Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_021_E12
(725 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q62422|OSTF1_MOUSE Osteoclast-stimulating factor 1 (SH3 ... 199 5e-51
sp|Q92882|OSTF1_HUMAN Osteoclast-stimulating factor 1 194 3e-49
sp|Q6UB98|ANR12_HUMAN Ankyrin repeat domain protein 12 (Ank... 88 3e-17
sp|Q6UB99|ANR11_HUMAN Ankyrin repeat domain protein 11 (Ank... 85 2e-16
sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (T... 77 4e-14
sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TN... 76 8e-14
sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DA... 76 8e-14
sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyr... 75 2e-13
sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4... 72 2e-12
sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DA... 72 2e-12
>sp|Q62422|OSTF1_MOUSE Osteoclast-stimulating factor 1 (SH3 domain protein 3)
Length = 215
Score = 199 bits (507), Expect = 5e-51
Identities = 99/199 (49%), Positives = 136/199 (68%), Gaps = 6/199 (3%)
Frame = +3
Query: 78 RAIYTYEAQSGDELSFEEGDLLYIFDMISSPDWWRARANGKEGLVPSNYVSQQTESIENP 257
RA+YT+E ++ DEL FEEGD++YI DM S WW+ G+ GL+PSNYV++Q ESI+NP
Sbjct: 18 RALYTFEPRTPDELYFEEGDIIYITDM-SDTSWWKGTCKGRTGLIPSNYVAEQAESIDNP 76
Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLI-DTKCQVDIK 434
+HEAAKRGNL +L ECL N+V VNGLD AG T L+WA GGH D ++L +++ +
Sbjct: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEVLFTQPNVELNQQ 136
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALLRSAD--- 605
NKLG+T LH A+ KG+A +V+LLL GA + NN+K+ +A N CA+LL+
Sbjct: 137 NKLGDTALHAAAWKGYADIVQLLLAKGARTDLRNNEKKLALDMATNAACASLLKKKQQGT 196
Query: 606 --SNFKPNFENYVDEEDSD 656
+ N E+Y+D+EDSD
Sbjct: 197 DGARTLSNAEDYLDDEDSD 215
>sp|Q92882|OSTF1_HUMAN Osteoclast-stimulating factor 1
Length = 214
Score = 194 bits (492), Expect = 3e-49
Identities = 96/198 (48%), Positives = 135/198 (68%), Gaps = 5/198 (2%)
Frame = +3
Query: 78 RAIYTYEAQSGDELSFEEGDLLYIFDMISSPDWWRARANGKEGLVPSNYVSQQTESIENP 257
RA+YT+E ++ DEL FEEGD++YI DM S +WW+ + G+ GL+PSNYV++Q ESI+NP
Sbjct: 18 RALYTFEPRTPDELYFEEGDIIYITDM-SDTNWWKGTSKGRTGLIPSNYVAEQAESIDNP 76
Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLI-DTKCQVDIK 434
+HEAAKRGNL +L ECL N+V VNGLD AG T L+WA GGH D ++L +++ +
Sbjct: 77 LHEAAKRGNLSWLRECLDNRVGVNGLDKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQ 136
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALLRSADS-- 608
NKLG+T A+ KG+A +V+LLL GA + N +K+ + +A N CA+LL+
Sbjct: 137 NKLGDTAFDAAAWKGYADIVQLLLAKGARTDLRNIEKKLAFDMATNAACASLLKKKQGTD 196
Query: 609 --NFKPNFENYVDEEDSD 656
N E+Y+D+EDSD
Sbjct: 197 AVRTLSNAEDYLDDEDSD 214
>sp|Q6UB98|ANR12_HUMAN Ankyrin repeat domain protein 12 (Ankyrin repeat-containing
cofactor 2) (GAC-1 protein)
Length = 2062
Score = 87.8 bits (216), Expect = 3e-17
Identities = 52/143 (36%), Positives = 80/143 (55%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
V+++ E E P+H AA RG+++ + E +S +VN D AG TPLH A G+YD AK+L
Sbjct: 178 VNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYDVAKIL 237
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECA 584
I V+ + +TPLH+++ GH +V+LLL+ G N N E P +A E
Sbjct: 238 IAAGADVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVDVAETEELE 297
Query: 585 ALLRSADSNFKPNFENYVDEEDS 653
LL+ + + E+Y D E++
Sbjct: 298 LLLK-REVPLSDDDESYTDSEEA 319
Score = 37.7 bits (86), Expect = 0.032
Identities = 21/53 (39%), Positives = 31/53 (58%)
Frame = +3
Query: 414 KCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
K +V+ +N+ GETPLH A+++G V+ L+ GAN N + TP A N
Sbjct: 175 KDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACN 227
>sp|Q6UB99|ANR11_HUMAN Ankyrin repeat domain protein 11 (Ankyrin repeat-containing
cofactor 1)
Length = 2664
Score = 84.7 bits (208), Expect = 2e-16
Identities = 49/123 (39%), Positives = 68/123 (55%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
V+++ E E +H AA RG+ + E +S VN D AG T LH A G+YD AK L
Sbjct: 162 VNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQL 221
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECA 584
+ +V+ K +TPLH+A+ GH +V+LLL+ G N N ETP K+A +P
Sbjct: 222 LAAGAEVNTKGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLKVANSPTMV 281
Query: 585 ALL 593
LL
Sbjct: 282 NLL 284
Score = 45.8 bits (107), Expect = 1e-04
Identities = 31/86 (36%), Positives = 41/86 (47%)
