Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_M02
(831 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P21265|PUR8_CHICK Adenylosuccinate lyase (Adenylosuccina... 351 2e-96
sp|P54822|PUR8_MOUSE Adenylosuccinate lyase (Adenylosuccina... 340 3e-93
sp|Q8HXY5|PUR8_MACFA Adenylosuccinate lyase (Adenylosuccina... 338 1e-92
sp|P30566|PUR8_HUMAN Adenylosuccinate lyase (Adenylosuccina... 337 2e-92
sp|Q05911|PUR8_YEAST Adenylosuccinate lyase (Adenylosuccina... 287 2e-77
sp|O60105|PUR8_SCHPO Adenylosuccinate lyase (Adenylosuccina... 285 1e-76
sp|Q9UZ99|PUR8_PYRAB Adenylosuccinate lyase (Adenylosuccina... 110 4e-24
sp|O58582|PUR8_PYRHO Adenylosuccinate lyase (Adenylosuccina... 110 4e-24
sp|O66856|PUR8_AQUAE Adenylosuccinate lyase (Adenylosuccina... 107 4e-23
sp|O28041|PUR8_ARCFU Adenylosuccinate lyase (Adenylosuccina... 107 5e-23
>sp|P21265|PUR8_CHICK Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 459
Score = 351 bits (900), Expect = 2e-96
Identities = 176/277 (63%), Positives = 218/277 (78%), Gaps = 1/277 (0%)
Frame = +1
Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180
ASFLQ+F+GDH KVEELD LV+AKAGF ++VTGQTY RK+D +LS LA L S+HKI
Sbjct: 181 ASFLQLFEGDHSKVEELDRLVTAKAGFKRSYMVTGQTYSRKVDIEVLSVLASLGASVHKI 240
Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360
CTD+RLLA++KEIEEPFE DQ GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS Q
Sbjct: 241 CTDIRLLANLKEIEEPFEKDQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDPLQTASVQ 300
Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540
W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+I++ I ELPFMATE I
Sbjct: 301 WFERTLDDSANRRVCLAEAFLTADIILSTLQNISEGLVVYPKVIDRRIRQELPFMATENI 360
Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720
++ MV+ G +RQ CHE I+ +SQ+AA VK+ G NDFI R+RAD YF+ IHE +D+LL+
Sbjct: 361 IMAMVKAGGNRQDCHEKIRVLSQQAAAVVKQEGGDNDFIARVRADPYFSPIHEHLDSLLD 420
Query: 721 PSHFTGRSAEQVDRFLKTALKP-LDKYKHLFDEKIEL 828
PS FTGR+ +QV +FLK ++P L Y+ + KIEL
Sbjct: 421 PSSFTGRAPQQVAKFLKEEVRPALIPYQSMMGGKIEL 457
>sp|P54822|PUR8_MOUSE Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 484
Score = 340 bits (872), Expect = 3e-93
Identities = 165/265 (62%), Positives = 210/265 (79%)
Frame = +1
Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180
ASFLQ+F+GDH+KVE+LD +V+ KAGF F++TGQTY RK+D +LS LA L S+HKI
Sbjct: 206 ASFLQLFEGDHQKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI 265
Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360
CTD+RLLA++KE+EEPFE Q GSSAMPYKRNPMRSER CSLARH+M ++PL TAS Q
Sbjct: 266 CTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMALTMDPLQTASVQ 325
Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540
W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I
Sbjct: 326 WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENI 385
Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720
++ MV+ G RQ CHE I+ +SQ+AA VK+ G ND IER+RAD+YF+ IH ++++LL+
Sbjct: 386 IMAMVKAGGSRQDCHEKIRVLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEHLLD 445
Query: 721 PSHFTGRSAEQVDRFLKTALKPLDK 795
PS FTGR+ +QV RFL+ ++PL K
Sbjct: 446 PSSFTGRAPQQVHRFLEEEVRPLLK 470
>sp|Q8HXY5|PUR8_MACFA Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 484
Score = 338 bits (867), Expect = 1e-92
Identities = 169/277 (61%), Positives = 214/277 (77%), Gaps = 1/277 (0%)
Frame = +1
Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180
ASFLQ+F+GD KVE+LD +V+ KAGF F++TGQTY RK+D +LS LA L S+HKI
Sbjct: 206 ASFLQLFEGDDHKVEQLDKMVTDKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI 265
Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360
CTD+RLLA++KE+EEPFE Q GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS Q
Sbjct: 266 CTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQ 325
Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540
W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I
Sbjct: 326 WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENI 385
Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720
++ MV+ G RQ CHE I+ +SQ+AA VK+ G ND IER++AD+YF+ IH ++D LL+
Sbjct: 386 IMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQADAYFSPIHSQLDRLLD 445
