Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_D14
(638 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P35520|CBS_HUMAN Cystathionine beta-synthase (Serine sul... 161 1e-39
sp|P32232|CBS_RAT Cystathionine beta-synthase (Serine sulfh... 144 2e-34
sp|P46794|CBS_DICDI Cystathionine beta-synthase (Serine sul... 87 3e-17
sp|P32582|CBS_YEAST Cystathionine beta-synthase (Serine sul... 75 1e-13
sp|P44334|IMDH_HAEIN Inosine-5'-monophosphate dehydrogenase... 42 0.001
sp|Q9L6B7|IMDH_PASMU Inosine-5'-monophosphate dehydrogenase... 41 0.003
sp|Q57564|Y100_METJA Hypothetical protein MJ0100 38 0.025
sp|P42851|IMDH_PYRFU Inosine-5'-monophosphate dehydrogenase... 37 0.043
sp|O67820|IMDH_AQUAE Inosine-5'-monophosphate dehydrogenase... 37 0.043
sp|P54606|YHCV_BACSU Hypothetical protein yhcV 37 0.056
>sp|P35520|CBS_HUMAN Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase)
Length = 551
Score = 161 bits (408), Expect = 1e-39
Identities = 72/173 (41%), Positives = 119/173 (68%)
Frame = +2
Query: 5 IVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSNDQQFERKISSLEMNAPMTVQPSVT 184
+VILPDSVRNYMTKFLSD WM + FL + + + ++ L ++AP+TV P++T
Sbjct: 371 VVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTIT 430
Query: 185 VQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMSMLMKKSLNLTDPISKAIYKNFKKV 364
+E+L+++GFDQ PVV+ G I+G+ T+G ++S L+ + +D + K IYK FK++
Sbjct: 431 CGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQI 490
Query: 365 NLNQTVQQLSRLLDIDHFVLVVHQQRQIGASGTEEVKEMIYGIITRIDLISYM 523
L T+ +LS +L++DHF LVVH+Q Q ++G ++M++G++T IDL++++
Sbjct: 491 RLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFV 543
>sp|P32232|CBS_RAT Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase)
(Hemoprotein H-450)
Length = 561
Score = 144 bits (362), Expect = 2e-34
Identities = 70/187 (37%), Positives = 120/187 (64%), Gaps = 14/187 (7%)
Frame = +2
Query: 5 IVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSNDQQFERKISSLEMNAPMTVQPSVT 184
+VILPDSVRNYM+KFLSD WM + F+ + ++ + + ++ L ++AP+TV P+VT
Sbjct: 368 VVILPDSVRNYMSKFLSDKWMLQKGFMKEELSVK-RPWWWHLRVQELSLSAPLTVLPTVT 426
Query: 185 VQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMSMLMKKSLNLTDPISKAIYKNFKKV 364
+ + +L+++GFDQ PVV +G I+G+ T+G ++S L+ + +D + K +YK FK +
Sbjct: 427 CEHTIAILREKGFDQAPVVNESGAILGMVTLGNMLSSLLAGKVRPSDEVCKVLYKQFKPI 486
Query: 365 NLNQTVQQLSRLLDIDHFVLVVHQQRQ---------IGA-----SGTEEVKEMIYGIITR 502
+L T+ LS +L++DHF LVVH+Q Q +G +G + M++G++T
Sbjct: 487 HLTDTLGMLSHILEMDHFALVVHEQIQSRDQAWSGVVGGPTDRNNGVSSKQLMVFGVVTA 546
Query: 503 IDLISYM 523
IDL++++
Sbjct: 547 IDLLNFV 553
>sp|P46794|CBS_DICDI Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase)
Length = 497
Score = 87.4 bits (215), Expect = 3e-17
Identities = 57/183 (31%), Positives = 101/183 (55%), Gaps = 5/183 (2%)
Frame = +2
Query: 5 IVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSNDQQFERK-----ISSLEMNAPMTV 169
+V+L DS+RNYMTK L+DDW+ D F+D ++ DQQ E K + L + P+T+
Sbjct: 324 VVLLADSIRNYMTKHLNDDWLVDNGFVDPEY--KTKDQQEEEKYHGATVKDLTLPKPITI 381
Query: 170 QPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMSMLMKKSLNLTDPISKAIYK 349
+ T A++LL++ GFDQ+PVV + ++ + + ++ KK++ TD +SK +++
Sbjct: 382 SATTTCAAAVQLLQQYGFDQLPVVSESKKVLVNSLLVTSLTYASKKAVP-TDAVSKVMFR 440
Query: 350 NFKKVNLNQTVQQLSRLLDIDHFVLVVHQQRQIGASGTEEVKEMIYGIITRIDLISYMID 529
F K + Q + L + F + A TE + I I+T+IDL++Y++
Sbjct: 441 -FTKNEKYIPITQSTSLATLSKFF-----ENHSSAIVTE--NDEIISIVTKIDLLTYLMK 492
Query: 530 NHK 538
+ +
Sbjct: 493 SQQ 495
>sp|P32582|CBS_YEAST Cystathionine beta-synthase (Serine sulfhydrase) (Beta-thionase)
Length = 507
Score = 75.1 bits (183), Expect = 1e-13
Identities = 51/202 (25%), Positives = 97/202 (48%), Gaps = 28/202 (13%)
Frame = +2
Query: 2 VIVILPDSVRNYMTKFLSDDWMYDRNFLDKPMTNQSNDQQFERK------------ISSL 145
++ I PDS+R+Y+TKF+ D+W+ N D + + + + E + L
Sbjct: 313 IVAIFPDSIRSYLTKFVDDEWLKKNNLWDDDVLARFDSSKLEASTTKYADVFGNATVKDL 372
