Planarian EST Database

DrC_00840

Cluster detail
GO Category : Not Available
Consensus Sequence :
>DrC_00840 GAATTCGGCACGAGGTTTTAATTTTCATGACTGCACCTCCTCCAAAACCAGTTAAGCCAG GCCAGGTTAAAGTTGTCAGAGCAATTTATACTTATGAAGCACAATCTGGTGATGAATTGT CATTTGAAGAAGGTGATTTACTCTACATCTTTGATATGATCTCCAGCCCAGACTGGTGGA GAGCAAGAGCAAATGGCAAGGAAGGACTTGTTCCGAGCAATTACGTATCACAACAAACTG AATCTATAGAAAACCCCATGCATGAGGCAGCTAAACGAGGAAATTTAGAATTCCTTCTTG AGTGTCTATCAAATAAGGTTTCTGTAAATGGTCTTGACAATGCTGGATGCACTCCATTAC ATTGGGCTGCTTTTGGGGGTCATTATGATTGCGCCAAGCTATTAATTGATACAAAATGTC AAGTTGATATTAAAAACAAATTGGGAGAAACTCCATTGCATAATGCTTCATTAAAAGGTC ACGCTGTCCTTGTGGAATTATTATTAAAAAGCGGTGCAAATGCAAACGCTTTAAACAATG ATAAAGAAACCCCTTATAAATTAGCCAGGAACCCTGAATGTGCTGCTTTATTGCGATCTG CAGATTCCAATTTTAAACCTAATTTTGAAAATTATGTCGACGAAGAAGATTCGGATTGAT TAACAATATATTTATTTATATGAATTGATTTGAATTTTTAATAAATCAATAATTTTTATA AATTC

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_00840
         (725 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|Q62422|OSTF1_MOUSE  Osteoclast-stimulating factor 1 (SH3 ...   199   5e-51
sp|Q92882|OSTF1_HUMAN  Osteoclast-stimulating factor 1            194   3e-49
sp|Q6UB98|ANR12_HUMAN  Ankyrin repeat domain protein 12 (Ank...    88   3e-17
sp|Q6UB99|ANR11_HUMAN  Ankyrin repeat domain protein 11 (Ank...    85   2e-16
sp|Q9H2K2|TNKS2_HUMAN  Tankyrase 2 (TANK2) (Tankyrase II) (T...    77   4e-14
sp|O95271|TNKS1_HUMAN  Tankyrase 1 (TANK1) (Tankyrase I) (TN...    76   8e-14
sp|Q80YE7|DAPK1_MOUSE  Death-associated protein kinase 1 (DA...    76   8e-14
sp|P16157|ANK1_HUMAN  Ankyrin-1 (Erythrocyte ankyrin) (Ankyr...    75   2e-13
sp|P57078|RIPK4_HUMAN  Serine/threonine-protein kinase RIPK4...    72   2e-12
sp|P53355|DAPK1_HUMAN  Death-associated protein kinase 1 (DA...    72   2e-12

>sp|Q62422|OSTF1_MOUSE Osteoclast-stimulating factor 1 (SH3 domain protein 3)
          Length = 215

 Score =  199 bits (507), Expect = 5e-51
 Identities = 99/199 (49%), Positives = 136/199 (68%), Gaps = 6/199 (3%)
 Frame = +3

Query: 78  RAIYTYEAQSGDELSFEEGDLLYIFDMISSPDWWRARANGKEGLVPSNYVSQQTESIENP 257
           RA+YT+E ++ DEL FEEGD++YI DM S   WW+    G+ GL+PSNYV++Q ESI+NP
Sbjct: 18  RALYTFEPRTPDELYFEEGDIIYITDM-SDTSWWKGTCKGRTGLIPSNYVAEQAESIDNP 76

Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLI-DTKCQVDIK 434
           +HEAAKRGNL +L ECL N+V VNGLD AG T L+WA  GGH D  ++L      +++ +
Sbjct: 77  LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQ 136

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALLRSAD--- 605
           NKLG+T LH A+ KG+A +V+LLL  GA  +  NN+K+    +A N  CA+LL+      
Sbjct: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQQGT 196

