Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_026_G20
(613 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 116 5e-26
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 110 2e-24
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 109 5e-24
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 108 1e-23
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 108 1e-23
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 107 2e-23
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 106 5e-23
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 106 5e-23
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 102 8e-22
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 100 2e-21
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 116 bits (290), Expect = 5e-26
Identities = 56/151 (37%), Positives = 91/151 (60%), Gaps = 1/151 (0%)
Frame = +2
Query: 53 GEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLSVFF 232
G+ +W++ K ++A G +FS FYT + GY++C R +G+G+GKGTHLS++F
Sbjct: 404 GKLIWKVTDYRVKKREAVEGHTVSVFSQPFYTSRCGYRLCARAYLNGDGSGKGTHLSLYF 463
Query: 233 YLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFPNHEYWNKPIDERNGGMG 412
+M+GEFD + QWPF+ VT L++Q + H+ ET K D PN + +P E N G
Sbjct: 464 VVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNHIVETFKAD--PNSSSFKRPDGEMNIASG 521
Query: 413 IFKFIELSELSTNAN-LILNNQIFIKCSVNI 502
+F+ S L + N I ++ +F+K +V++
Sbjct: 522 CPRFVSHSTLENSKNTYIKDDTLFLKVAVDL 552
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 110 bits (276), Expect = 2e-24
Identities = 60/167 (35%), Positives = 95/167 (56%)
Frame = +2
Query: 2 VENKLLEIEINQNKMNYGEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRV 181
+E K+ E+E++ G F+W+I K ++A G IFS +FYT ++GYKMCLRV
Sbjct: 338 LEQKVSELEVSTYD---GVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRV 394
Query: 182 DPDGNGAGKGTHLSVFFYLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFP 361
+G+G G+GTHLS+FF +MKG D + QWPF VT L++ R HV + + D
Sbjct: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNR-EHVIDAFRPD--V 451
Query: 362 NHEYWNKPIDERNGGMGIFKFIELSELSTNANLILNNQIFIKCSVNI 502
+ +P+ + N G F +S++ + + ++ IFIK V++
Sbjct: 452 TSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDL 498
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 109 bits (273), Expect = 5e-24
Identities = 60/167 (35%), Positives = 97/167 (58%)
Frame = +2
Query: 2 VENKLLEIEINQNKMNYGEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRV 181
+E K+LE+E + G F+W+I K ++A G IFS +FYT ++GYKMCLR+
Sbjct: 338 LEQKVLEMEASTYD---GVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRI 394
Query: 182 DPDGNGAGKGTHLSVFFYLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFP 361
+G+G G+GTHLS+FF +MKG D + +WPF VT L++Q R HV + + D
Sbjct: 395 YLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNR-EHVIDAFRPD--V 451
Query: 362 NHEYWNKPIDERNGGMGIFKFIELSELSTNANLILNNQIFIKCSVNI 502
+ +P+++ N G F +S++ + + ++ IFIK V++
Sbjct: 452 TSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDL 498
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 108 bits (270), Expect = 1e-23
Identities = 58/161 (36%), Positives = 94/161 (58%), Gaps = 10/161 (6%)
Frame = +2
Query: 53 GEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLSVFF 232
G +W+I ++++AK N FS +FYTHK+GYK+ + +GNG+G+GTHLS++
Sbjct: 308 GVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYI 367
Query: 233 YLMKGEFDDISQWPFKYAVTFSLINQQ----TRLVHVSETIKYDEFPNHEYWNKP----- 385
++ G FD++ +WP VTFSL++Q + HV+ET D PN + + KP
Sbjct: 368 RVLPGAFDNLLEWPLARRVTFSLLDQSDPGLAKPQHVTETFHPD--PNWKNFQKPGTWRG 425
Query: 386 -IDERNGGMGIFKFIELSELSTNANLILNNQIFIKCSVNIP 505
+DE + G G KFI ++ N + ++ +FI+ SV +P
Sbjct: 426 SLDESSLGFGYPKFISHQDI-RKRNYVRDDAVFIRASVELP 465
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 108 bits (269), Expect = 1e-23
Identities = 55/151 (36%), Positives = 92/151 (60%), Gaps = 1/151 (0%)
Frame = +2
Query: 53 GEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLSVFF 232
G+ +W++ K ++A +G IFS SFYT + GY++C R +G+G+G+G+HLS++F
Sbjct: 404 GKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYF 463
Query: 233 YLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFPNHEYWNKPIDERNGGMG 412
+M+GEFD + QWPF+ VT L++Q + ++ ET K D PN + +P E N G
Sbjct: 464 VVMRGEFDSLLQWPFRQRVTLMLLDQSGK-KNIMETFKPD--PNSSSFKRPDGEMNIASG 520
