Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_004_I17
(772 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P27636|CDC15_YEAST Cell division control protein 15 115 2e-25
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 114 4e-25
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 114 4e-25
sp|Q6FV07|IPL1_CANGA Spindle assembly checkpoint kinase (Au... 112 1e-24
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 111 2e-24
sp|Q9SZ67|WRK19_ARATH Probable WRKY transcription factor 19... 110 3e-24
sp|P38991|IPL1_YEAST Spindle assembly checkpoint kinase (Au... 110 4e-24
sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinas... 110 4e-24
sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11 110 6e-24
sp|Q10407|MKH1_SCHPO MAP kinase kinase kinase mkh1 109 9e-24
>sp|P27636|CDC15_YEAST Cell division control protein 15
Length = 974
Score = 115 bits (287), Expect = 2e-25
Identities = 65/160 (40%), Positives = 88/160 (55%)
Frame = +1
Query: 253 NLEHKNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGL 432
NL H NIVKY+G I + Y LEY +L +++ L E Y Q L GL
Sbjct: 76 NLNHNNIVKYHGFIRKSYELYILLEYCANGSL-RRLISRSSTGLSENESKTYVTQTLLGL 134
Query: 433 AFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMA 612
+LH VIHRDIK + IL+S DN VK+ G+S +V+++ LT GT N+MA
Sbjct: 135 KYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSA--------LTLAGTLNWMA 186
Query: 613 PEVINDEDYWYPVDIWSVGATITEMVTGLPPYHGFTQTKL 732
PE++ + DIWS+GAT+ EM+T PPYH T +
Sbjct: 187 PEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANI 226
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 114 bits (284), Expect = 4e-25
Identities = 73/233 (31%), Positives = 121/233 (51%), Gaps = 10/233 (4%)
Frame = +1
Query: 97 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEF----LDEKKYVENLIKET---- 252
A +++G+ L ++Y C + +GR K +F + K V L E
Sbjct: 358 APINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK 417
Query: 253 NLEHKNIVKYYGTIEIQNKDYF--FLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLE 426
NL+H+ IV+YYG + + + F+EY+ G ++ +++ L E V +YT+Q+LE
Sbjct: 418 NLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAY--GALTESVTRKYTRQILE 475
Query: 427 GLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNY 606
G+++LH N ++HRDIK + IL VK+ G S+ + T ++T GT +
Sbjct: 476 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVT--GTPYW 533
Query: 607 MAPEVINDEDYWYPVDIWSVGATITEMVTGLPPYHGFTQTKLIIEISMTKTIP 765
M+PEVI+ E Y D+WS+G T+ EM+T PP+ + I +I+ T P
Sbjct: 534 MSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNP 586
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 114 bits (284), Expect = 4e-25
Identities = 75/234 (32%), Positives = 123/234 (52%), Gaps = 11/234 (4%)
Frame = +1
Query: 97 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEF----LDEKKYVENLIKET---- 252
A +++G+ L ++Y C + +GR K +F + K V L E
Sbjct: 358 APINWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLK 417
Query: 253 NLEHKNIVKYYGTIEIQNKDYF--FLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLE 426
NL+H+ IV+YYG + + + F+EY+ G ++ +++ L E V +YT+Q+LE
Sbjct: 418 NLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAY--GALTESVTRKYTRQILE 475
Query: 427 GLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDT-TLSGNAMTDNLTRCGTYN 603
G+++LH N ++HRDIK + IL VK+ G S+ + T +SG M + GT
Sbjct: 476 GMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMR---SVTGTPY 532
Query: 604 YMAPEVINDEDYWYPVDIWSVGATITEMVTGLPPYHGFTQTKLIIEISMTKTIP 765
+M+PEVI+ E Y D+WS+G T+ EM+T PP+ + I +I+ T P
Sbjct: 533 WMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNP 586
