Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00481 (930 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|P21265|PUR8_CHICK Adenylosuccinate lyase (Adenylosuccina... 351 1e-96 sp|P54822|PUR8_MOUSE Adenylosuccinate lyase (Adenylosuccina... 340 3e-93 sp|Q8HXY5|PUR8_MACFA Adenylosuccinate lyase (Adenylosuccina... 338 1e-92 sp|P30566|PUR8_HUMAN Adenylosuccinate lyase (Adenylosuccina... 337 2e-92 sp|Q05911|PUR8_YEAST Adenylosuccinate lyase (Adenylosuccina... 289 9e-78 sp|O60105|PUR8_SCHPO Adenylosuccinate lyase (Adenylosuccina... 285 1e-76 sp|Q9UZ99|PUR8_PYRAB Adenylosuccinate lyase (Adenylosuccina... 110 4e-24 sp|O58582|PUR8_PYRHO Adenylosuccinate lyase (Adenylosuccina... 110 4e-24 sp|O66856|PUR8_AQUAE Adenylosuccinate lyase (Adenylosuccina... 107 5e-23 sp|O28041|PUR8_ARCFU Adenylosuccinate lyase (Adenylosuccina... 107 6e-23
>sp|P21265|PUR8_CHICK Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE) Length = 459 Score = 351 bits (901), Expect = 1e-96 Identities = 176/279 (63%), Positives = 219/279 (78%), Gaps = 1/279 (0%) Frame = +1 Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180 ASFLQ+F+GDH KVEELD LV+AKAGF ++VTGQTY RK+D +LS LA L S+HKI Sbjct: 181 ASFLQLFEGDHSKVEELDRLVTAKAGFKRSYMVTGQTYSRKVDIEVLSVLASLGASVHKI 240 Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360 CTD+RLLA++KEIEEPFE DQ GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS Q Sbjct: 241 CTDIRLLANLKEIEEPFEKDQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDPLQTASVQ 300 Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540 W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+I++ I ELPFMATE I Sbjct: 301 WFERTLDDSANRRVCLAEAFLTADIILSTLQNISEGLVVYPKVIDRRIRQELPFMATENI 360 Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720 ++ MV+ G +RQ CHE I+ +SQ+AA VK+ G NDFI R+RAD YF+ IHE +D+LL+ Sbjct: 361 IMAMVKAGGNRQDCHEKIRVLSQQAAAVVKQEGGDNDFIARVRADPYFSPIHEHLDSLLD 420 Query: 721 PSHFTGRSAEQVDRFLKTALKP-LDKYKHLFDEKIELNV 834 PS FTGR+ +QV +FLK ++P L Y+ + KIEL + Sbjct: 421 PSSFTGRAPQQVAKFLKEEVRPALIPYQSMMGGKIELTL 459
>sp|P54822|PUR8_MOUSE Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE) Length = 484 Score = 340 bits (872), Expect = 3e-93 Identities = 165/265 (62%), Positives = 210/265 (79%) Frame = +1 Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180 ASFLQ+F+GDH+KVE+LD +V+ KAGF F++TGQTY RK+D +LS LA L S+HKI Sbjct: 206 ASFLQLFEGDHQKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI 265 Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360 CTD+RLLA++KE+EEPFE Q GSSAMPYKRNPMRSER CSLARH+M ++PL TAS Q Sbjct: 266 CTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMALTMDPLQTASVQ 325 Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540 W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I Sbjct: 326 WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENI 385 Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720 ++ MV+ G RQ CHE I+ +SQ+AA VK+ G ND IER+RAD+YF+ IH ++++LL+ Sbjct: 386 IMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEHLLD 445 Query: 721 PSHFTGRSAEQVDRFLKTALKPLDK 795 PS FTGR+ +QV RFL+ ++PL K Sbjct: 446 PSSFTGRAPQQVHRFLEEEVRPLLK 470
>sp|Q8HXY5|PUR8_MACFA Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE) Length = 484 Score = 338 bits (867), Expect = 1e-92 Identities = 169/277 (61%), Positives = 214/277 (77%), Gaps = 1/277 (0%) Frame = +1 Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180 ASFLQ+F+GD KVE+LD +V+ KAGF F++TGQTY RK+D +LS LA L S+HKI Sbjct: 206 ASFLQLFEGDDHKVEQLDKMVTDKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI 265 Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360 CTD+RLLA++KE+EEPFE Q GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS Q Sbjct: 266 CTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQ 325 Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540 W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I Sbjct: 326 WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENI 385 Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720 ++ MV+ G RQ CHE I+ +SQ+AA VK+ G ND IER++AD+YF+ IH ++D LL+ Sbjct: 386 IMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQADAYFSPIHSQLDRLLD 445 Query: 721 PSHFTGRSAEQVDRFLKTALKPLDK-YKHLFDEKIEL 828 PS FTGR+++QV RFL+ + PL K Y+ + K EL Sbjct: 446 PSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAEL 482
