DrC_00662
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00662 (1066 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P35520|CBS_HUMAN Cystathionine beta-synthase (Serine sul... 321 2e-87 sp|P32232|CBS_RAT Cystathionine beta-synthase (Serine sulfh... 304 2e-82 sp|P46794|CBS_DICDI Cystathionine beta-synthase (Serine sul... 245 1e-64 sp|P32582|CBS_YEAST Cystathionine beta-synthase (Serine sul... 182 1e-45 sp|Q9ZMW6|CYSM_HELPJ Cysteine synthase (O-acetylserine sulf... 84 7e-16 sp|P0A535|CYSK_MYCBO Cysteine synthase A (O-acetylserine su... 82 3e-15 sp|P56067|CYSM_HELPY Cysteine synthase (O-acetylserine sulf... 80 8e-15 sp|O32978|CYSK_MYCLE Cysteine synthase A (O-acetylserine su... 80 1e-14 sp|O23735|CYSK2_BRAJU Cysteine synthase (O-acetylserine sul... 73 2e-12 sp|P0ABK5|CYSK_ECOLI Cysteine synthase A (O-acetylserine su... 71 6e-12
>sp|P35520|CBS_HUMAN Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase) Length = 551 Score = 321 bits (823), Expect = 2e-87 Identities = 153/317 (48%), Positives = 219/317 (69%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 PLAH+D TA+EIL CD K+DM ARK+K KCP C++IGVDP GSILA Sbjct: 229 PLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILA 288 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 +P+ LN+T T YEVEGIGYDFIPTVLDRT VDKW+K D+E+F AR LI +EGLLCGG Sbjct: 289 EPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGG 348 Query: 361 SSGTAVYATIQAIKDFNLPNTSRVIVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSN 540 S+G+ V ++A ++ L R +VILPDSVRNYMTKFLSD WM + FL + + Sbjct: 349 SAGSTVAVAVKAAQE--LQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKK 406 Query: 541 DQQFERKISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMS 720 + ++ L ++AP+TV P++T +E+L+++GFDQ PVV+ G I+G+ T+G ++S Sbjct: 407 PWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLS 466 Query: 721 MLMKKSLNLTDPISKAIYKNFKKVNLNQTVQQLSRLLDIDHFVLVVHQQRQIGASGTEEV 900 L+ + +D + K IYK FK++ L T+ +LS +L++DHF LVVH+Q Q ++G Sbjct: 467 SLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQ 526 Query: 901 KEMIYGIITRIDLISYM 951 ++M++G++T IDL++++ Sbjct: 527 RQMVFGVVTAIDLLNFV 543
>sp|P32232|CBS_RAT Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) Length = 561 Score = 304 bits (779), Expect = 2e-82 Identities = 153/331 (46%), Positives = 217/331 (65%), Gaps = 14/331 (4%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 PLAH+D TAEEIL CD K+DM ARK+K KCP CK+IGVDP GSILA Sbjct: 226 PLAHYDDTAEEILQQCDGKVDMLVASAGTGGTITGIARKLKEKCPGCKIIGVDPEGSILA 285 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 +P+ LN+T T YEVEGIGYDFIPTVLDR VD+W+K D +SF AR LI +EGLLCGG Sbjct: 286 EPEELNQTEQTAYEVEGIGYDFIPTVLDRAVVDRWFKSNDDDSFAFARMLISQEGLLCGG 345 Query: 361 SSGTAVYATIQAIKDFNLPNTSRVIVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSN 540 SSG+A+ ++A ++ L R +VILPDSVRNYM+KFLSD WM + F+ K + Sbjct: 346 