Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_025_E22
(873 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P21265|PUR8_CHICK Adenylosuccinate lyase (Adenylosuccina... 321 2e-87
sp|Q8HXY5|PUR8_MACFA Adenylosuccinate lyase (Adenylosuccina... 312 9e-85
sp|P30566|PUR8_HUMAN Adenylosuccinate lyase (Adenylosuccina... 311 2e-84
sp|P54822|PUR8_MOUSE Adenylosuccinate lyase (Adenylosuccina... 310 4e-84
sp|Q05911|PUR8_YEAST Adenylosuccinate lyase (Adenylosuccina... 266 7e-71
sp|O60105|PUR8_SCHPO Adenylosuccinate lyase (Adenylosuccina... 257 3e-68
sp|Q9UZ99|PUR8_PYRAB Adenylosuccinate lyase (Adenylosuccina... 108 2e-23
sp|O58582|PUR8_PYRHO Adenylosuccinate lyase (Adenylosuccina... 107 3e-23
sp|O66856|PUR8_AQUAE Adenylosuccinate lyase (Adenylosuccina... 107 4e-23
sp|O28041|PUR8_ARCFU Adenylosuccinate lyase (Adenylosuccina... 107 6e-23
>sp|P21265|PUR8_CHICK Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 459
Score = 321 bits (822), Expect = 2e-87
Identities = 161/260 (61%), Positives = 202/260 (77%), Gaps = 1/260 (0%)
Frame = +1
Query: 1 LVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLLASMKEIEEPFEP 180
LV+AKAGF ++VTGQTY RK+D +LS LA L S+HKICTD+RLLA++KEIEEPFE
Sbjct: 200 LVTAKAGFKRSYMVTGQTYSRKVDIEVLSVLASLGASVHKICTDIRLLANLKEIEEPFEK 259
Query: 181 DQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPES 360
DQ GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS QW ERTLDDSANRR+C+ E+
Sbjct: 260 DQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDPLQTASVQWFERTLDDSANRRVCLAEA 319
Query: 361 FLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIK 540
FL AD +L T N+S GLVVY K+I++ I ELPFMATE I++ MV+ G +RQ CHE I+
Sbjct: 320 FLTADIILSTLQNISEGLVVYPKVIDRRIRQELPFMATENIIMAMVKAGGNRQDCHEKIR 379
Query: 541 RISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLKTA 720
+SQ+AA VK+ G NDFI R+RAD YF+ IHE +D+LL+PS FTGR+ +QV +FLK
Sbjct: 380 VLSQQAAAVVKQEGGDNDFIARVRADPYFSPIHEHLDSLLDPSSFTGRAPQQVAKFLKEE 439
Query: 721 LKP-LDKYKHLFDEKIELNV 777
++P L Y+ + KIEL +
Sbjct: 440 VRPALIPYQSMMGGKIELTL 459
>sp|Q8HXY5|PUR8_MACFA Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 484
Score = 312 bits (799), Expect = 9e-85
Identities = 156/258 (60%), Positives = 198/258 (76%), Gaps = 1/258 (0%)
Frame = +1
Query: 1 LVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLLASMKEIEEPFEP 180
+V+ KAGF F++TGQTY RK+D +LS LA L S+HKICTD+RLLA++KE+EEPFE
Sbjct: 225 MVTDKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEK 284
Query: 181 DQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPES 360
Q GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS QW ERTLDDSANRR+C+ E+
Sbjct: 285 QQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEA 344
Query: 361 FLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIK 540
FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I++ MV+ G RQ CHE I+
Sbjct: 345 FLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIR 404
Query: 541 RISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLKTA 720
