Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_K18
(585 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P11348|DHPR_RAT Dihydropteridine reductase (HDHPR) (Quin... 166 3e-41
sp|Q8BVI4|DHPR_MOUSE Dihydropteridine reductase (HDHPR) (Qu... 164 1e-40
sp|P09417|DHPR_HUMAN Dihydropteridine reductase (HDHPR) (Qu... 164 1e-40
sp|Q8MJ30|DHPR_PIG Dihydropteridine reductase (HDHPR) (Quin... 163 3e-40
sp|P39333|YJGI_ECOLI Hypothetical oxidoreductase yjgI 42 0.001
sp|P50200|HDHA_CLOSO NADP-dependent 7-alpha-hydroxysteroid ... 36 0.062
sp|Q56632|VIBA_VIBCH Vibriobactin-specific 2,3-dihydro-2,3-... 35 0.11
sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family me... 32 1.5
sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reduc... 31 2.6
sp|P50162|TRN1_DATST Tropinone reductase-I (TR-I) (Tropine ... 30 3.4
>sp|P11348|DHPR_RAT Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 241
Score = 166 bits (421), Expect = 3e-41
Identities = 82/147 (55%), Positives = 106/147 (72%), Gaps = 1/147 (0%)
Frame = +2
Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181
LCVAGGWAGG+A ++ N LM KQ +W+S IS+HLA L E G L L GA AAL
Sbjct: 81 LCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDG 140
Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358
TPGM+GYGM K AVHQL +SLA ++S +P+G +A+LP+TLDT NR +MP ADF++WT
Sbjct: 141 TPGMIGYGMAKGAVHQLCQSLAGKNSGMPSGAAAIAVLPVTLDTPMNRKSMPEADFSSWT 200
Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439
PL ++ +WITG+K +P SGSL+Q
Sbjct: 201 PLEFLVETFHDWITGNK-RPNSGSLIQ 226
>sp|Q8BVI4|DHPR_MOUSE Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 241
Score = 164 bits (416), Expect = 1e-40
Identities = 81/147 (55%), Positives = 105/147 (71%), Gaps = 1/147 (0%)
Frame = +2
Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181
LCVAGGWAGG+A ++ N +M KQ +W+S IS+HLA L E G L L GA AAL
Sbjct: 81 LCVAGGWAGGNAKSKSLFKNCDMMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDG 140
Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358
TPGM+GYGM K AVHQL +SLA ++S +P G +A+LP+TLDT NR +MP ADF++WT
Sbjct: 141 TPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWT 200
Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439
PL ++ +WITG+K +P SGSL+Q
Sbjct: 201 PLEFLVETFHDWITGNK-RPNSGSLIQ 226
>sp|P09417|DHPR_HUMAN Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 244
Score = 164 bits (415), Expect = 1e-40
Identities = 82/147 (55%), Positives = 104/147 (70%), Gaps = 1/147 (0%)
Frame = +2
Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181
LCVAGGWAGG+A ++ N LM KQ +W+S IS+HLA L E G L L GA AAL
Sbjct: 84 LCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDG 143
Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358
TPGM+GYGM K AVHQL +SLA ++S +P G +A+LP+TLDT NR +MP ADF++WT
Sbjct: 144 TPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWT 203
Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439
PL ++ +WITG K +P SGSL+Q
Sbjct: 204 PLEFLVETFHDWITG-KNRPSSGSLIQ 229
>sp|Q8MJ30|DHPR_PIG Dihydropteridine reductase (HDHPR) (Quinoid dihydropteridine
reductase)
Length = 243
Score = 163 bits (412), Expect = 3e-40
Identities = 81/147 (55%), Positives = 104/147 (70%), Gaps = 1/147 (0%)
Frame = +2
Query: 2 LCVAGGWAGGSANDANMVNNVYLMEKQCLWSSVISAHLAAHFLTENGFLILTGANAALTP 181
LCVAGGWAGG+A ++ N LM KQ +W+S IS+HLA L E G L L GA AAL
Sbjct: 83 LCVAGGWAGGNAKSKSLFKNCDLMWKQSMWTSTISSHLATKHLKEGGLLTLAGAKAALDG 142
Query: 182 TPGMLGYGMVKAAVHQLTKSLA-QDSTLPNGTWVVAILPITLDTEANRHNMPTADFTTWT 358
TPGM+GYGM K AVHQL +SLA +DS +P+G +A+LP+TLDT NR +MP ADF++WT
Sbjct: 143 TPGMIGYGMAKGAVHQLCQSLAGKDSGMPSGAAAIAVLPVTLDTPLNRKSMPHADFSSWT 202
Query: 359 PLTYVANMVLEWITGDKVKPISGSLVQ 439
PL ++ +WI +K +P SGSL+Q
Sbjct: 203 PLEFLVETFHDWII-EKNRPSSGSLIQ 228
>sp|P39333|YJGI_ECOLI Hypothetical oxidoreductase yjgI
Length = 237
Score = 41.6 bits (96), Expect = 0.001
Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 8/114 (7%)
Frame = +2
Query: 116 AAHFLTENGFLILTGA-NAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAIL 292
