Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_020_J12
(930 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD4... 121 2e-27
sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD4... 119 2e-26
sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RIN... 117 5e-26
sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5 113 7e-25
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 113 9e-25
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 113 9e-25
sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1 104 3e-22
sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Eps... 104 4e-22
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 99 2e-20
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 98 3e-20
>sp|Q60803|TRAF3_MOUSE TNF receptor-associated factor 3 (CD40 receptor associated factor 1)
(CRAF1) (TRAFAMN)
Length = 567
Score = 121 bits (304), Expect = 2e-27
Identities = 83/304 (27%), Positives = 153/304 (50%), Gaps = 8/304 (2%)
Frame = +2
Query: 14 LRNVDKYMRDDVDELKLDGKRKQVEIDTLNKKLQEMESKFEIETKSIIEKEFDKLNLDGE 193
L+ + V L+ + K I +L+ ++ E + E + + + E L+L
Sbjct: 262 LKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHL--- 318
Query: 194 RKEKSIESLQKKCEQLNKQIEQFNNKYQQIENKFVNAKLERENKEKDLMRNIDETKNKQI 373
++ I+S +K ++L+K+I F +++ ++ + + +E + ++D++ +
Sbjct: 319 --QRVIDSQAEKLKELDKEIRPFRQNWEEADS--MKSSVESLQNRVTELESVDKSAGQAA 374
Query: 374 EMT----TRSNKIDETMKNVENKLLEIEIN----QNKMRNGEFVWRIDKINDKMKDAKNG 529
T ++ ++ D+T+ + +L ++++ + NG +W+I + ++A G
Sbjct: 375 RNTGLLESQLSRHDQTLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMG 434
Query: 530 INTRIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWPFKYDVT 709
+YS FYT GYKMC RV +G+G GKGTHL++ F +MRGE+D +L WPFK VT
Sbjct: 435 KTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVT 494
Query: 710 FSLINQQTRLVHHSWTIKYDDLPNSKNWNKPIDERNGRIGKFKFIELSELSTNANLILNN 889
L++Q + H K D PNS ++ KP E N G F+ + L N I ++
Sbjct: 495 LMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDD 551
Query: 890 QIFI 901
IFI
Sbjct: 552 TIFI 555
>sp|Q13114|TRAF3_HUMAN TNF receptor-associated factor 3 (CD40 receptor associated factor 1)
(CRAF1) (CD40 binding protein) (CD40BP) (LMP1 associated
protein) (LAP1) (CAP-1)
Length = 568
Score = 119 bits (297), Expect = 2e-26
Identities = 82/304 (26%), Positives = 152/304 (50%), Gaps = 8/304 (2%)
Frame = +2
Query: 14 LRNVDKYMRDDVDELKLDGKRKQVEIDTLNKKLQEMESKFEIETKSIIEKEFDKLNLDGE 193
L+ + V L+ + K I +L+ ++ E + E + + + E L+L
Sbjct: 263 LKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHL--- 319
Query: 194 RKEKSIESLQKKCEQLNKQIEQFNNKYQQIENKFVNAKLERENKEKDLMRNIDETKNKQI 373
++ I+S +K ++L+K+I F +++ ++ + + +E + ++D++ +
Sbjct: 320 --QRVIDSQAEKLKELDKEIRPFRQNWEEADS--MKSSVESLQNRVTELESVDKSAGQVA 375
Query: 374 EMT----TRSNKIDETMKNVENKLLEIEIN----QNKMRNGEFVWRIDKINDKMKDAKNG 529
T ++ ++ D+ + + +L ++++ + NG +W+I + ++A G
Sbjct: 376 RNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMG 435
Query: 530 INTRIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWPFKYDVT 709
+YS FYT GYKMC RV +G+G GKGTHL++ F +MRGE+D +L WPFK VT
Sbjct: 436 KTLSLYSQPFYTGYFGYKMCARVYLNGDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVT 495