>sp|P30566|PUR8_HUMAN Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE) Length = 484 Score = 337 bits (865), Expect = 2e-92 Identities = 168/277 (60%), Positives = 214/277 (77%), Gaps = 1/277 (0%) Frame = +1 Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180 ASFLQ+F+GD KVE+LD +V+ KAGF F++TGQTY RK+D +LS LA L S+HKI Sbjct: 206 ASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI 265 Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360 CTD+RLLA++KE+EEPFE Q GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS Q Sbjct: 266 CTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQ 325 Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540 W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I Sbjct: 326 WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENI 385 Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720 ++ MV+ G RQ CHE I+ +SQ+AA VK+ G ND IER++ D+YF+ IH ++D+LL+ Sbjct: 386 IMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLD 445 Query: 721 PSHFTGRSAEQVDRFLKTALKPLDK-YKHLFDEKIEL 828 PS FTGR+++QV RFL+ + PL K Y+ + K EL Sbjct: 446 PSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAEL 482
>sp|Q05911|PUR8_YEAST Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE) Length = 482 Score = 289 bits (739), Expect = 9e-78 Identities = 151/282 (53%), Positives = 200/282 (70%), Gaps = 4/282 (1%) Frame = +1 Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180 ASFL +F G+H+KVE LD V+ GF + VTGQTY RK+D +L+ L+ A + HK+ Sbjct: 203 ASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKM 262 Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360 TD+RLLA++KE+EEPFE Q GSSAM YKRNPMR ER+CSLARH+ + + + TAS Q Sbjct: 263 ATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQ 322 Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540 W ERTLDDSA RR+ +P +FL AD +L T N+S+GLVVY K+IE+ I ELPFMATE I Sbjct: 323 WFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENI 382 Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720 ++ MV+ RQ HE I+ +S +AA VKE G ND IER++ D +F I EE+D+LL Sbjct: 383 IMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLE 442 Query: 721 PSHFTGRSAEQVDRFLK----TALKPLDKYKHLFDEKIELNV 834 PS F GR+ +QV++F++ AL+P KY L DE+++LNV Sbjct: 443 PSTFVGRAPQQVEKFVQKDVNNALQPFQKY--LNDEQVKLNV 482
>sp|O60105|PUR8_SCHPO Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE) Length = 482 Score = 285 bits (730), Expect = 1e-76 Identities = 150/280 (53%), Positives = 196/280 (70%), Gaps = 2/280 (0%) Frame = +1 Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180 ASFL +F+GDH KVEELD LV+ +GF + + VTGQTY RK+D +L LA + HKI Sbjct: 203 ASFLALFEGDHAKVEELDKLVAKLSGFDNVYPVTGQTYDRKIDIDVLQPLASFGATAHKI 262 Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360 TD+RLLA++KE+EEPFE Q GSSAM YKRNPMR ERICS AR+IM N L TAS Q Sbjct: 263 ATDIRLLANLKEVEEPFEAGQIGSSAMAYKRNPMRCERICSQARYIMNLIPNALNTASVQ 322 Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540 W ERTLDDS+NRR +PE+FL D +L NV +G+V+Y K+I++HI AELPFMATE I Sbjct: 323 WFERTLDDSSNRRSLLPEAFLFTDSVLKILLNVISGMVIYPKVIQKHIRAELPFMATENI 382 Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720 ++ M + G R CHE I+ +S +A VKE G ND IER++ YFA I++E+D+LL+ Sbjct: 383 IMAMTKHGASRHECHEQIRVLSHQAGRVVKEEGGDNDLIERIKNTPYFAPIYDELDSLLD 442 Query: 721 PSHFTGRSAEQVDRFL-KTALKPLDKYKHLF-DEKIELNV 834 S F GR+ EQ + F+ K + L +K + +EK++L V Sbjct: 443 ASTFVGRAPEQTESFVNKDVSQALAPFKSMITEEKVDLAV 482
>sp|Q9UZ99|PUR8_PYRAB Adenylosuccinate lyase (Adenylosuccinase) (ASL) Length = 450 Score = 110 bits (276), Expect = 4e-24 Identities = 72/244 (29%), Positives = 130/244 (53%), Gaps = 15/244 (6%) Frame = +1 Query: 34 EKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--AS 207 +K E++ LV G L +T Q R + ++ LA +A+++ K+ ++R L Sbjct: 200 DKAFEIEKLVMEDLG-LKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE 258 Query: 208 MKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDS 387 + E+ EPF Q GSS MP+KRNP+R+E++C LAR + + I P + + W ER L +S Sbjct: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNS 317 Query: 388 ANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGE 567 + R+ +PESF+ D ML V GL + + I++++ + E +++++ + G Sbjct: 318 SVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGM 377 Query: 568 DRQVCHEHIKRISQEAAVNVKE-------------YGKANDFIERLRADSYFAKIHEEVD 708 RQ HE +++++ +A ++ Y ND +E L+ ++Y K E V+ Sbjct: 378 GRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTEND-LEGLKPENYIGKAREIVE 436 Query: 709 NLLN 720 N++N Sbjct: 437 NVVN 440