AA + E G +++ G+ N P GM Y K+A+ + + LA+D P G + +
Sbjct: 117 AARQMPEGGRILIIGSVNGDRMPVAGMAAYAASKSALQGMARGLARDFG-PRGITINVVQ 175
Query: 293 PITLDTEANRHNMPTAD-------FTTWTPLTYVANMVLEWITGDKVKPISGSL 433
P +DT+AN N P D VA MV W+ G + ++G++
Sbjct: 176 PGPIDTDANPANGPMRDMLHSLMAIKRHGQPEEVAGMV-AWLAGPEASFVTGAM 228
>sp|P50200|HDHA_CLOSO NADP-dependent 7-alpha-hydroxysteroid dehydrogenase (Bile acid
7-dehydroxylase) (7-alpha-HSDH)
Length = 267
Score = 36.2 bits (82), Expect = 0.062
Identities = 31/125 (24%), Positives = 58/125 (46%), Gaps = 9/125 (7%)
Frame = +2
Query: 92 SSVISAHLAAHFLTENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNG 271
S +I H+ + + G ++ + P +GYG+ K+ V+ +TK +A G
Sbjct: 125 SKLIIPHMIEN---KGGSIVNISSVGGSIPDISRIGYGVSKSGVNNITKQIAIQYA-KYG 180
Query: 272 TWVVAILPITLDTEANRHNMP---TADFTTWTPLTY------VANMVLEWITGDKVKPIS 424
A+LP + T+A ++MP F + PL +AN VL ++ + I+
Sbjct: 181 IRCNAVLPGLIATDAAMNSMPDEFRKSFLSHVPLNRIGNPEDIANSVLFFVPSEDSSYIT 240
Query: 425 GSLVQ 439
GS+++
Sbjct: 241 GSILE 245
>sp|Q56632|VIBA_VIBCH Vibriobactin-specific 2,3-dihydro-2,3-dihydroxybenzoate
dehydrogenase
Length = 262
Score = 35.4 bits (80), Expect = 0.11
Identities = 15/40 (37%), Positives = 24/40 (60%)
Frame = +2
Query: 134 ENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQD 253
+ G +++ G+NAA TP + YG KAA+H L K + +
Sbjct: 136 QQGSMVIIGSNAANTPRMSIGAYGASKAALHMLVKCIGME 175
>sp|Q9BTZ2|DHRS4_HUMAN Dehydrogenase/reductase SDR family member 4 (NADPH-dependent
carbonyl reductase/NADP-retinol dehydrogenase) (CR)
(PHCR) (Peroxisomal short-chain alcohol dehydrogenase)
(NADPH-dependent retinol dehydrogenase/reductase) (NDRD)
(SCAD-SRL) (humNRDR) (PSCD)
Length = 260
Score = 31.6 bits (70), Expect = 1.5
Identities = 19/61 (31%), Positives = 32/61 (52%)
Frame = +2
Query: 140 GFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSLAQDSTLPNGTWVVAILPITLDTEAN 319
G +++ + AA +P+PG Y + K A+ LTK+LA + P V + P + T +
Sbjct: 144 GSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIE-LAPRNIRVNCLAPGLIKTSFS 202
Query: 320 R 322
R
Sbjct: 203 R 203
>sp|P99093|FABG_STAAN 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|P0A0I0|FABG_STAAW 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|P0A0H9|FABG_STAAM 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|Q6GHK4|FABG_STAAR 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
sp|Q6G9Y2|FABG_STAAS 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier
protein reductase)
Length = 246
Score = 30.8 bits (68), Expect = 2.6
Identities = 33/145 (22%), Positives = 54/145 (37%), Gaps = 18/145 (12%)
Frame = +2
Query: 56 NNVYLMEKQCLWSSVISAHLAAHF-----------LTENGFLILTGANAALTPTPGMLGY 202
+N+ + K+ W VI +L F +G +I + PG Y
Sbjct: 95 DNLLMRMKEQEWDDVIDTNLKGVFNCIQKATPQMLRQRSGAIINLSSVVGAVGNPGQANY 154
Query: 203 GMVKAAVHQLTKSLAQDSTLPNGT-------WVVAILPITLDTEANRHNMPTADFTTWTP 361
KA V LTKS A++ T ++V+ + L E + +
Sbjct: 155 VATKAGVIGLTKSAARELASRGITVNAVAPGFIVSDMTDALSDELKEQMLTQIPLARFGQ 214
Query: 362 LTYVANMVLEWITGDKVKPISGSLV 436
T +AN V ++ DK K I+G +
Sbjct: 215 DTDIANTV-AFLASDKAKYITGQTI 238
>sp|P50162|TRN1_DATST Tropinone reductase-I (TR-I) (Tropine dehydrogenase)
Length = 273
Score = 30.4 bits (67), Expect = 3.4
Identities = 25/85 (29%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Frame = +2
Query: 131 TENGFLILTGANAALTPTPGMLGYGMVKAAVHQLTKSL----AQDSTLPNGTWVVAILPI 298
++NG +I + A + P + Y K A++Q+TKSL A+D+ N IL
Sbjct: 148 SQNGNVIFLSSIAGFSALPSVSLYSASKGAINQMTKSLACEWAKDNIRVNSVAPGVILTP 207
Query: 299 TLDT--EANRHNMPTAD-FTTWTPL 364
++T + N H D F TP+
Sbjct: 208 LVETAIKKNPHQKEEIDNFIVKTPM 232
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,696,549
Number of Sequences: 369166
Number of extensions: 1180185
Number of successful extensions: 2809
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2729
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2805
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4357244645
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)