>sp|Q6FV07|IPL1_CANGA Spindle assembly checkpoint kinase (Aurora kinase)
Length = 358
Score = 112 bits (279), Expect = 1e-24
Identities = 61/208 (29%), Positives = 106/208 (50%), Gaps = 8/208 (3%)
Frame = +1
Query: 109 FQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKETN--------LEH 264
F+ G KL + K+Y + +SG FIC +K + NL+K+ ++H
Sbjct: 100 FEVGRKLGKGKFGKVYCVRHKKSG--FICALKAIEKNEILQFNLLKQLKREVDIQLGMDH 157
Query: 265 KNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGLAFLH 444
NI+K Y + + Y +E+ L+K +++ P + + Y Q+ + L ++H
Sbjct: 158 PNIIKLYAHFHDEKRVYLLMEHSINGELYKSLKNNGP--FNDVLASHYIYQIADALHYMH 215
Query: 445 HNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVI 624
++IHRD+KP +LI DN+VK+ G S + + T CGT +Y++PE+I
Sbjct: 216 KKRIIHRDVKPENVLIGFDNVVKLADFGWS------ILNPEGSKRKTLCGTIDYLSPEMI 269
Query: 625 NDEDYWYPVDIWSVGATITEMVTGLPPY 708
+Y VD+W++G E+V G+PP+
Sbjct: 270 TpreYDEQVDVWALGVLAYELVVGVPPF 297
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 111 bits (277), Expect = 2e-24
Identities = 73/231 (31%), Positives = 113/231 (48%), Gaps = 12/231 (5%)
Frame = +1
Query: 109 FQKGEKLETTQTSKIYKCQESQSGRIFICK---VKEFLDEKKYVENLIKET--------N 255
++KGE + ++Y SG + K + K+ + I+E N
Sbjct: 68 WRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQLLKN 127
Query: 256 LEHKNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGLA 435
L H NIV+Y GT+ + +E+V G ++ + K E VI+ YTKQ+L GL
Sbjct: 128 LSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLE--KFGSFPEPVIIMYTKQLLLGLE 185
Query: 436 FLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAP 615
+LH+N ++HRDIK + IL+ +++ G S+ V + N + GT +MAP
Sbjct: 186 YLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATVNGAK---SMKGTPYWMAP 242
Query: 616 EVINDEDYWYPVDIWSVGATITEMVTGLPPY-HGFTQTKLIIEISMTKTIP 765
EVI + + DIWSVG T+ EM TG PP+ + Q ++ I TK P
Sbjct: 243 EVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHP 293
>sp|Q9SZ67|WRK19_ARATH Probable WRKY transcription factor 19 (WRKY DNA-binding protein 19)
Length = 1895
Score = 110 bits (276), Expect = 3e-24
Identities = 73/212 (34%), Positives = 112/212 (52%), Gaps = 12/212 (5%)
Frame = +1
Query: 109 FQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKE--------TNLEH 264
+QKG+ L +Y+ S G F K LD+ I++ + L+H
Sbjct: 1626 WQKGQLLGRGSLGSVYE-GISADGDFFAFKEVSLLDQGSQAHEWIQQVEGGIALLSQLQH 1684
Query: 265 KNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEGLAFLH 444
+NIV+Y GT + ++ Y FLE V +L K + N L + V+ YT+Q+L+GL +LH
Sbjct: 1685 QNIVRYRGTTKDESNLYIFLELVTQGSLRKLYQR---NQLGDSVVSLYTRQILDGLKYLH 1741
Query: 445 HNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGTYNYMAPEVI 624
IHR+IK + +L+ + VK+ G+++V+ +L R +N+MAPEVI
Sbjct: 1742 DKGFIHRNIKCANVLVDANGTVKLADFGLAKVM-----------SLWRTPYWNWMAPEVI 1790
Query: 625 -NDED---YWYPVDIWSVGATITEMVTGLPPY 708
N +D Y P DIWS+G T+ EM+TG PY
Sbjct: 1791 LNPKDYDGYGTPADIWSLGCTVLEMLTGQIPY 1822
>sp|P38991|IPL1_YEAST Spindle assembly checkpoint kinase (Aurora kinase)
(Increase-in-ploidy protein 1)
Length = 367
Score = 110 bits (275), Expect = 4e-24
Identities = 68/219 (31%), Positives = 110/219 (50%), Gaps = 8/219 (3%)
Frame = +1
Query: 76 KFCAASLADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLDEKKYVENLIKE-- 249
KF + SL DF + G+KL + K+Y + +G I KV E + KY NL K+
Sbjct: 95 KFKSLSLDDF--ELGKKLGKGKFGKVYCVRHRSTGYICALKVMEKEEIIKY--NLQKQFR 150
Query: 250 ------TNLEHKNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYT 411
T+L H N+ K YG + + Y +EY+ ++K +R P + + Y
Sbjct: 151 REVEIQTSLNHPNLTKSYGYFHDEKRVYLLMEYLVNGEMYKLLRLHGP--FNDILASDYI 208
Query: 412 KQVLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRC 591