+SQ+AA VK+ G ND IER++AD+YF+ IH ++D LL+PS FTGR+++QV RFL+
Sbjct: 405 VLSQQAASVVKQEGGDNDLIERIQADAYFSPIHSQLDRLLDPSSFTGRASQQVQRFLEEE 464
Query: 721 LKPLDK-YKHLFDEKIEL 771
+ PL K Y+ + K EL
Sbjct: 465 VYPLLKPYESVMKVKAEL 482
>sp|P30566|PUR8_HUMAN Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 484
Score = 311 bits (797), Expect = 2e-84
Identities = 155/258 (60%), Positives = 198/258 (76%), Gaps = 1/258 (0%)
Frame = +1
Query: 1 LVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLLASMKEIEEPFEP 180
+V+ KAGF F++TGQTY RK+D +LS LA L S+HKICTD+RLLA++KE+EEPFE
Sbjct: 225 MVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEK 284
Query: 181 DQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPES 360
Q GSSAMPYKRNPMRSER CSLARH+MT ++PL TAS QW ERTLDDSANRR+C+ E+
Sbjct: 285 QQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEA 344
Query: 361 FLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIK 540
FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I++ MV+ G RQ CHE I+
Sbjct: 345 FLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIR 404
Query: 541 RISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLKTA 720
+SQ+AA VK+ G ND IER++ D+YF+ IH ++D+LL+PS FTGR+++QV RFL+
Sbjct: 405 VLSQQAASVVKQEGGDNDLIERIQVDAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEE 464
Query: 721 LKPLDK-YKHLFDEKIEL 771
+ PL K Y+ + K EL
Sbjct: 465 VYPLLKPYESVMKVKAEL 482
>sp|P54822|PUR8_MOUSE Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 484
Score = 310 bits (793), Expect = 4e-84
Identities = 151/246 (61%), Positives = 192/246 (78%)
Frame = +1
Query: 1 LVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLLASMKEIEEPFEP 180
+V+ KAGF F++TGQTY RK+D +LS LA L S+HKICTD+RLLA++KE+EEPFE
Sbjct: 225 MVTEKAGFKRAFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEK 284
Query: 181 DQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPES 360
Q GSSAMPYKRNPMRSER CSLARH+M ++PL TAS QW ERTLDDSANRR+C+ E+
Sbjct: 285 QQIGSSAMPYKRNPMRSERCCSLARHLMALTMDPLQTASVQWFERTLDDSANRRICLAEA 344
Query: 361 FLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIK 540
FL AD +L T N+S GLVVY K+IE+ I ELPFMATE I++ MV+ G RQ CHE I+
Sbjct: 345 FLTADTILNTLQNISEGLVVYPKVIERRIRQELPFMATENIIMAMVKAGGSRQDCHEKIR 404
Query: 541 RISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLKTA 720
+SQ+AA VK+ G ND IER+RAD+YF+ IH ++++LL+PS FTGR+ +QV RFL+
Sbjct: 405 VLSQQAAAVVKQEGGDNDLIERIRADAYFSPIHSQLEHLLDPSSFTGRAPQQVHRFLEEE 464
Query: 721 LKPLDK 738
++PL K
Sbjct: 465 VRPLLK 470
>sp|Q05911|PUR8_YEAST Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 482
Score = 266 bits (679), Expect = 7e-71
Identities = 139/262 (53%), Positives = 185/262 (70%), Gaps = 4/262 (1%)
Frame = +1
Query: 4 VSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLLASMKEIEEPFEPD 183
V+ GF + VTGQTY RK+D +L+ L+ A + HK+ TD+RLLA++KE+EEPFE
Sbjct: 223 VTELLGFDKVYPVTGQTYSRKIDIDVLAPLSSFAATAHKMATDIRLLANLKEVEEPFEKS 282
Query: 184 QDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESF 363
Q GSSAM YKRNPMR ER+CSLARH+ + + + TAS QW ERTLDDSA RR+ +P +F
