Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_H15
(817 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P49657|MNB_DROME Serine/threonine-protein kinase minibrain 204 3e-52
sp|Q9Y463|DYR1B_HUMAN Dual specificity tyrosine-phosphoryla... 198 1e-50
sp|Q13627|DYR1A_HUMAN Dual specificity tyrosine-phosphoryla... 198 2e-50
sp|Q61214|DYR1A_MOUSE Dual specificity tyrosine-phosphoryla... 198 2e-50
sp|Q63470|DYR1A_RAT Dual specificity tyrosine-phosphorylati... 198 2e-50
sp|Q9Z188|DYR1B_MOUSE Dual specificity tyrosine-phosphoryla... 139 9e-33
sp|P83102|DYRK3_DROME Putative dual specificity tyrosine-ph... 117 4e-26
sp|Q9V3D5|DYRK2_DROME Dual specificity tyrosine-phosphoryla... 116 8e-26
sp|Q9NR20|DYRK4_HUMAN Dual specificity tyrosine-phosphoryla... 107 4e-23
sp|Q92630|DYRK2_HUMAN Dual specificity tyrosine-phosphoryla... 107 5e-23
>sp|P49657|MNB_DROME Serine/threonine-protein kinase minibrain
Length = 908
Score = 204 bits (518), Expect = 3e-52
Identities = 101/177 (57%), Positives = 128/177 (72%), Gaps = 1/177 (0%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+Y YIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 323 IYHYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVL 382
Query: 181 DMPPKNLLDRNSKSSKFFDK-AQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGG 357
MPPK LLD+ K+ KFFDK DG Y+ L + Q RK Y PG R+L +ILGV+ GG
Sbjct: 383 GMPPKYLLDQAHKTRKFFDKIVADGSYV--LKKNQNGRK--YKPPGSRKLHDILGVETGG 438
Query: 358 PNSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANST 528
P RRL+ PGH+ DY F++L+ ML +DP+ R+ P +L HNFF+R N++
Sbjct: 439 PGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHNFFKRTADEATNTS 495
>sp|Q9Y463|DYR1B_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 1B (Mirk
protein kinase) (Minibrain-related kinase)
Length = 629
Score = 198 bits (504), Expect = 1e-50
Identities = 98/175 (56%), Positives = 123/175 (70%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+YQYIQSRFYRSP+VLL YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM RI+EVL
Sbjct: 270 IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVL 329
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PP +LD+ K+ K+F++ G + L RT+E RK +Y PG R+L+ +LGV GGP
Sbjct: 330 GIPPAAMLDQAPKARKYFERLPGGGW--TLRRTKELRK-DYQGPGTRRLQEVLGVQTGGP 386
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANS 525
RR PGH+ DY FQ+LV ML Y+P RI P+ +L H FFRR N+
Sbjct: 387 GGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 441
>sp|Q13627|DYR1A_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 1A
(Protein kinase minibrain homolog) (MNBH) (HP86) (Dual
specificity YAK1-related kinase)
Length = 763
Score = 198 bits (503), Expect = 2e-50
Identities = 99/183 (54%), Positives = 129/183 (70%), Gaps = 3/183 (1%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+YQYIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 377
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PP ++LD+ K+ KFF+K DG + L +T++ K Y PG R+L NILGV+ GGP
Sbjct: 378 GIPPAHILDQAPKARKFFEKLPDGTW--NLKKTKD-GKREYKPPGTRKLHNILGVETGGP 434
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPT---PTTANSTD 531
RR GHT DY F++L+ ML YDP+ RI+P +L H+FF++ T+NS
Sbjct: 435 GGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
Query: 532 ICP 540
P
Sbjct: 495 TSP 497
>sp|Q61214|DYR1A_MOUSE Dual specificity tyrosine-phosphorylation regulated kinase 1A
(Protein kinase minibrain homolog) (MNBH) (MP86) (Dual
specificity YAK1-related kinase)
Length = 763
Score = 198 bits (503), Expect = 2e-50
Identities = 99/183 (54%), Positives = 129/183 (70%), Gaps = 3/183 (1%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+YQYIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 377
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PP ++LD+ K+ KFF+K DG + L +T++ K Y PG R+L NILGV+ GGP
Sbjct: 378 GIPPAHILDQAPKARKFFEKLPDGTW--SLKKTKD-GKREYKPPGTRKLHNILGVETGGP 434
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPT---PTTANSTD 531
RR GHT DY F++L+ ML YDP+ RI+P +L H+FF++ T+NS
Sbjct: 435 GGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
Query: 532 ICP 540
P
Sbjct: 495 TSP 497
>sp|Q63470|DYR1A_RAT Dual specificity tyrosine-phosphorylation regulated kinase 1A
(Protein kinase minibrain homolog) (MNBH) (RP86) (Dual
specificity YAK1-related kinase)
Length = 763
Score = 198 bits (503), Expect = 2e-50
Identities = 99/183 (54%), Positives = 129/183 (70%), Gaps = 3/183 (1%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+YQYIQSRFYRSP+VLL + YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM +I+EVL
Sbjct: 318 IYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVL 377
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PP ++LD+ K+ KFF+K DG + L +T++ K Y PG R+L NILGV+ GGP
Sbjct: 378 GIPPAHILDQAPKARKFFEKLPDGTW--SLKKTKD-GKREYKPPGTRKLHNILGVETGGP 434
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPT---PTTANSTD 531
RR GHT DY F++L+ ML YDP+ RI+P +L H+FF++ T+NS
Sbjct: 435 GGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTNTSNSVS 494
Query: 532 ICP 540
P
Sbjct: 495 TSP 497
>sp|Q9Z188|DYR1B_MOUSE Dual specificity tyrosine-phosphorylation regulated kinase 1B
Length = 589
Score = 139 bits (350), Expect = 9e-33
Identities = 77/175 (44%), Positives = 98/175 (56%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+YQYIQSRFYRSP+VLL YD +IDMWSLGCIL+EMHTGEPLF+G NEVDQM RI+EVL
Sbjct: 270 IYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVL 329
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PP +L++ K+ K+F++ G + L RT+E RK
Sbjct: 330 GIPPAPMLEQAPKARKYFERLPGGGW--TLRRTKELRK---------------------- 365
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANS 525
+LV ML Y+P RI P+ +L H FFRR N+
Sbjct: 366 -------------------DLVLRMLEYEPAARISPLGALQHGFFRRTADEATNT 401
>sp|P83102|DYRK3_DROME Putative dual specificity tyrosine-phosphorylation regulated kinase
3 homolog
Length = 828
Score = 117 bits (293), Expect = 4e-26
Identities = 72/179 (40%), Positives = 98/179 (54%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+Y YIQSRFYR+P+V+L Y +IDMWSLGCIL E+ +G LF G+NE DQ+ IIEVL
Sbjct: 433 IYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVL 492
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
MP KN+L + +S FF +Y T T + V Q + G RG P
Sbjct: 493 GMPNKNILASSKRSKSFFSPKGYPRYC-----TVRTMSDGMVVLIGGQSRR--GKQRGPP 545
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRRPTPTTANSTDIC 537
S+ L+ +D F N + L +D +KR+ P E+L H + RR P +S+ C
Sbjct: 546 CSKSLSKALDGCKD-PLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGC 603
>sp|Q9V3D5|DYRK2_DROME Dual specificity tyrosine-phosphorylation regulated kinase 2
(dDyrk2) (Smell impaired protein at 35A)
Length = 722
Score = 116 bits (290), Expect = 8e-26
Identities = 67/166 (40%), Positives = 94/166 (56%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
+Y YIQSRFYRSP+V+L L Y T+IDMWSLGCIL E++TG PLF G+NEV+Q+ I+EVL
Sbjct: 355 IYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQLACIMEVL 414
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PPK L+ + FFD P+ + RK +PG + L +IL
Sbjct: 415 GLPPKVLISVARRRRLFFDSRD----APRCITNTKGRKR---SPGSKSLAHIL------- 460
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFR 498
H + Y F + ++ L +DP +R+ P E+ H F +
Sbjct: 461 ---------HCQDRY--FIDFLQRCLEWDPAERMTPDEAAHHEFLQ 495
>sp|Q9NR20|DYRK4_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 4
Length = 520
Score = 107 bits (267), Expect = 4e-23
Identities = 67/184 (36%), Positives = 93/184 (50%), Gaps = 7/184 (3%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
VY YIQSRFYRSP+V+L YD +IDMWSLGCI E++TG PLF G+NEV+Q+ I+EVL
Sbjct: 261 VYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVL 320
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
+PP + S+ FF D + PK N T K Y P + L +L
Sbjct: 321 GLPPAGFIQTASRRQTFF----DSKGFPK-NITNNRGKKRY--PDSKDLTMVL------- 366
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAH-------NFFRRPTPTTA 519
K F + + L+++P R+ P ++L H N +P P T
Sbjct: 367 -----------KTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTL 415
Query: 520 NSTD 531
++
Sbjct: 416 RKSN 419
>sp|Q92630|DYRK2_HUMAN Dual specificity tyrosine-phosphorylation regulated kinase 2
Length = 528
Score = 107 bits (266), Expect = 5e-23
Identities = 67/180 (37%), Positives = 94/180 (52%), Gaps = 2/180 (1%)
Frame = +1
Query: 1 VYQYIQSRFYRSPDVLLNLNYDTSIDMWSLGCILMEMHTGEPLFAGQNEVDQMMRIIEVL 180
VY YIQSRFYR+P+V+L Y IDMWSLGCIL E+ TG PL G++E DQ+ +IE+L
Sbjct: 306 VYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELL 365
Query: 181 DMPPKNLLDRNSKSSKFFDKAQDGQYIPKLNRTQETRKNNYVNPGQRQLKNILGVDRGGP 360
MP + LLD + ++ F + P+ + V G R + L RG P
Sbjct: 366 GMPSQKLLDASKRAKNFV----SSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL---RGPP 418
Query: 361 NSRRLNHPGHTKQDYECFQNLVENMLIYDPEKRIKPIESLAHNFFRR--PTPTTANSTDI 534
SR + D F + ++ L +DP R+ P ++L H + RR P P T T +
Sbjct: 419 ESREWGNALKGCDD-PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSV 477
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.317 0.134 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,791,023
Number of Sequences: 369166
Number of extensions: 1943209
Number of successful extensions: 6602
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5866
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6411
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7811456130
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)