Query: 710 FSLINQQTRLVHHSWTIKYDDLPNSKNWNKPIDERNGRIGKFKFIELSELSTNANLILNN 889
L++Q + H K D PNS ++ KP E N G F+ + L N I ++
Sbjct: 496 LMLMDQGSSRRHLGDAFKPD--PNSSSFKKPTGEMNIASGCPVFVAQTVLE-NGTYIKDD 552
Query: 890 QIFI 901
IFI
Sbjct: 553 TIFI 556
>sp|O00463|TRAF5_HUMAN TNF receptor-associated factor 5 (RING finger protein 84)
Length = 557
Score = 117 bits (293), Expect = 5e-26
Identities = 85/286 (29%), Positives = 142/286 (49%), Gaps = 18/286 (6%)
Frame = +2
Query: 86 EIDTLNKKLQEMESKFE--IETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNK---- 247
+I L+K L++ ESK + ET +EKEF + + + ++Q ++K
Sbjct: 263 QISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWL 322
Query: 248 --QIEQFNNKYQQIENKF-VNAKLERENKEKDLMRNIDETKNKQIEMTTRSNKID----- 403
Q+ Q Q +NKF + +E + K + ++ + + +NK D
Sbjct: 323 EAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINI 382
Query: 404 ---ETMKNVEN-KLLEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTRIYSDSFYTHK 571
+ KN E KLLE NG+ +W++ K ++A +G I+S SFYT +
Sbjct: 383 HKAQLSKNEERFKLLE-----GTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSR 437
Query: 572 HGYKMCLRVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWPFKYDVTFSLINQQTRLVHHS 751
GY++C R +G+G+G+G+HL++ F +MRGEFD +LQWPF+ VT L++Q + +
Sbjct: 438 CGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGK-KNIM 496
Query: 752 WTIKYDDLPNSKNWNKPIDERNGRIGKFKFIELSELSTNANLILNN 889
T K D PNS ++ +P E N G +F+ S L N + +
Sbjct: 497 ETFKPD--PNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKD 540
>sp|P70191|TRAF5_MOUSE TNF receptor-associated factor 5
Length = 558
Score = 113 bits (283), Expect = 7e-25
Identities = 74/290 (25%), Positives = 136/290 (46%), Gaps = 39/290 (13%)
Frame = +2
Query: 137 IETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNKQIEQFNNKYQQIENKFVNAKLER 316
+E +E+ L E+KE I+ L + ++ K+++QF + + N +
Sbjct: 254 LEKNYQLEQRISDLYQSLEQKESKIQQLAETVKKFEKELKQFTQMFGRNGTFLSNVQALT 313
Query: 317 ENKEKD-------------------------LMRNIDETKNKQIEMTTRSNKI----DET 409
+ +K L+ +D K + ++ ++ ET
Sbjct: 314 SHTDKSAWLEAQVRQLLQIVNQQPSRLDLRSLVDAVDSVKQRITQLEASDQRLVLLEGET 373
Query: 410 MKNVEN-KLLEIEINQNKMR---------NGEFVWRIDKINDKMKDAKNGINTRIYSDSF 559
K+ + + + ++N+N+ R +G+ +W++ K ++A G ++S F
Sbjct: 374 SKHDAHINIHKAQLNKNEERFKQLEGACYSGKLIWKVTDYRVKKREAVEGHTVSVFSQPF 433
Query: 560 YTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWPFKYDVTFSLINQQTRL 739
YT + GY++C R +G+G+GKGTHL++ F +MRGEFD +LQWPF+ VT L++Q +
Sbjct: 434 YTSRCGYRLCARAYLNGDGSGKGTHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKK 493
Query: 740 VHHSWTIKYDDLPNSKNWNKPIDERNGRIGKFKFIELSELSTNANLILNN 889
H T K D PNS ++ +P E N G +F+ S L + N + +
Sbjct: 494 NHIVETFKAD--PNSSSFKRPDGEMNIASGCPRFVSHSTLENSKNTYIKD 541
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 113 bits (282), Expect = 9e-25
Identities = 80/282 (28%), Positives = 146/282 (51%), Gaps = 3/282 (1%)
Frame = +2
Query: 71 KRKQVEIDTLNKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNKQ 250
K+++ E+ L + L + S +E K ++ G++ E LQ+ CE L K+
Sbjct: 231 KQQEHEVQWLREHLAMLLSSV-LEAKPLL----------GDQSHAGSELLQR-CESLEKK 278
Query: 251 IEQFNNKYQQIENKFVNAKLERE--NKEKDLMRNIDETKNKQIEMTTRSNKI-DETMKNV 421
F N + + + E +++ L ++ E + +++ RS + D M ++
