Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00800 (1030 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 122 1e-27 sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 120 5e-27 sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 120 8e-27 sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 115 2e-25 sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 115 3e-25 sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 115 3e-25 sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 105 2e-22 sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 105 3e-22 sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 104 4e-22 sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 104 5e-22
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor 1) (CRAF1) (TRAFAMN) Length = 567 Score = 122 bits (307), Expect = 1e-27 Identities = 82/309 (26%), Positives = 157/309 (50%), Gaps = 8/309 (2%) Frame = +2 Query: 14 LRNVDKYMRDDVDELKLDGKRKQVEIDTLNKKLQEMESKFEIETKSIIEKEFDKLNLDGE 193 L+ + V L+ + K I +L+ ++ E + E + + + E L+L Sbjct: 262 LKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHL--- 318 Query: 194 RKEKSIESLQKKCEQLNKQIEQFNNKYQQIENKFVNAKLERENKEKDLMRNIDETKNKQI 373 ++ I+S +K ++L+K+I F +++ ++ + + +E + ++D++ + Sbjct: 319 --QRVIDSQAEKLKELDKEIRPFRQNWEEADS--MKSSVESLQNRVTELESVDKSAGQAA 374 Query: 374 EMT----TRSNKIDETMKNVENKLLEIEINQNKMK----NGEFVWRIDKINDKMKDAKNG 529 T ++ ++ D+T+ + +L ++++ ++ NG +W+I + ++A G Sbjct: 375 RNTGLLESQLSRHDQTLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMG 434 Query: 530 INTKIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWPFKYDVT 709 +YS FYT GYKMC RV +G+G GKGTHL++ F +M+GE+D + WPFK VT Sbjct: 435 KTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVT 494 Query: 710 FSLINQQTRLVHHSETIKYDELPNNKNWNKPIDERNGRMGKFKFIELSELSTNANLILNN 889 L++Q + H + K D PN+ ++ KP E N G F+ + L N I ++ Sbjct: 495 LMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDD 551 Query: 890 QIFIKCSVN 916 IFIK V+ Sbjct: 552 TIFIKVIVD 560
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84) Length = 557 Score = 120 bits (302), Expect = 5e-27 Identities = 84/295 (28%), Positives = 152/295 (51%), Gaps = 17/295 (5%) Frame = +2 Query: 86 EIDTLNKKLQEMESKFE--IETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNK---- 247 +I L+K L++ ESK + ET +EKEF + + + ++Q ++K Sbjct: 263 QISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWL 322 Query: 248 --QIEQFNNKYQQIENKF-VNAKLERENKEKDLMRNIDETKNKQIEMTTRSNKIDETMKN 418 Q+ Q Q +NKF + +E + K + ++ + + +NK D T N Sbjct: 323 EAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHD-THIN 381 Query: 419 VENKLLEIEINQNKMK-------NGEFVWRIDKINDKMKDAKNGINTKIYSDSFYTHKHG 577 + ++ N+ + K NG+ +W++ K ++A +G I+S SFYT + G Sbjct: 382 IHKA--QLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCG 439 Query: 578 YKMCLRVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWPFKYDVTFSLINQQTRLVHHSET 757 Y++C R +G+G+G+G+HL++ F +M+GEFD + QWPF+ VT L++Q + + ET Sbjct: 440 YRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGK-KNIMET 498 Query: 758 IKYDELPNNKNWNKPIDERNGRMGKFKFIELSELSTNAN-LILNNQIFIKCSVNI 919 K D PN+ ++ +P E N G +F+ S L N I ++ +F+K +V++ Sbjct: 499 FKPD--PNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDL 551