Query: 721 PSHFTGRSAEQVDRFLKTALKPLDK-YKHLFDEKIEL 828
PS FTGR+++QV RFL+ + PL K Y+ + K EL
Sbjct: 446 PSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAEL 482
>sp|P30566|PUR8_HUMAN Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 484
Score = 337 bits (865), Expect = 2e-92
Identities = 168/277 (60%), Positives = 214/277 (77%), Gaps = 1/277 (0%)
Frame = +1
Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180
ASFLQ+F+GD KVE+LD +V+ KAGF F++TGQTY RK+D +LS LA L S+HKI
Sbjct: 206 ASFLQLFEGDDHKVEQLDKMVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKI 265
Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360
CTD+RLLA++KE+EEPFE Q GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS Q
Sbjct: 266 CTDIRLLANLKEMEEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQ 325
Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540
W ERTLDDSANRR+C+ E+FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I
Sbjct: 326 WFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENI 385
Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720
++ MV+ G RQ CHE I+ +SQ+AA VK+ G ND IER++ D+YF+ IH ++D+LL+
Sbjct: 386 IMAMVKAGGSRQDCHEKIRVLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLD 445
Query: 721 PSHFTGRSAEQVDRFLKTALKPLDK-YKHLFDEKIEL 828
PS FTGR+++QV RFL+ + PL K Y+ + K EL
Sbjct: 446 PSSFTGRASQQVQRFLEEEVYPLLKPYESVMKVKAEL 482
>sp|Q05911|PUR8_YEAST Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 482
Score = 287 bits (735), Expect = 2e-77
Identities = 150/281 (53%), Positives = 199/281 (70%), Gaps = 4/281 (1%)
Frame = +1
Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180
ASFL +F G+H+KVE LD V+ GF + VTGQTY RK+D +L+ L+ A + HK+
Sbjct: 203 ASFLALFHGNHDKVEALDERVTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKM 262
Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360
TD+RLLA++KE+EEPFE Q GSSAM YKRNPMR ER+CSLARH+ + + + TAS Q
Sbjct: 263 ATDIRLLANLKEVEEPFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQ 322
Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540
W ERTLDDSA RR+ +P +FL AD +L T N+S+GLVVY K+IE+ I ELPFMATE I
Sbjct: 323 WFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENI 382
Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720
++ MV+ RQ HE I+ +S +AA VKE G ND IER++ D +F I EE+D+LL
Sbjct: 383 IMAMVEKNASRQEVHERIRVLSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLE 442
Query: 721 PSHFTGRSAEQVDRFLK----TALKPLDKYKHLFDEKIELN 831
PS F GR+ +QV++F++ AL+P KY L DE+++LN
Sbjct: 443 PSTFVGRAPQQVEKFVQKDVNNALQPFQKY--LNDEQVKLN 481
>sp|O60105|PUR8_SCHPO Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 482
Score = 285 bits (728), Expect = 1e-76
Identities = 149/278 (53%), Positives = 195/278 (70%), Gaps = 2/278 (0%)
Frame = +1
Query: 1 ASFLQMFDGDHEKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKI 180
ASFL +F+GDH KVEELD LV+ +GF + + VTGQTY RK+D +L LA + HKI
Sbjct: 203 ASFLALFEGDHAKVEELDKLVAKLSGFDNVYPVTGQTYDRKIDIDVLQPLASFGATAHKI 262
Query: 181 CTDLRLLASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQ 360
TD+RLLA++KE+EEPFE Q GSSAM YKRNPMR ERICS AR+IM N L TAS Q
Sbjct: 263 ATDIRLLANLKEVEEPFEAGQIGSSAMAYKRNPMRCERICSQARYIMNLIPNALNTASVQ 322
Query: 361 WMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAI 540
W ERTLDDS+NRR +PE+FL D +L NV +G+V+Y K+I++HI AELPFMATE I
Sbjct: 323 WFERTLDDSSNRRSLLPEAFLFTDSVLKILLNVISGMVIYPKVIQKHIRAELPFMATENI 382
Query: 541 LVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLN 720
++ M + G R CHE I+ +S +A VKE G ND IER++ YFA I++E+D+LL+
Sbjct: 383 IMAMTKHGASRHECHEQIRVLSHQAGRVVKEEGGDNDLIERIKNTPYFAPIYDELDSLLD 442
Query: 721 PSHFTGRSAEQVDRFL-KTALKPLDKYKHLF-DEKIEL 828
S F GR+ EQ + F+ K + L +K + +EK++L
Sbjct: 443 ASTFVGRAPEQTESFVNKDVSQALAPFKSMITEEKVDL 480
>sp|Q9UZ99|PUR8_PYRAB Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 450
Score = 110 bits (276), Expect = 4e-24
Identities = 72/244 (29%), Positives = 130/244 (53%), Gaps = 15/244 (6%)
Frame = +1
Query: 34 EKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--AS 207
+K E++ LV G L +T Q R + ++ LA +A+++ K+ ++R L