Sbjct: 279 TATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADL 338
Query: 422 ENKLLEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTRIYSDSFYTHKHGYKMCLRVD 601
E K+LE+E + +G F+W+I K ++A G I+S +FYT ++GYKMCLR+
Sbjct: 339 EQKVLEMEASTY---DGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIY 395
Query: 602 PDGNGAGKGTHLTVGFHLMRGEFDDILQWPFKYDVTFSLINQQTRLVHHSWTIKYDDLPN 781
+G+G G+GTHL++ F +M+G D +L+WPF VT L++Q R H D+
Sbjct: 396 LNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNR--EHVIDAFRPDV-T 452
Query: 782 SKNWNKPIDERNGRIGKFKFIELSELSTNANLILNNQIFINA 907
S ++ +P+++ N G F +S++ + + ++ IFI A
Sbjct: 453 SSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKA 494
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 113 bits (282), Expect = 9e-25
Identities = 81/285 (28%), Positives = 140/285 (49%), Gaps = 5/285 (1%)
Frame = +2
Query: 68 GKRKQVEIDTL-NKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLN 244
G + VE + L + +LQ + + S +E + L+ E L ++C+ L
Sbjct: 222 GCSEMVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQVGPE-----LLQRCQILE 276
Query: 245 KQIEQFNNKY----QQIENKFVNAKLERENKEKDLMRNIDETKNKQIEMTTRSNKIDETM 412
++I F N +++E V A+ D I+ NK ++ D M
Sbjct: 277 QKIATFENIVCVLNREVERVAVTAEACSRQHRLD-QDKIEALSNKVQQLERSIGLKDLAM 335
Query: 413 KNVENKLLEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTRIYSDSFYTHKHGYKMCL 592
++E K+ E+E++ +G F+W+I K ++A G I+S +FYT ++GYKMCL
Sbjct: 336 ADLEQKVSELEVSTY---DGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCL 392
Query: 593 RVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWPFKYDVTFSLINQQTRLVHHSWTIKYDD 772
RV +G+G G+GTHL++ F +M+G D +LQWPF VT L++ R H D
Sbjct: 393 RVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLDHNNR--EHVIDAFRPD 450
Query: 773 LPNSKNWNKPIDERNGRIGKFKFIELSELSTNANLILNNQIFINA 907
+ S ++ +P+ + N G F +S++ + + ++ IFI A
Sbjct: 451 V-TSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKA 494
>sp|P39428|TRAF1_MOUSE TNF receptor-associated factor 1
Length = 409
Score = 104 bits (260), Expect = 3e-22
Identities = 68/264 (25%), Positives = 139/264 (52%), Gaps = 8/264 (3%)
Frame = +2
Query: 98 LNKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESL--QKKCEQLNKQIEQFNN- 268
L + L E++ + +E +E + + ++E +++ L +K QL +++ F N
Sbjct: 134 LERNLSELQLQAAVEATGDLEVDCYRAPCCESQEELALQHLVKEKLLAQLEEKLRVFANI 193
Query: 269 -----KYQQIENKFVNAKLERENKEKDLMRNIDETKNKQIEMTTRSNKIDETMKNVENKL 433
K + + + A + + +++ + ++++ + +E+ + D+ + +E+ L
Sbjct: 194 VAVLNKEVEASHLALAASIHQSQLDREHLLSLEQ---RVVELQQTLAQKDQVLGKLEHSL 250
Query: 434 LEIEINQNKMRNGEFVWRIDKINDKMKDAKNGINTRIYSDSFYTHKHGYKMCLRVDPDGN 613
+ + +G F+W+I + + ++ G ++S +FYT K+GYK+CLR+ +G+
Sbjct: 251 ---RLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGD 307
Query: 614 GAGKGTHLTVGFHLMRGEFDDILQWPFKYDVTFSLINQQTRLVHHSWTIKYDDLPNSKNW 793
G+GK THL++ +MRGE+D +L WPF+ VTF L++Q R H+ DL +S ++
Sbjct: 308 GSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR--EHAIDAFRPDL-SSASF 364
Query: 794 NKPIDERNGRIGKFKFIELSELST 865
+P E N G F LS+L +
Sbjct: 365 QRPQSETNVASGCPLFFPLSKLQS 388
>sp|Q13077|TRAF1_HUMAN TNF receptor-associated factor 1 (Epstein-Barr virus-induced
protein 6)
Length = 416
Score = 104 bits (259), Expect = 4e-22