SSGSAMAVAVKAAQE--LKEGQRCVVILPDSVRNYMSKFLSDKWMLQKGFM-KEELSVKR 402 Query: 541 DQQFERKISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMS 720 + ++ L ++AP+TV P+VT + + +L+++GFDQ PVV +G I+G+ T+G ++S Sbjct: 403 PWWWHLRVQELSLSAPLTVLPTVTCEHTIAILREKGFDQAPVVNESGAILGMVTLGNMLS 462 Query: 721 MLMKKSLNLTDPISKAIYKNFKKVNLNQTVQQLSRLLDIDHFVLVVHQQRQ--------- 873 L+ + +D + K +YK FK ++L T+ LS +L++DHF LVVH+Q Q Sbjct: 463 SLLAGKVRPSDEVCKVLYKQFKPIHLTDTLGMLSHILEMDHFALVVHEQIQSRDQAWSGV 522 Query: 874 IGA-----SGTEEVKEMIYGIITRIDLISYM 951 +G +G + M++G++T IDL++++ Sbjct: 523 VGGPTDRNNGVSSKQLMVFGVVTAIDLLNFV 553
>sp|P46794|CBS_DICDI Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase) Length = 497 Score = 245 bits (626), Expect = 1e-64 Identities = 142/327 (43%), Positives = 201/327 (61%), Gaps = 5/327 (1%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 PLAH+DGTAEE+L C+ KIDM ARKIK + PNC V+GVDP GSILA Sbjct: 183 PLAHYDGTAEELLEQCEGKIDMIVCTAGTGGTITGIARKIKERLPNCIVVGVDPHGSILA 242 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 QP+SLN TN + Y++EGIGYDFIP VL+R VD+W K DKESFIMARRLI+EEGLLC G Sbjct: 243 QPESLNNTNKS-YKIEGIGYDFIPNVLERKLVDQWIKTDDKESFIMARRLIKEEGLLCAG 301 Query: 361 SSGTAVYATIQAIKDFNLPNTSRVIVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSN 540 SSG+A+ + A K L R +V+L DS+RNYMTK L+DDW+ D F+D ++ Sbjct: 302 SSGSAMVGALLAAK--QLKKGQRCVVLLADSIRNYMTKHLNDDWLVDNGFVDPEY--KTK 357 Query: 541 DQQFERK-----ISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATV 705 DQQ E K + L + P+T+ + T A++LL++ GFDQ+PVV + ++ + + Sbjct: 358 DQQEEEKYHGATVKDLTLPKPITISATTTCAAAVQLLQQYGFDQLPVVSESKKVLVNSLL 417 Query: 706 GLIMSMLMKKSLNLTDPISKAIYKNFKKVNLNQTVQQLSRLLDIDHFVLVVHQQRQIGAS 885 ++ KK++ TD +SK +++ F K + Q + L + F + A Sbjct: 418 VTSLTYASKKAVP-TDAVSKVMFR-FTKNEKYIPITQSTSLATLSKFF-----ENHSSAI 470 Query: 886 GTEEVKEMIYGIITRIDLISYMIDNHK 966 TE + I I+T+IDL++Y++ + + Sbjct: 471 VTE--NDEIISIVTKIDLLTYLMKSQQ 495
>sp|P32582|CBS_YEAST Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase) Length = 507 Score = 182 bits (462), Expect = 1e-45 Identities = 113/351 (32%), Positives = 184/351 (52%), Gaps = 34/351 (9%) Frame = +1 Query: 1 PLAHFDGTAEEIL-----IDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPF 165 P AH+ GT EI ++ + + ++ +K + +++G DPF Sbjct: 164 PEAHYFGTGREIQRQLEDLNLFDNLRAVVAGAGTGGTISGISKYLKEQNDKIQIVGADPF 223 Query: 166 GSILAQPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEG 345 GSILAQP++LNKT++T Y+VEGIGYDF+P VLDR +D WYK DK SF AR+LI EG Sbjct: 224 GSILAQPENLNKTDITDYKVEGIGYDFVPQVLDRKLIDVWYKTDDKPSFKYARQLISNEG 283 Query: 346 LLCGGSSGTAVYATIQAIKDF-NLPNTSRVIVILPDSVRNYMTKFLSDDWMYDRNFLDKP 522 +L GGSSG+A A ++ +D L ++ I PDS+R+Y+TKF+ D+W+ N D Sbjct: 284 VLVGGSSGSAFTAVVKYCEDHPELTEDDVIVAIFPDSIRSYLTKFVDDEWLKKNNLWDDD 343 Query: 523 MTNQSNDQQFERK------------ISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPV 666 + + + + E + L + ++V+ + V +++LK GFDQ+PV Sbjct: 344 VLARFDSSKLEASTTKYADVFGNATVKDLHLKPVVSVKETAKVTDVIKILKDNGFDQLPV 403 Query: 667 VEANGCIVGVATVGLIMSMLMKKSLNLTDPISKAIYKNFKKVNLNQTV------------ 810 + +G + G+ T+ ++ L + N D K Y +FKK+N V Sbjct: 404 LTEDGKLSGLVTLSELLRKLSINNSN-NDNTIKGKYLDFKKLNNFNDVSSYNENKSGKKK 462 Query: 811 ----QQLSRLLDIDHFVLVVHQQRQIGASGTEEVKEMIYGIITRIDLISYM 951 + S+L D++ F ++ A T+ +K + I+T++DL+SY+ Sbjct: 463 FIKFDENSKLSDLNRFF-----EKNSSAVITDGLKPI--HIVTKMDLLSYL 506
>sp|Q9ZMW6|CYSM_HELPJ Cysteine synthase (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase) Length = 305 Score = 84.0 bits (206), Expect = 7e-16 Identities = 50/158 (31%), Positives = 80/158 (50%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 P A++ A EI+ + + A+ +K + PN ++IGV+P GSIL Sbjct: 152 PAAYYHTLAPEIVQELGTNLTSFVAGIGSGGTFAGMAKYLKERIPNIRLIGVEPEGSIL- 210 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 N +E+EGIG +FIP +D++ + D+E F R+L ++ GLL G Sbjct: 211 -----NGGEPGPHEIEGIGVEFIPPFFANLDIDRFETISDEEGFSYTRKLAKKNGLLVGS 265 Query: 361 SSGTAVYATIQAIKDFNLPNTSRVIVILPDSVRNYMTK 474 SSG A A ++ ++ LP S+V+ I PD Y++K Sbjct: 266 SSGAAFAAALKEVQ--RLPEGSQVLTIFPDMADRYLSK 301
>sp|P0A535|CYSK_MYCBO Cysteine synthase A (O-acetylserine sulfhydrylase A) (O-acetylserine (Thiol)-lyase A) (CSase A) sp|P0A534|CYSK_MYCTU Cysteine synthase A (O-acetylserine sulfhydrylase A) (O-acetylserine (Thiol)-lyase A) (CSase A) Length = 310 Score = 82.0 bits (201), Expect = 3e-15 Identities = 54/164 (32%), Positives = 83/164 (50%), Gaps = 1/164 (0%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 P H TAEE+ D D K+D+ A+ IK + P+ + + V+P S + Sbjct: 151 PAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVL 210 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 + ++GIG F+P VLD+ VD+ VG++++ +ARRL REEGLL G Sbjct: 211 SGGQKGP-----HPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGI 265 Query: 361 SSGTAVYATIQAIKDFNLPNTSR-VIVILPDSVRNYMTKFLSDD 489 SSG A A +Q + N + ++V+LPD Y++ L D Sbjct: 266 SSGAATVAALQVAR--RPENAGKLIVVVLPDFGERYLSTPLFAD 307
>sp|P56067|CYSM_HELPY Cysteine synthase (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase) Length = 306 Score = 80.5 bits (197), Expect = 8e-15 Identities = 50/158 (31%), Positives = 78/158 (49%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 P A++ A EI+ + + AR +K + P ++IGV+P GSIL Sbjct: 153 PAAYYHTLAPEIVQELGTNLTSFVAGIGSGGTFAGTARYLKERIPAIRLIGVEPEGSIL- 211 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 N +E+EGIG +FIP + +D + + D+E F R+L ++ GLL G Sbjct: 212 -----NGGEPGPHEIEGIGVEFIPPFFENLDIDGFETISDEEGFSYTRKLAKKNGLLVGS 266 Query: 361 SSGTAVYATIQAIKDFNLPNTSRVIVILPDSVRNYMTK 474 SSG A A ++ + LP S+V+ I PD Y++K Sbjct: 267 SSGAAFVAALKEAQ--RLPEGSQVLTIFPDVADRYLSK 302
