Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00850 (585 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P11348|DHPR_RAT Dihydropteridine reductase (HDHPR) (Quin... 166 3e-41 sp|Q8BVI4|DHPR_MOUSE Dihydropteridine reductase (HDHPR) (Qu... 164 1e-40 sp|P09417|DHPR_HUMAN Dihydropteridine reductase (HDHPR) (Qu... 164 1e-40 sp|Q8MJ30|DHPR_PIG Dihydropteridine reductase (HDHPR) (Quin... 163 3e-40 sp|P39333|YJGI_ECOLI Hypothetical oxidoreductase yjgI 42 0.001 sp|P50200|HDHA_CLOSO NADP-dependent 7-alpha-hydroxysteroid ... 36 0.062 sp|Q56632|VIBA_VIBCH Vibriobactin-specific 2,3-dihydro-2,3-... 35 0.11 sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family me... 32 1.5 sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reduc... 31 2.6 sp|P50162|TRN1_DATST Tropinone reductase-I (TR-I) (Tropine ... 30 3.4
>sp|P11348|DHPR_RAT Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine reductase) Length = 241 Score = 166 bits (421), Expect = 3e-41 Identities = 82/147 (55%), Positives = 106/147 (72%), Gaps = 1/147 (0%) Frame = +2 Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181 LCVAGGWAGG+A ++ N LM KQ +W+S IS+HLA L E G L L GA AAL Sbjct: 81 LCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDG 140 Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358 TPGM+GYGM K AVHQL +SLA ++S +P+G +A+LP+TLDT NR +MP ADF++WT Sbjct: 141 TPGMIGYGMAKGAVHQLCQSLAGKNSGMPSGAAAIAVLPVTLDTPMNRKSMPEADFSSWT 200 Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439 PL ++ +WITG+K +P SGSL+Q Sbjct: 201 PLEFLVETFHDWITGNK-RPNSGSLIQ 226
>sp|Q8BVI4|DHPR_MOUSE Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine reductase) Length = 241 Score = 164 bits (416), Expect = 1e-40 Identities = 81/147 (55%), Positives = 105/147 (71%), Gaps = 1/147 (0%) Frame = +2 Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181 LCVAGGWAGG+A ++ N +M KQ +W+S IS+HLA L E G L L GA AAL Sbjct: 81 LCVAGGWAGGNAKSKSLFKNCDMMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDG 140 Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358 TPGM+GYGM K AVHQL +SLA ++S +P G +A+LP+TLDT NR +MP ADF++WT Sbjct: 141 TPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWT 200 Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439 PL ++ +WITG+K +P SGSL+Q Sbjct: 201 PLEFLVETFHDWITGNK-RPNSGSLIQ 226
>sp|P09417|DHPR_HUMAN Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine reductase) Length = 244 Score = 164 bits (415), Expect = 1e-40 Identities = 82/147 (55%), Positives = 104/147 (70%), Gaps = 1/147 (0%) Frame = +2 Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181 LCVAGGWAGG+A ++ N LM KQ +W+S IS+HLA L E G L L GA AAL Sbjct: 84 LCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDG 143 Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358 TPGM+GYGM K AVHQL +SLA ++S +P G +A+LP+TLDT NR +MP ADF++WT Sbjct: 144 TPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWT 203 Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439 PL ++ +WITG K +P SGSL+Q Sbjct: 204 PLEFLVETFHDWITG-KNRPSSGSLIQ 229
>sp|Q8MJ30|DHPR_PIG Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine reductase) Length = 243 Score = 163 bits (412), Expect = 3e-40 Identities = 81/147 (55%), Positives = 104/147 (70%), Gaps = 1/147 (0%) Frame = +2 Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181 LCVAGGWAGG+A ++ N LM KQ +W+S IS+HLA L E G L L GA AAL Sbjct: 83 LCVAGGWAGGNAKSKSLFKNCDLMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDG 142 Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358 TPGM+GYGM K AVHQL +SLA +DS +P+G +A+LP+TLDT NR +MP ADF++WT Sbjct: 143 TPGMIGYGMAKGAVHQLCQSLAGKDSGMPSGAAAIAVLPVTLDTPLNRKSMPHADFSSWT 202 Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439 PL ++ +WI +K +P SGSL+Q Sbjct: 203 PLEFLVETFHDWII-EKNRPSSGSLIQ 228
