Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00838 (895 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q9V0D5|MDH_PYRAB Malate dehydrogenase 213 8e-55 sp|O59028|MDH_PYRHO Malate dehydrogenase 208 2e-53 sp|P16142|MDH_METFE Malate/L-sulfolactate dehydrogenase ((R... 181 3e-45 sp|Q58820|COMC_METJA L-sulfolactate dehydrogenase ((R)-sulf... 174 3e-43 sp|O27273|COMC_METTH L-sulfolactate dehydrogenase ((R)-sulf... 163 5e-40 sp|O34736|YJMC_BACSU Hypothetical oxidoreductase yjmC 160 4e-39 sp|P58408|ALLD_ECO57 Ureidoglycolate dehydrogenase 140 6e-33 sp|P77555|ALLD_ECOLI Ureidoglycolate dehydrogenase 138 2e-32 sp|P58409|YBIC_ECO57 Hypothetical oxidoreductase ybiC 119 1e-26 sp|P30178|YBIC_ECOLI Hypothetical oxidoreductase ybiC 117 3e-26
>sp|Q9V0D5|MDH_PYRAB Malate dehydrogenase Length = 362 Score = 213 bits (541), Expect = 8e-55 Identities = 119/270 (44%), Positives = 171/270 (63%), Gaps = 3/270 (1%) Frame = +2 Query: 80 FKKCMSTESVIIAPT-EVREFCIKSMNSVQTKHEHSKALADVLLAADYSGHYSHGLNRLE 256 F+K E+ + P E+ F ++ + + T E +K +AD L+ AD G SHG+ RL+ Sbjct: 2 FEKGYVDENYVRIPKDELFSFVVRVLTKLGTPEEDAKIVADNLIMADLRGIESHGVQRLK 61 Query: 257 MYVDDIKANITSKSNEPCIISEKGATAFVDGMNCLGPVVGNFSMDIAINKALQVGVGWVA 436 YVD I + + II E + A +DG G VVG +M +AI KA + G+G VA Sbjct: 62 RYVDGILSGGINLHPRIKIIREGPSYALLDGDEGFGQVVGYKAMKLAIEKARKTGIGIVA 121 Query: 437 AKGSNHYGIAGWYSQRACDKGLLGMSFTNTSPLAFPTRSKQVAVGTNPLALAAPGEKESD 616 + SNHYGIAG+Y+ A ++G++G+S TN+ PL PT + +GTNP+ALAAP + Sbjct: 122 VRNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGVERILGTNPIALAAP--TKGK 179 Query: 617 NFLLDMATTAVALGKIEMARRKKEPIPEGWAADANGKVTKIADEGAKGG-LLPLGGI-EI 790 FLLDMAT+ V +GK+E+ RRK E IPEGWA ++ G++T+ +E GG LLPLGG E+ Sbjct: 180 PFLLDMATSVVPIGKLEVYRRKGEEIPEGWAINSKGEITRSVEEVFNGGSLLPLGGFGEL 239 Query: 791 TGGYKGYGLSMLVEIFCGILSGSLYGPQIR 880 GG+KGYGLS++V+I GILSG + ++ Sbjct: 240 LGGHKGYGLSLMVDILSGILSGGTWSKHVK 269
>sp|O59028|MDH_PYRHO Malate dehydrogenase Length = 360 Score = 208 bits (529), Expect = 2e-53 Identities = 118/270 (43%), Positives = 169/270 (62%), Gaps = 3/270 (1%) Frame = +2 Query: 80 FKKCMSTESVIIAPTE-VREFCIKSMNSVQTKHEHSKALADVLLAADYSGHYSHGLNRLE 256 F+K E+ I P + + F ++ + + E +K +AD L+ AD G SHG+ RL+ Sbjct: 2 FEKGYVDENYIRVPKDRLFSFIVRVLTKLGVPEEDAKIVADNLVMADLRGVESHGVQRLK 61 Query: 257 MYVDDIKANITSKSNEPCIISEKGATAFVDGMNCLGPVVGNFSMDIAINKALQVGVGWVA 436 YVD I + + + +I E + A +DG LG VVG SM +AI KA G+G V Sbjct: 62 RYVDGIISGGVNLHPKIRVIREGPSYALIDGDEGLGQVVGYRSMKLAIKKAKDTGIGIVI 121 Query: 437 AKGSNHYGIAGWYSQRACDKGLLGMSFTNTSPLAFPTRSKQVAVGTNPLALAAPGEKESD 616 A+ SNHYGIAG+Y+ A ++G++G+S TN+ PL PT + +GTNP+ALAAP + + Sbjct: 122 ARNSNHYGIAGYYALMAAEEGMIGISMTNSRPLVAPTGGIERILGTNPIALAAPTKDKP- 180 Query: 617 NFLLDMATTAVALGKIEMARRKKEPIPEGWAADANGKVTKIADEGAKGG-LLPLGGI-EI 790 FLLDMAT+ V +GK+E+ RRK + IPEGWA + G +T +E GG LLPLGG E+ Sbjct: 181 -FLLDMATSVVPIGKLEVYRRKGKDIPEGWAINREGNITTKVEEVFNGGALLPLGGFGEL 239 Query: 791 TGGYKGYGLSMLVEIFCGILSGSLYGPQIR 880 GG+KGYGLS++V+I GILSG + ++ Sbjct: 240 LGGHKGYGLSLMVDILSGILSGGTWSKYVK 269