Query: 606 --SNFKPNFENYVDEEDSD 656
             +    N E+Y+D+EDSD
Sbjct: 197 DGARTLSNAEDYLDDEDSD 215

>sp|Q92882|OSTF1_HUMAN Osteoclast-stimulating factor 1
          Length = 214

 Score =  194 bits (492), Expect = 3e-49
 Identities = 96/198 (48%), Positives = 135/198 (68%), Gaps = 5/198 (2%)
 Frame = +3

Query: 78  RAIYTYEAQSGDELSFEEGDLLYIFDMISSPDWWRARANGKEGLVPSNYVSQQTESIENP 257
           RA+YT+E ++ DEL FEEGD++YI DM S  +WW+  + G+ GL+PSNYV++Q ESI+NP
Sbjct: 18  RALYTFEPRTPDELYFEEGDIIYITDM-SDTNWWKGTSKGRTGLIPSNYVAEQAESIDNP 76

Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLI-DTKCQVDIK 434
           +HEAAKRGNL +L ECL N+V VNGLD AG T L+WA  GGH D  ++L      +++ +
Sbjct: 77  LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALLRSADS-- 608
           NKLG+T    A+ KG+A +V+LLL  GA  +  N +K+  + +A N  CA+LL+      
Sbjct: 137 NKLGDTAFDAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQGTD 196

Query: 609 --NFKPNFENYVDEEDSD 656
                 N E+Y+D+EDSD
Sbjct: 197 AVRTLSNAEDYLDDEDSD 214

>sp|Q6UB98|ANR12_HUMAN Ankyrin repeat domain protein 12 (Ankyrin repeat-containing
           cofactor 2) (GAC-1 protein)
          Length = 2062

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 52/143 (36%), Positives = 80/143 (55%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           V+++ E  E P+H AA RG+++ + E +S   +VN  D AG TPLH A   G+YD AK+L
Sbjct: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECA 584
           I     V+ +    +TPLH+++  GH  +V+LLL+ G N    N   E P  +A   E  
Sbjct: 238 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE 297

Query: 585 ALLRSADSNFKPNFENYVDEEDS 653
            LL+  +     + E+Y D E++
Sbjct: 298 LLLK-REVPLSDDDESYTDSEEA 319


 Score = 37.7 bits (86), Expect = 0.032
 Identities = 21/53 (39%), Positives = 31/53 (58%)
 Frame = +3

Query: 414 KCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
           K +V+ +N+ GETPLH A+++G    V+ L+  GAN N  +    TP   A N
Sbjct: 175 KDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227

>sp|Q6UB99|ANR11_HUMAN Ankyrin repeat domain protein 11 (Ankyrin repeat-containing
           cofactor 1)
          Length = 2664

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 49/123 (39%), Positives = 68/123 (55%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           V+++ E  E  +H AA RG+   + E +S    VN  D AG T LH A   G+YD AK L
Sbjct: 162 VNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQL 221

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECA 584
           +    +V+ K    +TPLH+A+  GH  +V+LLL+ G N    N   ETP K+A +P   
Sbjct: 222 LAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMV 281

Query: 585 ALL 593
            LL
Sbjct: 282 NLL 284


 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 31/86 (36%), Positives = 41/86 (47%)
 Frame = +3

Query: 315 KVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLV 494
           K  VN  +  G T LH AA  G     K LI     V++K+  G T LH A  +G+  + 
Sbjct: 159 KDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVA 218

Query: 495 ELLLKSGANANALNNDKETPYKLARN 572
           + LL +GA  N    D +TP   A N
Sbjct: 219 KQLLAAGAEVNTKGLDDDTPLHDAAN 244


 Score = 35.4 bits (80), Expect = 0.16
 Identities = 16/39 (41%), Positives = 27/39 (69%)
 Frame = +3

Query: 411 TKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANAN 527
           TK +V+ +N+ GET LH A+++G A  ++ L+  GA+ N
Sbjct: 158 TKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVN 196

>sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting
            ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like
            protein) (Tankyrase-related protein)
          Length = 1166

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 55/149 (36%), Positives = 70/149 (46%), Gaps = 7/149 (4%)
 Frame = +3