>sp|P39333|YJGI_ECOLI Hypothetical oxidoreductase yjgI Length = 237 Score = 41.6 bits (96), Expect = 0.001 Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 8/114 (7%) Frame = +2 Query: 116 AAHFLTENGFLILTGA-NAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAIL 292 AA + E G +++ G+ N P GM Y K+A+ + + LA+D P G + + Sbjct: 117 AARQMPEGGRILIIGSVNGDRMPVAGMAAYAASKSALQGMARGLARDFG-PRGITINVVQ 175 Query: 293 PITLDTEANRHNMPTAD-------FTTWTPLTYVANMVLEWITGDKVKPISGSL 433 P +DT+AN N P D VA MV W+ G + ++G++ Sbjct: 176 PGPIDTDANPANGPMRDMLHSLMAIKRHGQPEEVAGMV-AWLAGPEASFVTGAM 228
>sp|P50200|HDHA_CLOSO NADP-dependent 7-alpha-hydroxysteroid dehydrogenase (Bile acid 7-dehydroxylase) (7-alpha-HSDH) Length = 267 Score = 36.2 bits (82), Expect = 0.062 Identities = 31/125 (24%), Positives = 58/125 (46%), Gaps = 9/125 (7%) Frame = +2 Query: 92 SSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNG 271 S +I H+ + + G ++ + P +GYG+ K+ V+ +TK +A G Sbjct: 125 SKLIIPHMIEN---KGGSIVNISSVGGSIPDISRIGYGVSKSGVNNITKQIAIQYA-KYG 180 Query: 272 TWVVAILPITLDTEANRHNMP---TADFTTWTPLTY------VANMVLEWITGDKVKPIS 424 A+LP + T+A ++MP F + PL +AN VL ++ + I+ Sbjct: 181 IRCNAVLPGLIATDAAMNSMPDEFRKSFLSHVPLNRIGNPEDIANSVLFFVPSEDSSYIT 240 Query: 425 GSLVQ 439 GS+++ Sbjct: 241 GSILE 245
>sp|Q56632|VIBA_VIBCH Vibriobactin-specific 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase Length = 262 Score = 35.4 bits (80), Expect = 0.11 Identities = 15/40 (37%), Positives = 24/40 (60%) Frame = +2 Query: 134 ENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQD 253 + G +++ G+NAA TP + YG KAA+H L K + + Sbjct: 136 QQGSMVIIGSNAANTPRMSIGAYGASKAALHMLVKCIGME 175
>sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 (NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD) Length = 260 Score = 31.6 bits (70), Expect = 1.5 Identities = 19/61 (31%), Positives = 32/61 (52%) Frame = +2 Query: 140 GFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAILPITLDTEAN 319 G +++ + AA +P+PG Y + K A+ LTK+LA + P V + P + T + Sbjct: 144 GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE-LAPRNIRVNCLAPGLIKTSFS 202 Query: 320 R 322 R Sbjct: 203 R 203
>sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) sp|P0A0I0|FABG_STAAW 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) sp|P0A0H9|FABG_STAAM 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) sp|Q6GHK4|FABG_STAAR 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) sp|Q6G9Y2|FABG_STAAS 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase) Length = 246 Score = 30.8 bits (68), Expect = 2.6 Identities = 33/145 (22%), Positives = 54/145 (37%), Gaps = 18/145 (12%) Frame = +2 Query: 56 NNVYLMEKQCLWSSVISAHLAAHF-----------LTENGFLILTGANAALTPTPGMLGY 202 +N+ + K+ W VI +L F +G +I + PG Y Sbjct: 95 DNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANY 154 Query: 203 GMVKAAVHQLTKSLAQDSTLPNGT-------WVVAILPITLDTEANRHNMPTADFTTWTP 361 KA V LTKS A++ T ++V+ + L E + + Sbjct: 155 VATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQ 214 Query: 362 LTYVANMVLEWITGDKVKPISGSLV 436 T +AN V ++ DK K I+G + Sbjct: 215 DTDIANTV-AFLASDKAKYITGQTI 238
>sp|P50162|TRN1_DATST Tropinone reductase-I (TR-I) (Tropine dehydrogenase) Length = 273 Score = 30.4 bits (67), Expect = 3.4 Identities = 25/85 (29%), Positives = 40/85 (47%), Gaps = 7/85 (8%) Frame = +2 Query: 131 TENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSL----AQDSTLPNGTWVVAILPI 298 ++NG +I + A + P + Y K A++Q+TKSL A+D+ N IL Sbjct: 148 SQNGNVIFLSSIAGFSALPSVSLYSASKGAINQMTKSLACEWAKDNIRVNSVAPGVILTP 207 Query: 299 TLDT--EANRHNMPTAD-FTTWTPL 364 ++T + N H D F TP+ Sbjct: 208 LVETAIKKNPHQKEEIDNFIVKTPM 232
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 64,741,486 Number of Sequences: 369166 Number of extensions: 1183356 Number of successful extensions: 2793 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 2712 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 2789 length of database: 68,354,980 effective HSP length: 105 effective length of database: 48,957,805 effective search space used: 4357244645 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)