Identities = 69/263 (26%), Positives = 132/263 (50%), Gaps = 7/263 (2%)
Frame = +2
Query: 98 LNKKLQEMESKFEIETKSIIEKEFDKLNLDGERKEKSIESLQKKCEQLNKQIEQFNNKYQ 277
L + L +++ + +E +E + + ++E +++ K+ K + + K +
Sbjct: 141 LEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKE-----KLLAELEGKLR 195
Query: 278 QIENKFVNAKLERENKEKDLMRNIDET---KNKQIEMTTRSNKIDETMKNVENKLLEIEI 448
EN E E L +I ++ + + + + R ++ +T+ + L ++E
Sbjct: 196 VFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKLEQ 255
Query: 449 NQNKMR----NGEFVWRIDKINDKMKDAKNGINTRIYSDSFYTHKHGYKMCLRVDPDGNG 616
+ M +G F+W+I + + ++ G ++S +FYT K+GYK+CLR+ +G+G
Sbjct: 256 SLRLMEEASFDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDG 315
Query: 617 AGKGTHLTVGFHLMRGEFDDILQWPFKYDVTFSLINQQTRLVHHSWTIKYDDLPNSKNWN 796
GK THL++ +MRGE+D +L WPF+ VTF L++Q R H+ DL +S ++
Sbjct: 316 TGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNR--EHAIDAFRPDL-SSASFQ 372
Query: 797 KPIDERNGRIGKFKFIELSELST 865
+P E N G F LS+L +
Sbjct: 373 RPQSETNVASGCPLFFPLSKLQS 395
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 98.6 bits (244), Expect = 2e-20
Identities = 60/202 (29%), Positives = 110/202 (54%), Gaps = 11/202 (5%)
Frame = +2
Query: 335 LMRNIDETKNKQIEMTTRS-NKIDETMKNVENKLLEIEINQNKMRNGEFVWRIDKINDKM 511
+ R+++E+ + M ++ + ++ + +L E+ + + G +W+I ++
Sbjct: 266 MARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSD----GVLIWKIGSYGRRL 321
Query: 512 KDAKNGINTRIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWP 691
++AK N +S +FYTHK+GYK+ + +GNG+G+GTHL++ ++ G FD++L+WP
Sbjct: 322 QEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWP 381
Query: 692 FKYDVTFSLINQQ----TRLVHHSWTIKYDDLPNSKNWNKP------IDERNGRIGKFKF 841
F VTFSL++Q + H + T D PN KN+ KP +DE + G KF
Sbjct: 382 FARRVTFSLLDQSDPGLAKPQHVTETFHPD--PNWKNFQKPGTWRGSLDESSLGFGYPKF 439
Query: 842 IELSELSTNANLILNNQIFINA 907
I ++ N + ++ +FI A
Sbjct: 440 ISHQDI-RKRNYVRDDAVFIRA 460
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 98.2 bits (243), Expect = 3e-20
Identities = 60/200 (30%), Positives = 108/200 (54%), Gaps = 11/200 (5%)
Frame = +2
Query: 341 RNIDETKNKQIEMTTRS-NKIDETMKNVENKLLEIEINQNKMRNGEFVWRIDKINDKMKD 517
R+++E+ + M ++ + ++ + +L E+ I + G +W+I ++++
Sbjct: 268 RHVEESVKPHLAMMCALVSRQRQELQELRRELEELSIGSD----GVLIWKIGSYGRRLQE 323
Query: 518 AKNGINTRIYSDSFYTHKHGYKMCLRVDPDGNGAGKGTHLTVGFHLMRGEFDDILQWPFK 697
AK N +S +FYTHK+GYK+ + +GNG+G+GTHL++ ++ G FD++L+WP
Sbjct: 324 AKAKPNLECFSPAFYTHKYGYKLQVSASLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPLA 383
Query: 698 YDVTFSLINQQ----TRLVHHSWTIKYDDLPNSKNWNKP------IDERNGRIGKFKFIE 847
VTFSL++Q + H + T D PN KN+ KP +DE + G KFI
Sbjct: 384 RRVTFSLLDQSDPGLAKPQHVTETFHPD--PNWKNFQKPGTWRGSLDESSLGFGYPKFIS 441
Query: 848 LSELSTNANLILNNQIFINA 907
++ N + ++ +FI A
Sbjct: 442 HQDI-RKRNYVRDDAVFIRA 460
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,559,016
Number of Sequences: 369166
Number of extensions: 1828024
Number of successful extensions: 9949
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8136
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9529
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9558791870
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)