Frame = +3
Query: 315 KVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLV 494
K VN + G T LH AA G K LI V++K+ G T LH A +G+ +
Sbjct: 159 KDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVA 218
Query: 495 ELLLKSGANANALNNDKETPYKLARN 572
+ LL +GA N D +TP A N
Sbjct: 219 KQLLAAGAEVNTKGLDDDTPLHDAAN 244
Score = 35.4 bits (80), Expect = 0.16
Identities = 16/39 (41%), Positives = 27/39 (69%)
Frame = +3
Query: 411 TKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANAN 527
TK +V+ +N+ GET LH A+++G A ++ L+ GA+ N
Sbjct: 158 TKDKVNKRNERGETRLHRAAIRGDARRIKELISEGADVN 196
>sp|Q9H2K2|TNKS2_HUMAN Tankyrase 2 (TANK2) (Tankyrase II) (TNKS-2) (TRF1-interacting
ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like
protein) (Tankyrase-related protein)
Length = 1166
Score = 77.4 bits (189), Expect = 4e-14
Identities = 55/149 (36%), Positives = 70/149 (46%), Gaps = 7/149 (4%)
Frame = +3
Query: 213 PSNYVSQQTESIEN-PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYD 389
P N + T+ + P+H AA NLE L + VN D G PLH AA GH D
Sbjct: 667 PDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVD 726
Query: 390 CAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
A LLI V+ +K TPLH A+ KG L LLL GA+ N + +TP L
Sbjct: 727 VAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786
Query: 570 NPECAALLRSA------DSNFKPNFENYV 638
+ +ALL +A S +KP N V
Sbjct: 787 ADDVSALLTAAMPPSALPSCYKPQVLNGV 815
Score = 64.7 bits (156), Expect = 2e-10
Identities = 36/106 (33%), Positives = 54/106 (50%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AA + + L + V+ D G PLH A GHY+ A+LL+ V++
Sbjct: 529 PLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA 588
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
+ TPLH A+ KG + +LLL+ GA+ N D TP L ++
Sbjct: 589 DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD 634
Score = 58.9 bits (141), Expect = 1e-08
Identities = 41/133 (30%), Positives = 62/133 (46%), Gaps = 1/133 (0%)
Frame = +3
Query: 198 KEGLVPSNYVSQQTESIEN-PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAF 374
K + P S+ T ++ P+H AA G + + L N +V D+ G PLH A
Sbjct: 41 KRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACS 100
Query: 375 GGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
GH + LL+ + ++ TPLH A++KG + +LL+ GA N D T
Sbjct: 101 FGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTA 160
Query: 555 YKLARNPECAALL 593
LA +P A+L
Sbjct: 161 LDLA-DPSAKAVL 172
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 1/111 (0%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLE-CLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKL 401
+S + + EAAK G++E + + C V+ ++ TPLH+AA +
Sbjct: 485 ISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEY 544
Query: 402 LIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
L+ V K+K G PLHNA GH + ELL+K GA N + K TP
Sbjct: 545 LLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTP 595
Score = 54.3 bits (129), Expect = 3e-07
Identities = 36/98 (36%), Positives = 51/98 (52%), Gaps = 1/98 (1%)
Frame = +3
Query: 264 EAAKRGNLEFLLECLSN-KVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNK 440
E+A+ GN E ++ L+ V+ + D TPLH AA +LL+ V K+K
Sbjct: 183 ESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDK 242
Query: 441 LGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
PLHNA GH + ELL+K GA NA++ + TP
Sbjct: 243 GDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTP 280
Score = 54.3 bits (129), Expect = 3e-07
Identities = 33/108 (30%), Positives = 50/108 (46%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AA ++ + L + V+ D PLH A GHY+ +LL+ V+
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAM 273
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPE 578
+ TPLH A+ K + LLL GA+ LN ++ LA P+
Sbjct: 274 DLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQ 321
Score = 50.1 bits (118), Expect = 6e-06
Identities = 29/108 (26%), Positives = 55/108 (50%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
++++T+ P+H A+++ + + + + ++ VN LDN G T LH AA+ GH +LL
Sbjct: 393 INEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLL 452
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKE 548
+ C +I + G T L + V+ LL+ G + D++
Sbjct: 453 LSYGCDPNIISLQGFTALQMGNEN-----VQQLLQEGISLGNSEADRQ 495
