Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_J05
(354 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P11348|DHPR_RAT Dihydropteridine reductase (HDHPR) (Quin... 131 4e-31
sp|P09417|DHPR_HUMAN Dihydropteridine reductase (HDHPR) (Qu... 130 1e-30
sp|Q8BVI4|DHPR_MOUSE Dihydropteridine reductase (HDHPR) (Qu... 129 2e-30
sp|Q8MJ30|DHPR_PIG Dihydropteridine reductase (HDHPR) (Quin... 128 4e-30
sp|P39333|YJGI_ECOLI Hypothetical oxidoreductase yjgI 41 7e-04
sp|Q56632|VIBA_VIBCH Vibriobactin-specific 2,3-dihydro-2,3-... 35 0.041
sp|P50200|HDHA_CLOSO NADP-dependent 7-alpha-hydroxysteroid ... 32 0.34
sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family me... 32 0.59
sp|P50162|TRN1_DATST Tropinone reductase-I (TR-I) (Tropine ... 30 1.3
sp|P15047|ENTA_ECOLI 2,3-dihydro-2,3-dihydroxybenzoate dehy... 30 1.3
>sp|P11348|DHPR_RAT Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 241
Score = 131 bits (330), Expect = 4e-31
Identities = 64/117 (54%), Positives = 83/117 (70%), Gaps = 1/117 (0%)
Frame = +1
Query: 7 NVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTK 186
N LM KQ +W+S IS+HLA L E G L L GA AAL TPGM+GYGM K AVHQL +
Sbjct: 100 NCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQ 159
Query: 187 SLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWTPLTYVANMVLEWITGD 354
SLA ++S +P+G +A+LP+TLDT NR +MP ADF++WTPL ++ +WITG+
Sbjct: 160 SLAGKNSGMPSGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGN 216
>sp|P09417|DHPR_HUMAN Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 244
Score = 130 bits (326), Expect = 1e-30
Identities = 64/116 (55%), Positives = 81/116 (69%), Gaps = 1/116 (0%)
Frame = +1
Query: 7 NVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTK 186
N LM KQ +W+S IS+HLA L E G L L GA AAL TPGM+GYGM K AVHQL +
Sbjct: 103 NCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQ 162
Query: 187 SLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWTPLTYVANMVLEWITG 351
SLA ++S +P G +A+LP+TLDT NR +MP ADF++WTPL ++ +WITG
Sbjct: 163 SLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITG 218
>sp|Q8BVI4|DHPR_MOUSE Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 241
Score = 129 bits (325), Expect = 2e-30
Identities = 63/117 (53%), Positives = 82/117 (70%), Gaps = 1/117 (0%)
Frame = +1
Query: 7 NVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTK 186
N +M KQ +W+S IS+HLA L E G L L GA AAL TPGM+GYGM K AVHQL +
Sbjct: 100 NCDMMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQ 159
Query: 187 SLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWTPLTYVANMVLEWITGD 354
SLA ++S +P G +A+LP+TLDT NR +MP ADF++WTPL ++ +WITG+
Sbjct: 160 SLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGN 216
>sp|Q8MJ30|DHPR_PIG Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 243
Score = 128 bits (322), Expect = 4e-30
Identities = 63/114 (55%), Positives = 80/114 (70%), Gaps = 1/114 (0%)
Frame = +1
Query: 7 NVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTK 186
N LM KQ +W+S IS+HLA L E G L L GA AAL TPGM+GYGM K AVHQL +
Sbjct: 102 NCDLMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQ 161
Query: 187 SLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWTPLTYVANMVLEWI 345
SLA +DS +P+G +A+LP+TLDT NR +MP ADF++WTPL ++ +WI
Sbjct: 162 SLAGKDSGMPSGAAAIAVLPVTLDTPLNRKSMPHADFSSWTPLEFLVETFHDWI 215