>sp|P16142|MDH_METFE Malate/L-sulfolactate dehydrogenase ((R)-2-hydroxyacid dehydrogenase) Length = 339 Score = 181 bits (458), Expect = 3e-45 Identities = 102/258 (39%), Positives = 141/258 (54%) Frame = +2 Query: 107 VIIAPTEVREFCIKSMNSVQTKHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANI 286 +II+P E R IK +N++ EH+K ADV++ AD G SHG+ R YV+ IK Sbjct: 1 MIISPEEERSLIIKILNALGVSEEHAKITADVIVDADLKGFTSHGIGRFPQYVEGIKLGT 60 Query: 287 TSKSNEPCIISEKGATAFVDGMNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIA 466 S I E + A ++G + LG VV M +AI KA GVG V SNH+GIA Sbjct: 61 IKTSGNIEIEKETDSVALINGNHLLGQVVAYKGMKLAIEKAKNTGVGIVGIHDSNHFGIA 120 Query: 467 GWYSQRACDKGLLGMSFTNTSPLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTA 646 G+YS A ++G++ TNT P P K +GTNP+A++ P + +DM+T A Sbjct: 121 GYYSDMAMKNDMIGITMTNTEPAVAPLGGKIPVLGTNPIAISIPSNEY--YVAVDMSTAA 178 Query: 647 VALGKIEMARRKKEPIPEGWAADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSML 826 VA GK+ A RK E IPEG A D NG T +E G +LP GG+KGY L + Sbjct: 179 VARGKLLEAARKNEKIPEGIAVDKNGNPTTDPNEALNGSILPF------GGHKGYALCFM 232 Query: 827 VEIFCGILSGSLYGPQIR 880 +EI G L + +G +++ Sbjct: 233 IEILAGPLVKAEFGSKVK 250
>sp|Q58820|COMC_METJA L-sulfolactate dehydrogenase ((R)-sulfolactate dehydrogenase) ((R)-2-hydroxyacid dehydrogenase) Length = 344 Score = 174 bits (441), Expect = 3e-43 Identities = 101/258 (39%), Positives = 147/258 (56%) Frame = +2 Query: 107 VIIAPTEVREFCIKSMNSVQTKHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANI 286 +I+ P ++ I + E +K ADV + AD G SHG+ R Y+ +K Sbjct: 1 MILKPENEKKLIIDVLKKFGVPEEDAKITADVFVDADLKGFTSHGIGRFPQYITALKLGN 60 Query: 287 TSKSNEPCIISEKGATAFVDGMNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIA 466 + + I+ E ATA +DG LG VVG +M++AI KA VGVG VA + +NH+GIA Sbjct: 61 INPKPDIKIVKESPATAVIDGDLGLGQVVGKKAMELAIKKAKNVGVGVVATRNANHFGIA 120 Query: 467 GWYSQRACDKGLLGMSFTNTSPLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTA 646 G+YS+ A ++ ++G++ TNT P P K+ +GTNP+A+A G K F LDMAT + Sbjct: 121 GYYSELAMNQDMIGITITNTEPAMAPFGGKEKILGTNPIAIAFKGNKY--KFSLDMATAS 178 Query: 647 VALGKIEMARRKKEPIPEGWAADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSML 826 +A GKI A RKK IPEG A D +GK T + +G +LP GG KGYGL++ Sbjct: 179 IARGKILEALRKKIKIPEGCAVDKDGKPTTDPAKALEGCILPF------GGPKGYGLALA 232 Query: 827 VEIFCGILSGSLYGPQIR 880 +E+ I G+ G +++ Sbjct: 233 IEMLSAI-GGAEVGTKVK 249
>sp|O27273|COMC_METTH L-sulfolactate dehydrogenase ((R)-sulfolactate dehydrogenase) Length = 341 Score = 163 bits (413), Expect = 5e-40 Identities = 94/255 (36%), Positives = 136/255 (53%) Frame = +2 Query: 113 IAPTEVREFCIKSMNSVQTKHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANITS 292 I+P E + + + ++ E S +ADV L AD G SHG+ R YVD ++ Sbjct: 3 ISPEEEVKIIKEILTAMNVPEESSDIVADVTLDADLKGFSSHGIGRFPQYVDGLRHGTIR 62 Query: 293 KSNEPCIISEKGATAFVDGMNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIAGW 472 + I E +TA ++G + G VV +M++AI KA GVG V SNH+G+AG+ Sbjct: 63 ADGDITIERETESTALINGNHIFGHVVAYRAMELAIEKARNTGVGLVGVHDSNHFGVAGY 122 Query: 473 YSQRACDKGLLGMSFTNTSPLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTAVA 652 YS A ++G+ NT P P ++ +GTNP+A+ P + + +DMAT+A A Sbjct: 123 YSDMAVMNDMIGVVIANTEPAVAPIGGRKPILGTNPVAIGIPSNRYYVS--VDMATSASA 180 Query: 653 LGKIEMARRKKEPIPEGWAADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSMLVE 832 GK+ A RK E IPE A DA GK T + KG +LP GG+KGY LS ++E Sbjct: 181 RGKLLEAARKGESIPENVALDAEGKPTTDPEMALKGSILPF------GGHKGYALSFMIE 234 Query: 833 IFCGILSGSLYGPQI 877 I G L G+ +G + Sbjct: 235 ILAGPLVGAAFGTAV 249