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/111 (30%), Positives = 53/111 (47%), Gaps = 5/111 (4%)
Frame = +3
Query: 219 NYVSQQTESIENPMHEAA-----KRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGH 383
N+ QT E +H AA KR + LL L ++N TPLH A+ H
Sbjct: 357 NFKHPQTH--ETALHCAAASPYPKRKQICELL--LRKGANINEKTKEFLTPLHVASEKAH 412
Query: 384 YDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALN 536
D ++++ + +V+ + LG+T LH A+ GH LLL G + N ++
Sbjct: 413 NDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIIS 463
Score = 43.1 bits (100), Expect = 8e-04
Identities = 36/125 (28%), Positives = 47/125 (37%), Gaps = 21/125 (16%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H A G+ E + L + N DN TPLH AA G D +L+ + I+
Sbjct: 94 PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153
Query: 435 NKLGETPLHNASLKGHAVL---------------------VELLLKSGANANALNNDKET 551
N G T L A AVL + LL N +A + K T
Sbjct: 154 NTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKST 213
Query: 552 PYKLA 566
P LA
Sbjct: 214 PLHLA 218
Score = 38.1 bits (87), Expect = 0.024
Identities = 26/70 (37%), Positives = 37/70 (52%), Gaps = 3/70 (4%)
Frame = +3
Query: 351 TPLHWAA---FGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGAN 521
T LH AA + +LL+ ++ K K TPLH AS K H +VE+++K A
Sbjct: 366 TALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAK 425
Query: 522 ANALNNDKET 551
NAL+N +T
Sbjct: 426 VNALDNLGQT 435
>sp|O95271|TNKS1_HUMAN Tankyrase 1 (TANK1) (Tankyrase I) (TNKS-1) (TRF1-interacting
ankyrin-related ADP-ribose polymerase)
Length = 1327
Score = 76.3 bits (186), Expect = 8e-14
Identities = 51/131 (38%), Positives = 63/131 (48%), Gaps = 1/131 (0%)
Frame = +3
Query: 213 PSNYVSQQTESIEN-PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYD 389
P N + T+ + P+H AA NLE L + VN D G PLH AA GH D
Sbjct: 825 PENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVD 884
Query: 390 CAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
A LLI V+ +K TPLH A+ KG L LLL GA+ N + +TP LA
Sbjct: 885 IAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLAT 944
Query: 570 NPECAALLRSA 602
+ ALL A
Sbjct: 945 ADDIRALLIDA 955
Score = 65.9 bits (159), Expect = 1e-10
Identities = 37/105 (35%), Positives = 53/105 (50%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AA + + L + V+ D G PLH A GHY+ A+LL+ V++
Sbjct: 687 PLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVA 746
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
+ TPLH A+ KG + +LLLK GA+ N D TP L +
Sbjct: 747 DLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVK 791
Score = 63.5 bits (153), Expect = 5e-10
Identities = 48/151 (31%), Positives = 72/151 (47%), Gaps = 10/151 (6%)
Frame = +3
Query: 234 QTESIENPMHEAAKRGNLEFLLE-CLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLID 410
+T ++ + EA+K G+LE + + C S V+ L+ TPLH+AA + L+
Sbjct: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705
Query: 411 TKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA----RNPE 578
V K+K G PLHNA GH + ELL++ GA+ N + K TP A +
Sbjct: 706 HGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765
Query: 579 CAALLRSADSNFKPNFE-----NYVDEEDSD 656
C LL+ K N + + V E D+D
Sbjct: 766 CKLLLKHGADPTKKNRDGNTPLDLVKEGDTD 796
Score = 59.7 bits (143), Expect = 8e-09
Identities = 40/98 (40%), Positives = 52/98 (53%), Gaps = 1/98 (1%)
Frame = +3
Query: 264 EAAKRGNLEFLLECLSN-KVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNK 440
EAA+ GN E L+ L+ V+ + D TPLH AA +LL+ V K+K
Sbjct: 341 EAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDK 400
Query: 441 LGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
G PLHNA GH + ELLLK GA NA++ + TP
Sbjct: 401 GGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTP 438
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/114 (31%), Positives = 58/114 (50%)
Frame = +3
Query: 252 NPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDI 431
+P+H AA G + + L +V+ D+ G PLH A GH + LL+ +
Sbjct: 218 SPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNA 277
Query: 432 KNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALL 593
++ TPLH A++KG + +LL+ GA+ N N D ++ LA +P A+L
Sbjct: 278 RDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLA-DPSAKAVL 330
Score = 55.1 bits (131), Expect = 2e-07
Identities = 33/108 (30%), Positives = 50/108 (46%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AA + + L + V+ D G PLH A GHY+ +LL+ V+
