Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00749 (522 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P40629|ZEF2_IRV6 Zinc finger protein 50 3e-06 sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of ap... 47 2e-05 sp|Q9VUX2|MIB_DROME Ubiquitin ligase protein mind-bomb (Min... 47 3e-05 sp|Q8WY64|MYLIP_HUMAN Ubiquitin ligase MYLIP (Myosin regula... 45 8e-05 sp|Q6TEM9|MYLIP_BRARE Ubiquitin ligase MYLIP (Myosin regula... 45 1e-04 sp|Q13490|BIRC2_HUMAN Baculoviral IAP repeat-containing pro... 44 2e-04 sp|Q24306|IAP1_DROME Apoptosis 1 inhibitor (Inhibitor of ap... 44 2e-04 sp|P41436|IAP_GVCP Apoptosis inhibitor IAP 44 2e-04 sp|Q13489|BIRC3_HUMAN Baculoviral IAP repeat-containing pro... 44 2e-04 sp|Q62210|BIRC2_MOUSE Baculoviral IAP repeat-containing pro... 44 2e-04
>sp|P40629|ZEF2_IRV6 Zinc finger protein Length = 145 Score = 50.1 bits (118), Expect = 3e-06 Identities = 21/63 (33%), Positives = 36/63 (57%) Frame = +3 Query: 258 ELEKYLKILDNLESIIFYRLSEISKKFLNCMVCQSDRVSVLYLPCGHVVLCNKCHLATNE 437 E EK+ ++ D L ++ K L C++C +++V +L +PCGH+++CN C L N Sbjct: 65 EKEKFNQVEDKLTTL---------SKNLTCIICLTNQVQILTIPCGHLIMCNPCSLNLNN 115 Query: 438 GSC 446 C Sbjct: 116 SVC 118
>sp|Q24307|IAP2_DROME Apoptosis 2 inhibitor (Inhibitor of apoptosis 2) (dIAP2) (DIAP) (IAP homolog A) (IAP-like protein) (DILP) Length = 498 Score = 47.4 bits (111), Expect = 2e-05 Identities = 18/44 (40%), Positives = 28/44 (63%) Frame = +3 Query: 345 CMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQIQEF 476 C VC + V V++LPCGH+ CN+C A + +C +C+ I+ F Sbjct: 451 CKVCLDEEVGVVFLPCGHLATCNQC--APSVANCPMCRADIKGF 492
>sp|Q9VUX2|MIB_DROME Ubiquitin ligase protein mind-bomb (Mind bomb homolog) (D-mib) Length = 1226 Score = 47.0 bits (110), Expect = 3e-05 Identities = 20/48 (41%), Positives = 27/48 (56%) Frame = +3 Query: 330 KKFLNCMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQIQE 473 +K C+VC R +V + PCGH+V C C + C LC+TQI E Sbjct: 1012 EKIDECLVCSDRRAAVFFRPCGHMVACEHCSALMKK--CVLCRTQIDE 1057
Score = 34.7 bits (78), Expect = 0.14 Identities = 13/41 (31%), Positives = 20/41 (48%) Frame = +3 Query: 345 CMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQI 467 C+VC + ++ PCGHV C C A C +C+ + Sbjct: 970 CLVCSDAKRDTVFKPCGHVSCCETC--APRVKKCLICRETV 1008
>sp|Q8WY64|MYLIP_HUMAN Ubiquitin ligase MYLIP (Myosin regulatory light chain interacting protein) (MIR) Length = 445 Score = 45.4 bits (106), Expect = 8e-05 Identities = 17/53 (32%), Positives = 30/53 (56%) Frame = +3 Query: 330 KKFLNCMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQIQEFHTIY 488 K+ + CMVC + ++ + PCGH V C C A SC +C+++++ +Y Sbjct: 382 KEAMLCMVCCEEEINSTFCPCGHTVCCESC--AAQLQSCPVCRSRVEHVQHVY 432