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor 1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1 associated protein) (LAP1) (CAP-1) Length = 568 Score = 120 bits (300), Expect = 8e-27 Identities = 81/309 (26%), Positives = 156/309 (50%), Gaps = 8/309 (2%) Frame = +2 Query: 14 LRNVDKYMRDDVDELKLDGKRKQVEIDTLNKKLQEMESKFEIETKSIIEKEFDKLNLDGE 193 L+ + V L+ + K I +L+ ++ E + E + + + E L+L Sbjct: 263 LKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHL--- 319 Query: 194 RKEKSIESLQKKCEQLNKQIEQFNNKYQQIENKFVNAKLERENKEKDLMRNIDETKNKQI 373 ++ I+S +K ++L+K+I F +++ ++ + + +E + ++D++ + Sbjct: 320 --QRVIDSQAEKLKELDKEIRPFRQNWEEADS--MKSSVESLQNRVTELESVDKSAGQVA 375 Query: 374 EMT----TRSNKIDETMKNVENKLLEIEINQNKMK----NGEFVWRIDKINDKMKDAKNG 529 T ++ ++ D+ + + +L ++++ ++ NG +W+I + ++A G Sbjct: 376 RNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMG 435 Query: 530 INTKIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWPFKYDVT 709 +YS FYT GYKMC RV +G+G GKGTHL++ F +M+GE+D + WPFK VT Sbjct: 436 KTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVT 495 Query: 710 FSLINQQTRLVHHSETIKYDELPNNKNWNKPIDERNGRMGKFKFIELSELSTNANLILNN 889 L++Q + H + K D PN+ ++ KP E N G F+ + L N I ++ Sbjct: 496 LMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDD 552 Query: 890 QIFIKCSVN 916 IFIK V+ Sbjct: 553 TIFIKVIVD 561
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 Length = 558 Score = 115 bits (289), Expect = 2e-25 Identities = 75/301 (24%), Positives = 145/301 (48%), Gaps = 40/301 (13%) Frame = +2 Query: 137 IETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNKQIEQFNNKYQQIENKFVNAKLER 316 +E +E+ L E+KE I+ L + ++ K+++QF + + N + Sbjct: 254 LEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALT 313 Query: 317 ENKEKD-------------------------LMRNIDETKNKQIEMTTRSNKI----DET 409 + +K L+ +D K + ++ ++ ET Sbjct: 314 SHTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGET 373 Query: 410 MKNVEN-KLLEIEINQNKMK---------NGEFVWRIDKINDKMKDAKNGINTKIYSDSF 559 K+ + + + ++N+N+ + +G+ +W++ K ++A G ++S F Sbjct: 374 SKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPF 433 Query: 560 YTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWPFKYDVTFSLINQQTRL 739 YT + GY++C R +G+G+GKGTHL++ F +M+GEFD + QWPF+ VT L++Q + Sbjct: 434 YTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKK 493 Query: 740 VHHSETIKYDELPNNKNWNKPIDERNGRMGKFKFIELSELSTNAN-LILNNQIFIKCSVN 916 H ET K D PN+ ++ +P E N G +F+ S L + N I ++ +F+K +V+ Sbjct: 494 NHIVETFKAD--PNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKDDTLFLKVAVD 551 Query: 917 I 919 + Sbjct: 552 L 552
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2 receptor-associated protein 3) Length = 501 Score = 115 bits (287), Expect = 3e-25 Identities = 80/286 (27%), Positives = 149/286 (52%), Gaps = 3/286 (1%) Frame = +2 Query: 71 KRKQVEIDTLNKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNKQ 250 K+++ E+ L + L + S +E K ++ G++ E LQ+ CE L K+ Sbjct: 231 KQQEHEVQWLREHLAMLLSSV-LEAKPLL----------GDQSHAGSELLQR-CESLEKK 278 Query: 251 IEQFNNKYQQIENKFVNAKLERE--NKEKDLMRNIDETKNKQIEMTTRSNKI-DETMKNV 421 F N + + + E +++ L ++ E + +++ RS + D M ++ Sbjct: 279 TATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADL 338 Query: 422 ENKLLEIEINQNKMKNGEFVWRIDKINDKMKDAKNGINTKIYSDSFYTHKHGYKMCLRVD 601 E K+LE+E + +G F+W+I