Query: 213  PSNYVSQQTESIEN-PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYD 389
            P N   + T+   + P+H AA   NLE     L +   VN  D  G  PLH AA  GH D
Sbjct: 667  PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVD 726

Query: 390  CAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
             A LLI     V+  +K   TPLH A+ KG   L  LLL  GA+    N + +TP  L  
Sbjct: 727  VAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786

Query: 570  NPECAALLRSA------DSNFKPNFENYV 638
              + +ALL +A       S +KP   N V
Sbjct: 787  ADDVSALLTAAMPPSALPSCYKPQVLNGV 815


 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 36/106 (33%), Positives = 54/106 (50%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AA    +  +   L +   V+  D  G  PLH A   GHY+ A+LL+     V++ 
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
           +    TPLH A+ KG   + +LLL+ GA+    N D  TP  L ++
Sbjct: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD 634


 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 41/133 (30%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
 Frame = +3

Query: 198 KEGLVPSNYVSQQTESIEN-PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAF 374
           K  + P    S+ T   ++ P+H AA  G  + +   L N  +V   D+ G  PLH A  
Sbjct: 41  KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACS 100

Query: 375 GGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
            GH +   LL+      + ++    TPLH A++KG   +  +LL+ GA     N D  T 
Sbjct: 101 FGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTA 160

Query: 555 YKLARNPECAALL 593
             LA +P   A+L
Sbjct: 161 LDLA-DPSAKAVL 172


 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 1/111 (0%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLE-CLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKL 401
           +S      +  + EAAK G++E + + C    V+   ++    TPLH+AA        + 
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544

Query: 402 LIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
           L+     V  K+K G  PLHNA   GH  + ELL+K GA  N  +  K TP
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595


 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 36/98 (36%), Positives = 51/98 (52%), Gaps = 1/98 (1%)
 Frame = +3

Query: 264 EAAKRGNLEFLLECLSN-KVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNK 440
           E+A+ GN E ++  L+   V+ +  D    TPLH AA        +LL+     V  K+K
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242

Query: 441 LGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
               PLHNA   GH  + ELL+K GA  NA++  + TP
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280


 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 33/108 (30%), Positives = 50/108 (46%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AA    ++ +   L +   V+  D     PLH A   GHY+  +LL+     V+  
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM 273

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPE 578
           +    TPLH A+ K    +  LLL  GA+   LN   ++   LA  P+
Sbjct: 274 DLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQ 321


 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 29/108 (26%), Positives = 55/108 (50%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           ++++T+    P+H A+++ + + +   + ++  VN LDN G T LH AA+ GH    +LL
Sbjct: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKE 548
           +   C  +I +  G T L   +       V+ LL+ G +      D++
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSEADRQ 495


 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 34/111 (30%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
 Frame = +3

Query: 219 NYVSQQTESIENPMHEAA-----KRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGH 383
           N+   QT   E  +H AA     KR  +  LL  L    ++N       TPLH A+   H
Sbjct: 357 NFKHPQTH--ETALHCAAASPYPKRKQICELL--LRKGANINEKTKEFLTPLHVASEKAH 412

Query: 384 YDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALN 536
            D  ++++  + +V+  + LG+T LH A+  GH     LLL  G + N ++
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS 463


 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 36/125 (28%), Positives = 47/125 (37%), Gaps = 21/125 (16%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H A   G+ E +   L +    N  DN   TPLH AA  G  D   +L+    +  I+
Sbjct: 94  PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153

Query: 435 NKLGETPLHNASLKGHAVL---------------------VELLLKSGANANALNNDKET 551
           N  G T L  A     AVL                     + LL     N +A +  K T
Sbjct: 154 NTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKST 213

Query: 552 PYKLA 566
           P  LA
Sbjct: 214 PLHLA 218


 Score = 38.1 bits (87), Expect = 0.024
 Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
 Frame = +3

Query: 351 TPLHWAA---FGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGAN 521
           T LH AA   +       +LL+     ++ K K   TPLH AS K H  +VE+++K  A 
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425

Query: 522 ANALNNDKET 551
            NAL+N  +T
Sbjct: 426 VNALDNLGQT 435

>sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting
            ankyrin-related ADP-ribose polymerase)
          Length = 1327

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 51/131 (38%), Positives = 63/131 (48%), Gaps = 1/131 (0%)
 Frame = +3