>sp|P39333|YJGI_ECOLI Hypothetical oxidoreductase yjgI
Length = 237
Score = 41.2 bits (95), Expect = 7e-04
Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 1/77 (1%)
Frame = +1
Query: 64 AAHFLTENGFLILTGA-NAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAIL 240
AA + E G +++ G+ N P GM Y K+A+ + + LA+D P G + +
Sbjct: 117 AARQMPEGGRILIIGSVNGDRMPVAGMAAYAASKSALQGMARGLARDFG-PRGITINVVQ 175
Query: 241 PITLDTEANRHNMPTAD 291
P +DT+AN N P D
Sbjct: 176 PGPIDTDANPANGPMRD 192
>sp|Q56632|VIBA_VIBCH Vibriobactin-specific 2,3-dihydro-2,3-dihydroxybenzoate
dehydrogenase
Length = 262
Score = 35.4 bits (80), Expect = 0.041
Identities = 15/40 (37%), Positives = 24/40 (60%)
Frame = +1
Query: 82 ENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQD 201
+ G +++ G+NAA TP + YG KAA+H L K + +
Sbjct: 136 QQGSMVIIGSNAANTPRMSIGAYGASKAALHMLVKCIGME 175
>sp|P50200|HDHA_CLOSO NADP-dependent 7-alpha-hydroxysteroid dehydrogenase (Bile acid
7-dehydroxylase) (7-alpha-HSDH)
Length = 267
Score = 32.3 bits (72), Expect = 0.34
Identities = 25/99 (25%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Frame = +1
Query: 40 SSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNG 219
S +I H+ + + G ++ + P +GYG+ K+ V+ +TK +A G
Sbjct: 125 SKLIIPHMIEN---KGGSIVNISSVGGSIPDISRIGYGVSKSGVNNITKQIAIQYA-KYG 180
Query: 220 TWVVAILPITLDTEANRHNMP---TADFTTWTPLTYVAN 327
A+LP + T+A ++MP F + PL + N
Sbjct: 181 IRCNAVLPGLIATDAAMNSMPDEFRKSFLSHVPLNRIGN 219
>sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
(SCAD-SRL) (humNRDR) (PSCD)
Length = 260
Score = 31.6 bits (70), Expect = 0.59
Identities = 19/61 (31%), Positives = 32/61 (52%)
Frame = +1
Query: 88 GFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAILPITLDTEAN 267
G +++ + AA +P+PG Y + K A+ LTK+LA + P V + P + T +
Sbjct: 144 GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE-LAPRNIRVNCLAPGLIKTSFS 202
Query: 268 R 270
R
Sbjct: 203 R 203
>sp|P50162|TRN1_DATST Tropinone reductase-I (TR-I) (Tropine dehydrogenase)
Length = 273
Score = 30.4 bits (67), Expect = 1.3
Identities = 25/85 (29%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Frame = +1
Query: 79 TENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSL----AQDSTLPNGTWVVAILPI 246
++NG +I + A + P + Y K A++Q+TKSL A+D+ N IL
Sbjct: 148 SQNGNVIFLSSIAGFSALPSVSLYSASKGAINQMTKSLACEWAKDNIRVNSVAPGVILTP 207
Query: 247 TLDT--EANRHNMPTAD-FTTWTPL 312
++T + N H D F TP+
Sbjct: 208 LVETAIKKNPHQKEEIDNFIVKTPM 232
>sp|P15047|ENTA_ECOLI 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
Length = 248
Score = 30.4 bits (67), Expect = 1.3
Identities = 19/61 (31%), Positives = 30/61 (49%)
Frame = +1
Query: 88 GFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAILPITLDTEAN 267
G ++ ++AA TP GM YG KAA+ L S+ + +G + P + DT+
Sbjct: 124 GAIVTVASDAAHTPRIGMSAYGASKAALKSLALSVGLE-LAGSGVRCNVVSPGSTDTDMQ 182
Query: 268 R 270
R
Sbjct: 183 R 183
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,239,135
Number of Sequences: 369166
Number of extensions: 766431
Number of successful extensions: 1947
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1897
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1943
length of database: 68,354,980
effective HSP length: 85
effective length of database: 52,652,505
effective search space used: 1684880160
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)