Sbjct: 200 DKAFEIEKLVMEDLG-LKPARITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTE 258
Query: 208 MKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDS 387
+ E+ EPF Q GSS MP+KRNP+R+E++C LAR + + I P + + W ER L +S
Sbjct: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNS 317
Query: 388 ANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGE 567
+ R+ +PESF+ D ML V GL + + I++++ + E +++++ + G
Sbjct: 318 SVERVILPESFVLLDEMLKVMKKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGM 377
Query: 568 DRQVCHEHIKRISQEAAVNVKE-------------YGKANDFIERLRADSYFAKIHEEVD 708
RQ HE +++++ +A ++ Y ND +E L+ ++Y K E V+
Sbjct: 378 GRQEAHELVRQLAMKAFKEGRDLLEVVRKNEEAMKYLTEND-LEGLKPENYIGKAREIVE 436
Query: 709 NLLN 720
N++N
Sbjct: 437 NVVN 440
>sp|O58582|PUR8_PYRHO Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 450
Score = 110 bits (276), Expect = 4e-24
Identities = 74/249 (29%), Positives = 131/249 (52%), Gaps = 3/249 (1%)
Frame = +1
Query: 34 EKVEELDVLVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--AS 207
EK E++ LV G L +T Q R + +L LA +A+++ K+ ++R L
Sbjct: 200 EKAFEIERLVMEDLG-LKPARITNQIVQRDVYAELLFFLALVASTLDKMGLEIRNLQRTE 258
Query: 208 MKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDS 387
+ E+ EPF Q GSS MP+KRNP+R+E++C LAR + + I P + + W ER L +S
Sbjct: 259 ILEVSEPFGEKQVGSSTMPHKRNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNS 317
Query: 388 ANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGE 567
+ R+ +PESF+ D ML T V GL + + I +++ + E +++++ + G
Sbjct: 318 SVERVILPESFVLLDEMLKTMKKVLTGLEFFPENIRRNLYLTKNLIMAEPLMLKLAEKGM 377
Query: 568 DRQVCHEHIKRISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVD-NLLNPSHFTGRS 744
RQ HE +++++ +K + + D +E + K E D L P ++ G++
Sbjct: 378 GRQEAHEVVRQLA------MKAFRENRDLLEVAKESREITKYLTERDLEELKPENYIGKA 431
Query: 745 AEQVDRFLK 771
E V + ++
Sbjct: 432 REIVKKVIE 440
>sp|O66856|PUR8_AQUAE Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 437
Score = 107 bits (267), Expect = 4e-23
Identities = 68/201 (33%), Positives = 109/201 (54%), Gaps = 2/201 (0%)
Frame = +1
Query: 136 ILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLA 309
+L+ L +A+S+ K T++R L + E+ EPF Q GSSAMP+K+NP+ SERIC LA
Sbjct: 225 LLTTLGLIASSLEKFATEIRHLQRTEVLEVLEPFTKGQRGSSAMPHKKNPIHSERICGLA 284
Query: 310 RHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKM 489
R I I P M W ER + S+ R+ +P+SF+A D +L F + GLVV K+
Sbjct: 285 RVIRANSI-PAMEDVVLWHERDISHSSVERVILPDSFIALDYILNLFYEILKGLVVNKER 343
Query: 490 IEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLR 669
+ +++ A+ ILV + Q G R ++ ++R + +A + K + + +E
Sbjct: 344 MRKNMELSKGLYASSKILVLLTQKGLSRDYAYDIVQRCAMKAWESDKTFKET--LLEDPE 401
Query: 670 ADSYFAKIHEEVDNLLNPSHF 732
Y + EE++ L+P F
Sbjct: 402 VTKYLTE--EEIEKALDPWEF 420
>sp|O28041|PUR8_ARCFU Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 444
Score = 107 bits (266), Expect = 5e-23
Identities = 68/228 (29%), Positives = 121/228 (53%), Gaps = 2/228 (0%)
Frame = +1
Query: 94 LVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPY 267
L++ Q PR L LA LA ++ KI + RLL A + E+ E FE Q GSS MP+
Sbjct: 215 LISSQIIPRDSYCEYLEFLANLAATLEKIALNFRLLQRAEVGELMEKFEAKQVGSSTMPH 274
Query: 268 KRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMT 447
KRNP+ E +C LAR ++ + P ++ W ER L +S+ R+ + ES + AD +L
Sbjct: 275 KRNPIDCENVCGLAR-VVRGFVEPQHQSAILWEERDLTNSSAERITLVESTVLADHILTK 333
Query: 448 FDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNV 627
V + + + + I +++ + +EA+++ M + G RQ HE +++ + A N
Sbjct: 334 MIKVVSSVSLNLENIRRNLEMQRGLNLSEAVMIEMTKRGVGRQEAHEILRQAAMRAYEN- 392
Query: 628 KEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLK 771
++ ++ R YF + +E+ +L P ++ G + E+V+R ++
Sbjct: 393 -NSSLLDELLKDERVMKYFKE--DELREILKPENYLGTARERVERVVR 437
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,842,242
Number of Sequences: 369166
Number of extensions: 1707917
Number of successful extensions: 5042
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4817
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4982
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8052550455
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)