Sbjct: 283 QIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAF 342
Query: 364 LAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKR 543
L AD +L T N+S+GLVVY K+IE+ I ELPFMATE I++ MV+ RQ HE I+
Sbjct: 343 LTADILLSTLLNISSGLVVYPKVIERRIKGELPFMATENIIMAMVEKNASRQEVHERIRV 402
Query: 544 ISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLK--- 714
+S +AA VKE G ND IER++ D +F I EE+D+LL PS F GR+ +QV++F++
Sbjct: 403 LSHQAAAVVKEEGGENDLIERVKRDEFFKPIWEELDSLLEPSTFVGRAPQQVEKFVQKDV 462
Query: 715 -TALKPLDKYKHLFDEKIELNV 777
AL+P KY L DE+++LNV
Sbjct: 463 NNALQPFQKY--LNDEQVKLNV 482
>sp|O60105|PUR8_SCHPO Adenylosuccinate lyase (Adenylosuccinase) (ASL) (ASASE)
Length = 482
Score = 257 bits (657), Expect = 3e-68
Identities = 136/261 (52%), Positives = 180/261 (68%), Gaps = 2/261 (0%)
Frame = +1
Query: 1 LVSAKAGFLHHFLVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLLASMKEIEEPFEP 180
LV+ +GF + + VTGQTY RK+D +L LA + HKI TD+RLLA++KE+EEPFE
Sbjct: 222 LVAKLSGFDNVYPVTGQTYDRKIDIDVLQPLASFGATAHKIATDIRLLANLKEVEEPFEA 281
Query: 181 DQDGSSAMPYKRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPES 360
Q GSSAM YKRNPMR ERICS AR+IM N L TAS QW ERTLDDS+NRR +PE+
Sbjct: 282 GQIGSSAMAYKRNPMRCERICSQARYIMNLIPNALNTASVQWFERTLDDSSNRRSLLPEA 341
Query: 361 FLAADGMLMTFDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIK 540
FL D +L NV +G+V+Y K+I++HI AELPFMATE I++ M + G R CHE I+
Sbjct: 342 FLFTDSVLKILLNVISGMVIYPKVIQKHIRAELPFMATENIIMAMTKHGASRHECHEQIR 401
Query: 541 RISQEAAVNVKEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFL-KT 717
+S +A VKE G ND IER++ YFA I++E+D+LL+ S F GR+ EQ + F+ K
Sbjct: 402 VLSHQAGRVVKEEGGDNDLIERIKNTPYFAPIYDELDSLLDASTFVGRAPEQTESFVNKD 461
Query: 718 ALKPLDKYKHLF-DEKIELNV 777
+ L +K + +EK++L V
Sbjct: 462 VSQALAPFKSMITEEKVDLAV 482
>sp|Q9UZ99|PUR8_PYRAB Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 450
Score = 108 bits (270), Expect = 2e-23
Identities = 66/223 (29%), Positives = 121/223 (54%), Gaps = 15/223 (6%)
Frame = +1
Query: 40 VTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPYK 213
+T Q R + ++ LA +A+++ K+ ++R L + E+ EPF Q GSS MP+K
Sbjct: 220 ITNQIIQRDVYAELMFFLALVASTLDKMALEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
Query: 214 RNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMTF 393
RNP+R+E++C LAR + + I P + + W ER L +S+ R+ +PESF+ D ML
Sbjct: 280 RNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKVM 338
Query: 394 DNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNVK 573
V GL + + I++++ + E +++++ + G RQ HE +++++ +A +
Sbjct: 339 KKVLKGLEFFPENIKRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHELVRQLAMKAFKEGR 398
Query: 574 E-------------YGKANDFIERLRADSYFAKIHEEVDNLLN 663
+ Y ND +E L+ ++Y K E V+N++N
Sbjct: 399 DLLEVVRKNEEAMKYLTEND-LEGLKPENYIGKAREIVENVVN 440
>sp|O58582|PUR8_PYRHO Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 450
Score = 107 bits (268), Expect = 3e-23
Identities = 67/228 (29%), Positives = 122/228 (53%), Gaps = 3/228 (1%)
Frame = +1
Query: 40 VTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPYK 213