>sp|O58582|PUR8_PYRHO Adenylosuccinate lyase (Adenylosuccinase) (ASL) Length = 450 Score = 110 bits (276), Expect = 4e-24 Identities = 74/249 (29%), Positives = 131/249 (52%), Gaps = 3/249 (1%) Frame = +1 Query: 34 EKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--AS 207 EK E++ LV G L +T Q R + +L LA +A+++ K+ ++R L Sbjct: 200 EKAFEIERLVMEDLG-LKPARITNQIVQRDVYAELLFFLALVASTLDKMGLEIRNLQRTE 258 Query: 208 MKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDS 387 + E+ EPF Q GSS MP+KRNP+R+E++C LAR + + I P + + W ER L +S Sbjct: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNS 317 Query: 388 ANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGE 567 + R+ +PESF+ D ML T V GL + + I +++ + E +++++ + G Sbjct: 318 SVERVILPESFVLLDEMLKTMKKVLTGLEFFPENIRRNLYLTKNLIMAEPLMLKLAEKGM 377 Query: 568 DRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVD-NLLNPSHFTGRS 744 RQ HE +++++ +K + + D +E + K E D L P ++ G++ Sbjct: 378 GRQEAHEVVRQLA------MKAFRENRDLLEVAKESREITKYLTERDLEELKPENYIGKA 431 Query: 745 AEQVDRFLK 771 E V + ++ Sbjct: 432 REIVKKVIE 440
>sp|O66856|PUR8_AQUAE Adenylosuccinate lyase (Adenylosuccinase) (ASL) Length = 437 Score = 107 bits (267), Expect = 5e-23 Identities = 68/201 (33%), Positives = 109/201 (54%), Gaps = 2/201 (0%) Frame = +1 Query: 136 ILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLA 309 +L+ L +A+S+ K T++R L + E+ EPF Q GSSAMP+K+NP+ SERIC LA Sbjct: 225 LLTTLGLIASSLEKFATEIRHLQRTEVLEVLEPFTKGQRGSSAMPHKKNPIHSERICGLA 284 Query: 310 RHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKM 489 R I I P M W ER + S+ R+ +P+SF+A D +L F + GLVV K+ Sbjct: 285 RVIRANSI-PAMEDVVLWHERDISHSSVERVILPDSFIALDYILNLFYEILKGLVVNKER 343 Query: 490 IEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLR 669 + +++ A+ ILV + Q G R ++ ++R + +A + K + + +E Sbjct: 344 MRKNMELSKGLYASSKILVLLTQKGLSRDYAYDIVQRCAMKAWESDKTFKET--LLEDPE 401 Query: 670 ADSYFAKIHEEVDNLLNPSHF 732 Y + EE++ L+P F Sbjct: 402 VTKYLTE--EEIEKALDPWEF 420
>sp|O28041|PUR8_ARCFU Adenylosuccinate lyase (Adenylosuccinase) (ASL) Length = 444 Score = 107 bits (266), Expect = 6e-23 Identities = 68/228 (29%), Positives = 121/228 (53%), Gaps = 2/228 (0%) Frame = +1 Query: 94 LVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPY 267 L++ Q PR L LA LA ++ KI + RLL A + E+ E FE Q GSS MP+ Sbjct: 215 LISSQIIPRDSYCEYLEFLANLAATLEKIALNFRLLQRAEVGELMEKFEAKQVGSSTMPH 274 Query: 268 KRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMT 447 KRNP+ E +C LAR ++ + P ++ W ER L +S+ R+ + ES + AD +L Sbjct: 275 KRNPIDCENVCGLAR-VVRGFVEPQHQSAILWEERDLTNSSAERITLVESTVLADHILTK 333 Query: 448 FDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNV 627 V + + + + I +++ + +EA+++ M + G RQ HE +++ + A N Sbjct: 334 MIKVVSSVSLNLENIRRNLEMQRGLNLSEAVMIEMTKRGVGRQEAHEILRQAAMRAYEN- 392 Query: 628 KEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLK 771 ++ ++ R YF + +E+ +L P ++ G + E+V+R ++ Sbjct: 393 -NSSLLDELLKDERVMKYFKE--DELREILKPENYLGTARERVERVVR 437
Database: Non-redundant SwissProt sequences Posted date: Dec 6, 2005 7:40 AM Number of letters in database: 68,354,980 Number of sequences in database: 184,735 Database: swissprot.01 Posted date: Dec 6, 2005 8:18 AM Number of letters in database: 66,202,850 Number of sequences in database: 184,431 Lambda K H 0.318 0.134 0.401 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 97,747,331 Number of Sequences: 369166 Number of extensions: 1864329 Number of successful extensions: 5306 Number of sequences better than 10.0: 10 Number of HSP's better than 10.0 without gapping: 5060 Number of HSP's successfully gapped in prelim test: 0 Number of HSP's that attempted gapping in prelim test: 0 Number of HSP's gapped (non-prelim): 5246 length of database: 68,354,980 effective HSP length: 110 effective length of database: 48,034,130 effective search space used: 9558791870 frameshift window, decay const: 40, 0.1 T: 12 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits)