Planaria EST Database

DrC_00513

BLASTX 2.2.13 [Nov-27-2005]

Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= DrC_00513
         (1339 letters)

Database: Non-redundant SwissProt sequences 
           184,735 sequences; 68,354,980 total letters



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

sp|P49657|MNB_DROME  Serine/threonine-protein kinase minibrain    204   6e-52
sp|Q9Y463|DYR1B_HUMAN  Dual specificity tyrosine-phosphoryla...   198   3e-50
sp|Q13627|DYR1A_HUMAN  Dual specificity tyrosine-phosphoryla...   198   3e-50
sp|Q61214|DYR1A_MOUSE  Dual specificity tyrosine-phosphoryla...   198   3e-50
sp|Q63470|DYR1A_RAT  Dual specificity tyrosine-phosphorylati...   198   3e-50
sp|Q9Z188|DYR1B_MOUSE  Dual specificity tyrosine-phosphoryla...   139   2e-32
sp|P83102|DYRK3_DROME  Putative dual specificity tyrosine-ph...   117   8e-26
sp|Q9V3D5|DYRK2_DROME  Dual specificity tyrosine-phosphoryla...   116   2e-25
sp|Q9NR20|DYRK4_HUMAN  Dual specificity tyrosine-phosphoryla...   107   8e-23
sp|Q92630|DYRK2_HUMAN  Dual specificity tyrosine-phosphoryla...   107   1e-22

>sp|P49657|MNB_DROME Serine/threonine-protein kinase minibrain
          Length = 908

 Score =  204 bits (518), Expect = 6e-52
 Identities = 101/177 (57%), Positives = 128/177 (72%), Gaps = 1/177 (0%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +Y YIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 323 IYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVL 382

Query: 181 DMPPKNLLDRNSKSSKFFDK-AQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGG 357
            MPPK LLD+  K+ KFFDK   DG Y+  L + Q  RK  Y  PG R+L +ILGV+ GG
Sbjct: 383 GMPPKYLLDQAHKTRKFFDKIVADGSYV--LKKNQNGRK--YKPPGSRKLHDILGVETGG 438

Query: 358 PNSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANST 528
           P  RRL+ PGH+  DY  F++L+  ML +DP+ R+ P  +L HNFF+R      N++
Sbjct: 439 PGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTS 495

>sp|Q9Y463|DYR1B_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 1B (Mirk
           protein kinase) (Minibrain-related kinase)
          Length = 629

 Score =  198 bits (504), Expect = 3e-50
 Identities = 98/175 (56%), Positives = 123/175 (70%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +YQYIQSRFYRSP+VLL   YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM RI+EVL
Sbjct: 270 IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVL 329

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PP  +LD+  K+ K+F++   G +   L RT+E RK +Y  PG R+L+ +LGV  GGP
Sbjct: 330 GIPPAAMLDQAPKARKYFERLPGGGW--TLRRTKELRK-DYQGPGTRRLQEVLGVQTGGP 386

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANS 525
             RR   PGH+  DY  FQ+LV  ML Y+P  RI P+ +L H FFRR      N+
Sbjct: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 441

>sp|Q13627|DYR1A_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 1A
           (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual
           specificity YAK1-related kinase)
          Length = 763

 Score =  198 bits (503), Expect = 3e-50
 Identities = 99/183 (54%), Positives = 129/183 (70%), Gaps = 3/183 (1%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +YQYIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 377

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PP ++LD+  K+ KFF+K  DG +   L +T++  K  Y  PG R+L NILGV+ GGP
Sbjct: 378 GIPPAHILDQAPKARKFFEKLPDGTW--NLKKTKD-GKREYKPPGTRKLHNILGVETGGP 434

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPT---PTTANSTD 531
             RR    GHT  DY  F++L+  ML YDP+ RI+P  +L H+FF++       T+NS  
Sbjct: 435 GGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494

Query: 532 ICP 540
             P
Sbjct: 495 TSP 497

>sp|Q61214|DYR1A_MOUSE Dual specificity tyrosine-phosphorylation regulated kinase 1A
           (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual
           specificity YAK1-related kinase)
          Length = 763

 Score =  198 bits (503), Expect = 3e-50
 Identities = 99/183 (54%), Positives = 129/183 (70%), Gaps = 3/183 (1%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +YQYIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 377

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PP ++LD+  K+ KFF+K  DG +   L +T++  K  Y  PG R+L NILGV+ GGP
Sbjct: 378 GIPPAHILDQAPKARKFFEKLPDGTW--SLKKTKD-GKREYKPPGTRKLHNILGVETGGP 434

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPT---PTTANSTD 531
             RR    GHT  DY  F++L+  ML YDP+ RI+P  +L H+FF++       T+NS  
Sbjct: 435 GGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494

Query: 532 ICP 540
             P
Sbjct: 495 TSP 497

>sp|Q63470|DYR1A_RAT Dual specificity tyrosine-phosphorylation regulated kinase 1A
           (Protein kinase minibrain homolog) (MNBH) (RP86) (Dual
           specificity YAK1-related kinase)
          Length = 763

 Score =  198 bits (503), Expect = 3e-50
 Identities = 99/183 (54%), Positives = 129/183 (70%), Gaps = 3/183 (1%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +YQYIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 377