>sp|Q6TEM9|MYLIP_BRARE Ubiquitin ligase MYLIP (Myosin regulatory light chain interacting protein) (MIR) Length = 472 Score = 45.1 bits (105), Expect = 1e-04 Identities = 16/53 (30%), Positives = 30/53 (56%) Frame = +3 Query: 330 KKFLNCMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQIQEFHTIY 488 ++ L CM+C + + + PCGH+V C C A SC +C+++++ +Y Sbjct: 379 REALLCMLCCEEEIDAAFCPCGHMVCCQNC--AAQLQSCPVCRSEVEHVQHVY 429
>sp|Q13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B) Length = 618 Score = 44.3 bits (103), Expect = 2e-04 Identities = 24/78 (30%), Positives = 41/78 (52%) Frame = +3 Query: 225 DERLDKISFYEELEKYLKILDNLESIIFYRLSEISKKFLNCMVCQSDRVSVLYLPCGHVV 404 D L K F ++ KY+ D + +L + ++ C VC VSV+++PCGH+V Sbjct: 532 DSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEE-RTCKVCMDKEVSVVFIPCGHLV 590 Query: 405 LCNKCHLATNEGSCRLCK 458 +C +C A + C +C+ Sbjct: 591 VCQEC--APSLRKCPICR 606
>sp|Q24306|IAP1_DROME Apoptosis 1 inhibitor (Inhibitor of apoptosis 1) (dIAP1) (Thread protein) Length = 438 Score = 44.3 bits (103), Expect = 2e-04 Identities = 18/49 (36%), Positives = 26/49 (53%) Frame = +3 Query: 345 CMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQIQEFHTIYF 491 C +C + +LPCGHVV C KC A++ C LC+ + +YF Sbjct: 391 CKICYGAEYNTAFLPCGHVVACAKC--ASSVTKCPLCRKPFTDVMRVYF 437
>sp|P41436|IAP_GVCP Apoptosis inhibitor IAP Length = 275 Score = 43.9 bits (102), Expect = 2e-04 Identities = 17/49 (34%), Positives = 28/49 (57%) Frame = +3 Query: 345 CMVCQSDRVSVLYLPCGHVVLCNKCHLATNEGSCRLCKTQIQEFHTIYF 491 C +C + V ++PCGHVV C KC L+ ++ C +C+ + +YF Sbjct: 228 CKICYVEECIVCFVPCGHVVACAKCALSVDK--CPMCRKIVTSVLKVYF 274
>sp|Q13489|BIRC3_HUMAN Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2) Length = 604 Score = 43.9 bits (102), Expect = 2e-04 Identities = 21/74 (28%), Positives = 41/74 (55%) Frame = +3 Query: 249 FYEELEKYLKILDNLESIIFYRLSEISKKFLNCMVCQSDRVSVLYLPCGHVVLCNKCHLA 428 F ++ KY+ D + + +L + ++ C VC VS++++PCGH+V+C C A Sbjct: 526 FVQQDIKYIPTEDVSDLPVEEQLRRLQEE-RTCKVCMDKEVSIVFIPCGHLVVCKDC--A 582 Query: 429 TNEGSCRLCKTQIQ 470 + C +C++ I+ Sbjct: 583 PSLRKCPICRSTIK 596
>sp|Q62210|BIRC2_MOUSE Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2) Length = 612 Score = 43.9 bits (102), Expect = 2e-04 Identities = 24/82 (29%), Positives = 43/82 (52%) Frame = +3 Query: 225 DERLDKISFYEELEKYLKILDNLESIIFYRLSEISKKFLNCMVCQSDRVSVLYLPCGHVV 404 D L + F E+ KY+ D + +L + ++ C VC VS++++PCGH+V Sbjct: 526 DSTLYENLFVEKNMKYIPTEDVSGLSLEEQLRRLQEE-RTCKVCMDREVSIVFIPCGHLV 584 Query: 405 LCNKCHLATNEGSCRLCKTQIQ 470 +C +C A + C +C+ I+ Sbjct: 585 VCQEC--APSLRKCPICRGTIK 604
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 56,790,121 Number of Sequences: 369166 Number of extensions: 1098293 Number of successful extensions: 3031 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 2943 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 3029 length of database: 68,354,980 effective HSP length: 103 effective length of database: 49,327,275 effective search space used: 3452909250 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)