DrC_00472
- Cluster detail
- GO Category :
- Consensus Sequence :
BLASTX 2.2.13 [Nov-27-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= DrC_00472 (811 letters) Database: Non-redundant SwissProt sequences 184,735 sequences; 68,354,980 total letters Score E Sequences producing significant alignments: (bits) Value sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 113 7e-25 sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 113 7e-25 sp|Q9SZ67|WRK19_ARATH Probable WRKY transcription factor 19... 112 2e-24 sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinas... 111 2e-24 sp|P27636|CDC15_YEAST Cell division control protein 15 110 3e-24 sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 110 5e-24 sp|Q6FV07|IPL1_CANGA Spindle assembly checkpoint kinase (Au... 110 5e-24 sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinas... 109 8e-24 sp|P38991|IPL1_YEAST Spindle assembly checkpoint kinase (Au... 108 1e-23 sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 108 1e-23
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 113 bits (282), Expect = 7e-25 Identities = 74/233 (31%), Positives = 120/233 (51%), Gaps = 10/233 (4%) Frame = +1 Query: 136 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEF----LDEKKYVENLIKET---- 291 A +++G+ L ++Y C + +GR K +F + K V L E Sbjct: 358 APINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK 417 Query: 292 NLEHKNIVKYYGTTEIQNKDYF--FLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLE 465 NL+H+ IV+YYG + + F+EY+ G ++ +++ L E V +YT+Q+LE Sbjct: 418 NLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAY--GALTESVTRKYTRQILE 475 Query: 466 GLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNY 645 G+++LH N ++HRDIK + IL VK+ G S+ + T ++T GT + Sbjct: 476 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVT--GTPYW 533 Query: 646 MAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGYTQTKLIIEISMTKTIP 804 M+PEVI+ E Y D+WS+G T+ EM+T PP+ Y I +I+ T P Sbjct: 534 MSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNP 586
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) Length = 626 Score = 113 bits (282), Expect = 7e-25 Identities = 76/234 (32%), Positives = 122/234 (52%), Gaps = 11/234 (4%) Frame = +1 Query: 136 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEF----LDEKKYVENLIKET---- 291 A +++G+ L ++Y C + +GR K +F + K V L E Sbjct: 358 APINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK 417 Query: 292 NLEHKNIVKYYGTTEIQNKDYF--FLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLE 465 NL+H+ IV+YYG + + F+EY+ G ++ +++ L E V +YT+Q+LE Sbjct: 418 NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAY--GALTESVTRKYTRQILE 475 Query: 466 GLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDT-TLSGNAMTDNLTRCGTYN 642 G+++LH N ++HRDIK + IL VK+ G S+ + T +SG M + GT Sbjct: 476 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMR---SVTGTPY 532 Query: 643 YMAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGYTQTKLIIEISMTKTIP 804 +M+PEVI+ E Y D+WS+G T+ EM+T PP+ Y I +I+ T P Sbjct: 533 WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNP 586
>sp|Q9SZ67|WRK19_ARATH Probable WRKY transcription factor 19 (WRKY DNA-binding protein 19) Length = 1895 Score = 112 bits (279), Expect = 2e-24 Identities = 74/212 (34%), Positives = 113/212 (53%), Gaps = 12/212 (5%) Frame = +1 Query: 148 FQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKE--------TNLEH 303 +QKG+ L +Y+ S G F K LD+ I++ + L+H Sbjct: 1626 WQKGQLLGRGSLGSVYE-GISADGDFFAFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQH 1684 Query: 304 KNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGLAFLH 483 +NIV+Y GTT+ ++ Y FLE V +L K + N L + V+ YT+Q+L+GL +LH Sbjct: 1685 QNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQR---NQLGDSVVSLYTRQILDGLKYLH 1741 Query: 484 HNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVI 663 IHR+IK + +L+ + VK+ G+++V+ +L R +N+MAPEVI Sbjct: 1742 DKGFIHRNIKCANVLVDANGTVKLADFGLAKVM-----------SLWRTPYWNWMAPEVI 1790 Query: 664 -NDED---YWYPVDIWSVGPTITEMVTGLPPY 747 N +D Y P DIWS+G T+ EM+TG PY Sbjct: 1791 LNPKDYDGYGTPADIWSLGCTVLEMLTGQIPY 1822
>sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) Length = 1597 Score = 111 bits (278), Expect = 2e-24 Identities = 75/222 (33%), Positives = 109/222 (49%), Gaps = 17/222 (7%) Frame = +1 Query: 142 FTFQKGEKLETTQTSKIYKCQESQSGRIFICK-----------VKEFLDEKKYVENLIKE 288 F +Q+G K+ Q K+Y C +G + K +KE DE K E + Sbjct: 1330 FKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--- 1386 Query: 289 TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEG 468 +H N+V+Y+G + + Y F+EY + TL + R LQE VI YTKQ+ Sbjct: 1387 ---KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSR----LGLQEHVIRLYTKQITVA 1439 Query: 469 LAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMT---DNLTRCGTY 639 + LH + ++HRDIK + I ++ ++K+ G S L NA T + + GT Sbjct: 1440 INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS----VKLKNNAQTMPGEVNSTLGTA 1495 Query: 640 NYMAPEVI---NDEDYWYPVDIWSVGPTITEMVTGLPPYHGY 756 YMAPEVI E + DIWS+G + EMVTG P+H Y Sbjct: 1496 AYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1537
>sp|P27636|CDC15_YEAST Cell division control protein 15 Length = 974 Score = 110 bits (276), Expect = 3e-24 Identities = 63/160 (39%), Positives = 86/160 (53%) Frame = +1 Query: 292 NLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGL 471 NL H NIVKY+G + Y LEY +L +++ L E Y Q L GL Sbjct: 76 NLNHNNIVKYHGFIRKSYELYILLEYCANGSL-RRLISRSSTGLSENESKTYVTQTLLGL 134 Query: 472 AFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMA 651 +LH VIHRDIK + IL+S DN VK+ G+S +V+++ LT GT N+MA Sbjct: 135 KYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSA--------LTLAGTLNWMA 186 Query: 652 PEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGYTQTKL 771 PE++ + DIWS+G T+ EM+T PPYH T + Sbjct: 187 PEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANI 226
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis NPK1-related protein kinase 3) Length = 651 Score = 110 bits (275), Expect = 5e-24 Identities = 74/231 (32%), Positives = 112/231 (48%), Gaps = 12/231 (5%) Frame = +1 Query: 148 FQKGEKLETTQTSKIYKCQESQSGRIFICK---VKEFLDEKKYVENLIKET--------N 294 ++KGE + ++Y SG + K + K+ + I+E N Sbjct: 68 WRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKN 127 Query: 295 LEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGLA 474 L H NIV+Y GT + +E+V G ++ + K E VI+ YTKQ+L GL Sbjct: 128 LSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLE--KFGSFPEPVIIMYTKQLLLGLE 185 Query: 475 FLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAP 654 +LH+N ++HRDIK + IL+ +++ G S+ V + N + GT +MAP Sbjct: 186 YLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAK---SMKGTPYWMAP 242 Query: 655 EVINDEDYWYPVDIWSVGPTITEMVTGLPPY-HGYTQTKLIIEISMTKTIP 804 EVI + + DIWSVG T+ EM TG PP+ Y Q ++ I TK P Sbjct: 243 EVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHP 293
>sp|Q6FV07|IPL1_CANGA Spindle assembly checkpoint kinase (Aurora kinase) Length = 358 Score = 110 bits (275), Expect = 5e-24 Identities = 61/208 (29%), Positives = 106/208 (50%), Gaps = 8/208 (3%) Frame = +1 Query: 148 FQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKETN--------LEH 303 F+ G KL + K+Y + +SG FIC +K + NL+K+ ++H Sbjct: 100 FEVGRKLGKGKFGKVYCVRHKKSG--FICALKAIEKNEILQFNLLKQLKREVDIQLGMDH 157 Query: 304 KNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGLAFLH 483 NI+K Y + + Y +E+ L+K +++ P + + Y Q+ + L ++H Sbjct: 158 PNIIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGP--FNDVLASHYIYQIADALHYMH 215 Query: 484 HNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVI 663 ++IHRD+KP +LI DN+VK+ G S + + T CGT +Y++PE+I Sbjct: 216 KKRIIHRDVKPENVLIGFDNVVKLADFGWS------ILNPEGSKRKTLCGTIDYLSPEMI 269 Query: 664 NDEDYWYPVDIWSVGPTITEMVTGLPPY 747 +Y VD+W++G E+V G+PP+ Sbjct: 270 TpreYDEQVDVWALGVLAYELVVGVPPF 297