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PP ++LD+  K+ KFF+K  DG +   L +T++  K  Y  PG R+L NILGV+ GGP
Sbjct: 378 GIPPAHILDQAPKARKFFEKLPDGTW--SLKKTKD-GKREYKPPGTRKLHNILGVETGGP 434

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPT---PTTANSTD 531
             RR    GHT  DY  F++L+  ML YDP+ RI+P  +L H+FF++       T+NS  
Sbjct: 435 GGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494

Query: 532 ICP 540
             P
Sbjct: 495 TSP 497

>sp|Q9Z188|DYR1B_MOUSE Dual specificity tyrosine-phosphorylation regulated kinase 1B
          Length = 589

 Score =  139 bits (350), Expect = 2e-32
 Identities = 77/175 (44%), Positives = 98/175 (56%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +YQYIQSRFYRSP+VLL   YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM RI+EVL
Sbjct: 270 IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVL 329

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PP  +L++  K+ K+F++   G +   L RT+E RK                      
Sbjct: 330 GIPPAPMLEQAPKARKYFERLPGGGW--TLRRTKELRK---------------------- 365

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANS 525
                              +LV  ML Y+P  RI P+ +L H FFRR      N+
Sbjct: 366 -------------------DLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 401

>sp|P83102|DYRK3_DROME Putative dual specificity tyrosine-phosphorylation regulated kinase
           3 homolog
          Length = 828

 Score =  117 bits (293), Expect = 8e-26
 Identities = 72/179 (40%), Positives = 98/179 (54%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +Y YIQSRFYR+P+V+L   Y  +IDMWSLGCIL E+ +G  LF G+NE DQ+  IIEVL
Sbjct: 433 IYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVL 492

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            MP KN+L  + +S  FF      +Y      T  T  +  V     Q +   G  RG P
Sbjct: 493 GMPNKNILASSKRSKSFFSPKGYPRYC-----TVRTMSDGMVVLIGGQSRR--GKQRGPP 545

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANSTDIC 537
            S+ L+      +D   F N +   L +D +KR+ P E+L H + RR  P   +S+  C
Sbjct: 546 CSKSLSKALDGCKD-PLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGC 603

>sp|Q9V3D5|DYRK2_DROME Dual specificity tyrosine-phosphorylation regulated kinase 2
           (dDyrk2) (Smell impaired protein at 35A)
          Length = 722

 Score =  116 bits (290), Expect = 2e-25
 Identities = 67/166 (40%), Positives = 94/166 (56%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           +Y YIQSRFYRSP+V+L L Y T+IDMWSLGCIL E++TG PLF G+NEV+Q+  I+EVL
Sbjct: 355 IYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVL 414

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PPK L+    +   FFD        P+     + RK    +PG + L +IL       
Sbjct: 415 GLPPKVLISVARRRRLFFDSRD----APRCITNTKGRKR---SPGSKSLAHIL------- 460

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFR 498
                    H +  Y  F + ++  L +DP +R+ P E+  H F +
Sbjct: 461 ---------HCQDRY--FIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495

>sp|Q9NR20|DYRK4_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 4
          Length = 520

 Score =  107 bits (267), Expect = 8e-23
 Identities = 67/184 (36%), Positives = 93/184 (50%), Gaps = 7/184 (3%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           VY YIQSRFYRSP+V+L   YD +IDMWSLGCI  E++TG PLF G+NEV+Q+  I+EVL
Sbjct: 261 VYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVL 320

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            +PP   +   S+   FF    D +  PK N T    K  Y  P  + L  +L       
Sbjct: 321 GLPPAGFIQTASRRQTFF----DSKGFPK-NITNNRGKKRY--PDSKDLTMVL------- 366

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAH-------NFFRRPTPTTA 519
                      K     F + +   L+++P  R+ P ++L H       N   +P P T 
Sbjct: 367 -----------KTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTL 415

Query: 520 NSTD 531
             ++
Sbjct: 416 RKSN 419

>sp|Q92630|DYRK2_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 2
          Length = 528

 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/180 (37%), Positives = 94/180 (52%), Gaps = 2/180 (1%)
 Frame = +1

Query: 1   VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
           VY YIQSRFYR+P+V+L   Y   IDMWSLGCIL E+ TG PL  G++E DQ+  +IE+L
Sbjct: 306 VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELL 365

Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
            MP + LLD + ++  F       +  P+          + V  G R  +  L   RG P
Sbjct: 366 GMPSQKLLDASKRAKNFV----SSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL---RGPP 418

Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRR--PTPTTANSTDI 534
            SR   +      D   F + ++  L +DP  R+ P ++L H + RR  P P T   T +
Sbjct: 419 ESREWGNALKGCDD-PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSV 477

  Database: Non-redundant SwissProt sequences
    Posted date:  Dec 6, 2005  7:40 AM
  Number of letters in database: 68,354,980
  Number of sequences in database:  184,735
  
  Database: swissprot.01
    Posted date:  Dec 6, 2005  8:18 AM
  Number of letters in database: 66,202,850
  Number of sequences in database:  184,431
  
Lambda     K      H
   0.315    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 153,287,214
Number of Sequences: 369166
Number of extensions: 3118378
Number of successful extensions: 9494
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8505
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9301
length of database: 68,354,980
effective HSP length: 114
effective length of database: 47,295,190
effective search space used: 15654707890
frameshift window, decay const: 40,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)

Cluster detail

DrC_00513

  1. Dr_sW_013_H15
  2. Dr_sW_018_C20