+T Q R + +L LA +A+++ K+ ++R L + E+ EPF Q GSS MP+K
Sbjct: 220 ITNQIVQRDVYAELLFFLALVASTLDKMGLEIRNLQRTEILEVSEPFGEKQVGSSTMPHK 279
Query: 214 RNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMTF 393
RNP+R+E++C LAR + + I P + + W ER L +S+ R+ +PESF+ D ML T
Sbjct: 280 RNPIRTEKVCGLARVLYSNVI-PALLNNPLWHERDLTNSSVERVILPESFVLLDEMLKTM 338
Query: 394 DNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNVK 573
V GL + + I +++ + E +++++ + G RQ HE +++++ +K
Sbjct: 339 KKVLTGLEFFPENIRRNLYLTKNLIMAEPLMLKLAEKGMGRQEAHEVVRQLA------MK 392
Query: 574 EYGKANDFIERLRADSYFAKIHEEVD-NLLNPSHFTGRSAEQVDRFLK 714
+ + D +E + K E D L P ++ G++ E V + ++
Sbjct: 393 AFRENRDLLEVAKESREITKYLTERDLEELKPENYIGKAREIVKKVIE 440
>sp|O66856|PUR8_AQUAE Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 437
Score = 107 bits (267), Expect = 4e-23
Identities = 68/201 (33%), Positives = 109/201 (54%), Gaps = 2/201 (0%)
Frame = +1
Query: 79 ILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPYKRNPMRSERICSLA 252
+L+ L +A+S+ K T++R L + E+ EPF Q GSSAMP+K+NP+ SERIC LA
Sbjct: 225 LLTTLGLIASSLEKFATEIRHLQRTEVLEVLEPFTKGQRGSSAMPHKKNPIHSERICGLA 284
Query: 253 RHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMTFDNVSAGLVVYKKM 432
R I I P M W ER + S+ R+ +P+SF+A D +L F + GLVV K+
Sbjct: 285 RVIRANSI-PAMEDVVLWHERDISHSSVERVILPDSFIALDYILNLFYEILKGLVVNKER 343
Query: 433 IEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNVKEYGKANDFIERLR 612
+ +++ A+ ILV + Q G R ++ ++R + +A + K + + +E
Sbjct: 344 MRKNMELSKGLYASSKILVLLTQKGLSRDYAYDIVQRCAMKAWESDKTFKET--LLEDPE 401
Query: 613 ADSYFAKIHEEVDNLLNPSHF 675
Y + EE++ L+P F
Sbjct: 402 VTKYLTE--EEIEKALDPWEF 420
>sp|O28041|PUR8_ARCFU Adenylosuccinate lyase (Adenylosuccinase) (ASL)
Length = 444
Score = 107 bits (266), Expect = 6e-23
Identities = 68/228 (29%), Positives = 121/228 (53%), Gaps = 2/228 (0%)
Frame = +1
Query: 37 LVTGQTYPRKLDFTILSALAGLATSMHKICTDLRLL--ASMKEIEEPFEPDQDGSSAMPY 210
L++ Q PR L LA LA ++ KI + RLL A + E+ E FE Q GSS MP+
Sbjct: 215 LISSQIIPRDSYCEYLEFLANLAATLEKIALNFRLLQRAEVGELMEKFEAKQVGSSTMPH 274
Query: 211 KRNPMRSERICSLARHIMTQCINPLMTASTQWMERTLDDSANRRLCIPESFLAADGMLMT 390
KRNP+ E +C LAR ++ + P ++ W ER L +S+ R+ + ES + AD +L
Sbjct: 275 KRNPIDCENVCGLAR-VVRGFVEPQHQSAILWEERDLTNSSAERITLVESTVLADHILTK 333
Query: 391 FDNVSAGLVVYKKMIEQHIAAELPFMATEAILVRMVQLGEDRQVCHEHIKRISQEAAVNV 570
V + + + + I +++ + +EA+++ M + G RQ HE +++ + A N
Sbjct: 334 MIKVVSSVSLNLENIRRNLEMQRGLNLSEAVMIEMTKRGVGRQEAHEILRQAAMRAYEN- 392
Query: 571 KEYGKANDFIERLRADSYFAKIHEEVDNLLNPSHFTGRSAEQVDRFLK 714
++ ++ R YF + +E+ +L P ++ G + E+V+R ++
Sbjct: 393 -NSSLLDELLKDERVMKYFKE--DELREILKPENYLGTARERVERVVR 437
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,356,912
Number of Sequences: 369166
Number of extensions: 1780324
Number of successful extensions: 5065
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4819
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5005
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8646143400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)