>sp|O34736|YJMC_BACSU Hypothetical oxidoreductase yjmC Length = 337 Score = 160 bits (405), Expect = 4e-39 Identities = 91/261 (34%), Positives = 142/261 (54%) Frame = +2 Query: 101 ESVIIAPTEVREFCIKSMNSVQTKHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKA 280 +++ IA E +E + ++ ++ +ADVL+ AD +SHG+ E YV+ + A Sbjct: 2 KTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNVHSHGVLHTEHYVNRLLA 61 Query: 281 NITSKSNEPCIISEKGATAFVDGMNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYG 460 + +P T +DG + G V + +MD AI+ A + GVG V A S+H G Sbjct: 62 GGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAIDMAKKKGVGMVTAVNSSHCG 121 Query: 461 IAGWYSQRACDKGLLGMSFTNTSPLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMAT 640 ++ Q+A D+ L+GM+ T+T + P + +GTNP+A P K F+LDMAT Sbjct: 122 ALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTNPIAYGVPA-KHKKPFILDMAT 180 Query: 641 TAVALGKIEMARRKKEPIPEGWAADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLS 820 + VA GKI AR + + IPEGW D NG+ D+ + + GG KGYGLS Sbjct: 181 SKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDK--------VVSLSTFGGPKGYGLS 232 Query: 821 MLVEIFCGILSGSLYGPQIRK 883 ++V++F G+L+G+ +GP I K Sbjct: 233 IVVDVFSGLLAGAAFGPHIAK 253
>sp|P58408|ALLD_ECO57 Ureidoglycolate dehydrogenase Length = 349 Score = 140 bits (352), Expect = 6e-33 Identities = 86/236 (36%), Positives = 120/236 (50%) Frame = +2 Query: 170 KHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANITSKSNEPCIISEKGATAFVDG 349 K EH+ +A+VL+ AD G +SHG R+E Y + I T++ E + +A + Sbjct: 22 KREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGGTNREPEFRLEETGPCSAILHA 81 Query: 350 MNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIAGWYSQRACDKGLLGMSFTNTS 529 N G V M+ AI A Q GV V H G ++ Q+A GL+G+S + Sbjct: 82 DNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAISYFVQQAARAGLIGISMCQSD 141 Query: 530 PLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTAVALGKIEMARRKKEPIPEGWA 709 P+ P ++ GTNPLA AAPGE + + DMATT A GK+ AR + IP+ WA Sbjct: 142 PMVVPFGGAEIYYGTNPLAFAAPGEGD-EILTFDMATTVQAWGKVLDARSRNMSIPDTWA 200 Query: 710 ADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSMLVEIFCGILSGSLYGPQI 877 D NG T D A LLP G KGYGL M++++ G+L G +G Q+ Sbjct: 201 VDKNGAPT--TDPFAVHALLP------AAGPKGYGLMMMIDVLSGVLLGLPFGRQV 248