Q+ L ++H +IHRDIKP ILI +N++K+ G S + T C
Sbjct: 209 YQIANALDYMHKKNIIHRDIKPENILIGFNNVIKLTDFGWSII------NPPENRRKTVC 262
Query: 592 GTYNYMAPEVINDEDYWYPVDIWSVGATITEMVTGLPPY 708
GT +Y++PE++ +Y + +D W++G E++TG PP+
Sbjct: 263 GTIDYLSPEMVESREYDHTIDAWALGVLAFELLTGAPPF 301
>sp|O08648|M3K4_MOUSE Mitogen-activated protein kinase kinase kinase 4 (MAPK/ERK kinase
kinase 4) (MEK kinase 4) (MEKK 4)
Length = 1597
Score = 110 bits (275), Expect = 4e-24
Identities = 74/222 (33%), Positives = 109/222 (49%), Gaps = 17/222 (7%)
Frame = +1
Query: 103 FTFQKGEKLETTQTSKIYKCQESQSGRIFICK-----------VKEFLDEKKYVENLIKE 249
F +Q+G K+ Q K+Y C +G + K +KE DE K E +
Sbjct: 1330 FKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGI--- 1386
Query: 250 TNLEHKNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQVLEG 429
+H N+V+Y+G + + Y F+EY + TL + R LQE VI YTKQ+
Sbjct: 1387 ---KHPNLVRYFGVELHREEMYIFMEYCDEGTLEEVSR----LGLQEHVIRLYTKQITVA 1439
Query: 430 LAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMT---DNLTRCGTY 600
+ LH + ++HRDIK + I ++ ++K+ G S L NA T + + GT
Sbjct: 1440 INVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCS----VKLKNNAQTMPGEVNSTLGTA 1495
Query: 601 NYMAPEVI---NDEDYWYPVDIWSVGATITEMVTGLPPYHGF 717
YMAPEVI E + DIWS+G + EMVTG P+H +
Sbjct: 1496 AYMAPEVITRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEY 1537
>sp|P23561|STE11_YEAST Serine/threonine-protein kinase STE11
Length = 738
Score = 110 bits (274), Expect = 6e-24
Identities = 65/188 (34%), Positives = 100/188 (53%)
Frame = +1
Query: 202 KEFLDEKKYVENLIKETNLEHKNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNC 381
++ +D ++ NL+KE L H+NIV YYG + FLEYV G ++ + + P
Sbjct: 516 RKMVDALQHEMNLLKE--LHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGP-- 571
Query: 382 LQEKVILQYTKQVLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSG 561
+E +I +T+Q+L G+A+LH +IHRDIK + ILI + VKI G+S+ +
Sbjct: 572 FEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFGISKKLSPL--N 629
Query: 562 NAMTDNLTRCGTYNYMAPEVINDEDYWYPVDIWSVGATITEMVTGLPPYHGFTQTKLIIE 741
+ G+ +M+PEV+ DIWS G + EM TG P+ F+Q + I +
Sbjct: 630 KKQNKRASLQGSVFWMSPEVVKQTATTAKADIWSTGCVVIEMFTGKHPFPDFSQMQAIFK 689
Query: 742 ISMTKTIP 765
I T T P
Sbjct: 690 IG-TNTTP 696
>sp|Q10407|MKH1_SCHPO MAP kinase kinase kinase mkh1
Length = 1116
Score = 109 bits (272), Expect = 9e-24
Identities = 70/238 (29%), Positives = 120/238 (50%), Gaps = 15/238 (6%)
Frame = +1
Query: 97 ADFTFQKGEKLETTQTSKIYKCQESQSGRIFICKVKEFLD---------EKKYVENLIKE 249
A F + KGE + K++ +G + K E K V+++ E
Sbjct: 821 ATFKWMKGELIGNGTYGKVFLAMNINTGELIAVKQVEIPQTINGRHDQLRKDIVDSINAE 880
Query: 250 ----TNLEHKNIVKYYGTIEIQNKDYFFLEYVNGCTLHKKMRDIKPNCLQEKVILQYTKQ 417
+L+H NIV+Y G + + FLEYV+G ++ + +R+ P +E+++ ++Q
Sbjct: 881 ISMIADLDHLNIVQYLGFEKTETDISIFLEYVSGGSIGRCLRNYGP--FEEQLVRFVSRQ 938
Query: 418 VLEGLAFLHHNKVIHRDIKPSKILISVDNIVKICGLGMSRVVDTTLSGNAMTDNLTRCGT 597
VL GL++LH +IHRD+K +LI D + KI G+S+ D +A NL+ G+
Sbjct: 939 VLYGLSYLHSKGIIHRDLKADNLLIDFDGVCKISDFGISKHSDNVYDNDA---NLSMQGS 995
Query: 598 YNYMAPEVINDEDYWY--PVDIWSVGATITEMVTGLPPYHGFTQTKLIIEISMTKTIP 765
+MAPEVI+++ Y VD+WS+G + EM+ G P+ + + ++ K P
Sbjct: 996 IFWMAPEVIHNDHQGYSAKVDVWSLGCVVLEMLAGRRPWSTDEAIQAMFKLGTEKKAP 1053
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,870,070
Number of Sequences: 369166
Number of extensions: 1985045
Number of successful extensions: 8875
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6485
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6817
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7163732800
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)