K ++A G I+S +FYT ++GYKMCLR+ Sbjct: 339 EQKVLEMEASTY---DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIY 395 Query: 602 PDGNGAGKGTHLTVGFHLMKGEFDDISQWPFKYDVTFSLINQQTRLVHHSETIKYDELPN 781 +G+G G+GTHL++ F +MKG D + +WPF VT L++Q R H + + D Sbjct: 396 LNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNR-EHVIDAFRPD--VT 452 Query: 782 NKNWNKPIDERNGRMGKFKFIELSELSTNANLILNNQIFIKCSVNI 919 + ++ +P+++ N G F +S++ + + ++ IFIK V++ Sbjct: 453 SSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDL 498
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 Length = 501 Score = 115 bits (287), Expect = 3e-25 Identities = 81/289 (28%), Positives = 143/289 (49%), Gaps = 5/289 (1%) Frame = +2 Query: 68 GKRKQVEIDTL-NKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLN 244 G + VE + L + +LQ + + S +E + L+ E L ++C+ L Sbjct: 222 GCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPE-----LLQRCQILE 276 Query: 245 KQIEQFNNKY----QQIENKFVNAKLERENKEKDLMRNIDETKNKQIEMTTRSNKIDETM 412 ++I F N +++E V A+ D I+ NK ++ D M Sbjct: 277 QKIATFENIVCVLNREVERVAVTAEACSRQHRLD-QDKIEALSNKVQQLERSIGLKDLAM 335 Query: 413 KNVENKLLEIEINQNKMKNGEFVWRIDKINDKMKDAKNGINTKIYSDSFYTHKHGYKMCL 592 ++E K+ E+E++ +G F+W+I K ++A G I+S +FYT ++GYKMCL Sbjct: 336 ADLEQKVSELEVSTY---DGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCL 392 Query: 593 RVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWPFKYDVTFSLINQQTRLVHHSETIKYDE 772 RV +G+G G+GTHL++ F +MKG D + QWPF VT L++ R H + + D Sbjct: 393 RVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNR-EHVIDAFRPD- 450 Query: 773 LPNNKNWNKPIDERNGRMGKFKFIELSELSTNANLILNNQIFIKCSVNI 919 + ++ +P+ + N G F +S++ + + ++ IFIK V++ Sbjct: 451 -VTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDL 498
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 Length = 409 Score = 105 bits (263), Expect = 2e-22 Identities = 70/285 (24%), Positives = 149/285 (52%), Gaps = 9/285 (3%) Frame = +2 Query: 98 LNKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESL--QKKCEQLNKQIEQFNN- 268 L + L E++ + +E +E + + ++E +++ L +K QL +++ F N Sbjct: 134 LERNLSELQLQAAVEATGDLEVDCYRAPCCESQEELALQHLVKEKLLAQLEEKLRVFANI 193 Query: 269 -----KYQQIENKFVNAKLERENKEKDLMRNIDETKNKQIEMTTRSNKIDETMKNVENKL 433 K + + + A + + +++ + ++++ + +E+ + D+ + +E+ L Sbjct: 194 VAVLNKEVEASHLALAASIHQSQLDREHLLSLEQ---RVVELQQTLAQKDQVLGKLEHSL 250 Query: 434 LEIEINQNKMKNGEFVWRIDKINDKMKDAKNGINTKIYSDSFYTHKHGYKMCLRVDPDGN 613 + + +G F+W+I + + ++ G ++S +FYT K+GYK+CLR+ +G+ Sbjct: 251 ---RLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGD 307 Query: 614 GAGKGTHLTVGFHLMKGEFDDISQWPFKYDVTFSLINQQTRLVHHSETIKYDELPNNKNW 793 G+GK THL++ +M+GE+D + WPF+ VTF L++Q R H + + D ++ ++ Sbjct: 308 GSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPD--LSSASF 364 Query: 794 NKPIDERNGRMGKFKFIELSEL-STNANLILNNQIFIKCSVNIPA 925 +P E N G F LS+L S + ++ +F+KC V+ A Sbjct: 365 QRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTSA 409