>sp|P77555|ALLD_ECOLI Ureidoglycolate dehydrogenase Length = 349 Score = 138 bits (347), Expect = 2e-32 Identities = 85/236 (36%), Positives = 119/236 (50%) Frame = +2 Query: 170 KHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANITSKSNEPCIISEKGATAFVDG 349 K EH+ +A+VL+ AD G +SHG R+E Y + I T++ E + +A + Sbjct: 22 KREHAATVAEVLVYADARGIHSHGAVRVEYYAERISKGGTNREPEFRLEETGPCSAILHA 81 Query: 350 MNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIAGWYSQRACDKGLLGMSFTNTS 529 N G V M+ AI A Q GV V H G ++ Q+A G +G+S + Sbjct: 82 DNAAGQVAAKMGMEHAIKTAQQNGVAVVGISRMGHSGAISYFVQQAARAGFIGISMCQSD 141 Query: 530 PLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTAVALGKIEMARRKKEPIPEGWA 709 P+ P ++ GTNPLA AAPGE + + DMATT A GK+ AR + IP+ WA Sbjct: 142 PMVVPFGGAEIYYGTNPLAFAAPGEGD-EILTFDMATTVQAWGKVLDARSRNMSIPDTWA 200 Query: 710 ADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSMLVEIFCGILSGSLYGPQI 877 D NG T D A LLP G KGYGL M++++ G+L G +G Q+ Sbjct: 201 VDKNGVPT--TDPFAVHALLP------AAGPKGYGLMMMIDVLSGVLLGLPFGRQV 248
>sp|P58409|YBIC_ECO57 Hypothetical oxidoreductase ybiC Length = 361 Score = 119 bits (298), Expect = 1e-26 Identities = 75/232 (32%), Positives = 114/232 (49%), Gaps = 2/232 (0%) Frame = +2 Query: 167 TKHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANITSKSNEPCIISEKGATAFVD 346 ++ + +K +AD L+AA+ +GH SHG+ + YV ++ I+ E GA +D Sbjct: 25 SEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKIVKEAGAAVTLD 84 Query: 347 GMNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIAGWYSQRACDKGLLGMSFTNT 526 G G V + +M + I KA Q G+ VA S+H G G+++++ G + + F + Sbjct: 85 GDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSV 144 Query: 527 --SPLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTAVALGKIEMARRKKEPIPE 700 P+ P + GTNP + P K+ LLD AT+A+A GK +A K P+P Sbjct: 145 VGIPMVAPFHGRDSRFGTNPFCVVFP-RKDDFPLLLDYATSAIAFGKTRVAWHKGVPVPP 203 Query: 701 GWAADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSMLVEIFCGILSG 856 G D NG T A PLG + +KGY L+ + EI G LSG Sbjct: 204 GCLIDVNGVPT---TNPAVMQESPLGSLLTFAEHKGYALAAMCEILGGALSG 252
>sp|P30178|YBIC_ECOLI Hypothetical oxidoreductase ybiC Length = 361 Score = 117 bits (294), Expect = 3e-26 Identities = 74/232 (31%), Positives = 114/232 (49%), Gaps = 2/232 (0%) Frame = +2 Query: 167 TKHEHSKALADVLLAADYSGHYSHGLNRLEMYVDDIKANITSKSNEPCIISEKGATAFVD 346 ++ + +K +AD L+AA+ +GH SHG+ + YV ++ + E GA +D Sbjct: 25 SEEQEAKLVADHLIAANLAGHDSHGIGMIPSYVRSWSQGHLQINHHAKTVKEAGAAVTLD 84 Query: 347 GMNCLGPVVGNFSMDIAINKALQVGVGWVAAKGSNHYGIAGWYSQRACDKGLLGMSFTNT 526 G G V + +M + I KA Q G+ VA S+H G G+++++ G + + F + Sbjct: 85 GDRAFGQVAAHEAMALGIEKAHQHGIAAVALHNSHHIGRIGYWAEQCAAAGFVSIHFVSV 144 Query: 527 --SPLAFPTRSKQVAVGTNPLALAAPGEKESDNFLLDMATTAVALGKIEMARRKKEPIPE 700 P+ P + GTNP + P K++ LLD AT+A+A GK +A K P+P Sbjct: 145 VGIPMVAPFHGRDSRFGTNPFCVVFP-RKDNFPLLLDYATSAIAFGKTRVAWHKGVPVPP 203 Query: 701 GWAADANGKVTKIADEGAKGGLLPLGGIEITGGYKGYGLSMLVEIFCGILSG 856 G D NG T A PLG + +KGY L+ + EI G LSG Sbjct: 204 GCLIDVNGVPT---TNPAVMQESPLGSLLTFAEHKGYALAAMCEILGGALSG 252
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 106,268,356 Number of Sequences: 369166 Number of extensions: 2246462 Number of successful extensions: 6440 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 6049 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 6400 length of database: 68,354,980 effective HSP length: 110 effective length of database: 48,034,130 effective search space used: 8982382310 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)