Sbjct: 372 PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAM 431
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPE 578
+ TPLH A+ K + LLL GA+ +N ++ +A PE
Sbjct: 432 DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPE 479
Score = 53.5 bits (127), Expect = 6e-07
Identities = 44/152 (28%), Positives = 69/152 (45%), Gaps = 12/152 (7%)
Frame = +3
Query: 198 KEGLVPSNYVSQQTESIENPMH------EAAKRGNLEFLLE-CLSNKVSVNGLDNAGCTP 356
++G P + V + I++ + +AAK+G L + + C ++ TP
Sbjct: 781 RDGNTPLDLVKEGDTDIQDLLKGDAALLDAAKKGCLARVQKLCTPENINCRDTQGRNSTP 840
Query: 357 LHWAAFGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALN 536
LH AA + + A+ L++ V+ ++K G PLHNA+ GH + LL+K NA +
Sbjct: 841 LHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATD 900
Query: 537 NDKETPYKLA----RNPECAALL-RSADSNFK 617
TP A R CA LL AD K
Sbjct: 901 KWAFTPLHEAAQKGRTQLCALLLAHGADPTMK 932
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/107 (31%), Positives = 53/107 (49%), Gaps = 5/107 (4%)
Frame = +3
Query: 231 QQTESIENPMHEAA-----KRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCA 395
+Q +S E +H A KR + LL L +VN + TPLH AA H D
Sbjct: 517 KQPQSHETALHCAVASLHPKRKQVTELL--LRKGANVNEKNKDFMTPLHVAAERAHNDVM 574
Query: 396 KLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALN 536
++L +++ + LG+T LH A+L GH LLL G++ + ++
Sbjct: 575 EVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIIS 621
Score = 37.0 bits (84), Expect = 0.054
Identities = 26/70 (37%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Frame = +3
Query: 351 TPLHWAAFGGH---YDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGAN 521
T LH A H +LL+ V+ KNK TPLH A+ + H ++E+L K GA
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 522 ANALNNDKET 551
NAL+ +T
Sbjct: 584 MNALDTLGQT 593
Score = 33.1 bits (74), Expect = 0.78
Identities = 37/161 (22%), Positives = 51/161 (31%), Gaps = 57/161 (35%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H A G+ E L + VN +D TPLH AA + LL+ +
Sbjct: 405 PLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLV 464
Query: 435 NKLGETPLHNA-----------SLKGHAVL------------------------------ 491
N G++ + A KGH++L
Sbjct: 465 NCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHET 524
Query: 492 ----------------VELLLKSGANANALNNDKETPYKLA 566
ELLL+ GAN N N D TP +A
Sbjct: 525 ALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVA 565
>sp|Q80YE7|DAPK1_MOUSE Death-associated protein kinase 1 (DAP kinase 1)
Length = 1442
Score = 76.3 bits (186), Expect = 8e-14
Identities = 42/121 (34%), Positives = 66/121 (54%)
Frame = +3
Query: 204 GLVPSNYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGH 383
G + S V+Q + P+ AA GN++ L + ++ D G ++WA+ GH
Sbjct: 365 GSLSSYDVNQPNKHGTPPLLIAAGCGNIQMLQLLIKRGSRIDVQDKGGSNAIYWASRHGH 424
Query: 384 YDCAKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKL 563
D K L + KC +D+K+K GET LH A+ GHA +V+LL G+N + + ++ETP
Sbjct: 425 VDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHC 484
Query: 564 A 566
A
Sbjct: 485 A 485
Score = 70.5 bits (171), Expect = 4e-12
Identities = 42/109 (38%), Positives = 61/109 (55%)
Frame = +3
Query: 240 ESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKC 419
+S E +H AA+ G+ + + S + + D TPLH AA+ G+Y AK L + C
Sbjct: 443 KSGETALHVAARYGHADVVQLLCSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVGC 502
Query: 420 QVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
V+IKN+ GETPL AS +G+ +VE L + GA+ NA + D LA
Sbjct: 503 NVNIKNREGETPLLTASARGYHDIVECLAEHGADLNASDKDGHIALHLA 551
Score = 63.2 bits (152), Expect = 7e-10
Identities = 38/104 (36%), Positives = 51/104 (49%)
Frame = +3
Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
+H A +R +E + L + V+ D G TPLH A G L + C +DI N
Sbjct: 548 LHLAVRRCQMEVIKTLLGHGSFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISN 607
Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
K G TPLH A+ G +V L GAN AL +D +T LA+
Sbjct: 608 KYGRTPLHLAANNGILDVVRYLCLMGANVEALTSDGKTAEDLAK 651
Score = 60.8 bits (146), Expect = 3e-09
Identities = 36/110 (32%), Positives = 57/110 (51%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
+ Q + N ++ A++ G+++ L NK ++ D +G T LH AA GH D +LL
Sbjct: 405 IDVQDKGGSNAIYWASRHGHVDTLKFLNENKCPLDVKDKSGETALHVAARYGHADVVQLL 464
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETP 554