>sp|O32978|CYSK_MYCLE Cysteine synthase A (O-acetylserine sulfhydrylase A) (O-acetylserine (Thiol)-lyase A) (CSase A) Length = 310 Score = 80.1 bits (196), Expect = 1e-14 Identities = 54/164 (32%), Positives = 82/164 (50%), Gaps = 1/164 (0%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 P H TAEE+ D D K+D+ AR IK + P + + V+P S + Sbjct: 151 PAIHAATTAEEVWRDTDGKVDIFVSGIGTGGTITGVARIIKERRPATQFVAVEPAASPVL 210 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 + ++GIG F+P+VL VD+ VG++E+ +ARRL +EEGLL G Sbjct: 211 SGGQKGP-----HPIQGIGAGFVPSVLVLDLVDEIVTVGNEEALDLARRLAKEEGLLVGI 265 Query: 361 SSGTAVYATIQAIKDFNLPNTSR-VIVILPDSVRNYMTKFLSDD 489 S+G AV A + + NT + ++V+LPD Y++ L D Sbjct: 266 SAGAAVCAALHVAR--RPENTGKLIVVVLPDFGERYLSTMLFAD 307
>sp|O23735|CYSK2_BRAJU Cysteine synthase (O-acetylserine sulfhydrylase) (O-acetylserine (Thiol)-lyase) (CSase) (OAS-TL) (OAS-TL6) Length = 324 Score = 72.8 bits (177), Expect = 2e-12 Identities = 52/163 (31%), Positives = 75/163 (46%), Gaps = 1/163 (0%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGVDPFGSILA 180 P H++ T EI + KID + +K + PN K+ GV+P S + Sbjct: 156 PKIHYETTGPEIWKGTEGKIDGFISGIGTGGTITGAGKYLKEQNPNVKLYGVEPVESAIL 215 Query: 181 QPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLLCGG 360 ++++GIG FIP VL+ +D+ +V ES MAR L REEGLL G Sbjct: 216 SGGKPGP-----HKIQGIGAGFIPNVLETNLIDEVVQVSSDESIDMARLLAREEGLLVGI 270 Query: 361 SSGTAVYATIQAIKDFNLPNTSRVIV-ILPDSVRNYMTKFLSD 486 SSG A A I+ K N ++ V + P Y++ L D Sbjct: 271 SSGAAAAAAIKLAK--RPENAGKLFVAVFPSFGERYLSTVLFD 311
>sp|P0ABK5|CYSK_ECOLI Cysteine synthase A (O-acetylserine sulfhydrylase A) (O-acetylserine (Thiol)-lyase A) (CSase A) (Sulfate starvation-induced protein 5) (SSI5) sp|P0ABK6|CYSK_ECO57 Cysteine synthase A (O-acetylserine sulfhydrylase A) (O-acetylserine (Thiol)-lyase A) (CSase A) (Sulfate starvation-induced protein 5) (SSI5) Length = 323 Score = 70.9 bits (172), Expect = 6e-12 Identities = 54/166 (32%), Positives = 82/166 (49%), Gaps = 3/166 (1%) Frame = +1 Query: 1 PLAHFDGTAEEILIDCDNKIDMXXXXXXXXXXXXXXARKIKLKCPNCKVIGV--DPFGS- 171 P H T EI D D ++D+ +R IK +I V +P S Sbjct: 150 PEIHEKTTGPEIWEDTDGQVDVFIAGVGTGGTLTGVSRYIKGTKGKTDLISVAVEPTDSP 209 Query: 172 ILAQPDSLNKTNLTFYEVEGIGYDFIPTVLDRTYVDKWYKVGDKESFIMARRLIREEGLL 351 ++AQ + + ++++GIG FIP LD VDK + ++E+ ARRL+ EEG+L Sbjct: 210 VIAQALAGEEIKPGPHKIQGIGAGFIPANLDLKLVDKVIGITNEEAISTARRLMEEEGIL 269 Query: 352 CGGSSGTAVYATIQAIKDFNLPNTSRVIVILPDSVRNYMTKFLSDD 489 G SSG AV A ++ +D + N ++VILP S Y++ L D Sbjct: 270 AGISSGAAVAAALKLQEDESFTN-KNIVVILPSSGERYLSTALFAD 314
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 116,109,817
Number of Sequences: 369166
Number of extensions: 2244344
Number of successful extensions: 6552
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6241
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6517
length of database: 68,354,980
effective HSP length: 112
effective length of database: 47,664,660
effective search space used: 11534847720
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