Query: 213  PSNYVSQQTESIEN-PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYD 389
            P N   + T+   + P+H AA   NLE     L +   VN  D  G  PLH AA  GH D
Sbjct: 825  PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVD 884

Query: 390  CAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
             A LLI     V+  +K   TPLH A+ KG   L  LLL  GA+    N + +TP  LA 
Sbjct: 885  IAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944

Query: 570  NPECAALLRSA 602
              +  ALL  A
Sbjct: 945  ADDIRALLIDA 955


 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 37/105 (35%), Positives = 53/105 (50%)
 Frame = +3

Query: 255  PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
            P+H AA    +  +   L +   V+  D  G  PLH A   GHY+ A+LL+     V++ 
Sbjct: 687  PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVA 746

Query: 435  NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
            +    TPLH A+ KG   + +LLLK GA+    N D  TP  L +
Sbjct: 747  DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 791


 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 48/151 (31%), Positives = 72/151 (47%), Gaps = 10/151 (6%)
 Frame = +3

Query: 234  QTESIENPMHEAAKRGNLEFLLE-CLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLID 410
            +T  ++  + EA+K G+LE + + C S  V+   L+    TPLH+AA        + L+ 
Sbjct: 646  RTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705

Query: 411  TKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA----RNPE 578
                V  K+K G  PLHNA   GH  + ELL++ GA+ N  +  K TP   A    +   
Sbjct: 706  HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765

Query: 579  CAALLRSADSNFKPNFE-----NYVDEEDSD 656
            C  LL+      K N +     + V E D+D
Sbjct: 766  CKLLLKHGADPTKKNRDGNTPLDLVKEGDTD 796


 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 40/98 (40%), Positives = 52/98 (53%), Gaps = 1/98 (1%)
 Frame = +3

Query: 264 EAAKRGNLEFLLECLSN-KVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNK 440
           EAA+ GN E L+  L+   V+ +  D    TPLH AA        +LL+     V  K+K
Sbjct: 341 EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDK 400

Query: 441 LGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
            G  PLHNA   GH  + ELLLK GA  NA++  + TP
Sbjct: 401 GGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTP 438


 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 36/114 (31%), Positives = 58/114 (50%)
 Frame = +3

Query: 252 NPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDI 431
           +P+H AA  G  + +   L    +V+  D+ G  PLH A   GH +   LL+      + 
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277

Query: 432 KNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALL 593
           ++    TPLH A++KG   +  +LL+ GA+ N  N D ++   LA +P   A+L
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA-DPSAKAVL 330


 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 33/108 (30%), Positives = 50/108 (46%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AA    +  +   L +   V+  D  G  PLH A   GHY+  +LL+     V+  
Sbjct: 372 PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAM 431

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPE 578
           +    TPLH A+ K    +  LLL  GA+   +N   ++   +A  PE
Sbjct: 432 DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479


 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 12/152 (7%)
 Frame = +3

Query: 198  KEGLVPSNYVSQQTESIENPMH------EAAKRGNLEFLLE-CLSNKVSVNGLDNAGCTP 356
            ++G  P + V +    I++ +       +AAK+G L  + + C    ++         TP
Sbjct: 781  RDGNTPLDLVKEGDTDIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP 840

Query: 357  LHWAAFGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALN 536
            LH AA   + + A+ L++    V+ ++K G  PLHNA+  GH  +  LL+K     NA +
Sbjct: 841  LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900

Query: 537  NDKETPYKLA----RNPECAALL-RSADSNFK 617
                TP   A    R   CA LL   AD   K
Sbjct: 901  KWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932


 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 34/107 (31%), Positives = 53/107 (49%), Gaps = 5/107 (4%)
 Frame = +3

Query: 231 QQTESIENPMHEAA-----KRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCA 395
           +Q +S E  +H A      KR  +  LL  L    +VN  +    TPLH AA   H D  
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTELL--LRKGANVNEKNKDFMTPLHVAAERAHNDVM 574

Query: 396 KLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALN 536
           ++L     +++  + LG+T LH A+L GH     LLL  G++ + ++
Sbjct: 575 EVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS 621


 Score = 37.0 bits (84), Expect = 0.054
 Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
 Frame = +3

Query: 351 TPLHWAAFGGH---YDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGAN 521
           T LH A    H       +LL+     V+ KNK   TPLH A+ + H  ++E+L K GA 
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583

Query: 522 ANALNNDKET 551
            NAL+   +T
Sbjct: 584 MNALDTLGQT 593


 Score = 33.1 bits (74), Expect = 0.78
 Identities = 37/161 (22%), Positives = 51/161 (31%), Gaps = 57/161 (35%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H A   G+ E     L +   VN +D    TPLH AA     +   LL+       + 
Sbjct: 405 PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLV 464

Query: 435 NKLGETPLHNA-----------SLKGHAVL------------------------------ 491
           N  G++ +  A             KGH++L                              
Sbjct: 465 NCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHET 524

Query: 492 ----------------VELLLKSGANANALNNDKETPYKLA 566
                            ELLL+ GAN N  N D  TP  +A
Sbjct: 525 ALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVA 565

>sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DAP kinase 1)
          Length = 1442

 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 42/121 (34%), Positives = 66/121 (54%)
 Frame = +3

Query: 204 GLVPSNYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGH 383
           G + S  V+Q  +    P+  AA  GN++ L   +     ++  D  G   ++WA+  GH
Sbjct: 365 GSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGH 424

Query: 384 YDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKL 563
            D  K L + KC +D+K+K GET LH A+  GHA +V+LL   G+N +  + ++ETP   
Sbjct: 425 VDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHC 484

Query: 564 A 566
           A
Sbjct: 485 A 485


 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 42/109 (38%), Positives = 61/109 (55%)
 Frame = +3

Query: 240 ESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKC 419
           +S E  +H AA+ G+ + +    S   + +  D    TPLH AA+ G+Y  AK L +  C
Sbjct: 443 KSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVGC 502

Query: 420 QVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
            V+IKN+ GETPL  AS +G+  +VE L + GA+ NA + D      LA
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNASDKDGHIALHLA 551


 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 38/104 (36%), Positives = 51/104 (49%)
 Frame = +3

Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
           +H A +R  +E +   L +   V+  D  G TPLH A   G       L +  C +DI N
Sbjct: 548 LHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISN 607

Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
           K G TPLH A+  G   +V  L   GAN  AL +D +T   LA+
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGKTAEDLAK 651


 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 36/110 (32%), Positives = 57/110 (51%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           +  Q +   N ++ A++ G+++ L     NK  ++  D +G T LH AA  GH D  +LL
Sbjct: 405 IDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLL 464

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
                  D ++K  ETPLH A+  G+  + + L + G N N  N + ETP
Sbjct: 465 CSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETP 514


 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
 Frame = +3

Query: 249 ENPMHEAAKRGNLEFLLECLSNK-VSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
           E P+  A+ RG  + ++ECL+     +N  D  G   LH A      +  K L+     V
Sbjct: 512 ETPLLTASARGYHD-IVECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFV 570

Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
           D +++ G TPLH A   G A +V  L ++  N +  N    TP  LA N
Sbjct: 571 DFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISNKYGRTPLHLAAN 619


 Score = 33.1 bits (74), Expect = 0.78
 Identities = 24/97 (24%), Positives = 40/97 (41%)
 Frame = +3

Query: 219 NYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAK 398
           ++V  Q      P+H A K G+   ++       +++  +  G TPLH AA  G  D  +
Sbjct: 568 SFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISNKYGRTPLHLAANNGILDVVR 627

Query: 399 LLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLK 509
            L      V+     G+T    A  + H  +  LL +
Sbjct: 628 YLCLMGANVEALTSDGKTAEDLAKAEQHEHVAGLLAR 664

>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
          Length = 1881

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 38/105 (36%), Positives = 61/105 (58%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H  A+ G++      + + V V+     G TPLH A+  G+    K L+  +  V+ K
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
            KLG +PLH A+ +GH  +V LLLK+GA+ N +++D  TP  +A+
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775


 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 43/110 (39%), Positives = 59/110 (53%)
 Frame = +3

Query: 237 TESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTK 416
           TES   P+H A+  G+L  +   L    S N  +    TPLH AA  GH + AK L+  K
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460