Query: 413 IFKFIELSELSTNAN-LILNNQIFIKCSVNI 502
+F+ S L N I ++ +F+K +V++
Sbjct: 521 CPRFVAHSVLENAKNAYIKDDTLFLKVAVDL 551
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 107 bits (268), Expect = 2e-23
Identities = 58/161 (36%), Positives = 95/161 (59%), Gaps = 10/161 (6%)
Frame = +2
Query: 53 GEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLSVFF 232
G +W+I ++++AK N FS +FYTHK+GYK+ + +GNG+G+GTHLS++
Sbjct: 308 GVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYI 367
Query: 233 YLMKGEFDDISQWPFKYAVTFSLINQQ----TRLVHVSETIKYDEFPNHEYWNKP----- 385
++ G FD++ +WPF VTFSL++Q + HV+ET D PN + + KP
Sbjct: 368 RVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPD--PNWKNFQKPGTWRG 425
Query: 386 -IDERNGGMGIFKFIELSELSTNANLILNNQIFIKCSVNIP 505
+DE + G G KFI ++ N + ++ +FI+ +V +P
Sbjct: 426 SLDESSLGFGYPKFISHQDI-RKRNYVRDDAVFIRAAVELP 465
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (CD40 binding protein) (CD40BP) (LMP1
associated protein) (LAP1) (CAP-1)
Length = 568
Score = 106 bits (264), Expect = 5e-23
Identities = 59/161 (36%), Positives = 87/161 (54%)
Frame = +2
Query: 17 LEIEINQNKMNYGEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGN 196
L ++ + G +W+I + ++A G ++S FYT GYKMC RV +G+
Sbjct: 404 LRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGD 463
Query: 197 GAGKGTHLSVFFYLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFPNHEYW 376
G GKGTHLS+FF +M+GE+D + WPFK VT L++Q + H+ + K D PN +
Sbjct: 464 GMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSF 521
Query: 377 NKPIDERNGGMGIFKFIELSELSTNANLILNNQIFIKCSVN 499
KP E N G F+ + L N I ++ IFIK V+
Sbjct: 522 KKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFIKVIVD 561
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor
1) (CRAF1) (TRAFAMN)
Length = 567
Score = 106 bits (264), Expect = 5e-23
Identities = 59/161 (36%), Positives = 87/161 (54%)
Frame = +2
Query: 17 LEIEINQNKMNYGEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGN 196
L ++ + G +W+I + ++A G ++S FYT GYKMC RV +G+
Sbjct: 403 LRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLNGD 462
Query: 197 GAGKGTHLSVFFYLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFPNHEYW 376
G GKGTHLS+FF +M+GE+D + WPFK VT L++Q + H+ + K D PN +
Sbjct: 463 GMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPD--PNSSSF 520
Query: 377 NKPIDERNGGMGIFKFIELSELSTNANLILNNQIFIKCSVN 499
KP E N G F+ + L N I ++ IFIK V+
Sbjct: 521 KKPTGEMNIASGCPVFVAQTVLE-NGTYIKDDTIFIKVIVD 560
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 102 bits (254), Expect = 8e-22
Identities = 55/153 (35%), Positives = 89/153 (58%), Gaps = 1/153 (0%)
Frame = +2
Query: 53 GEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLSVFF 232
G F+W+I + + ++ G +FS +FYT K+GYK+CLR+ +G+G+GK THLS+F
Sbjct: 260 GTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFI 319
Query: 233 YLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFPNHEYWNKPIDERNGGMG 412
+M+GE+D + WPF+ VTF L++Q R H + + D + + +P E N G
Sbjct: 320 VIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPD--LSSASFQRPQSETNVASG 376
Query: 413 IFKFIELSEL-STNANLILNNQIFIKCSVNIPA 508
F LS+L S + ++ +F+KC V+ A
Sbjct: 377 CPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTSA 409
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 100 bits (250), Expect = 2e-21
Identities = 54/149 (36%), Positives = 86/149 (57%), Gaps = 1/149 (0%)
Frame = +2
Query: 53 GEFVWRIDKINDKMKDAKNGINTYIFSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLSVFF 232
G F+W+I + + ++ G +FS +FYT K+GYK+CLR+ +G+G GK THLS+F
Sbjct: 267 GTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHLSLFI 326
Query: 233 YLMKGEFDDISQWPFKYAVTFSLINQQTRLVHVSETIKYDEFPNHEYWNKPIDERNGGMG 412
+M+GE+D + WPF+ VTF L++Q R H + + D + + +P E N G
Sbjct: 327 VIMRGEYDALLPWPFRNKVTFMLLDQNNR-EHAIDAFRPD--LSSASFQRPQSETNVASG 383
Query: 413 IFKFIELSEL-STNANLILNNQIFIKCSV 496
F LS+L S + ++ +F+KC V
Sbjct: 384 CPLFFPLSKLQSPKHAYVKDDTMFLKCIV 412
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,103,149
Number of Sequences: 369166
Number of extensions: 1324375
Number of successful extensions: 3218
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3143
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3214
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4797864890
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)