>sp|Q9Y6R4|M3K4_HUMAN Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) (MAP three kinase 1) Length = 1607 Score = 109 bits (273), Expect = 8e-24 Identities = 74/222 (33%), Positives = 109/222 (49%), Gaps = 17/222 (7%) Frame = +1 Query: 142 FTFQKGEKLETTQTSKIYKCQESQSGRIFICK-----------VKEFLDEKKYVENLIKE 288 F +Q+G K+ Q K+Y C +G + K +KE DE K E + Sbjct: 1340 FKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--- 1396 Query: 289 TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEG 468 +H N+V+Y+G + + Y F+EY + TL + R LQE VI Y+KQ+ Sbjct: 1397 ---KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSR----LGLQEHVIRLYSKQITIA 1449 Query: 469 LAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMT---DNLTRCGTY 639 + LH + ++HRDIK + I ++ ++K+ G S L NA T + + GT Sbjct: 1450 INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS----VKLKNNAQTMPGEVNSTLGTA 1505 Query: 640 NYMAPEVI---NDEDYWYPVDIWSVGPTITEMVTGLPPYHGY 756 YMAPEVI E + DIWS+G + EMVTG P+H Y Sbjct: 1506 AYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1547
>sp|P38991|IPL1_YEAST Spindle assembly checkpoint kinase (Aurora kinase) (Increase-in-ploidy protein 1) Length = 367 Score = 108 bits (271), Expect = 1e-23 Identities = 68/219 (31%), Positives = 110/219 (50%), Gaps = 8/219 (3%) Frame = +1 Query: 115 KFCATSLADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKE-- 288 KF + SL DF + G+KL + K+Y + +G I KV E + KY NL K+ Sbjct: 95 KFKSLSLDDF--ELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKY--NLQKQFR 150 Query: 289 ------TNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYT 450 T+L H N+ K YG + + Y +EY+ ++K +R P + + Y Sbjct: 151 REVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGP--FNDILASDYI 208 Query: 451 KQVLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRC 630 Q+ L ++H +IHRDIKP ILI +N++K+ G S + T C Sbjct: 209 YQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSII------NPPENRRKTVC 262 Query: 631 GTYNYMAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPY 747 GT +Y++PE++ +Y + +D W++G E++TG PP+ Sbjct: 263 GTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPF 301
>sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 Length = 738 Score = 108 bits (271), Expect = 1e-23 Identities = 64/188 (34%), Positives = 101/188 (53%) Frame = +1 Query: 241 KEFLDEKKYVENLIKETNLEHKNIVKYYGTTEIQNKDYFFLEYVNGCTLHKKMRDIKPNC 420 ++ +D ++ NL+KE L H+NIV YYG ++ FLEYV G ++ + + P Sbjct: 516 RKMVDALQHEMNLLKE--LHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGP-- 571 Query: 421 LQEKVILQYTKQVLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSG 600 +E +I +T+Q+L G+A+LH +IHRDIK + ILI + VKI G+S+ + Sbjct: 572 FEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPL--N 629 Query: 601 NAMTDNLTRCGTYNYMAPEVINDEDYWYPVDIWSVGPTITEMVTGLPPYHGYTQTKLIIE 780 + G+ +M+PEV+ DIWS G + EM TG P+ ++Q + I + Sbjct: 630 KKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFK 689 Query: 781 ISMTKTIP 804 I T T P Sbjct: 690 IG-TNTTP 696
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,758,375
Number of Sequences: 369166
Number of extensions: 2099214
Number of successful extensions: 8861
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6520
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6881
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
Cluster detail