Query: 417 CQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
            +V+ K K  +TPLH A+  GH  +V+LLL++ AN N       TP  +A
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510


 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 35/104 (33%), Positives = 54/104 (51%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H A K+ ++  +   L    S++ +  +G TPLH A+F GH    K L+      ++ 
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           N   ETPLH A+  GH  + + LL++ A  NA   D +TP   A
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477


 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 38/107 (35%), Positives = 53/107 (49%)
 Frame = +3

Query: 246 IENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
           +E P+H AA+ G+ E     L NK  VN       TPLH AA  GH +  KLL++     
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496

Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           ++    G TPLH A+ +GH   V  LL+  A+   +     TP  +A
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543


 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 40/103 (38%), Positives = 57/103 (55%), Gaps = 2/103 (1%)
 Frame = +3

Query: 228 SQQTESIEN--PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKL 401
           S   ES++   P+H AA+ G+ E +   LS + + N  + +G TPLH  A  GH   A +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686

Query: 402 LIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANA 530
           LI     VD   ++G TPLH AS  G+  LV+ LL+  A+ NA
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729


 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 38/114 (33%), Positives = 64/114 (56%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           +  +T++  +P+H AA+  +L+ +   L     ++ +     TPLH AA  GH+  AK+L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           +D   + + +   G TPLH A  K H  ++ELLLK+GA+ +A+     TP  +A
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411


 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 36/104 (34%), Positives = 52/104 (50%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AAK+  +E     L    S N     G TPLH AA  GH +   LL+  +   ++ 
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           NK G TPLH  + +GH  + ++L+K G   +A      TP  +A
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708


 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 33/105 (31%), Positives = 59/105 (56%)
 Frame = +3

Query: 252 NPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDI 431
           N +H A+K G+++ ++E L  ++ +      G T LH AA  G  +  + L++    V+ 
Sbjct: 47  NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106

Query: 432 KNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           +++ G TPL+ A+ + H  +V+ LL++GAN N    D  TP  +A
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151


 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 42/121 (34%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AA   NL      L+   SVN     G TPLH A+  G+    +LL+D   Q++ K
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR---NPECAALLRSAD 605
            K   TPLH A+  GH  + E+LL  GA   A   +  +P  +A    + +C  LL   D
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328

Query: 606 S 608
           +
Sbjct: 329 A 329


 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 38/114 (33%), Positives = 57/114 (50%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           V+ + +  + P+H AA+ G+   +   L N  + N    AG TPLH AA  GH +    L
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           ++ +       K G TPLH A+  G   + ELLL+  A+ NA   +  TP  +A
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576


 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 38/104 (36%), Positives = 49/104 (47%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AA  G+       L      N     G TPLH A    H    +LL+ T   +D  
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
            + G TPLH AS  GH  +V+ LL+ GA+ N  N   ETP  +A
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444


 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 34/114 (29%), Positives = 56/114 (49%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           +  +T+    P+H AA+ G++      L +   +      G +P+H AA G H DC +LL
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           +    ++D       TPLH A+  GH  + ++LL  GA  N+   +  TP  +A
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378


 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 35/103 (33%), Positives = 52/103 (50%)
 Frame = +3

Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
           +H AA+  +       L N  + + L   G TPLH AA   + + A+LL++    V+   
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236

Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           + G TPLH AS +G+ ++V LLL  GA       D+ TP   A
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279


 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 33/104 (31%), Positives = 51/104 (49%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H A++RGN+  +   L     +        TPLH AA  GH   +++L+D    +  K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
            K G +P+H A+   H   V LLL+  A  + +  D  TP  +A
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345


 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 35/100 (35%), Positives = 50/100 (50%)
 Frame = +3

Query: 267 AAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNKLG 446
           AA+ GNL+  L+ L N V +N  +  G   LH A+  GH      L+  +  ++   K G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 447 ETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
            T LH A+L G   +V  L+  GAN NA +    TP  +A
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118


 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 38/121 (31%), Positives = 59/121 (48%)
 Frame = +3

Query: 237 TESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTK 416
           T +   P+H AA+ G++E +L  L  + S   +   G TPLH AA  G    A+LL++  
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559