D ++K ETPLH A+ G+ + + L + G N N N + ETP
Sbjct: 465 CSFGSNPDFQDKEEETPLHCAAWHGYYSVAKALCEVGCNVNIKNREGETP 514
Score = 48.9 bits (115), Expect = 1e-05
Identities = 35/109 (32%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
Frame = +3
Query: 249 ENPMHEAAKRGNLEFLLECLSNK-VSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
E P+ A+ RG + ++ECL+ +N D G LH A + K L+ V
Sbjct: 512 ETPLLTASARGYHD-IVECLAEHGADLNASDKDGHIALHLAVRRCQMEVIKTLLGHGSFV 570
Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
D +++ G TPLH A G A +V L ++ N + N TP LA N
Sbjct: 571 DFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISNKYGRTPLHLAAN 619
Score = 33.1 bits (74), Expect = 0.78
Identities = 24/97 (24%), Positives = 40/97 (41%)
Frame = +3
Query: 219 NYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAK 398
++V Q P+H A K G+ ++ +++ + G TPLH AA G D +
Sbjct: 568 SFVDFQDRHGNTPLHVACKDGSAPIVVALCEASCNLDISNKYGRTPLHLAANNGILDVVR 627
Query: 399 LLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLK 509
L V+ G+T A + H + LL +
Sbjct: 628 YLCLMGANVEALTSDGKTAEDLAKAEQHEHVAGLLAR 664
>sp|P16157|ANK1_HUMAN Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin R)
Length = 1881
Score = 74.7 bits (182), Expect = 2e-13
Identities = 38/105 (36%), Positives = 61/105 (58%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H A+ G++ + + V V+ G TPLH A+ G+ K L+ + V+ K
Sbjct: 671 PLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR 569
KLG +PLH A+ +GH +V LLLK+GA+ N +++D TP +A+
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775
Score = 71.6 bits (174), Expect = 2e-12
Identities = 43/110 (39%), Positives = 59/110 (53%)
Frame = +3
Query: 237 TESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTK 416
TES P+H A+ G+L + L S N + TPLH AA GH + AK L+ K
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460
Query: 417 CQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+V+ K K +TPLH A+ GH +V+LLL++ AN N TP +A
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510
Score = 67.4 bits (163), Expect = 4e-11
Identities = 35/104 (33%), Positives = 54/104 (51%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H A K+ ++ + L S++ + +G TPLH A+F GH K L+ ++
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
N ETPLH A+ GH + + LL++ A NA D +TP A
Sbjct: 434 NVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Score = 67.4 bits (163), Expect = 4e-11
Identities = 38/107 (35%), Positives = 53/107 (49%)
Frame = +3
Query: 246 IENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
+E P+H AA+ G+ E L NK VN TPLH AA GH + KLL++
Sbjct: 437 VETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANP 496
Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
++ G TPLH A+ +GH V LL+ A+ + TP +A
Sbjct: 497 NLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543
Score = 65.5 bits (158), Expect = 1e-10
Identities = 40/103 (38%), Positives = 57/103 (55%), Gaps = 2/103 (1%)
Frame = +3
Query: 228 SQQTESIEN--PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKL 401
S ES++ P+H AA+ G+ E + LS + + N + +G TPLH A GH A +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 402 LIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANA 530
LI VD ++G TPLH AS G+ LV+ LL+ A+ NA
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNA 729
Score = 65.1 bits (157), Expect = 2e-10
Identities = 38/114 (33%), Positives = 64/114 (56%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
+ +T++ +P+H AA+ +L+ + L ++ + TPLH AA GH+ AK+L
Sbjct: 298 IQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+D + + + G TPLH A K H ++ELLLK+GA+ +A+ TP +A
Sbjct: 358 LDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411
Score = 63.9 bits (154), Expect = 4e-10
Identities = 36/104 (34%), Positives = 52/104 (50%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AAK+ +E L S N G TPLH AA GH + LL+ + ++
Sbjct: 605 PLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLG 664
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
NK G TPLH + +GH + ++L+K G +A TP +A
Sbjct: 665 NKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708
Score = 63.5 bits (153), Expect = 5e-10
Identities = 33/105 (31%), Positives = 59/105 (56%)
Frame = +3
Query: 252 NPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDI 431
N +H A+K G+++ ++E L ++ + G T LH AA G + + L++ V+