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to RING and Traf domains protein 1) Length = 470 Score = 105 bits (261), Expect = 3e-22 Identities = 62/205 (30%), Positives = 113/205 (55%), Gaps = 11/205 (5%) Frame = +2 Query: 341 RNIDETKNKQIEMTTRS-NKIDETMKNVENKLLEIEINQNKMKNGEFVWRIDKINDKMKD 517 R+++E+ + M ++ + ++ + +L E+ I + G +W+I ++++ Sbjct: 268 RHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSD----GVLIWKIGSYGRRLQE 323 Query: 518 AKNGINTKIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWPFK 697 AK N + +S +FYTHK+GYK+ + +GNG+G+GTHL++ ++ G FD++ +WP Sbjct: 324 AKAKPNLECFSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLA 383 Query: 698 YDVTFSLINQQ----TRLVHHSETIKYDELPNNKNWNKP------IDERNGRMGKFKFIE 847 VTFSL++Q + H +ET D PN KN+ KP +DE + G KFI Sbjct: 384 RRVTFSLLDQSDPGLAKPQHVTETFHPD--PNWKNFQKPGTWRGSLDESSLGFGYPKFIS 441 Query: 848 LSELSTNANLILNNQIFIKCSVNIP 922 ++ N + ++ +FI+ SV +P Sbjct: 442 HQDI-RKRNYVRDDAVFIRASVELP 465
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6) Length = 416 Score = 104 bits (260), Expect = 4e-22 Identities = 70/280 (25%), Positives = 141/280 (50%), Gaps = 8/280 (2%) Frame = +2 Query: 98 LNKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNKQIEQFNNKYQ 277 L + L +++ + +E +E + + ++E +++ K+ K + + K + Sbjct: 141 LEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKE-----KLLAELEGKLR 195 Query: 278 QIENKFVNAKLERENKEKDLMRNIDET---KNKQIEMTTRSNKIDETMKNVENKLLEIEI 448 EN E E L +I ++ + + + + R ++ +T+ + L ++E Sbjct: 196 VFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQ 255 Query: 449 NQNKMK----NGEFVWRIDKINDKMKDAKNGINTKIYSDSFYTHKHGYKMCLRVDPDGNG 616 + M+ +G F+W+I + + ++ G ++S +FYT K+GYK+CLR+ +G+G Sbjct: 256 SLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDG 315 Query: 617 AGKGTHLTVGFHLMKGEFDDISQWPFKYDVTFSLINQQTRLVHHSETIKYDELPNNKNWN 796 GK THL++ +M+GE+D + WPF+ VTF L++Q R H + + D ++ ++ Sbjct: 316 TGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPD--LSSASFQ 372 Query: 797 KPIDERNGRMGKFKFIELSEL-STNANLILNNQIFIKCSV 913 +P E N G F LS+L S + ++ +F+KC V Sbjct: 373 RPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIV 412
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated with RING and Traf domains protein 1) (Malignant 62) (RING finger protein 83) Length = 470 Score = 104 bits (259), Expect = 5e-22 Identities = 61/207 (29%), Positives = 115/207 (55%), Gaps = 11/207 (5%) Frame = +2 Query: 335 LMRNIDETKNKQIEMTTRS-NKIDETMKNVENKLLEIEINQNKMKNGEFVWRIDKINDKM 511 + R+++E+ + M ++ + ++ + +L E+ + + G +W+I ++ Sbjct: 266 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSD----GVLIWKIGSYGRRL 321 Query: 512 KDAKNGINTKIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMKGEFDDISQWP 691 ++AK N + +S +FYTHK+GYK+ + +GNG+G+GTHL++ ++ G FD++ +WP Sbjct: 322 QEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWP 381 Query: 692 FKYDVTFSLINQQ----TRLVHHSETIKYDELPNNKNWNKP------IDERNGRMGKFKF 841 F VTFSL++Q + H +ET D PN KN+ KP +DE + G KF Sbjct: 382 FARRVTFSLLDQSDPGLAKPQHVTETFHPD--PNWKNFQKPGTWRGSLDESSLGFGYPKF 439 Query: 842 IELSELSTNANLILNNQIFIKCSVNIP 922 I ++ N + ++ +FI+ +V +P Sbjct: 440 ISHQDI-RKRNYVRDDAVFIRAAVELP 465
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 101,781,850 Number of Sequences: 369166 Number of extensions: 1995264 Number of successful extensions: 10411 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 8502 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 9978 length of database: 68,354,980 effective HSP length: 111 effective length of database: 47,849,395 effective search space used: 11053210245 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)