Query: 417 CQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALLR 596
              +   K G TPLH A    +  +V+LLL  G + ++   +  TP  +A       + R
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619

Query: 597 S 599
           S
Sbjct: 620 S 620


 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 36/103 (34%), Positives = 49/103 (47%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H A    NL+ +   L    S +     G TPLH AA     + A+ L+      + +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKL 563
           +  G TPLH A+ +GHA +V LLL   AN N  N    TP  L
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674


 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 40/122 (32%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
 Frame = +3

Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
           P+H AAK G +      L      N     G TPLH A    + D  KLL+         
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598

Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR---NPECAALLRSAD 605
              G TPLH A+ +    +   LL+ G +ANA +    TP  LA    + E  ALL S  
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658

Query: 606 SN 611
           +N
Sbjct: 659 AN 660


 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 9/121 (7%)
 Frame = +3

Query: 237 TESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTK 416
           T+     +H AA  G  E + E ++   +VN     G TPL+ AA   H +  K L++  
Sbjct: 75  TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134

Query: 417 CQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANAN---------ALNNDKETPYKLAR 569
              ++  + G TPL  A  +GH  +V  L+  G             A N+D  T   L +
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194

Query: 570 N 572
           N
Sbjct: 195 N 195


 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 36/129 (27%), Positives = 55/129 (42%), Gaps = 23/129 (17%)
 Frame = +3

Query: 186  RANG----KEGLVPSNYVSQQ-------------------TESIENPMHEAAKRGNLEFL 296
            +ANG    K GL P + V+Q+                   T     P+H A+  GN++ +
Sbjct: 658  QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717

Query: 297  LECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLK 476
               L ++  VN     G +PLH AA  GH D   LL+      +  +  G TPL  A   
Sbjct: 718  KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777

Query: 477  GHAVLVELL 503
            G+  + ++L
Sbjct: 778  GYISVTDVL 786


 Score = 41.2 bits (95), Expect = 0.003
 Identities = 40/137 (29%), Positives = 59/137 (43%), Gaps = 5/137 (3%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           V+ Q++    P++ AA+  +LE +   L N  + N     G TPL  A   GH +    L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA---RNP 575
           I+       K K+    LH A+         +LL++  N + L+    TP  +A    N 
Sbjct: 164 IN----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219

Query: 576 ECAALL--RSADSNFKP 620
             A LL  R A  NF P
Sbjct: 220 NVAQLLLNRGASVNFTP 236

>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
            serine/threonine-protein kinase 4) (Ankyrin repeat domain
            protein 3) (PKC-delta-interacting protein kinase)
          Length = 832

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 62/177 (35%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
 Frame = +3

Query: 93   YEAQSGDELS----FEEGDLLYIFDMISSPDWWRARANGKEGLVPSNY-----VSQQTES 245
            + AQ+GDE S     E+   +   D         A  +G+E +V         VS Q + 
Sbjct: 558  FAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKD 617

Query: 246  IENPMHEAAKRGNLEFL-LECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQ 422
               P+H AA +G+L  + L      VSVN     G TPLH AA  GHY  A++LID    
Sbjct: 618  AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 677

Query: 423  VDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKL-ARNPECAAL 590
            V++ + L +TPLH A+  GH     LLL  GA   A+ +D  T   L ARN   A +
Sbjct: 678  VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATV 734


 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
 Frame = +3

Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
           V+ + E     +H AA+ G+       L    SVN +D  G TP+H A   G  +  ++L
Sbjct: 545 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 604

Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKS-GANANALNNDKETPYKLA 566
           +     V ++ K    PLH A+ +GH  +V+LL K  G + NA   D  TP  LA
Sbjct: 605 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 659


 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 3/107 (2%)
 Frame = +3

Query: 255 PMHEAAKR---GNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
           P+H A +R   G +E LL   + K+SVN  D    T LH+AA  G     +LL++    V
Sbjct: 522 PLHMAVERRVRGVVELLL---ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV 578

Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           +  +  G TP+H A   G   +V +LL+ G + +    D   P   A
Sbjct: 579 NEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYA 625


 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 29/88 (32%), Positives = 44/88 (50%)
 Frame = +3