Sbjct: 47 NGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNA 106
Query: 432 KNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+++ G TPL+ A+ + H +V+ LL++GAN N D TP +A
Sbjct: 107 QSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVA 151
Score = 62.8 bits (151), Expect = 9e-10
Identities = 42/121 (34%), Positives = 59/121 (48%), Gaps = 3/121 (2%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AA NL L+ SVN G TPLH A+ G+ +LL+D Q++ K
Sbjct: 209 PLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR---NPECAALLRSAD 605
K TPLH A+ GH + E+LL GA A + +P +A + +C LL D
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 606 S 608
+
Sbjct: 329 A 329
Score = 62.4 bits (150), Expect = 1e-09
Identities = 38/114 (33%), Positives = 57/114 (50%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
V+ + + + P+H AA+ G+ + L N + N AG TPLH AA GH + L
Sbjct: 463 VNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLAL 522
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
++ + K G TPLH A+ G + ELLL+ A+ NA + TP +A
Sbjct: 523 LEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/104 (36%), Positives = 49/104 (47%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AA G+ L N G TPLH A H +LL+ T +D
Sbjct: 341 PLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAV 400
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+ G TPLH AS GH +V+ LL+ GA+ N N ETP +A
Sbjct: 401 TESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Score = 59.3 bits (142), Expect = 1e-08
Identities = 34/114 (29%), Positives = 56/114 (49%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
+ +T+ P+H AA+ G++ L + + G +P+H AA G H DC +LL
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLL 324
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+ ++D TPLH A+ GH + ++LL GA N+ + TP +A
Sbjct: 325 LQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIA 378
Score = 58.2 bits (139), Expect = 2e-08
Identities = 35/103 (33%), Positives = 52/103 (50%)
Frame = +3
Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
+H AA+ + L N + + L G TPLH AA + + A+LL++ V+
Sbjct: 177 LHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTP 236
Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+ G TPLH AS +G+ ++V LLL GA D+ TP A
Sbjct: 237 QNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCA 279
Score = 57.4 bits (137), Expect = 4e-08
Identities = 33/104 (31%), Positives = 51/104 (49%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H A++RGN+ + L + TPLH AA GH +++L+D + K
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
K G +P+H A+ H V LLL+ A + + D TP +A
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345
Score = 56.2 bits (134), Expect = 9e-08
Identities = 35/100 (35%), Positives = 50/100 (50%)
Frame = +3
Query: 267 AAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNKLG 446
AA+ GNL+ L+ L N V +N + G LH A+ GH L+ + ++ K G
Sbjct: 19 AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78
Query: 447 ETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
T LH A+L G +V L+ GAN NA + TP +A
Sbjct: 79 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118
Score = 56.2 bits (134), Expect = 9e-08
Identities = 38/121 (31%), Positives = 59/121 (48%)
Frame = +3
Query: 237 TESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTK 416
T + P+H AA+ G++E +L L + S + G TPLH AA G A+LL++
Sbjct: 500 TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERD 559
Query: 417 CQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPECAALLR 596
+ K G TPLH A + +V+LLL G + ++ + TP +A + R
Sbjct: 560 AHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVAR 619
Query: 597 S 599
S
Sbjct: 620 S 620
Score = 54.7 bits (130), Expect = 2e-07
Identities = 36/103 (34%), Positives = 49/103 (47%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H A NL+ + L S + G TPLH AA + A+ L+ + +
Sbjct: 572 PLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKL 563
+ G TPLH A+ +GHA +V LLL AN N N TP L
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHL 674
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/122 (32%), Positives = 52/122 (42%), Gaps = 3/122 (2%)
Frame = +3
Query: 255 PMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIK 434
P+H AAK G + L N G TPLH A + D KLL+
Sbjct: 539 PLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 435 NKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLAR---NPECAALLRSAD 605