Query: 146 EMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMSMLMKKSLNLTD 325
+ ++V+ + V +++LK GFDQ+PV+ +G + G+ T+ ++ L + N D
Sbjct: 373 HLKPVVSVKETAKVTDVIKILKDNGFDQLPVLTEDGKLSGLVTLSELLRKLSINNSN-ND 431
Query: 326 PISKAIYKNFKKVNLNQTV----------------QQLSRLLDIDHFVLVVHQQRQIGAS 457
K Y +FKK+N V + S+L D++ F ++ A
Sbjct: 432 NTIKGKYLDFKKLNNFNDVSSYNENKSGKKKFIKFDENSKLSDLNRFF-----EKNSSAV 486
Query: 458 GTEEVKEMIYGIITRIDLISYM 523
T+ +K + I+T++DL+SY+
Sbjct: 487 ITDGLKPI--HIVTKMDLLSYL 506
>sp|P44334|IMDH_HAEIN Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH)
(IMPD)
Length = 488
Score = 42.0 bits (97), Expect = 0.001
Identities = 22/67 (32%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Frame = +2
Query: 80 FLDKPMT--NQSNDQQFERKISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANG 253
F+ K MT Q++ + +K S ++ P+TV P++T+ + E++KK GF PVV+
Sbjct: 70 FIHKNMTIERQADRVRKVKKFESGIVSEPVTVLPNLTLAELAEMVKKNGFAGYPVVDGEN 129
Query: 254 CIVGVAT 274
++G+ T
Sbjct: 130 NLIGIIT 136
>sp|Q9L6B7|IMDH_PASMU Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH)
(IMPD)
Length = 487
Score = 40.8 bits (94), Expect = 0.003
Identities = 23/63 (36%), Positives = 37/63 (58%), Gaps = 5/63 (7%)
Frame = +2
Query: 101 NQSNDQQFER-----KISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVG 265
N S ++Q ER K S ++ P+TV P++++ + EL+KK GF PVV+ +VG
Sbjct: 73 NMSIERQAERVRKVKKFESGIVSDPVTVSPTLSLAELSELVKKNGFASFPVVDDEKNLVG 132
Query: 266 VAT 274
+ T
Sbjct: 133 IIT 135
>sp|Q57564|Y100_METJA Hypothetical protein MJ0100
Length = 509
Score = 37.7 bits (86), Expect = 0.025
Identities = 20/111 (18%), Positives = 56/111 (50%)
Frame = +2
Query: 158 PMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMSMLMKKSLNLTDPISK 337
P+T ++++ +A ++L K + +P+V+ +G +VG+ T I L + + + +++
Sbjct: 398 PITAHSNISIMEAAKILIKHNINHLPIVDEHGKLVGIITSWDIAKALAQNKKTIEEIMTR 457
Query: 338 AIYKNFKKVNLNQTVQQLSRLLDIDHFVLVVHQQRQIGASGTEEVKEMIYG 490
+ + ++ ++S+ +I +V +R +G +E++ + G
Sbjct: 458 NVITAHEDEPVDHVAIKMSK-YNISGVPVVDDYRRVVGIVTSEDISRLFGG 507
>sp|P42851|IMDH_PYRFU Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH)
(IMPD)
Length = 485
Score = 37.0 bits (84), Expect = 0.043
Identities = 17/50 (34%), Positives = 31/50 (62%)
Frame = +2
Query: 128 RKISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATV 277
R + L +TV SV V++AL+++ + D++PVV +G +VG+ T+
Sbjct: 150 RTVKELMTREVITVPESVDVEEALKIMMENRIDRLPVVNEDGKLVGLITM 199
Score = 33.5 bits (75), Expect = 0.47
Identities = 16/38 (42%), Positives = 25/38 (65%)
Frame = +2
Query: 161 MTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVAT 274
+T+ P T+ AL L++K G D +PVVE + +VG+ T
Sbjct: 104 ITIAPDETIDYALFLMEKHGIDGLPVVEEDR-VVGIIT 140
>sp|O67820|IMDH_AQUAE Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH)
(IMPD)
Length = 490
Score = 37.0 bits (84), Expect = 0.043
Identities = 17/61 (27%), Positives = 35/61 (57%)
Frame = +2
Query: 92 PMTNQSNDQQFERKISSLEMNAPMTVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVA 271
P+ Q+ + + +K S + P+TV+P V++AL+++ K +PVV+ ++G+
Sbjct: 78 PIKKQAEEVEKVKKSESGMIINPVTVKPDTRVKEALDIMAKYKISGVPVVDEERKLIGIL 137
Query: 272 T 274
T
Sbjct: 138 T 138
>sp|P54606|YHCV_BACSU Hypothetical protein yhcV
Length = 140
Score = 36.6 bits (83), Expect = 0.056
Identities = 23/80 (28%), Positives = 40/80 (50%)
Frame = +2
Query: 164 TVQPSVTVQQALELLKKEGFDQIPVVEANGCIVGVATVGLIMSMLMKKSLNLTDPISKAI 343
TV P+ T+Q+A L+K+ IPVVE G + G+ T I + + P+S+ +
Sbjct: 14 TVSPNQTIQEAASLMKQHNVGAIPVVE-QGVLKGMLTDRDIALRTTAQGRDGQTPVSEVM 72
Query: 344 YKNFKKVNLNQTVQQLSRLL 403
N N +++ S+L+
Sbjct: 73 STELVSGNPNMSLEDASQLM 92
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,824,476
Number of Sequences: 369166
Number of extensions: 1122863
Number of successful extensions: 3431
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3323
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3424
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5169945420
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)