Query: 249 ENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVD 428
           + P+H AA+ G+       L        + + G T LH AA  GH    KLL++ K  V 
Sbjct: 686 QTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVL 745

Query: 429 IKNKLGETPLHNASLKGHAVLVELLLKS 512
            +  L +T LH A+  GH+ +VE L+ +
Sbjct: 746 ARGPLNQTALHLAAAHGHSEVVEELVSA 773


 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 38/118 (32%), Positives = 52/118 (44%)
 Frame = +3

Query: 213 PSNYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDC 392
           P   V+ QT     P+H AA+RG+       +     VN       TPLH AA  GH   
Sbjct: 641 PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTST 700

Query: 393 AKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           A+LL+      +     G T LH A+  GH   V+LL++  A+  A     +T   LA
Sbjct: 701 ARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLA 758


 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 35/118 (29%), Positives = 55/118 (46%)
 Frame = +3

Query: 213 PSNYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDC 392
           PS      T+  +  + +A   G+   L++ L  +     LD+ G + LH A   G  +C
Sbjct: 443 PSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS-GASLLHLAVEAGQEEC 501

Query: 393 AKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           AK L+      ++ N+ G TPLH A  +    +VELLL    + NA + D+ T    A
Sbjct: 502 AKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFA 559


 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 31/103 (30%), Positives = 47/103 (45%)
 Frame = +3

Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
           +H A + G  E     L N  + N  +  G TPLH A         +LL+  K  V+ K+
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549

Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
           +   T LH A+  G      LLL+  A+ N ++ +  TP  +A
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVA 592

>sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1)
          Length = 1432

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 3/120 (2%)
 Frame = +3

Query: 216 SNY-VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDC 392
           SNY V+Q  +    P+  AA  GN++ L   +     ++  D  G   ++WAA  GH D 
Sbjct: 368 SNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT 427

Query: 393 AKLLIDTKCQVDIKNKLGETPLHNASLKGHA--VLVELLLKSGANANALNNDKETPYKLA 566
            K L + KC +D+K+K GE  LH A+  GHA    V++L   G+N N  + ++ETP   A
Sbjct: 428 LKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCA 487


 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 43/111 (38%), Positives = 61/111 (54%), Gaps = 2/111 (1%)
 Frame = +3

Query: 240 ESIENPMHEAAKRGNLEF--LLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDT 413
           +S E  +H AA+ G+ +   +    S   + N  D    TPLH AA+ G+Y  AK L + 
Sbjct: 443 KSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 502

Query: 414 KCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
            C V+IKN+ GETPL  AS +G+  +VE L + GA+ NA + D      LA
Sbjct: 503 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 553


 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 39/107 (36%), Positives = 53/107 (49%)
 Frame = +3

Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
           +H A +R  +E +   LS    V+  D  G TPLH A   G+      L +  C +DI N
Sbjct: 550 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 609

Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPE 578
           K G TPLH A+  G   +V  L   GA+  AL  D +T   LAR+ +
Sbjct: 610 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 656


 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/109 (32%), Positives = 52/109 (47%), Gaps = 1/109 (0%)
 Frame = +3

Query: 249 ENPMHEAAKRGNLEFLLECLSNK-VSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
           E P+  A+ RG  + ++ECL+     +N  D  G   LH A      +  K L+   C V
Sbjct: 514 ETPLLTASARGYHD-IVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 572

Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
           D +++ G TPLH A   G+  +V  L ++  N +  N    TP  LA N
Sbjct: 573 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAAN 621


 Score = 35.4 bits (80), Expect = 0.16
 Identities = 25/96 (26%), Positives = 40/96 (41%)
 Frame = +3

Query: 222 YVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKL 401
           +V  Q      P+H A K GN+  ++       +++  +  G TPLH AA  G  D  + 
Sbjct: 571 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 630

Query: 402 LIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLK 509
           L      V+     G+T    A  + H  +  LL +
Sbjct: 631 LCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 666

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.318    0.134    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,693,339
Number of Sequences: 369166
Number of extensions: 1583382
Number of successful extensions: 6483
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4528
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5753
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6510836890
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)

Cluster detail

DrC_00840

Planaria EST Database

DrC_00840

BLASTX 2.2.13 [Nov-27-2005]

Cluster detail