G TPLH A+ + + LL+ G +ANA + TP LA + E ALL S
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 606 SN 611
+N
Sbjct: 659 AN 660
Score = 46.6 bits (109), Expect = 7e-05
Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 9/121 (7%)
Frame = +3
Query: 237 TESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTK 416
T+ +H AA G E + E ++ +VN G TPL+ AA H + K L++
Sbjct: 75 TKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENG 134
Query: 417 CQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANAN---------ALNNDKETPYKLAR 569
++ + G TPL A +GH +V L+ G A N+D T L +
Sbjct: 135 ANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQ 194
Query: 570 N 572
N
Sbjct: 195 N 195
Score = 46.6 bits (109), Expect = 7e-05
Identities = 36/129 (27%), Positives = 55/129 (42%), Gaps = 23/129 (17%)
Frame = +3
Query: 186 RANG----KEGLVPSNYVSQQ-------------------TESIENPMHEAAKRGNLEFL 296
+ANG K GL P + V+Q+ T P+H A+ GN++ +
Sbjct: 658 QANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLV 717
Query: 297 LECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKNKLGETPLHNASLK 476
L ++ VN G +PLH AA GH D LL+ + + G TPL A
Sbjct: 718 KFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRL 777
Query: 477 GHAVLVELL 503
G+ + ++L
Sbjct: 778 GYISVTDVL 786
Score = 41.2 bits (95), Expect = 0.003
Identities = 40/137 (29%), Positives = 59/137 (43%), Gaps = 5/137 (3%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
V+ Q++ P++ AA+ +LE + L N + N G TPL A GH + L
Sbjct: 104 VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHL 163
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA---RNP 575
I+ K K+ LH A+ +LL++ N + L+ TP +A N
Sbjct: 164 IN----YGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENL 219
Query: 576 ECAALL--RSADSNFKP 620
A LL R A NF P
Sbjct: 220 NVAQLLLNRGASVNFTP 236
>sp|P57078|RIPK4_HUMAN Serine/threonine-protein kinase RIPK4 (Receptor-interacting
serine/threonine-protein kinase 4) (Ankyrin repeat domain
protein 3) (PKC-delta-interacting protein kinase)
Length = 832
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/177 (35%), Positives = 84/177 (47%), Gaps = 11/177 (6%)
Frame = +3
Query: 93 YEAQSGDELS----FEEGDLLYIFDMISSPDWWRARANGKEGLVPSNY-----VSQQTES 245
+ AQ+GDE S E+ + D A +G+E +V VS Q +
Sbjct: 558 FAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKD 617
Query: 246 IENPMHEAAKRGNLEFL-LECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQ 422
P+H AA +G+L + L VSVN G TPLH AA GHY A++LID
Sbjct: 618 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 677
Query: 423 VDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKL-ARNPECAAL 590
V++ + L +TPLH A+ GH LLL GA A+ +D T L ARN A +
Sbjct: 678 VNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATV 734
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/115 (33%), Positives = 56/115 (48%), Gaps = 1/115 (0%)
Frame = +3
Query: 225 VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLL 404
V+ + E +H AA+ G+ L SVN +D G TP+H A G + ++L
Sbjct: 545 VNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRIL 604
Query: 405 IDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKS-GANANALNNDKETPYKLA 566
+ V ++ K PLH A+ +GH +V+LL K G + NA D TP LA
Sbjct: 605 LRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLA 659
Score = 52.8 bits (125), Expect = 9e-07
Identities = 35/107 (32%), Positives = 52/107 (48%), Gaps = 3/107 (2%)
Frame = +3
Query: 255 PMHEAAKR---GNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
P+H A +R G +E LL + K+SVN D T LH+AA G +LL++ V
Sbjct: 522 PLHMAVERRVRGVVELLL---ARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASV 578
Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+ + G TP+H A G +V +LL+ G + + D P A
Sbjct: 579 NEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYA 625
Score = 52.4 bits (124), Expect = 1e-06
Identities = 29/88 (32%), Positives = 44/88 (50%)
Frame = +3
Query: 249 ENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVD 428
+ P+H AA+ G+ L + + G T LH AA GH KLL++ K V
Sbjct: 686 QTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVL 745
Query: 429 IKNKLGETPLHNASLKGHAVLVELLLKS 512
+ L +T LH A+ GH+ +VE L+ +
Sbjct: 746 ARGPLNQTALHLAAAHGHSEVVEELVSA 773
Score = 51.6 bits (122), Expect = 2e-06
Identities = 38/118 (32%), Positives = 52/118 (44%)
