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCP 161 Query: 201 QVVIKFYEERLTWHT-PTNATTNEK 272 Q+VI FYEERLTWH P +A EK Sbjct: 162 QIVIAFYEERLTWHAYPEDAENKEK 186
Score = 32.7 bits (73), Expect = 0.26 Identities = 16/65 (24%), Positives = 30/65 (46%) Frame = +3 Query: 87 DKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVVIKFYEERLTWHTPTNATTN 266 +K++ G++ +L+KWK E E N+ CP+++ +F ++ N Sbjct: 23 EKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPR 82 Query: 267 EKVSS 281 EK S Sbjct: 83 EKSES 87
>sp|Q5R6X7|CBX3_PONPY Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) Length = 183 Score = 108 bits (271), Expect = 3e-24 Identities = 48/72 (66%), Positives = 65/72 (90%) Frame = +3 Query: 30 EKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVV 209 +K + A++ +GF+RGL+ ++IIGATDS+GELMFL+KWK+S+EADLV A+EAN+KCPQ+V Sbjct: 105 KKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIV 164 Query: 210 IKFYEERLTWHT 245 I FYEERLTWH+ Sbjct: 165 IAFYEERLTWHS 176
Score = 35.4 bits (80), Expect = 0.040 Identities = 18/68 (26%), Positives = 33/68 (48%), Gaps = 4/68 (5%) Frame = +3 Query: 27 EEKGKVQANRSKGFSRG----LEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVK 194 ++ GK Q +SK +K++ NG++ + +KWK +AD E N+ Sbjct: 9 QKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLD 68 Query: 195 CPQVVIKF 218 CP+++ F Sbjct: 69 CPELIEAF 76
>sp|P23198|CBX3_MOUSE Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (M32) Length = 183 Score = 108 bits (271), Expect = 3e-24 Identities = 48/72 (66%), Positives = 65/72 (90%) Frame = +3 Query: 30 EKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVV 209 +K + A++ +GF+RGL+ ++IIGATDS+GELMFL+KWK+S+EADLV A+EAN+KCPQ+V Sbjct: 105 KKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIV 164 Query: 210 IKFYEERLTWHT 245 I FYEERLTWH+ Sbjct: 165 IAFYEERLTWHS 176
Score = 35.4 bits (80), Expect = 0.040 Identities = 18/68 (26%), Positives = 33/68 (48%), Gaps = 4/68 (5%) Frame = +3 Query: 27 EEKGKVQANRSKGFSRG----LEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVK 194 ++ GK Q +SK +K++ NG++ + +KWK +AD E N+ Sbjct: 9 QKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLD 68 Query: 195 CPQVVIKF 218 CP+++ F Sbjct: 69 CPELIEDF 76
>sp|Q13185|CBX3_HUMAN Chromobox protein homolog 3 (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein) (HECH) Length = 183 Score = 106 bits (265), Expect = 1e-23 Identities = 47/72 (65%), Positives = 64/72 (88%) Frame = +3 Query: 30 EKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVV 209 +K + A++ +GF+RGL+ ++IIGA DS+GELMFL+KWK+S+EADLV A+EAN+KCPQ+V Sbjct: 105 KKKRDAADKPRGFARGLDPERIIGAIDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIV 164 Query: 210 IKFYEERLTWHT 245 I FYEERLTWH+ Sbjct: 165 IAFYEERLTWHS 176
Score = 35.4 bits (80), Expect = 0.040 Identities = 18/68 (26%), Positives = 33/68 (48%), Gaps = 4/68 (5%) Frame = +3 Query: 27 EEKGKVQANRSKGFSRG----LEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVK 194 ++ GK Q +SK +K++ NG++ + +KWK +AD E N+ Sbjct: 9 QKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLD 68 Query: 195 CPQVVIKF 218 CP+++ F Sbjct: 69 CPELIEAF 76
>sp|P29227|HP1_DROVI Heterochromatin protein 1 (HP1) Length = 213 Score = 88.6 bits (218), Expect = 4e-18 Identities = 39/75 (52%), Positives = 59/75 (78%) Frame = +3 Query: 21 KTEEKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCP 200 ++E+ G + GF RGLEA+KI+GA+D+NG L FLI++K ++A++VP+ ANVK P Sbjct: 135 ESEDTGDIVPAGGTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEMVPSTVANVKIP 194 Query: 201 QVVIKFYEERLTWHT 245 Q+VI+FYEERL+W++ Sbjct: 195 QMVIRFYEERLSWYS 209
>sp|P05205|HP1_DROME Heterochromatin protein 1 (HP1) (Nonhistone chromosomal protein C1A9 antigen) Length = 206 Score = 85.9 bits (211), Expect = 3e-17 Identities = 41/86 (47%), Positives = 63/86 (73%), Gaps = 5/86 (5%) Frame = +3 Query: 3 TAPAPKKTE-----EKGKVQANRSKGFSRGLEADKIIGATDSNGELMFLIKWKNSEEADL 167 TAP+ K++ E+ + + S GF RGLEA+KI+GA+D+NG L FLI++K ++A++ Sbjct: 117 TAPSGNKSKRTTDAEQDTIPVSGSTGFDRGLEAEKILGASDNNGRLTFLIQFKGVDQAEM 176 Query: 168 VPAREANVKCPQVVIKFYEERLTWHT 245 VP+ AN K P++VI FYEERL+W++ Sbjct: 177 VPSSVANEKIPRMVIHFYEERLSWYS 202
Score = 28.5 bits (62), Expect = 4.9 Identities = 19/69 (27%), Positives = 33/69 (47%) Frame = +3 Query: 87 DKIIGATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVVIKFYEERLTWHTPTNATTN 266 +KII G++ + +KWK E + E N+ C Q +I+ YE + A+ Sbjct: 27 EKIIDRRVRKGKVEYYLKWKGYPETENTWEPENNLDC-QDLIQQYEASRKDEEKSAASKK 85 Query: 267 EKVSSTGDA 293 ++ SS+ A Sbjct: 86 DRPSSSAKA 94
>sp|P40381|SWI6_SCHPO Chromatin-associated swi6 protein Length = 328 Score = 33.5 bits (75), Expect = 0.15 Identities = 16/42 (38%), Positives = 24/42 (57%) Frame = +3 Query: 114 NGELMFLIKWKNSEEADLVPAREANVKCPQVVIKFYEERLTW 239 +G L + WKN + P+ N KCPQ +++FYE LT+ Sbjct: 284 DGTLEIYLTWKNGAISHH-PSTITNKKCPQKMLQFYESHLTF 324
>sp|P47134|BIR1_YEAST Protein BIR1 Length = 954 Score = 29.6 bits (65), Expect = 2.2 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 8/59 (13%) Frame = +3 Query: 102 ATDSNGELMFLIKWKNSEEADLVPAREANVKCPQVVIKFYEE--------RLTWHTPTN 254 A D +G+L FLIK +EE D+ N+K + +F ++ R ++T TN Sbjct: 875 ANDKDGDLAFLIKQMPAEELDMTFNNWVNLKVQSIKREFIDDCDKKLDILRRDYYTATN 933
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 37,037,474 Number of Sequences: 369166 Number of extensions: 640692 Number of successful extensions: 1512 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 1487 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 1511 length of database: 68,354,980 effective HSP length: 87 effective length of database: 52,283,035 effective search space used: 1673057120 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)