Frame = +3
Query: 213 PSNYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDC 392
P V+ QT P+H AA+RG+ + VN TPLH AA GH
Sbjct: 641 PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTST 700
Query: 393 AKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
A+LL+ + G T LH A+ GH V+LL++ A+ A +T LA
Sbjct: 701 ARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLA 758
Score = 45.8 bits (107), Expect = 1e-04
Identities = 35/118 (29%), Positives = 55/118 (46%)
Frame = +3
Query: 213 PSNYVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDC 392
PS T+ + + +A G+ L++ L + LD+ G + LH A G +C
Sbjct: 443 PSTSDLGTTDVQKKKLVDAIVSGDTSKLMKILQPQDVDLALDS-GASLLHLAVEAGQEEC 501
Query: 393 AKLLIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
AK L+ ++ N+ G TPLH A + +VELLL + NA + D+ T A
Sbjct: 502 AKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFA 559
Score = 43.9 bits (102), Expect = 4e-04
Identities = 31/103 (30%), Positives = 47/103 (45%)
Frame = +3
Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
+H A + G E L N + N + G TPLH A +LL+ K V+ K+
Sbjct: 490 LHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKD 549
Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
+ T LH A+ G LLL+ A+ N ++ + TP +A
Sbjct: 550 EDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVA 592
>sp|P53355|DAPK1_HUMAN Death-associated protein kinase 1 (DAP kinase 1)
Length = 1432
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/120 (35%), Positives = 64/120 (53%), Gaps = 3/120 (2%)
Frame = +3
Query: 216 SNY-VSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDC 392
SNY V+Q + P+ AA GN++ L + ++ D G ++WAA GH D
Sbjct: 368 SNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDT 427
Query: 393 AKLLIDTKCQVDIKNKLGETPLHNASLKGHA--VLVELLLKSGANANALNNDKETPYKLA 566
K L + KC +D+K+K GE LH A+ GHA V++L G+N N + ++ETP A
Sbjct: 428 LKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCA 487
Score = 67.0 bits (162), Expect = 5e-11
Identities = 43/111 (38%), Positives = 61/111 (54%), Gaps = 2/111 (1%)
Frame = +3
Query: 240 ESIENPMHEAAKRGNLEF--LLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDT 413
+S E +H AA+ G+ + + S + N D TPLH AA+ G+Y AK L +
Sbjct: 443 KSGEMALHVAARYGHADVAQVQVLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEA 502
Query: 414 KCQVDIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLA 566
C V+IKN+ GETPL AS +G+ +VE L + GA+ NA + D LA
Sbjct: 503 GCNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLA 553
Score = 65.5 bits (158), Expect = 1e-10
Identities = 39/107 (36%), Positives = 53/107 (49%)
Frame = +3
Query: 258 MHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQVDIKN 437
+H A +R +E + LS V+ D G TPLH A G+ L + C +DI N
Sbjct: 550 LHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISN 609
Query: 438 KLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARNPE 578
K G TPLH A+ G +V L GA+ AL D +T LAR+ +
Sbjct: 610 KYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQ 656
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/109 (32%), Positives = 52/109 (47%), Gaps = 1/109 (0%)
Frame = +3
Query: 249 ENPMHEAAKRGNLEFLLECLSNK-VSVNGLDNAGCTPLHWAAFGGHYDCAKLLIDTKCQV 425
E P+ A+ RG + ++ECL+ +N D G LH A + K L+ C V
Sbjct: 514 ETPLLTASARGYHD-IVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV 572
Query: 426 DIKNKLGETPLHNASLKGHAVLVELLLKSGANANALNNDKETPYKLARN 572
D +++ G TPLH A G+ +V L ++ N + N TP LA N
Sbjct: 573 DYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAAN 621
Score = 35.4 bits (80), Expect = 0.16
Identities = 25/96 (26%), Positives = 40/96 (41%)
Frame = +3
Query: 222 YVSQQTESIENPMHEAAKRGNLEFLLECLSNKVSVNGLDNAGCTPLHWAAFGGHYDCAKL 401
+V Q P+H A K GN+ ++ +++ + G TPLH AA G D +
Sbjct: 571 FVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRY 630
Query: 402 LIDTKCQVDIKNKLGETPLHNASLKGHAVLVELLLK 509
L V+ G+T A + H + LL +
Sbjct: 631 LCLMGASVEALTTDGKTAEDLARSEQHEHVAGLLAR 666
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 79,901,504
Number of Sequences: 369166
Number of extensions: 1591670
Number of successful extensions: 6500
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4543
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5770
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6510836890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)